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Volumn 36, Issue 18, 2008, Pages 5933-5945

Mutagenicity of tamoxifen DNA adducts in human endometrial cells and in silico prediction of p53 mutation hotspots

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; ALANINE; CYSTEINE; GENE PRODUCT; GLYCINE; PROTEIN P53; PROTEIN SUPF; TAMOXIFEN; THREONINE; UNCLASSIFIED DRUG;

EID: 54549089028     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn586     Document Type: Article
Times cited : (9)

References (66)
  • 3
    • 0028208456 scopus 로고
    • Endometrial cancer in tamoxifen-treated breast cancer patients: Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14
    • Fisher,B., Costantino,J.P., Redmond,C.K., Fisher,E.R., Wickerham,D.L. and Cronin,W.M. (1994) Endometrial cancer in tamoxifen-treated breast cancer patients: Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. J. Natl Cancer Inst., 86, 527-537.
    • (1994) J. Natl Cancer Inst , vol.86 , pp. 527-537
    • Fisher, B.1    Costantino, J.P.2    Redmond, C.K.3    Fisher, E.R.4    Wickerham, D.L.5    Cronin, W.M.6
  • 4
    • 0038063512 scopus 로고    scopus 로고
    • Breast cancer chemoprevention: Risk-benefit effects of the antioestrogen tamoxifen
    • Brown,K. (2000) Breast cancer chemoprevention: Risk-benefit effects of the antioestrogen tamoxifen. Expert Opin. Drug Saf., 1, 253-267.
    • (2000) Expert Opin. Drug Saf , vol.1 , pp. 253-267
    • Brown, K.1
  • 5
    • 0029985407 scopus 로고    scopus 로고
    • Phillips,D.H., Carmichael,P.L., Hewer,A., Cole,K.J., Hardcastle,I.R., Poon,G.K., Keough,A. and Strain,A.J. (1996) Activation of tamoxifen and its metabolite α-hydroxytamoxifen to DNA-binding products: Comparisons between human, rat and mouse hepatocytes. Carcinogenesis, 17 89-94.
    • Phillips,D.H., Carmichael,P.L., Hewer,A., Cole,K.J., Hardcastle,I.R., Poon,G.K., Keough,A. and Strain,A.J. (1996) Activation of tamoxifen and its metabolite α-hydroxytamoxifen to DNA-binding products: Comparisons between human, rat and mouse hepatocytes. Carcinogenesis, 17 89-94.
  • 6
    • 0032519594 scopus 로고    scopus 로고
    • α-hydroxytamoxifen is a substrate of hydroxysteroid. (alcohol) sulf6transferase, resulting in tamoxifen DNA adducts
    • Shibutani,S., Dasaradhi,L., Terashima,I., Banoglu,E. and Duffel,M.W. (1998) α-hydroxytamoxifen is a substrate of hydroxysteroid. (alcohol) sulf6transferase, resulting in tamoxifen DNA adducts. Cancer Res., 58, 647-653.
    • (1998) Cancer Res , vol.58 , pp. 647-653
    • Shibutani, S.1    Dasaradhi, L.2    Terashima, I.3    Banoglu, E.4    Duffel, M.W.5
  • 7
    • 0031867191 scopus 로고    scopus 로고
    • The metabolic activation of tamoxifen and a-hydroxytamoxifen to DNA-binding species in rat hepatocytes proceeds via sulphation
    • Davis,W., Venitt,S. and Phillips,D.H. (1998) The metabolic activation of tamoxifen and a-hydroxytamoxifen to DNA-binding species in rat hepatocytes proceeds via sulphation. Carcinogenesis, 19, 861-866.
    • (1998) Carcinogenesis , vol.19 , pp. 861-866
    • Davis, W.1    Venitt, S.2    Phillips, D.H.3
  • 8
    • 0028911210 scopus 로고
    • Identification of tamoxifen metabolites in human Hep G2 cell line, human liver homogenate, and patients on long-term therapy for breast cancer
    • Poon,G.K., Walter,B., Lonning,P.E., Horton,M.N. and McCague,R. (1995) Identification of tamoxifen metabolites in human Hep G2 cell line, human liver homogenate, and patients on long-term therapy for breast cancer. Drug Metab. Dispos., 23, 377-382.
