DNA alkylation with N-methylquinolinium quinone methide to N2-dG adducts resulting in extensive stops in primer extension with DNA polymerases and subsequent suppression of GFP expression in A549 cells

Chemical Research in Toxicology

Volumn 24, Issue 3, 2011, Pages 402-411

  Zhou, Qibing ^a,b   Qu, Yun ^b   Mangrum, John B ^b   Wang, Xing ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; DNA POLYMERASE; DOUBLE STRANDED DNA; GREEN FLUORESCENT PROTEIN; N METHYLQUINOLIUM QUINONE METHIDE; NUCLEIC ACID BASE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA ALKYLATION; ELIMINATION REACTION; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN EXPRESSION; SYNTHESIS;

ALKYLATION; CELL LINE, TUMOR; DEOXYGUANOSINE; DNA; DNA ADDUCTS; DNA POLYMERASE BETA; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI PROTEINS; GREEN FLUORESCENT PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PLASMIDS; POLYMERASE CHAIN REACTION; QUINOLINIUM COMPOUNDS;

EID: 79952983434     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100351c     Document Type: Article

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