Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity II. Possible involvement of the γ-glutamyl cycle

Toxicology and Applied Pharmacology

Volumn 202, Issue 2, 2005, Pages 160-171

  Stern, Stephan T ^a   Bruno, Mary K ^a   Horton, Robert A ^b   Hill, Dennis W ^a   Roberts, Jeanette C ^b   Cohen, Steven D ^a,c  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c Massachusetts Coll Pharm Hlth S   (United States)

Author keywords

Glutamyl cycle; Glutamyl transpeptidase; Acetaminophen nephrotoxicity; Acetaminophen cysteine; Acivicin; Glutathione conjugate mediated toxicity

Indexed keywords

ACIVICIN; CYSTEINE; GAMMA GLUTAMYLCYSTEINE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; PARACETAMOL;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPLETION; DRUG CONJUGATION; HYPOTHESIS; IN VITRO STUDY; MALE; METABOLITE; MOUSE; NEPHROTOXICITY; NONHUMAN; URINALYSIS;

ACETAMINOPHEN; ANIMALS; CELL MEMBRANE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; INJECTIONS, INTRAPERITONEAL; ISOXAZOLES; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED STRAINS; MICROVILLI; MOLECULAR STRUCTURE; TOXICITY TESTS;

ANIMALIA; BOVINAE; MURINAE;

EID: 11144256937     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.06.029     Document Type: Article

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