    • (1995) Drug Metab. Dispos , vol.23 , pp. 377-382
    • Poon, G.K.1    Walter, B.2    Lonning, P.E.3    Horton, M.N.4    McCague, R.5
  • 17
    • 0031416520 scopus 로고    scopus 로고
    • Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide
    • Marques,M.M. and Beland,F.A. (1997) Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide. Carcinogenesis 18, 1949-1954.
    • (1997) Carcinogenesis , vol.18 , pp. 1949-1954
    • Marques, M.M.1    Beland, F.A.2
  • 20
    • 0033135051 scopus 로고    scopus 로고
    • 2-deoxyguanosinyl)tamoxifen lesions, the major DNA adducts detected in endometrial tissues of patients treated with tamoxifen
    • 2-deoxyguanosinyl)tamoxifen lesions, the major DNA adducts detected in endometrial tissues of patients treated with tamoxifen. Cancer Res., 59, 2091-2195.
    • (1999) Cancer Res , vol.59 , pp. 2091-2195
    • Terashima, I.1    Suzuki, N.2    Shibutani, S.3
  • 21
    • 0037118685 scopus 로고    scopus 로고
    • DNA adducts formed from 4-hydroxytamoxifen are more mutagenic than those formed by α-acetoxytamoxifen in a shuttle vector target gene replicated in human Ad293 cells
    • McLuckie,K.I.E., Routledge,M.N., Brown,K., Gaskell,M., Farmer,P.B., Roberts,G.C.K. and Martin,E.A. (2002) DNA adducts formed from 4-hydroxytamoxifen are more mutagenic than those formed by α-acetoxytamoxifen in a shuttle vector target gene replicated in human Ad293 cells. Biochemistry, 41, 8899-8906.
    • (2002) Biochemistry , vol.41 , pp. 8899-8906
    • McLuckie, K.I.E.1    Routledge, M.N.2    Brown, K.3    Gaskell, M.4    Farmer, P.B.5    Roberts, G.C.K.6    Martin, E.A.7
  • 22
    • 20144376201 scopus 로고    scopus 로고
    • Mutation spectra induced by α-acetoxytamoxifen-DNA adducts in human DNA repair proficient and deficient (xeroderma pigmentosum complementation group A) cells
    • McLuckie,K.I.E., Crookston,R.J., Gaskell,M., Farmer,P.B., Routledge,M.N., Martin,E.A. and Brown,K. (2005) Mutation spectra induced by α-acetoxytamoxifen-DNA adducts in human DNA repair proficient and deficient (xeroderma pigmentosum complementation group A) cells. Biochemistry, 44, 8198-8205.
    • (2005) Biochemistry , vol.44 , pp. 8198-8205
    • McLuckie, K.I.E.1    Crookston, R.J.2    Gaskell, M.3    Farmer, P.B.4    Routledge, M.N.5    Martin, E.A.6    Brown, K.7
  • 23
    • 14644438645 scopus 로고    scopus 로고
    • Mutations induced by ultraviolet light
    • Pfeifer,G.P., You,Y.H. and Besaratinia,A. (2005) Mutations induced by ultraviolet light. Mutat. Res., 571, 19-31.
    • (2005) Mutat. Res , vol.571 , pp. 19-31
    • Pfeifer, G.P.1    You, Y.H.2    Besaratinia, A.3
  • 25
    • 0030791718 scopus 로고    scopus 로고
    • p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan
    • Lunn,R.M., Zhang,Y.J., Wang,L.Y., Chen,C.J., Lee,P.H., Lee,C.S., Tsai,W.Y. and Santella,R.M. (1997) p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan. Cancer Res., 57, 3471-3477.
