The unsialylated subpopulation of recombinant activated factor VII binds to the asialo-glycoprotein receptor (ASGPR) on primary rat hepatocytes

Thrombosis and Haemostasis

Volumn 104, Issue 6, 2010, Pages 1166-1173

  Seested, Torben ^a,b   Nielsen, Hanne M ^a   Christensen, Erik I ^c   Appa, Rupa S ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Asialo orosomucoid (ASOR); Asialoglycoprotein receptor (ASGPR); Electron microscopic autoradiography; Primary rat hepatocytes; Recombinant activated factor VII (rFVIIa)

Indexed keywords

ASIALOGLYCOPROTEIN RECEPTOR; ASIALOOROSOMUCOID; IODINE 125; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; ELECTRON MICROSCOPY; ENDOCYTOSIS; ENDOSOME; IMMUNOFLUORESCENCE MICROSCOPY; LIVER CELL; LYSOSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODIES; ASIALOGLYCOPROTEIN RECEPTOR; AUTORADIOGRAPHY; BINDING, COMPETITIVE; CELL MEMBRANE; CELLS, CULTURED; CYTOPLASMIC VESICLES; ENDOCYTOSIS; FACTOR VIIA; HEPATOCYTES; IODINE RADIOISOTOPES; MALE; MICROSCOPY, FLUORESCENCE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 78649736215     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH10-06-0356     Document Type: Article

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