A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression

Molecular Pharmacology

Volumn 79, Issue 4, 2011, Pages 710-723

  Zhou, Xin ^a   Wei, Yuan ^a   Xie, Fang ^a   Laukaitis, Christina M ^b   Karn, Robert C ^b   Kluetzman, Kerri ^a   Gu, Jun ^a   Zhang, Qing Yu ^a   Roberts, Dean W ^c   Ding, Xinxin ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN BINDING PROTEIN; CELL PROTEIN; CYTOCHROME P450 2A5; PARACETAMOL DERIVATIVE; PARACETAMOL GLUCURONIDE; PARACETAMOL GLUTATHIONE; PARACETAMOL SULFATE; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FEMALE; HOMEOSTASIS; IN VITRO STUDY; LATERAL NASAL GLAND; MALE; METABOLITE; NONHUMAN; NOSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TESTOSTERONE METABOLISM; WILD TYPE; XENOBIOTIC METABOLISM; XENOBIOTIC STRESS;

ACETAMINOPHEN; ANDROGEN-BINDING PROTEIN; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL AVAILABILITY; GENE EXPRESSION REGULATION; HOMEOSTASIS; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NASAL MUCOSA; SALIVARY PROTEINS AND PEPTIDES; TESTOSTERONE;

EID: 79952996327     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.070045     Document Type: Article

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