Nitric oxide and TNFα effects in experimental autoimmune encephalomyelitis demyelination

NeuroImmunoModulation

Volumn 14, Issue 1, 2007, Pages 32-38

  Farias, Alessandro S ^a   De La Hoz, Cristiane ^a   Castro, Fabiano R ^a   Oliveira, Elaine C ^a   Ribeiro Dos Reis, Jose R ^a   Silva, João S ^b   Langone, Francesco ^a   Santos, Leonilda M B ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Encephalomyelitis; Macrophage activation; Nitric oxide

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; NITRIC OXIDE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEMYELINATING DISEASE; DISEASE COURSE; DRUG EFFECT; FEMALE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; WILD TYPE; ANIMAL; C57BL MOUSE; CONFOCAL MICROSCOPY; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; SPINAL CORD; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; SPINAL CORD; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34548341775     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000107286     Document Type: Article

References (30)

1. Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C: Multiple sclerosis. Immunol Rev 2005;204:208-231.
2. Sakuma H, Park IK, Kohyama K, Feng D, Matsumoto Y: Quantitation of myelin oligodendrocyte glycoprotein and myelin basic protein in the thymus and central nervous system and its relationship to the clinicopathologic features of autoimmune encephalomyelitis. J Neurosci Res 2006;84:606-613.
3. Kuchroo VK, Martin CA, Greer JM, Ju ST, Sobel RA, Dorf ME: Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J Immunol 1993;151:4371-4382.
4. McRae BL, Kennedy MK, Tan LJ, Dal Canto MC, Picha KS, Miller SD: Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein. J Neuroimmunol 1992;38:229-240.
5. al-Sabbagh AM, Goad EP, Weiner HL, Nelson PA: Decreased CNS inflammation and absence of clinical exacerbation of disease after six months oral administration of bovine myelin in diseased SJL/J mice with chronic relapsing experimental autoimmune encephalomyelitis. J Neurosci Res 1996;45:424-429.
6. Merrill JE, Ignarro LJ, Sherman MP, Melinek J, Lane TE: Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol 1993;151:2132-2141.
7. Bo L, Dawson TM, Wesselingh S, Mork S, Choi S, Kong PA, Hanley D, Trapp BD: Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol 1994;36:778-786.
8. Cross AH, Misko TP, Lin RF, Hickey WF, Trotter JL, Tilton RG: Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J Clin Invest 1994;93:2684-2690.
9. Bagasra O, Michaels FH, Zheng YM, Bobroski LE, Spitsin SV, Fu ZF, Tawadros R, Koprowski H: Local nitric oxide production in viral and autoimmune diseases of the central nervous system. Proc Natl Acad Sci USA 1995;92:5312-5316.
10. Hooper DC, Ohnishi ST, Kean R, Numagami Y, Dietzschold B, Koprowski H: Local nitric oxide production in viral and autoimmune diseases of the central nervous system. Proc Natl Acad Sci USA 1995;92:5312-5316.
11. Misko TP, Trotter JL, Cross AH: Mediation of inflammation by encephalitogenic cells, interferon gamma induction of nitric oxide synthase and cyclooxygenase 2. J Neuroimmunol 1995;61:195-204.
12. Zhao W, Tilton RG, Corbett JA, McDaniel ML, Misko TP, Williamson JR, Cross AH, Hickey WF: Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase. J Neuroimmunol 1996;64:123-133.
13. Ding M, Zhang M, Wong JL, Rogers NE, Ignarro LJ, Voskuhl RR: Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice. J Immunol 1998;160:2560-2564.
14. Zielasek J, Jung S, Gold R, Liew FY, Toyka KV, Hartung HP: Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis. J Neuroimmunol 1995;58:81-88.
15. Dawson VL, Dawson TM: Nitric oxide in neuronal degeneration. Proc Soc Exp Biol Med 1996;211:33-40.
16. Langermans JA, van der Hulst ME, Nibbering PH, Hiemstra PS, Fransen L, Van Furth R: IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha. J Immunol 1992;148:568-574.
17. Teixeira SA, Castro GM, Papes F, Martins ML, Rogerio F, Langone F, Santos LM, Arruda P, de Nucci G, Muscara MN: Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis. Mol Brain Res 2002;99:17-25.
18. Crocker SJ, Whitmire JK, Chertboonmuang P, Soloway PD, Whitton JL, Campbell IL: Persistent macrophage/microglia activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1 deficient mice. Immunopathol Infect Dis 2006;169:2104-2116.
19. Mendel I, Kerlero de Rosbo N, Ben-Nun A: A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T-cell Vβ expression of encephalitogenic T cells. Eur J Immunol 1995;25:1951-1959.
20. Sicher SC, Vazquez MA, Lu CY: Inhibition of macrophage Ia expression by nitric oxide. J Immunol 1994;153:1293-1300.
21. Kubes P, Suzuki M, Granger DN: Nitric oxide, an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991;88:4651-4655.
22. Young DA, Lowe LD, Booth SS, Whitters MJ, Nicholson L, Kuchroo VK, Collins M: IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone downregulate adoptive transfer of experimental autoimmune encephalomyelitis. J Immunol 2000;164:3563-3572.
23. Selmaj K, Raine CS, Cannella B, Brosnan CF: Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 1991;87:949-954.
24. Selmaj KW, Raine CS: Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 1988;23:339-346.
25. Pollak Y, Ovadia H, Orion E, Weidenfeld J, Yirmiya R: The EAE-associated behavioral syndrome. I. Temporal correlation with inflammatory mediators. J Neuroimmunol 2003;137:94-99.
26. Ahn M, Kang J, Lee Y, Riu K, Kim Y, Jee Y, Matsumoto Y, Shin T: Pertussis toxin-induced hyperacute autoimmune encephalomyelitis in Lewis rats is correlated with increased expression of inducible nitric oxide synthase and tumor necrosis factor alpha. Neurosci Lett 2001;308:41-44.
27. Borderie D, Hilliquin P, Hernvann A, Lemarechal H, Kahan A, Menkes CJ, Ekindjian OG: Inhibition of inducible NO synthase by Th2 cytokines and TGFβ in rheumatoid arthritic synoviocytes: effects on nitrosothiol production. Nitric Oxide 2002;10:1-12.
28. Oswald IP, Gazzinelli RT, Sher A, James SL: IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity. J Immunol 1992;148:3578-3582.
29. Papadopoulos D, Pham-Dinh D, Reynolds R: Axon loss is responsible for chronic neurological deficit following inflammatory demyelination in the rat. Exp Neurol 2006;197:373-385.
30. Marques KB, Santos LM, Oliveira AL: Spinal motoneuron synaptic plasticity during the course of an animal model of multiple sclerosis. Eur J Neurosci 2006;24:3053-3062.