The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in regulatory T cells

Journal of Immunotherapy

Volumn 34, Issue 3, 2011, Pages 229-235

  Mader, Jamie S ^a   Ewen, Catherine ^a   Hancock, Robert E W ^b   Bleackley, Robert C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

apoptosis; granzyme; host defense peptide; regulatory T cells

Indexed keywords

CASPASE; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CD4 ANTIGEN; GRANZYME A; GRANZYME B; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; GENE MUTATION; IN VITRO STUDY; LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; WILD TYPE;

ADAPTIVE IMMUNITY; AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; APOPTOSIS; CASPASES; CHROMATIN; DNA FRAGMENTATION; GRANZYMES; HOMOZYGOTE; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, NULL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NEOPLASMS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY;

EID: 79953047075     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e318207ecdf     Document Type: Article

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