A novel series of 4-piperidinopyridine and 4-piperidinopyrimidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase

Journal of Medicinal Chemistry

Volumn 43, Issue 26, 2000, Pages 4964-4972

  Brown, G R ^a   Hollinshead, D M ^a   Stokes, E S E ^a   Waterson, D ^a   Clarke, D S ^a   Foubister, A J ^a   Glossop, S C ^a   McTaggart, F ^a   Mirrlees, D J ^a   Smith, G J ^a   Wood, R ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 PIPERIDINOPYRIDINE; 4 PIPERIDINOPYRIMIDINE; CHOLESTEROL; ENZYME INHIBITOR; LANOSTEROL SYNTHASE; PIPERIDINE DERIVATIVE; QUINUCLIDINE DERIVATIVE; SIMVASTATIN; UNCLASSIFIED DRUG;

ARTICLE; CARDIOVASCULAR DISEASE; CHOLESTEROL SYNTHESIS; CYCLIZATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; NONHUMAN; PKA; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; FEMALE; INTRAMOLECULAR TRANSFERASES; MICROSOMES; PIPERAZINES; PIPERIDINES; PYRIDINES; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034727848     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000139k     Document Type: Article

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