Mesenchymal stem cells stimulate angiogenesis in a murine xenograft model of A549 human adenocarcinoma through an LPA1 receptor-dependent mechanism

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1801, Issue 11, 2010, Pages 1205-1213

  Jeon, Eun Su ^a,c,d   Lee, Il Hwan ^a,b   Heo, Soon Chul ^a,b   Shin, Sang Hun ^a,b   Choi, Yoon Ji ^a,b   Park, Ji Hye ^a,b   Park, Do Youn ^d   Kim, Jae Ho ^a,b  

^a Pusan National University Yangsan   (South Korea)

^b Department of Physiology ^*  (South Korea)

^c Pusan National University Hospital   (South Korea)

^d Pusan National University School of Medicine   (South Korea)

Author keywords

Angiogenesis; Carcinoma associated fibroblasts; Lysophosphatidic acid; Mesenchymal stem cells; VEGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; LYSOPHOSPHATIDIC ACID RECEPTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN;

ADIPOSE TISSUE; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ADENOCARCINOMA; MESENCHYME CELL; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; TUMOR GROWTH; XENOGRAFT;

ADENOCARCINOMA; ADIPOSE TISSUE; ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; HUMANS; LUNG NEOPLASMS; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, LYSOPHOSPHATIDIC ACID; STEM CELLS;

MURINAE;

EID: 79951982581     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2010.08.003     Document Type: Article

References (44)