    • (1997) Cancer Res , vol.57 , pp. 3471-3477
    • Lunn, R.M.1    Zhang, Y.J.2    Wang, L.Y.3    Chen, C.J.4    Lee, P.H.5    Lee, C.S.6    Tsai, W.Y.7    Santella, R.M.8
  • 26
    • 3242791018 scopus 로고    scopus 로고
    • In silico p53 mutation hotspots in lung cancer
    • Lewis,P.D. and Parry,J.M. (2004) In silico p53 mutation hotspots in lung cancer. Carcinogenesis, 25, 1099-1107.
    • (2004) Carcinogenesis , vol.25 , pp. 1099-1107
    • Lewis, P.D.1    Parry, J.M.2
  • 27
    • 0029806936 scopus 로고    scopus 로고
    • Preferential formation of benzo [a]pyrene adducts at lung cancer mutational hotspots in p53
    • Denissenko,M.F., Pao,A., Tang,M. and Pfeifer,G.P. (1996) Preferential formation of benzo [a]pyrene adducts at lung cancer mutational hotspots in p53. Science, 274, 430-432.
    • (1996) Science , vol.274 , pp. 430-432
    • Denissenko, M.F.1    Pao, A.2    Tang, M.3    Pfeifer, G.P.4
  • 28
    • 0030050137 scopus 로고    scopus 로고
    • Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen
    • Osborne,M.R., Hewer,A., Hardcastle,I.R., Carmichael,P.L. and Phillips,D.H. (1996) Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen. Cancer Res., 56, 66-71.
    • (1996) Cancer Res , vol.56 , pp. 66-71
    • Osborne, M.R.1    Hewer, A.2    Hardcastle, I.R.3    Carmichael, P.L.4    Phillips, D.H.5
  • 29
    • 0032827816 scopus 로고    scopus 로고
    • Further characterization of the DNA adducts formed in rat liver after the administration of tamoxifen, N-desmethyltamoxifen or N, N didesmethyltamoxifen
    • Brown,K., Heydon,R.T., Jukes,R., White,I.N. and Martin,E.A. (1999) Further characterization of the DNA adducts formed in rat liver after the administration of tamoxifen, N-desmethyltamoxifen or N, N didesmethyltamoxifen. Carcinogenesis, 20, 2011-2016.
    • (1999) Carcinogenesis , vol.20 , pp. 2011-2016
    • Brown, K.1    Heydon, R.T.2    Jukes, R.3    White, I.N.4    Martin, E.A.5
  • 30
    • 0035477426 scopus 로고    scopus 로고
    • Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo [a]pyrene diol epoxide in mammalian cells: Similarities with the p53 mutation spectrum in smoking-associated lung cancers
    • Yoon,J.H., Smith,L.E., Feng,Z., Tang,M., Lee,C.S. and Pfeifer,G.P. (2001) Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo [a]pyrene diol epoxide in mammalian cells: Similarities with the p53 mutation spectrum in smoking-associated lung cancers. Cancer Res., 61, 110-117.
    • (2001) Cancer Res , vol.61 , pp. 110-117
    • Yoon, J.H.1    Smith, L.E.2    Feng, Z.3    Tang, M.4    Lee, C.S.5    Pfeifer, G.P.6
  • 31
    • 0035977005 scopus 로고    scopus 로고
    • Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells
    • You,Y.-H., Lee,D.-H., Yoon,J.-H., Nakajima,S., Yasui,A. and Pfeifer,G.P. (2001) Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells. J. Biol. Chem., 276, 44688-44694.
    • (2001) J. Biol. Chem , vol.276 , pp. 44688-44694
    • You, Y.-H.1    Lee, D.-H.2    Yoon, J.-H.3    Nakajima, S.4    Yasui, A.5    Pfeifer, G.P.6
  • 32
    • 0035910281 scopus 로고    scopus 로고
    • Similarities in sunlight-induced mutational spectra of CpG-methylated transgenes and the p53 gene in skin cancer point to an important role of 5-methylcytosine residues in solar UV mutagenesis
    • You,Y.-H. and Pfeifer,G.P. (2001) Similarities in sunlight-induced mutational spectra of CpG-methylated transgenes and the p53 gene in skin cancer point to an important role of 5-methylcytosine residues in solar UV mutagenesis. J. Mol. Biol., 105, 389-399.
