Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: Further evidence for cannabinoid CB2 receptor absence in the rat central nervous system

European Journal of Pharmacology

Volumn 377, Issue 1, 1999, Pages 117-125

  Griffin, Graeme ^a   Wray, Emma J ^a   Tao, Qing ^a   McAllister, Sean D ^a   Rorrer, William K ^a   Aung, Miemie ^a   Martin, Billy R ^a   Abood, Mary E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cannabinoid; Cannabinoid CB2 receptor; Cannabinoid receptor antagonist; GTP S binding; Radioligand binding; SR144528

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANANDAMIDE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); RECEPTOR SUBTYPE; RIMONABANT; UNCLASSIFIED DRUG; BORNANE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR CB2, RAT; DRUG RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; MESSENGER RNA; MORPHOLINE DERIVATIVE; NAPHTHALENE DERIVATIVE; POTASSIUM CHANNEL; PYRAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RADIOASSAY; RAT; XENOPUS LAEVIS; ANIMAL; BINDING COMPETITION; BRAIN; CELL MEMBRANE POTENTIAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; MEMBRANE; METABOLISM; OOCYTE; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; BINDING, COMPETITIVE; BLOTTING, NORTHERN; BORNANES; BRAIN; CALCIUM CHANNEL BLOCKERS; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MALE; MEMBRANE POTENTIALS; MEMBRANES; MORPHOLINES; NAPHTHALENES; OOCYTES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PYRAZOLES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RNA, MESSENGER; TISSUE DISTRIBUTION; XENOPUS LAEVIS;

EID: 0032588414     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00402-1     Document Type: Article

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