Mechanisms of cellular uptake of thrombin-antithrombin II complexes: Role of the low-density lipoprotein receptor-related protein as a serpin- enzyme complex receptor

Trends in Cardiovascular Medicine

Volumn 7, Issue 1, 1997, Pages 9-16

  Strickland, Dudley K ^a   Kounnas, Maria Z ^b  

^a American Red Cross ^*  (United States)

^b SIBIA Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; LOW DENSITY LIPOPROTEIN RECEPTOR; SERINE PROTEINASE INHIBITOR; THROMBIN;

CELL MEMBRANE TRANSPORT; COMPLEX FORMATION; ENZYME INHIBITOR INTERACTION; HUMAN; MOLECULAR INTERACTION; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW; TRANSPORT KINETICS;

EID: 0031034416     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(96)00120-X     Document Type: Review

References (44)

1. Argraves KM, Battey FD, MacCalman CDet al. The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type 1 complexes. J.Biol Chem. 270:1995;26,550-26,557.
2. Ashcom JD, Tiller SE, Dickerson K., Cravens JL, Argraves WS, Strickland DK The human α2-macroglobulin receptor: identification of a 420-kD cell surface glycoprotein specific for the activated conformation of α2-macroglobulin. J Cell Biol. 110:1990;1041-1048.
3. 1-proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase. J Biol Chem. 263:1988;4481-4484.
4. Brown MS, Goldstein JL A receptor-mediated pathway for cholesterol homeostasis. Science. 232:1986;34-47.
5. Frykman PK, Brown MS, Yamamoto T, Goldstein JL, Herz J Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc Natl Acad Sci USA. 92:1995;8453-8457.
6. 2-macroglobulin-methylamine. Biochim Biophys Acta. 716:1982;151-157.
7. 2-antiplasmin-protease complexes in mice. Thromb Haemostas. 48:1982;208-219.
8. Herz J, Hamann U, Rogne S, Myklebost O, Gausepohl H, Stanley KK Surface location and high affinity for calcium of a 500kDa liver membrane protein closely related to the LDL-receptor suggest a physiolocical role as lipoprotein receptor. EMBO J. 7:1988;4119-4127.
9. Herz J, Kowal RC, Goldstein JL, Brown MS Proteolytic processing of the 600 kD low density liprotein receptor related protein LRP occurs in a trans-Golgi compartment. EMBO J. 9:1990;1769-1776.
10. Herz J, Clouthier DE, Hammer RE LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Cell. 71:1992;411-421.
11. Joslin G, Fallon RJ, Bullock J, Adams SP, Perlmutter DH The SEC receptor recognizes a pentapeptide neodomain of alpha 1-antitrypsin-protease complexes. J Biol Chem. 266:1991;11,282-11,288.
12. Kim DH, Iijima H, Goto K Human apolipoprotein E receptor 2: a novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J Biol Chem. 271:1996;8373-8380.
13. 2-macroglobulin receptor mediates cellular uptake of prourokinase. J Biol Chem. 268:1993;21,862-21,867.
14. 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein. J Biol Chem. 271:1996;6523-6529.
15. Krieger M, Herz J Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem. 63:1994;601-637.
16. 2M receptor. FEBS Lett. 276:1990;151-155.
17. 1-antichymotrypsincathepsin G complexes: evidence for the involvement of interleukin-6. J Biol Chem. 265:1990;21,023-21,026.
18. Lollar P, Owen WG Clearance of thrombin from circulation in rabbits by high-affinity binding sites on endothelium. Possible role in the inactivation of thrombin by anti-thrombin III. J Clin Invest. 66:1980;1222-1230.
19. Maekawa H, Tollefsen DM Role of the proposed serpin-enzyme complex receptor recognition site in binding and internalization of thrombin-heparin cofactor II complexes by hepatocytes. J Biol Chem. 271:1996;18,604-18,610.
20. 2-antiplasmin, angiotensinogen, and ovalbumin. Biochemistry. 30:1991;1723-1730.
21. 2-macroglobulin receptor mediates the cellular internalization and degradation of thrombospondin: a process facilitated by cell-surface proteoglycans. J Biol Chem. 270:1995;9543-9549.
22. 2-macroglobulin receptor containing a cluster of eight complement-type repeats. J Biol Chem. 268:1993;13,691-13,696.
23. 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J Biol Chem. 267:1992;14,543-14,546.
24. 2-macroglobulin receptor/low density lipoprotein receptor-related protein: evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor. J Biol Chem. 269:1994;25,668-25,676.
25. 1-PI deficiency. J Clin Invest. 81:1988;1774-1780.
26. Perlmutter DH, Glover GI, Rivetna M, Schasteen CS, Fallon RJ Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes. Proc Natl Acad Sci USA. 87:1990;3753-3757.
27. Perlmutter DH, Joslin G, Nelson P, Schasteen C, Adams SPI, Fallon RJ Endocytosis and degradation of alpha-antitrypsin-protease complexes is mediated by the serpin-enzyme complex (SEC) receptor. J Biol Chem. 265:1990;16,713-16,716.
28. 1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein. J Biol Chem. 270:1995;2841-2845.
29. Pratt CW, Church FC, Pizzo SV In vivo catabolism of heparin cofactor II and its complex with thrombin: evidence for a common receptor-mediated clearance pathway for three serine proteinase inhibitors. Arch Biochem Biophys. 262:1988;111-117.
30. Preissner KT, De Boer H, Pannekoek H, De Groot PG Thrombin regulation by physiological inhibitors: The role of vitronectin. Semin Thromb Hemost. 22:1996;165-172.
31. Saito A, Pietromonaco S, Loo AK-C, Farquhar MG Complete cloning and sequencing of rat gp330/"megalin", a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci USA. 91:1994;9725-9729.
32. Sakai J, Hoshino A, Takahashi S Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. J Biol Chem. 269:1994;2173-2182.
33. Shifman MA, Pizzo SV The in vivo metabolism of antithrombin III and antithrombin III complexes. J Biol Chem. 257:1982;3243-3248.
34. 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem. 265:1990;17,401-17,404.
35. Strickland DK, Ashcom JD, Williams Set al. Primary structure of α2-macroglobulin receptor-associated protein: human homologue of a Heymann nephritis antigen. J Biol Chem. 266:1991;13,364-13,369.
36. Strickland DK, Kounnas MZ, Argraves WS LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism. FASEB J. 9:1995;890-898.
37. Takahashi S, Kawarabayasi Y, Nakai T, Sakai J, Yamamoto T Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci USA. 89:1992;9252-9256.
38. Thaler E, Lechner K Antithrombin deficiency and thromboembolism. Clin Hematol. 28:1981;8951-8966.
39. 2-macroglobulin receptor/low density lipoprotein receptor-related protein: multiple regulatory sites for 39-kDa receptor-associated protein. J Biol Chem. 267:1992;9035-9040.
40. Willnow TE, Herz J Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A: evidence that this protein is required for uptake and degradation of multiple ligands. J Cell Sci. 107:1994;719-726.
41. Willnow TE, Goldstein JL, Orth K, Brown MS, Herz J Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J Biol Chem. 267:1992;26,172-26,180.
42. Willnow TE, Sheng Z, Ishibashi S, Herz J Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science. 264:1994;1471-1474.
43. Willnow TE, Hilpert J, Armstrong SAet al. Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci USA. 93:1996;8460-8464.
44. Willnow TE, Rohlmann A, Horton Jet al. RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. EMBO J. 15:1996;2632-2639.