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1
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Aiming drug discovery at lysophosphatidic acid targets
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Tigyi G, Aiming drug discovery at lysophosphatidic acid targets. Br J Pharmacol 2010;161(2):241-70
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Br J Pharmacol
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Tigyi, G.1
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Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate
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van Meeteren LA, Ruurs P, Christodoulou E, et al Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. J Biol Chem 2005;280(22):21155-61 (Pubitemid 40805676)
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Perrakis, A.7
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Moolenaar, W.H.9
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3
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0037203315
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Lysophosphatidic acid as a novel cell survival/apoptotic factor
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DOI 10.1016/S1388-1981(02)00330-X, PII S138819810200330X
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Ye X, Ishii I, Kingsbury MA, et al Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochim Biophys Acta 2002;1585(2-3):108-13 (Pubitemid 36092074)
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Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
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Ye, X.1
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13944280988
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G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival
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Radeff-Huang J, Seasholtz TM, Matteo RG, et al G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J Cell Biochem 2004;92(5):949-66 (Pubitemid 44264244)
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34247850836
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The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury
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Deng W, Shuyu E, Tsukahara R, et al The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology 2007;132(5):1834-51
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67649817281
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Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect
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This publication provides insight into the mechanism of LPA2-mediated cytoprotection
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E S, Lai YJ, Tsukahara R, et al Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect. J Biol Chem 2009;284(21):14558-71 This publication provides insight into the mechanism of LPA2-mediated cytoprotection.
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Es Lai, Y.J.1
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79952981125
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(The Regents of the University of California, USA; Allelix Biopharmaceuticals Inc.). Application: WO2000009139
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Chun JJM, Weiner JA, Wickens PL, et al Methods using a lysophosphatidic acid receptor agonist for promoting survival of myelin-producing cells. (The Regents of the University of California, USA; Allelix Biopharmaceuticals Inc.). Application: WO2000009139, 37pp; 2000
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Methods using a Lysophosphatidic Acid Receptor Agonist for Promoting Survival of Myelin-Producing Cells
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Chun, J.J.M.1
Weiner, J.A.2
Wickens, P.L.3
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8
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79952902842
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benzyl-12b-methyl-1, 2, 3,4,6,7,12,12boctahydroindolo[ 2,3-a]quinolizine derivatives as LPA receptor agonists. (Astellas Pharma Inc., Japan). Application: JP2008297278
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Kanan E, Kondo H, Shishikura J, et al benzyl-12b-methyl-1,2,3,4,6,7,12, 12boctahydroindolo[ 2,3-a]quinolizine derivatives as LPA receptor agonists. (Astellas Pharma Inc., Japan). Application: JP2008297278, 15pp; 2008
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Kanan, E.1
Kondo, H.2
Shishikura, J.3
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Lysophosphatidic acid production and action: Critical new players in breast cancer initiation and progression
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Panupinthu N, Lee HY, Mills GB. Lysophosphatidic acid production and action: Critical new players in breast cancer initiation and progression. Br J Cancer 2010;102(6):941-6
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Panupinthu, N.1
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The emerging role of lysophosphatidic acid in cancer
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DOI 10.1038/nrc1143
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Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer 2003;3(8):582-91 (Pubitemid 37328830)
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Mills, G.B.1
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12
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Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression
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DOI 10.1017/S1462399407000476, PII S1462399407000476
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Murph M, Mills GB, Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. Expert Rev Mol Med 2007;9(28):1-18 (Pubitemid 47617558)
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Expert Reviews in Molecular Medicine
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Murph, M.1
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Roles of LPA in ovarian cancer development and progression
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Pua TL, Wang FQ, Fishman DA. Roles of LPA in ovarian cancer development and progression. Future Oncol 2009;5(10):1659-73
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Future Oncol
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Pua, T.L.1
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14
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77956918126
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Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription
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Ramachandran S, Shida D, Nagahashi M, et al Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription. FEBS Lett 2010;584(18):4077-82
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FEBS Lett
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Ramachandran, S.1
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79951982581
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Mesenchymal stem cells stimulate angiogenesis in a murine xenograft model of A549 human adenocarcinoma through an LPA1 receptor-dependent mechanism
