Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible and -suppressive genes in the rat placenta: Induction of interferon-regulated genes with possible inhibitory roles for angiogenesis in the placenta

Endocrine Journal

Volumn 51, Issue 6, 2004, Pages 569-577

  Mizutani, Tetsuya ^a,b   Yoshino, Miki ^a,b   Satake, Tomoko ^a,b   Nakagawa, Miyuki ^a,b   Ishimura, Ryuta ^b,c   Tohyama, Chiharu ^b,c   Kokame, Koichi ^d   Kangawa, Kenji ^d   Miyamoto, Kaoru ^a,b  

^a UNIVERSITY OF FUKUI   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^d NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

DNA microarray; Gene expression; Placenta; Real time PCR; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANGIOGENESIS INHIBITOR; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCOSE TRANSPORTER; INTERFERON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; EVALUATION; FEMALE; FETUS DEATH; GENE EXPRESSION; GENE INDUCTION; GENE REPRESSION; GESTATIONAL AGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLACENTA FUNCTION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UNINDEXED SEQUENCE; UPREGULATION;

ANIMALS; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; INTERFERONS; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES; PLACENTA; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TERATOGENS; TETRACHLORODIBENZODIOXIN;

EID: 13444292895     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.51.569     Document Type: Article

References (27)

1. Couture L, Abbott B, Birnbaum L (1990) A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p- dioxin: recent advances toward understanding the mechanism. Teratology 42: 619-627.
2. Birnbaum L (1995) Developmental effects of dioxins and related endocrine disrupting chemicals. Toxicol Lett 82-83: 743-750.
3. Lindstrom G, Hooper K, Petreas M, Stephens R, Gilman A (1995) Workshop on perinatal exposure to dioxin-like compounds. I. Summary. Environ Health Perspect 103: 135-142.
4. Ohsako S, Miyabara Y, Nishimura N, Kurosawa S, Sakaue M, Ishimura R, Sato M, Takeda K, Aoki Y, Sone H, Tohyama C, Yonemoto J (2001) Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of 5alpha-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate. Toxicol Sci 60: 132-143.
5. Couture L, Harris M, Birnbaum L (1990) Characterization of the peak period of sensitivity for the induction of hydronephrosis in C57BL/6N mice following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol 15: 142-150.
6. Schecter A, Olson J, Papke O (1996) Exposure of laboratory animals to polychlorinated dibenzodioxins and polychlorinated dibenzofurans from commercial rodent chow. Chemosphere 32: 501-508.
7. Guo Y, Hendrickx A, Overstreet J, Dieter J, Stewart D, Tarantal A, Laughlin L, Lasley B (1999) Endocrine biomarkers of early fetal loss in cynomolgus macaques (Macaca fascicularis) following exposure to dioxin. Biol Reprod 60: 707-713.
8. Ishimura R, Ohsako S, Miyabara Y, Sakaue M, Kawakami T, Aoki Y, Yonemoto J, Tohyama C (2002) Increased glycogen content and glucose transporter 3 mRNA level in the placenta of Holtzman rats after exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 178: 161-171.
9. Ishimura R, Ohsako S, Kawakami T, Sakaue M, Aoki Y, Tohyama C (2002) Altered protein profile and possible hypoxia in the placenta of 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed rats. Toxicol Appl Pharmacol 185: 197-206.
10. Pastorian K, Hawel L, Byus C (2000) Optimization of cDNA representational difference analysis for the identification of differentially expressed mRNAs. Anal Biochem 283: 89-98.
11. Mizutani T, Sonoda Y, Minegishi T, Wakabayashi K, Miyamoto K (1997) Cloning, characterization, and cellular distribution of rat scavenger receptor class B type I (SRBI) in the ovary. Biochem Biophys Res Commun 234: 499-505.
12. Sekiguchi T, Mizutani T, Yamada K, Yazawa T, Kawata H, Yoshino M, Kajitani T, Kameda T, Minegishi T, Miyamoto K (2002) Transcriptional regulation of the epiregulin gene in the rat ovary. Endocrinology 143: 4718-4729.
13. Mizutani T, Yamada K, Yazawa T, Okada T, Minegishi T, Miyamoto K (2001) Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. Mol Endocrinol 15: 1693-1705.
14. Lancaster J, Dressman H, Whitaker R, Havrilesky L, Gray J, Marks J, Nevins J, Berchuck A (2004) Gene expression patterns that characterize advanced stage serous ovarian cancers. J Soc Gynecol Investig 11: 51-59.
15. Whitlock JJ (1999) Induction of cytochrome P4501A1. Annu Rev Pharmacol Toxicol 39: 103-125.
16. Whitlock JJ, Chichester C, Bedgood R, Okino S, Ko H, Ma Q, Dong L, Li H, Clarke-Katzenberg R (1997) Induction of drug-metabolizing enzymes by dioxin. Drug Metab Rev 29: 1107-1127.
17. Angiolillo A, Sgadari C, Taub D, Liao F, Farber J, Maheshwari S, Kleinman H, Reaman G, Tosato G (1995) Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med 182: 155-162.
18. Stricter R, Kunkel S, Arenberg D, Burdick M, Polverini P (1995) Interferon gamma-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis. Biochem Biophys Res Commun 210: 51-51.
19. Singh U, Singh S, Iqbal N, Weaver C, McGhee J, Lillard JJ (2003) IFN-gamma-inducible chemokines enhance adaptive immunity and colitis. J Interferon Cytokine Res 23: 591-600.
20. Neumann B, Emmanuilidis K, Stadler M, Holzmann B (1998) Distinct functions of interferon-gamma for chemokine expression in models of acute lung inflammation. Immunology 95: 512-521.
21. Semenza G (1999) Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15: 551-578.
22. Leonard W (2001) Role of Jak kinases and STATs in cytokine signal transduction. Int J Hematol 73: 271-277.
23. Yu-Lee L (2002) Prolactin modulation of immune and inflammatory responses. Recent Prog Harm Res 57: 435-455.
24. Southard J, Talamantes F (1991) Placental prolactin-like proteins in rodents: variations on a structural theme. Mol Cell Endocrinol 79: 133-140.
25. Friesel R, Komoriya A, Maciag T (1987) Inhibition of endothelial cell proliferation by gamma-interferon. J Cell Biol 104: 689-696.
26. Good D, Polverini P, Rastinejad F, Le Beau M, Lemons R, Frazier W, Bouck N (1990) A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc Natl Acad Sci USA 87: 6624-6628.
27. Takigawa M, Nishida Y, Suzuki F, Kishi J, Yamashita K, Hayakawa T (1990) Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2). Biochem Biophys Res Commun 171: 1264-1271.