Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, and Tissue-Selective Effects on Cyp2a5 Expression

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 2, 2004, Pages 719-728

  Zhuo, Xiaoliang ^a,b   Gu, Jun ^a   Behr, Melissa J ^a   Swiatek, Pam J ^a,c   Cui, Huadong ^a   Zhang, Qing Yu ^a   Xie, Yingqiu ^a   Collins, Doris N ^a   Ding, Xinxin ^a,d  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c VAN ANDEL RESEARCH INSTITUTE   (United States)

^d WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN; COUMARIN 7 HYDROXYLASE; COUMARIN 7-HYDROXYLASE; CYTOCHROME P 450 CYP2G1; CYTOCHROME P-450 CYP2G1; CYTOCHROME P450 OXYGENASE; MIXED FUNCTION OXIDASE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PROGESTERONE; STEROID; STEROID HORMONE; STEROID MONOOXYGENASE; TESTOSTERONE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; XENOBIOTIC AGENT;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYP2A5 GENE; CYP2G1 GENE; DRUG EFFECT; DRUG METABOLISM; DRUG TOXICITY; EMBRYO DEATH; ENZYMOLOGY; FEMALE; GENE; GENE DISRUPTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCATION; GENE TARGETING; HOMOZYGOSITY; KIDNEY; LETHALITY; LIVER; LIVER TOXICITY; MALE; METABOLISM; MICROSOME; MOUSE; MOUSE STRAIN; MUTATION; NONHUMAN; NOSE MUCOSA; NULL ALLELE; OLFACTORY EPITHELIUM; PARACRINE SIGNALING; PRIORITY JOURNAL; PROGESTERONE METABOLISM; TESTOSTERONE METABOLISM; TOXICITY; TRANSGENIC MOUSE;

ACETAMINOPHEN; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARYL HYDROCARBON HYDROXYLASES; DRUG TOXICITY; FEMALE; GENE EXPRESSION; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MIXED FUNCTION OXYGENASES; MUTATION; NASAL MUCOSA; OLFACTORY MUCOSA; STEROID HYDROXYLASES; STEROIDS;

EID: 1642498170     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.060301     Document Type: Article

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