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Jeon ES, Lee IH, Heo SC, et al Mesenchymal stem cells stimulate angiogenesis in a murine xenograft model of A549 human adenocarcinoma through an LPA1 receptor-dependent mechanism. Biochim Biophys Acta 2010;1801(11):1205-13
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Biochim Biophys Acta
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Jeon, E.S.1
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16
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22744456880
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Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARγ, and inhibitors of autotaxin
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DOI 10.1021/jm049609r
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Durgam GG, Virag T, Walker MD, et al Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. J Med Chem 2005;48(15):4919-30 (Pubitemid 41033134)
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Journal of Medicinal Chemistry
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Durgam, G.G.1
Virag, T.2
Walker, M.D.3
Tsukahara, R.4
Yasuda, S.5
Liliom, K.6
Van Meeteren, L.A.7
Moolenaar, W.H.8
Wilke, N.9
Siess, W.10
Tigyi, G.11
Miller, D.D.12
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17
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Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors
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DOI 10.1124/mol.63.5.1032
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Virag T, Elrod DB, Liliom K, et al Fatty alcohol phosphates are subtype-selective agonists and antagonists of LPA receptors. Mol Pharmacol 2003;63(5):1032-42 This paper represents the first report of the LPA receptor-mediated functions of compounds claimed in the current application. (Pubitemid 36529921)
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Molecular Pharmacology
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Virag, T.1
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Yokoyama, K.6
Durgam, G.7
Deng, W.8
Miller, D.D.9
Tigyi, G.10
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Hasegawa Y, Erickson JR, Goddard GJ, et al Identification of a phosphothionate analogue of lysophosphatidic acid as a selective agonist of the LPA3 receptor. J Biol Chem 2003;278(14):11962-9 (Pubitemid 36800170)
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Bandoh, K.8
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Structure-activity relationships of fluorinated lysophosphatidic acid analogues
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Xu Y, Aoki J, Shimizu K, et al Structure-activity relationships of fluorinated lysophosphatidic acid analogues. J Med Chem 2005;48(9):3319-27 (Pubitemid 40628050)
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20
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Inhibition of eukaryotic DNA polymerase alpha with a novel lysophosphatidic acid (PHYLPA) isolated from myxoamoebae of Physarum polycephalum
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Murakami-Murofushi K, Shioda M, Kaji K, et al Inhibition of eukaryotic DNA polymerase alpha with a novel lysophosphatidic acid (PHYLPA) isolated from myxoamoebae of Physarum polycephalum. J Biol Chem 1992;267(30):21512-17
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79952960802
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U.S.P.a.T. Office. The University of Tennessee Research Foundation: US7217704 This is the pre-existing patent supported by the same in vivo data as the current application
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Miller DD, Tigyi G, Durgam GG, et al LPA Receptor Agonists and Antagonists and Methods of Use, U.S.P.a.T. Office. The University of Tennessee Research Foundation: US7217704; 2007 . This is the pre-existing patent supported by the same in vivo data as the current application.
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LPA Receptor Agonists and Antagonists and Methods of Use
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Miller, D.D.1
Tigyi, G.2
Durgam, G.G.3
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22
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77956264496
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Development of an LC-MS/MS assay to determine plasma pharmacokinetics of the radioprotectant octadecyl thiophosphate (OTP) in monkeys
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. This paper describes the pharmacokinetics of orally-administered oleoyl thiophosphate in primates to extend the significance of the claimed radioprotection from rodents to an organism more relevant to human clinical use
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Kosanam H, Ma F, He H, et al Development of an LC-MS/MS assay to determine plasma pharmacokinetics of the radioprotectant octadecyl thiophosphate (OTP) in monkeys. J Chromatogr B Analyt Technol Biomed Life Sci 2010;878(26):2379-83 . This paper describes the pharmacokinetics of orally-administered oleoyl thiophosphate in primates to extend the significance of the claimed radioprotection from rodents to an organism more relevant to human clinical use.
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J Chromatogr B Analyt Technol Biomed Life Sci
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Xu Y, Qian L, Prestwich GD. Synthesis of monofluorinated analogues of lysophosphatidic acid. J Org Chem 2003;68(13):5320-30 (Pubitemid 36750207)
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Synthesis of difluoromethyl-substituted lysophosphatidic acid analogues
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Xu Y, Qian L, Pontsler AV, et al Synthesis of difluoromethyl-substituted lysophosphatidic acid analogues. Tetrahedron 2004;60(1):47-53
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Tetrahedron
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Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors
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DOI 10.1016/j.bmcl.2004.08.019, PII S0960894X04010273
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Xu Y, Tanaka M, Arai H, et al Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors. Bioorg Med Chem Lett 2004;14(21):5323-8 (Pubitemid 39348922)
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Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA
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Jiang G, Xu Y, Fujiwara Y, et al Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA. ChemMedChem 2007;2(5):679-90
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Heise CE, Santos WL, Schreihofer AM, et al Activity of 2-substituted LPA analogs at LPA receptors: Discovery of a LPA1/LPA3 receptor antagonist. Mol Pharmacol 2001;60(6):1173-80 (Pubitemid 33144887)
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Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid
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DOI 10.1016/j.bmcl.2004.04.061, PII S0960894X04005591
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Santos WL, Heasley BH, Jarosz R, et al Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorg Med Chem Lett 2004;14(13):3473-6 (Pubitemid 38737149)
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