    • (2001) J. Mol. Biol , vol.105 , pp. 389-399
    • You, Y.-H.1    Pfeifer, G.P.2
  • 33
    • 41849118779 scopus 로고    scopus 로고
    • Comparison of induced and cancer-associated mutational spectra using multivariate data analysis
    • Lewis,P.D., Manshian,B., Routledge,M.N., Scott,G.B. and Burns,P.A. (2008) Comparison of induced and cancer-associated mutational spectra using multivariate data analysis. Carcinogenesis, 29, 772-778.
    • (2008) Carcinogenesis , vol.29 , pp. 772-778
    • Lewis, P.D.1    Manshian, B.2    Routledge, M.N.3    Scott, G.B.4    Burns, P.A.5
  • 34
    • 0038193611 scopus 로고    scopus 로고
    • Deamination of 5-methylcytosines within cyclobutane pyrimidine dimers is an important component of UVB mutagenesis
    • Lee,D.-H. and Pfeifer,G.P. (2003) Deamination of 5-methylcytosines within cyclobutane pyrimidine dimers is an important component of UVB mutagenesis. J. Biol. Chem., 278, 10314-10321.
    • (2003) J. Biol. Chem , vol.278 , pp. 10314-10321
    • Lee, D.-H.1    Pfeifer, G.P.2
  • 35
    • 0037264384 scopus 로고    scopus 로고
    • Simulated sunlight and benzo [a]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: Lack of correspondence to tumor mutation spectra
    • Yoon,J.H., Lee,C.S. and Pfeifer,G.P. (2003) Simulated sunlight and benzo [a]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: Lack of correspondence to tumor mutation spectra. Carcinogenesis, 24, 113-119.
    • (2003) Carcinogenesis , vol.24 , pp. 113-119
    • Yoon, J.H.1    Lee, C.S.2    Pfeifer, G.P.3
  • 36
    • 0031844522 scopus 로고    scopus 로고
    • Ultraviolet-light induced p53 mutational spectrum in yeast is indistinguishable from p53 mutations in human skin cancer
    • Inga,A., Scott,G., Monti,P., Aprile,A., Abbondandolo,A., Burns,P.A. and Fronza,G. (1998) Ultraviolet-light induced p53 mutational spectrum in yeast is indistinguishable from p53 mutations in human skin cancer. Carcinogenesis, 19, 741-746.
    • (1998) Carcinogenesis , vol.19 , pp. 741-746
    • Inga, A.1    Scott, G.2    Monti, P.3    Aprile, A.4    Abbondandolo, A.5    Burns, P.A.6    Fronza, G.7
  • 37
    • 0032814944 scopus 로고    scopus 로고
    • Tamoxifen induces G:C→T:A mutations in the cII gene in the liver of lambda/lacI transgenic rats but not at 5′-CpG'3′ dinucleotide sequences as found in the lacI transgene
    • Davies,R., Gant,T.W., Smith,L.L. and Styles,J.A. (1999) Tamoxifen induces G:C→T:A mutations in the cII gene in the liver of lambda/lacI transgenic rats but not at 5′-CpG'3′ dinucleotide sequences as found in the lacI transgene. Carcinogenesis, 20, 1351-1356.
    • (1999) Carcinogenesis , vol.20 , pp. 1351-1356
    • Davies, R.1    Gant, T.W.2    Smith, L.L.3    Styles, J.A.4
  • 39
    • 0032565510 scopus 로고    scopus 로고
    • Yeast ARMs (DNA at-risk motifs) can reveal sources of genome instability
    • Gordenin,D.A. and Resnick,M.A. (1998) Yeast ARMs (DNA at-risk motifs) can reveal sources of genome instability. Mutat. Res., 400, 45-58.
    • (1998) Mutat. Res , vol.400 , pp. 45-58
    • Gordenin, D.A.1    Resnick, M.A.2
  • 40
    • 0019996193 scopus 로고
    • On the formation of spontaneous deletions: The importance of short sequence homologies in the generation of large deletions
    • Albertini,A.M., Hofer,M., Calos,M.P. and Miller,J.H. (1982) On the formation of spontaneous deletions: The importance of short sequence homologies in the generation of large deletions. Cell, 29, 319-328.
