Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone

Archives of Biochemistry and Biophysics

Volumn 475, Issue 2, 2008, Pages 175-183

  Hummel, Matthew A ^a   Gannett, Peter M ^b   Aguilar, Jarrett ^c   Tracy, Timothy S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c West Liberty State College   (United States)

Author keywords

Activation; Binding affinity; CYP2C9; Cytochrome P450; Genetic polymorphism; Kinetics; Proton distance; T1 NMR; Variant

Indexed keywords

CYTOCHROME P450 2C9; DAPSONE; FLURBIPROFEN; HEME; PROTON;

ALLELE; ARTICLE; BINDING AFFINITY; CATALYSIS; GENETIC VARIABILITY; MOLECULAR MECHANICS; MUTATION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN VARIANT;

ALLELES; ANTI-INFECTIVE AGENTS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; DAPSONE; HEME; KINETICS; MOLECULAR STRUCTURE; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTONS; SUBSTRATE SPECIFICITY;

EID: 44949121516     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2008.04.034     Document Type: Article

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