Development of an LC-MS/MS assay to determine plasma pharmacokinetics of the radioprotectant octadecyl thiophosphate (OTP) in monkeys

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 26, 2010, Pages 2379-2383

  Kosanam, Hari ^a   Ma, Fei ^b   He, Hui ^b   Ramagiri, Suma ^c   Gududuru, Veeresa ^d   Tigyi, Gabor J ^e   Van Rompay, Koen ^f   Miller, Duane D ^b   Yates, Charles R ^b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TENNESSEE COLLEGE OF PHARMACY   (United States)

^c MDS SCIEX   (Canada)

^d RxBio Inc   (United States)

^e UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Liquid chromatography tandem mass spectrometry (LC MS MS); Lysophosphatidic acid (LPA); Octadecenyl thiophosphate (OTP); Pharmacokinetics

Indexed keywords

AMMONIUM ACETATE; GROWTH FACTOR; INTERNAL STANDARDS; LC-MS/MS; LETHAL DOSE; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; LYSOPHOSPHATIDIC ACID; MOUSE MODELS; MULTIPLE REACTION MONITORING; OCTADECENYL THIOPHOSPHATE (OTP); OCTADECYL; PHARMACOKINETIC PARAMETERS; PRE-CLINICAL TESTING; RADIATION EXPOSURE; REVERSED-PHASE LIQUID CHROMATOGRAPHY; SAMPLE EXTRACTION; SYNTHETIC ANALOGUES; TRIPLE-QUADRUPOLE MASS SPECTROMETER; WHOLE-BODY;

ACETONITRILE; ACIDS; AMMONIUM COMPOUNDS; COLUMN CHROMATOGRAPHY; DEUTERIUM; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PHOSPHOLIPIDS; SOLVENT EXTRACTION;

LIQUIDS;

OCTADECYLTHIOPHOSPHATE; RADIOPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; LIQUID CHROMATOGRAPHY; NONHUMAN; PLASMA; PRIORITY JOURNAL; RADIATION PROTECTION; RHESUS MONKEY; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

ANIMALS; BUTANOLS; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FEMALE; LINEAR MODELS; MACACA MULATTA; ORGANOPHOSPHORUS COMPOUNDS; RADIATION-PROTECTIVE AGENTS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 77956264496     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.07.004     Document Type: Article

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