    • (1982) Cell , vol.29 , pp. 319-328
    • Albertini, A.M.1    Hofer, M.2    Calos, M.P.3    Miller, J.H.4
  • 41
    • 0031581858 scopus 로고    scopus 로고
    • Short-homology-independent illegitimate recombination in Escherichia coli: Distinct mechanism from short-homology-dependent illegitimate recombination
    • Shimizu,H., Yamaguchi,H., Ashizawa,Y., Kohno,Y., Asami,M., Kato,J. and Ikeda,H. (1997) Short-homology-independent illegitimate recombination in Escherichia coli: Distinct mechanism from short-homology-dependent illegitimate recombination. J. Mol. Biol., 266, 297-305.
    • (1997) J. Mol. Biol , vol.266 , pp. 297-305
    • Shimizu, H.1    Yamaguchi, H.2    Ashizawa, Y.3    Kohno, Y.4    Asami, M.5    Kato, J.6    Ikeda, H.7
  • 42
    • 0028034656 scopus 로고
    • Computer program for the analysis of mutational spectra: Application to p53 mutations
    • Cariello,N.F., Piegorsch,W.W., Adams,W.T. and Skopek,T.R. (1994) Computer program for the analysis of mutational spectra: Application to p53 mutations. Carcinogenesis, 15, 2281-2285.
    • (1994) Carcinogenesis , vol.15 , pp. 2281-2285
    • Cariello, N.F.1    Piegorsch, W.W.2    Adams, W.T.3    Skopek, T.R.4
  • 43
    • 0036129237 scopus 로고    scopus 로고
    • 2-dG adduct induced by a 5′-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context
    • 2-dG adduct induced by a 5′-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context. Chem. Res. Toxicol., 15, 438-444.
    • (2002) Chem. Res. Toxicol , vol.15 , pp. 438-444
    • Huang, X.1    Colgate, K.C.2    Kolbanovskiy, A.3    Amin, S.4    Geacintov, N.E.5
  • 44
    • 0033588231 scopus 로고    scopus 로고
    • Cytosine methylation in a CpG sequence leads to enhanced reactivity with benzo [a]pyrene diol epox ide that correlates with a conformational change
    • Weisenberger,D.J. and Romano,L.J. (1999) Cytosine methylation in a CpG sequence leads to enhanced reactivity with benzo [a]pyrene diol epox ide that correlates with a conformational change. J. Biol. Chem., 274, 23948-23955.
    • (1999) J. Biol. Chem , vol.274 , pp. 23948-23955
    • Weisenberger, D.J.1    Romano, L.J.2
  • 45
    • 0026502120 scopus 로고
    • Mutagenic specificities of four stereoisomeric benzo[c]phenanthrene dihydrodiol epoxides
    • Bigger,C.A.H., St John,J., Yagi,H., Jerina,D.M. and Dipple,A. (1992) Mutagenic specificities of four stereoisomeric benzo[c]phenanthrene dihydrodiol epoxides. Proc. Natl Acad. Sci. USA, 89, 368-372.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 368-372
    • Bigger, C.A.H.1    St John, J.2    Yagi, H.3    Jerina, D.M.4    Dipple, A.5
  • 46
    • 0026036071 scopus 로고
    • Kinds of mutations found when a shuttle vector, containing adducts of 1,6-dinitropyrene replicates in human cells
    • Boldt,J., Mah,M.C.M., Wang,Y.C., Smith,B.A., Beland,F.A., Maher,V.M. and McCormick,J.J. (1991) Kinds of mutations found when a shuttle vector, containing adducts of 1,6-dinitropyrene replicates in human cells. Carcinogenesis, 12, 119-126.
