Regulatory T cell induction during Plasmodium chabaudi infection modifies the clinical course of experimental autoimmune encephalomyelitis

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Farias, Alessandro S ^a   Talaisys, Rafael L ^a   Blanco, Yara C ^a   Lopes, Stefanie C P ^a   Longhini, Ana Leda F ^a   Pradella, Fernando ^a   Santos, Leonilda M B ^a   Costa, Fabio T M ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; TRANSFORMING GROWTH FACTOR BETA1; CYTOKINE; INTERLEUKIN 2 RECEPTOR ALPHA;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE COURSE; IMMUNOREGULATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM CHABAUDI INFECTION; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SYMPTOMATOLOGY; ANIMAL; AUTOIMMUNITY; C57BL MOUSE; CELL SURVIVAL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; MALARIA; METABOLISM; PARASITOLOGY; PLASMODIUM CHABAUDI;

ANIMALIA; MUS; PLASMODIUM CHABAUDI;

ANIMALS; AUTOIMMUNITY; CELL SURVIVAL; CYTOKINES; DISEASE PROGRESSION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALARIA; MICE; MICE, INBRED C57BL; PLASMODIUM CHABAUDI; T-LYMPHOCYTES, REGULATORY;

EID: 79953056711     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017849     Document Type: Article

References (39)

1. Hauser SL, Oksenberg JR, (2006) The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 52: 61-76.
2. Brocke S, Gaur A, Piercy C, Gautam A, Gijbels K, et al. (1993) Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature 365: 642-644.
3. Peacock JW, Elsawa SF, Petty CC, Hickey WF, Bost KL, (2003) Exacerbation of experimental autoimmune encephalomyelitis in rodents infected with murine gammaherpesvirus-68. Eur J Immunol 33: 1849-1858.
4. Lehmann D, Ben-Nun A, (1992) Bacterial agents protect against autoimmune disease. I. Mice pre-exposed to Bordetella pertussis or Mycobacterium tuberculosis are highly refractory to induction of experimental autoimmune encephalomyelitis. J Autoimmun 5: 675-690.
5. Tadokoro CE, Vallochi AL, Rios LS, Martins GA, Schlesinger D, et al. (2004) Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi. J Autoimmun 23: 103-115.
6. Bach JF, (2001) Protective role of infections and vaccinations on autoimmune diseases. J Autoimmun 16: 347-353.
7. Korn T, Oukka M, Kuchroo V, Bettelli E, (2007) Th17 cells: effector T cells with inflammatory properties. Semin Immunol 19: 362-371.
8. O'Connor RA, Prendergast CT, Sabatos CA, Lau CW, Leech MD, et al. (2008) Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J Immunol 181: 3750-3754.
9. Shevach EM, (2009) Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30: 636-645.
10. Wing K, Sakaguchi S, (2010) Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 11: 7-13.
11. Tang Q, Bluestone JA, (2008) The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 9: 239-244.
12. Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, et al. (2006) Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 212: 8-27.
13. O'Connor RA, Anderton SM, (2008) Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease. J Neuroimmunol 193: 1-11.
14. Feger U, Luther C, Poeschel S, Melms A, Tolosa E, et al. (2007) Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients. Clin Exp Immunol 147: 412-418.
15. Anderton SM, Liblau RS, (2008) Regulatory T cells in the control of inflammatory demyelinating diseases of the central nervous system. Curr Opin Neurol 21: 248-254.
16. McGeachy MJ, Stephens LA, Anderton SM, (2005) Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system. J Immunol 175: 3025-3032.
17. Hisaeda H, Yasutomo K, Himeno K, (2005) Malaria: immune evasion by parasites. Int J Biochem Cell Biol 37: 700-706.
18. Finney OC, Nwakanma D, Conway DJ, Walther M, Riley EM, (2009) Homeostatic regulation of T effector to Treg ratios in an area of seasonal malaria transmission. Eur J Immunol 39: 1288-1300.
19. Walther M, Jeffries D, Finney OC, Njie M, Ebonyi A, et al. (2009) Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria. PLoS Pathog 5: e1000364.
20. Riley EM, Wahl S, Perkins DJ, Schofield L, (2006) Regulating immunity to malaria. Parasite Immunol 28: 35-49.
21. Bueno LL, Morais CG, Araujo FF, Gomes JA, Correa-Oliveira R, et al. Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites. PLoS ONE 5: e9623.
22. Minigo G, Woodberry T, Piera KA, Salwati E, Tjitra E, et al. (2009) Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria. PLoS Pathog 5: e1000402.
23. Walther M, Tongren JE, Andrews L, Korbel D, King E, et al. (2005) Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. Immunity 23: 287-296.
24. Farias AS, de la Hoz C, Castro FR, Oliveira EC, Ribeiro dos Reis JR, et al. (2007) Nitric oxide and TNFalpha effects in experimental autoimmune encephalomyelitis demyelination. Neuroimmunomodulation 14: 32-38.
25. Blanco YC, Farias AS, Goelnitz U, Lopes SC, Arrais-Silva WW, et al. (2008) Hyperbaric oxygen prevents early death caused by experimental cerebral malaria. PLoS ONE 3: e3126.
26. Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, et al. (2005) Multiple sclerosis. Immunol Rev 204: 208-231.
27. Omer FM, de Souza JB, Corran PH, Sultan AA, Riley EM, (2003) Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule. J Exp Med 198: 1817-1827.
28. Chen W, Jin W, Hardegen N, Lei KJ, Li L, et al. (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198: 1875-1886.
29. Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S, et al. (2008) A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol 9: 632-640.
30. Nie CQ, Bernard NJ, Schofield L, Hansen DS, (2007) CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis. Infect Immun 75: 2275-2282.
31. Cambos M, Belanger B, Jacques A, Roulet A, Scorza T, (2008) Natural regulatory (CD4+CD25+FOXP+) T cells control the production of pro-inflammatory cytokines during Plasmodium chabaudi adami infection and do not contribute to immune evasion. Int J Parasitol 38: 229-238.
32. Scholzen A, Mittag D, Rogerson SJ, Cooke BM, Plebanski M, (2009) Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta. PLoS Pathog 5: e1000543.
33. Furtado GC, Olivares-Villagomez D, Curotto de Lafaille MA, Wensky AK, Latkowski JA, et al. (2001) Regulatory T cells in spontaneous autoimmune encephalomyelitis. Immunol Rev 182: 122-134.
34. Olivares-Villagomez D, Wang Y, Lafaille JJ, (1998) Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med 188: 1883-1894.
35. Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, et al. (2007) Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 13: 423-431.
36. Bettini M, Vignali DA, (2009) Regulatory T cells and inhibitory cytokines in autoimmunity. Curr Opin Immunol 21: 612-618.
37. Strauch UG, Obermeier F, Grunwald N, Gurster S, Dunger N, et al. (2005) Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis. Gut 54: 1546-1552.
38. Todryk SM, Walther M, Bejon P, Hutchings C, Thompson FM, et al. (2009) Multiple functions of human T cells generated by experimental malaria challenge. Eur J Immunol 39: 3042-3051.
39. Thornton AM, Shevach EM, (2000) Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol 164: 183-190.