The low-density lipoprotein receptor-related protein (LRP) mediates clearance of coagulation factor Xa in vivo

Blood

Volumn 91, Issue 2, 1998, Pages 555-560

  Narita, Masaaki ^a   Rudolph, Amy E ^b   Miletich, Joseph P ^b   Schwartz, Alan L ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; LOW DENSITY LIPOPROTEIN RECEPTOR; RECEPTOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; ENZYME DEGRADATION; HEMOSTASIS; LIPOPROTEIN METABOLISM; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL;

EID: 0031983597     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.2.555     Document Type: Article

References (36)

1. Hertzberg M: Biochemistry of factor X. Blood Rev 8:56, 1994
2. Colman RW, Marder VJ, Salzman EW, Hirsh J: Plasma coagulation factors, in Colman RW, Hirsh J, Marder VJ, Salzman EW (eds): Hemostasis and Thrombosis, vol 3. Philadelphia, PA, Lippincott, 1987, P 3
3. Jackson CM, Nemerson Y: Blood coagulation. Annu Rev Biochem 49:765, 1980
4. αβ by antithrombin III. Biochemistry 15:373, 1976
5. Broze GJ Jr, Girard TJ, Novotny WF: Regulation of coagulation by a multivalent kunitz-type inhibitor. Biochemistry 29:7539, 1990
6. Ellis V, Scully M, MacGregor I, Kakkar V: Inhibition of human factor Xa by various plasma proteinase inhibitors. Biochim Biophys Acta 701:24, 1982
7. Fuchs HE, Pizzo SV: The regulation of factor Xa in vitro in human and mouse plasma and in vivo in mouse. The role of the endothelium and the plasma proteinase inhibitors. J Clin Invest 72:2041, 1983
8. 1-proteinase inhibitor in human plasma. J Biol Chem 259:6890, 1984
9. Herz J, Hamann U, Rogne SK, Kyklebost O, Gausepohl H, Stanley KK: Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J 7:4119, 1988
10. Krieger M, Herz J: Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem 63:601, 1994
11. 2-macroglobulin receptor. FEBS Lett 276:151, 1990
12. 2-macroglobulin receptor is a hepatic receptor for tissue-type plasminogen activator. Proc Natl Acad Sci USA 89:7427, 1992
13. 2-macroglobulin receptor. Proc Natl Acad Sci USA 89:7422, 1992
14. Warshawsky I, Broze GJ Jr, Schwartz AL: The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor. Proc Natl Acad Sci USA 91:6664, 1994
15. 2-macroglobulin receptor. J Biol Chem 266: 21232, 1991
16. Bu G, Morton PA, Schwartz AL: Identification and partial characterization by chemical cross-linking of a binding protein for tissue-type plasminogen activator (t-PA) on rat hepatoma cells. J Biol Chem 267:15595,1992
17. Willnow TE, Sheng Z, Ishibashi S, Herz J: Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science 264:1471, 1994
18. Narita M, Bu G, Herz J, Schwartz AL: Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo. J Clin Invest 96:1164, 1995
19. Narita M, Bu G, Olins GM, Higuchi DA, Herz J, Broze GJ Jr, Schwartz AL: Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo. J Biol Chem 270:24800, 1995
20. Warshawsky I, Bu G, Schwartz AL: Identifications of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein. J Biol Chem 268:22046, 1993
21. Miletich JP, Jackson CM, Majerus PW: Properties of the factor Xa binding site on platelets. J Biol Chem 253:6908, 1978
22. Rudolph AE, Mullane MP, Porche-Sorbet R, Tsuda S, Miletich JP: Factor X St Louis II: Identification of a glycine substitution at residue 7 and characterization of the recombinant protein. J Biol Chem 271:28601, 1996
23. Esmon C: Function of factor V in prothrombin activation. Doctoral thesis. Washington University. St Louis, MO, 1974
24. Rudolph AE, Mullane MP, Porche-Sorbet R, Miletich JP: Expression, purification, and characterization of recombinant human factor X. Protein Expression Purification 10:373, 1997
25. 2 (Stuart factor). Isolation and characterization. Biochemistry 11:4882, 1972
26. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680, 1970
27. 2-macroglobulin-methylamine. Biochim Biophys Acta 716:151, 1982
28. Kounnas MZ, Church FC, Argraves WS, Strickland DK: Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, and alpha1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein. J Biol Chem 271:6523, 1996
29. Lollar P, Owen WG: Clearance of thrombin from circulation in rabbits by high-affinity binding sites on endothelium. J Clin Invest 66:1222, 1980
30. Altieri DC: Xa receptor EPR-1. FASEB J 9:860, 1995
31. Tracy PB, Nesheim ME, Mann KG: Platelet factor Xa receptor. Methods Enzymol 215:329, 1992
32. Rodgers GM, Shuman MA: Prothrombin is activated on vascular endothelial cells by factor Xa and calcium. Proc Natl Acad Sci USA 80:7001,1983
33. McGee MP, Rothberger H: Assembly of the prothrombin activator complex on rabbit alveolar macrophage high-affinity factor Xa receptors. A kinetic study. J Exp Med 164:1902, 1986
34. Kazama Y, Komiyama Y, Kisiel W: Tissue factor pathway inhibitor and protease nexin-1 are major factor Xa binding proteins on HepG2 cell surface. Blood 81:676, 1993
35. Nicholson AC, Nachman RL, Altieri DC, Summers BD, Ruf W, Edgington TS, Hajjar DP: Effector cell protease receptor-1 is a vascular receptor for coagulation factor Xa. J Biol Chem 271:28407, 1996
36. Ho G, Toomy JR, Broze GJ Jr, Schwartz AL: Receptor-mediated endocytosis of coagulation factor Xa requires cell surface-bound tissue factor pathway inhibitor. J Biol Chem 271:9497, 1996