    • (1991) Carcinogenesis , vol.12 , pp. 119-126
    • Boldt, J.1    Mah, M.C.M.2    Wang, Y.C.3    Smith, B.A.4    Beland, F.A.5    Maher, V.M.6    McCormick, J.J.7
  • 47
    • 3142555696 scopus 로고
    • Kinds of mutations formed when a shuttle vector containing adducts of (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 α-epoxy-7,8,9, 10-tetrahydrobenzo [a]pyrene replicates in human cells
    • Yang,J.L., Maher,V.M. and McCormick,J.J. (1987) Kinds of mutations formed when a shuttle vector containing adducts of (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 α-epoxy-7,8,9, 10-tetrahydrobenzo [a]pyrene replicates in human cells. Proc. Natl Acad. Sci. USA 84, 3787-3791.
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 3787-3791
    • Yang, J.L.1    Maher, V.M.2    McCormick, J.J.3
  • 48
    • 0034903020 scopus 로고    scopus 로고
    • Presence of benzo [a]pyrene diol epoxide adducts in target DNA leads to an increase in UV-induced DNA single strand breaks and supF gene mutations
    • Routledge,M.N., McLuckie,K.I.E., Jones,G.D.D., Farmer,P.B. and Martin,E.A. (2001) Presence of benzo [a]pyrene diol epoxide adducts in target DNA leads to an increase in UV-induced DNA single strand breaks and supF gene mutations. Carcinogenesis, 22, 1231-1238.
    • (2001) Carcinogenesis , vol.22 , pp. 1231-1238
    • Routledge, M.N.1    McLuckie, K.I.E.2    Jones, G.D.D.3    Farmer, P.B.4    Martin, E.A.5
  • 49
    • 0030042984 scopus 로고    scopus 로고
    • Peroxynitrite-induced mutation spectra of pSP189 following replication in bacteria and in human cells
    • Juedes,M.J. and Wogan,G.N. (1996) Peroxynitrite-induced mutation spectra of pSP189 following replication in bacteria and in human cells. Murat. Res., 349, 51-61.
    • (1996) Murat. Res , vol.349 , pp. 51-61
    • Juedes, M.J.1    Wogan, G.N.2
  • 50
    • 0025742699 scopus 로고
    • Dependence of the mutation spectrum in a shuttle plasmid replicated in human lymphoblasts on dose of gamma radiation
    • Sikpi,M.O., Freedman,M.L., Ziobron,E.R., Upholt,W.B. and Lurie,A.G. (1991) Dependence of the mutation spectrum in a shuttle plasmid replicated in human lymphoblasts on dose of gamma radiation. Int. J. Radiat. Biol., 59, 1115-1126.
    • (1991) Int. J. Radiat. Biol , vol.59 , pp. 1115-1126
    • Sikpi, M.O.1    Freedman, M.L.2    Ziobron, E.R.3    Upholt, W.B.4    Lurie, A.G.5
  • 51
    • 0023781397 scopus 로고
    • Determination of the spectrum of mutations induced by defined-wavelength solar UVB (313-nm) radiation in mammalian cells by use of a shuttle vector
    • Keyse,S.M., Amaudruz,F. and Tyrrell,R.M. (1989) Determination of the spectrum of mutations induced by defined-wavelength solar UVB (313-nm) radiation in mammalian cells by use of a shuttle vector. Mol. Cell. Biol., 8, 5425-5431.
    • (1989) Mol. Cell. Biol , vol.8 , pp. 5425-5431
    • Keyse, S.M.1    Amaudruz, F.2    Tyrrell, R.M.3
  • 52
    • 33749342111 scopus 로고    scopus 로고
    • Translesion synthesis past tamoxifen-derived DNA adducts by human DNA polymerases eta and kappa
    • Yasui,M., Suzuki,N., Laxmi,Y.R. and Shibutani,S. (2006) Translesion synthesis past tamoxifen-derived DNA adducts by human DNA polymerases eta and kappa. Biochemistry, 45, 12167-12174.
