In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver

Thrombosis Research

Volumn 127, Issue 4, 2011, Pages 356-362

  Seested, T ^a,b   Appa, R S ^b   Christensen, E I ^d   Ioannou, Y A ^c   Krogh, T N ^b   Karpf, D M ^b   Nielsen, H M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

Active site inhibited rFVIIa (rFVIIai); Antithrombin III (ATIII); Clearance; Hepatocytes; Kupffer cells; recombinant activated factor VII (rFVIIa)

Indexed keywords

ALPHA 2 MACROGLOBULIN; ANTITHROMBIN III; DEXTRAN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; SUPERPARAMAGNETIC IRON OXIDE; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; ENDOSOME; ENZYME LINKED IMMUNOSORBENT ASSAY; KUPFFER CELL; LIVER CELL; LIVER LYSOSOME; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; CHROMATOGRAPHY; DEXTRANS; FACTOR VIIA; FERRIC COMPOUNDS; HEPATOCYTES; INJECTIONS, INTRAVENOUS; LIVER; MAGNETICS; MALE; MICE; PROTEASE INHIBITORS; RECOMBINANT PROTEINS;

EID: 79952990949     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2010.12.016     Document Type: Article

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