Dioxin exposure of human CD34+ hemopoietic cells induces gene expression modulation that recapitulates its in vivo clinical and biological effects

Toxicology

Volumn 283, Issue 1, 2011, Pages 18-23

  Fracchiolla, Nicola Stefano ^a,b   Todoerti, Katia ^a,b,f   Bertazzi, Pier Alberto ^b,d,f   Servida, Federica ^c   Corradini, Paolo ^e,f   Carniti, Cristiana ^e   Colombi, Antonio ^d,f   Cecilia Pesatori, Angela ^b,d,f   Neri, Antonino ^a,b,f   Deliliers, Giorgio Lambertenghi ^a,b,f  

^a UO Ematologia 1 Centro Trapianti di Midollo   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c Fondazione Matarelli   (Italy)

^d Epidemiology Research Center   (Italy)

^e NATIONAL CANCER INSTITUTE   (Italy)

^f UNIVERSITY OF MILAN   (Italy)

Author keywords

CD34+ cells; Cytotoxicity; Dioxin; Gene expression; Microarrays

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CD34 ANTIGEN; DIOXIN;

ANGIOGENESIS; ARTICLE; CELL ADHESION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DIABETOGENESIS; DYSLIPIDEMIA; FEMALE INFERTILITY; GABAERGIC TRANSMISSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; IN VITRO STUDY; LIPID METABOLISM; MALE INFERTILITY; MALIGNANT TRANSFORMATION; MICROARRAY ANALYSIS; NEUROLOGIC DISEASE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANTIGENS, CD34; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HEMATOPOIETIC SYSTEM; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TETRACHLORODIBENZODIOXIN;

EID: 79953098784     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2011.01.025     Document Type: Article

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