Chemistry of pyrrolo[1,2-a]indole- and pyrido[1,2-a]indole-based quinone methides. Mechanistic explanations for differences in cytostatic/cytotoxic properties

Journal of Organic Chemistry

Volumn 72, Issue 23, 2007, Pages 8636-8647

  Khdour, Omar ^a   Skibo, Edward B ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC PROPERTIES; HYDROGEN ATOMS; QUINONE METHIDES; SPECTRAL GLOBAL FITTING;

ATOMS; CYTOTOXICITY; HYDROGEN; NUCLEOPHILES; PROTONATION; REDUCTION;

INORGANIC COMPOUNDS;

CARBONYL DERIVATIVE; INDOLE DERIVATIVE; NUCLEOPHILE; PYRIDO[1,2 A]INDOLE DERIVATIVE; PYRROLO[1,2 A]INDOLE DERIVATIVE; QUINONE DERIVATIVE; QUINONE METHIDE DERIVATIVE; UNCLASSIFIED DRUG; VINYL DERIVATIVE; VINYLQUINONE DERIVATIVE;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CATION TRANSPORT; CHEMICAL ANALYSIS; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; ELIMINATION REACTION; HYDROGEN BOND; NONHUMAN; PKA; PROTON TRANSPORT; SPECTRAL GLOBAL FITTING TECHNIQUE; STEREOCHEMISTRY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOSTATIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROGEN-ION CONCENTRATION; INDOLEQUINONES; INDOLES; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35948963949     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo070866o     Document Type: Article

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