1. De Wever O., Mareel M. Role of tissue stroma in cancer cell invasion. J. Pathol. 2003, 200:429-447.
2. Bhowmick N.A., Neilson E.G., Moses H.L. Stromal fibroblasts in cancer initiation and progression. Nature 2004, 432:332-337.
3. De Wever O., Demetter P., Mareel M., Bracke M. Stromal myofibroblasts are drivers of invasive cancer growth. Int. J. Cancer 2008, 123:2229-2238.
4. Desmouliere A., Guyot C., Gabbiani G. The stroma reaction myofibroblast: a key player in the control of tumor cell behavior. Int. J. Dev. Biol. 2004, 48:509-517.
5. Orimo A., Weinberg R.A. Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 2006, 5:1597-1601.
6. Sappino A.P., Skalli O., Jackson B., Schurch W., Gabbiani G. Smooth-muscle differentiation in stromal cells of malignant and non-malignant breast tissues. Int. J. Cancer 1988, 41:707-712.
7. Ganss R. Tumor stroma fosters neovascularization by recruitment of progenitor cells into the tumor bed. J. Cell. Mol. Med. 2006, 10:857-865.
8. Olumi A.F., Grossfeld G.D., Hayward S.W., Carroll P.R., Tlsty T.D., Cunha G.R. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 1999, 59:5002-5011.
9. Orimo A., Gupta P.B., Sgroi D.C., Arenzana-Seisdedos F., Delaunay T., Naeem R., Carey V.J., Richardson A.L., Weinberg R.A. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348.
10. Li H., Fan X., Houghton J. Tumor microenvironment: the role of the tumor stroma in cancer. J. Cell. Biochem. 2007, 101:805-815.
11. Barry F.P., Murphy J.M. Mesenchymal stem cells: clinical applications and biological characterization. Int. J. Biochem. Cell Biol. 2004, 36:568-584.
12. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997, 276:71-74.
13. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman M.A., Simonetti D.W., Craig S., Marshak D.R. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
14. Short B., Brouard N., Occhiodoro-Scott T., Ramakrishnan A., Simmons P.J. Mesenchymal stem cells. Arch. Med. Res. 2003, 34:565-571.
15. Crisan M., Yap S., Casteilla L., Chen C.W., Corselli M., Park T.S., Andriolo G., Sun B., Zheng B., Zhang L., Norotte C., Teng P.N., Traas J., Schugar R., Deasy B.M., Badylak S., Buhring H.J., Giacobino J.P., Lazzari L., Huard J., Peault B. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008, 3:301-313.
16. Hall B., Andreeff M., Marini F. The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles. Handb. Exp. Pharmacol. 2007, 263-283.
17. Zhu W., Xu W., Jiang R., Qian H., Chen M., Hu J., Cao W., Han C., Chen Y. Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp. Mol. Pathol. 2006, 80:267-274.
18. Karnoub A.E., Dash A.B., Vo A.P., Sullivan A., Brooks M.W., Bell G.W., Richardson A.L., Polyak K., Tubo R., Weinberg R.A. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007, 449:557-563.
19. Mishra P.J., Mishra P.J., Humeniuk R., Medina D.J., Alexe G., Mesirov J.P., Ganesan S., Glod J.W., Banerjee D. Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res. 2008, 68:4331-4339.
20. Spaeth E.L., Dembinski J.L., Sasser A.K., Watson K., Klopp A., Hall B., Andreeff M., Marini F. Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS ONE 2009, 4:e4992.
21. Aoki J. Mechanisms of lysophosphatidic acid production. Semin. Cell Dev. Biol. 2004, 15:477-489.
22. Mills G.B., Moolenaar W.H. The emerging role of lysophosphatidic acid in cancer. Nat. Rev. Cancer 2003, 3:582-591.
23. Gaits F., Fourcade O., Le Balle F., Gueguen G., Gaige B., Gassama-Diagne A., Fauvel J., Salles J.P., Mauco G., Simon M.F., Chap H. Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis. FEBS Lett. 1997, 410:54-58.
24. Okudaira S., Yukiura H., Aoki J. Biological roles of lysophosphatidic acid signaling through its production by autotaxin. Biochimie 2010, 92:698-706.
25. Birgbauer E., Chun J. New developments in the biological functions of lysophospholipids. Cell. Mol. Life Sci. 2006, 63:2695-2701.
26. Jeon E.S., Moon H.J., Lee M.J., Song H.Y., Kim Y.M., Cho M., Suh D.S., Yoon M.S., Chang C.L., Jung J.S., Kim J.H. Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells. Stem Cells 2008, 26:789-797.
27. Jeon E.S., Heo S.C., Lee I.H., Choi Y.J., Park J.H., Choi K.U., Park D.Y., Suh D.S., Yoon M.S., Kim J.H. Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1 alpha from human mesenchymal stem cells. Exp. Mol. Med. 2010, 42:280-293.
28. Lee M.J., Jeon E.S., Lee J.S., Cho M., Suh D.S., Chang C.L., Kim J.H. Lysophosphatidic acid in malignant ascites stimulates migration of human mesenchymal stem cells. J. Cell. Biochem. 2008, 104:499-510.
29. Jeon E.S., Moon H.J., Lee M.J., Song H.Y., Kim Y.M., Bae Y.C., Jung J.S., Kim J.H. Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-β-dependent mechanism. J. Cell Sci. 2006, 119:4994-5005.
30. Jeon E.S., Park W.S., Lee M.J., Kim Y.M., Han J., Kim J.H. A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells. Circ. Res. 2008, 103:635-642.
31. Folkman J. Angiogenesis. Annu. Rev. Med. 2006, 57:1-18.
32. Khosravi Shahi P., Fernandez Pineda I. Tumoral angiogenesis: review of the literature. Cancer Invest. 2008, 26:104-108.
33. Kryczek I., Wei S., Keller E., Liu R., Zou W. Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis. Am. J. Physiol. Cell Physiol. 2007, 292:C987-C995.
34. Direkze N.C., Hodivala-Dilke K., Jeffery R., Hunt T., Poulsom R., Oukrif D., Alison M.R., Wright N.A. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res. 2004, 64:8492-8495.
35. Ishii G., Sangai T., Oda T., Aoyagi Y., Hasebe T., Kanomata N., Endoh Y., Okumura C., Okuhara Y., Magae J., Emura M., Ochiya T., Ochiai A. Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. Biochem. Biophys. Res. Commun. 2003, 309:232-240.
36. Ishii G., Ito T.K., Aoyagi K., Fujimoto H., Chiba H., Hasebe T., Fujii S., Nagai K., Sasaki H., Ochiai A. Presence of human circulating progenitor cells for cancer stromal fibroblasts in the blood of lung cancer patients. Stem Cells 2007, 25:1469-1477.
37. Emura M., Ochiai A., Horino M., Arndt W., Kamino K., Hirohashi S. Development of myofibroblasts from human bone marrow mesenchymal stem cells cocultured with human colon carcinoma cells and TGF beta 1. In Vitro Cell. Dev. Biol. Anim. 2000, 36:77-80.
38. Beckermann B.M., Kallifatidis G., Groth A., Frommhold D., Apel A., Mattern J., Salnikov A.V., Moldenhauer G., Wagner W., Diehlmann A., Saffrich R., Schubert M., Ho A.D., Giese N., Buchler M.W., Friess H., Buchler P., Herr I. VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma. Br. J. Cancer 2008, 99:622-631.
39. Xu Y., Shen Z., Wiper D.W., Wu M., Morton R.E., Elson P., Kennedy A.W., Belinson J., Markman M., Casey G. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers. JAMA 1998, 280:719-723.
40. Umezu-Goto M., Kishi Y., Taira A., Hama K., Dohmae N., Takio K., Yamori T., Mills G.B., Inoue K., Aoki J., Arai H. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J. Cell Biol. 2002, 158:227-233.
41. Stracke M.L., Krutzsch H.C., Unsworth E.J., Arestad A., Cioce V., Schiffmann E., Liotta L.A. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J. Biol. Chem. 1992, 267:2524-2529.
42. Yang S.Y., Lee J., Park C.G., Kim S., Hong S., Chung H.C., Min S.K., Han J.W., Lee H.W., Lee H.Y. Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. Clin. Exp. Metastasis 2002, 19:603-608.
43. Kishi Y., Okudaira S., Tanaka M., Hama K., Shida D., Kitayama J., Yamori T., Aoki J., Fujimaki T., Arai H. Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J. Biol. Chem. 2006, 281:17492-17500.
44. Yang Y., Mou L., Liu N., Tsao M.S. Autotaxin expression in non-small-cell lung cancer. Am. J. Respir. Cell Mol. Biol. 1999, 21:216-222.