    • (2006) Biochemistry , vol.45 , pp. 12167-12174
    • Yasui, M.1    Suzuki, N.2    Laxmi, Y.R.3    Shibutani, S.4
  • 54
    • 0035162401 scopus 로고    scopus 로고
    • Spontaneous mutation spectra in supF: Comparative analysis of mammalian cell line base substitution spectra
    • Lewis,P.D., Harvey,J.S., Waters,E.M., Skibinski,D.O. and Parry,J.M. (2001) Spontaneous mutation spectra in supF: Comparative analysis of mammalian cell line base substitution spectra. Mutagenesis, 16 503-515.
    • (2001) Mutagenesis , vol.16 , pp. 503-515
    • Lewis, P.D.1    Harvey, J.S.2    Waters, E.M.3    Skibinski, D.O.4    Parry, J.M.5
  • 55
    • 0033804390 scopus 로고    scopus 로고
    • Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens
    • Seo,K.Y., Jelinsky,S.A. and Loechler,E.L. (2000) Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens. Mutat. Res. Rev. Mutat. Res., 463, 215-246.
    • (2000) Mutat. Res. Rev. Mutat. Res , vol.463 , pp. 215-246
    • Seo, K.Y.1    Jelinsky, S.A.2    Loechler, E.L.3
  • 56
    • 30144433850 scopus 로고    scopus 로고
    • Locus-specific mutation databases: Pitfalls and good practice based on the p53 experience
    • Soussi,T. and Lozano,G. (2006) Locus-specific mutation databases: pitfalls and good practice based on the p53 experience. Nat. Rev. Cancer, 6, 83-90.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 83-90
    • Soussi, T.1    Lozano, G.2
  • 59
    • 33646410147 scopus 로고    scopus 로고
    • Comparison of uterine malignancies that develop during and following tamoxifen therapy
    • Ferguson,S.E., Soslow,R.A., Amsterdam,A. and Barakat,R.R. (2006) Comparison of uterine malignancies that develop during and following tamoxifen therapy. Gynecol. Oncol., 101, 322-326.
    • (2006) Gynecol. Oncol , vol.101 , pp. 322-326
    • Ferguson, S.E.1    Soslow, R.A.2    Amsterdam, A.3    Barakat, R.R.4
  • 61
    • 10844238937 scopus 로고    scopus 로고
    • Mutagenic potential of benzo [a] pyrene-derived D NA adducts positioned in codon 273 of the human p53 gene
    • Dong,H., Bonala,R.R., Suzuki,N., Johnson,F., Grollman,A.P. and Shibutani,S. (2004) Mutagenic potential of benzo [a] pyrene-derived D NA adducts positioned in codon 273 of the human p53 gene. Biochemistry, 43, 15922-15928.
    • (2004) Biochemistry , vol.43 , pp. 15922-15928
    • Dong, H.1    Bonala, R.R.2    Suzuki, N.3    Johnson, F.4    Grollman, A.P.5    Shibutani, S.6
  • 62
    • 0032510267 scopus 로고    scopus 로고
    • Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers
    • Denissenko,M.F., Pao,A., Pfeifer,G.P. and Tang,M. (1998) Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers. Oncogene, 16, 1241-1247.
    • (1998) Oncogene , vol.16 , pp. 1241-1247
    • Denissenko, M.F.1    Pao, A.2    Pfeifer, G.P.3    Tang, M.4
  • 63
  • 65
    • 0028890630 scopus 로고
    • Alterations of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado
    • Enomoto,T., Fujita,M., Inoue,M., Nomura,T. and Shroyer,K.R. (1995) Alterations of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado. Am. J. Clin. Pathol., 103, 224-230.
    • (1995) Am. J. Clin. Pathol , vol.103 , pp. 224-230
    • Enomoto, T.1    Fujita, M.2    Inoue, M.3    Nomura, T.4    Shroyer, K.R.5
  • 66
    • 0028097882 scopus 로고
    • Statistical approaches for analyzing mutational spectra: Some recommendations for categorical data
    • Piegorsch,W.W. and Bailer,A.J. (1994) Statistical approaches for analyzing mutational spectra: Some recommendations for categorical data. Genetics, 136, 403-416.
    • (1994) Genetics , vol.136 , pp. 403-416
    • Piegorsch, W.W.1    Bailer, A.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.