Cytoprotection by natural and synthetic polyphenols in the heart: Novel mechanisms and perspectives

Current Pharmaceutical Design

Volumn 16, Issue 37, 2010, Pages 4103-4112

  Jiang, Fan ^a,b   Chang, Catherine W T ^b   Dusting, Gregory J ^b  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Heart; Histone acetyltransferase; Ischemia reperfusion injury; Mitochondria; Myocardial cytoprotection; Polyphenol; Preconditioning; Synthetic

Indexed keywords

3',4' DIHYDROXYFLAVONOL; ASTRINGININ; BAICALEIN; CURCUMIN; DIAZOXIDE; EPIGALLOCATECHIN; EPIGALLOCATECHIN DI GALLATE; EPIGALLOCATECHIN GALLATE; EPITHEAFLAGALLIN GALLATE; FLAVONOID; GENISTEIN; GENISTIN; HISTONE ACETYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KAEMPFEROL; MAGNOLOL; MATRIX METALLOPROTEINASE; MORIN; NICORANDIL; NITRIC OXIDE; OLEUROPEIN; OPIATE; POLYPHENOL; PROCYANIDIN; QUERCETIN; RESVERATROL; RUTOSIDE; SILDENAFIL; UNCLASSIFIED DRUG;

ACUTE DISEASE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; DRUG EFFECT; DRUG MECHANISM; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HUMAN; ISCHEMIC PRECONDITIONING; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; CYTOPROTECTION; FLAVONOIDS; HEART; HUMANS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHENOLS;

EID: 79952734249     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210794519174     Document Type: Article

References (129)

1. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000; 130: 2073S-2085S.
2. Scalbert A, Manach C, Morand C, Remesy C, Jimenez L. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 2005; 45: 287-306.
3. Jiang F, Dusting GJ. Natural phenolic compounds as cardiovascular therapeutics: Potential role of their anti inflammatory effects. Curr Vasc Pharmacol 2003; 1: 135-156.
4. Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. Am J Clin Nutr 2005; 81: 215S-217S.
5. Uyama H. Artificial polymeric flavonoids: synthesis and applications. Macromol Biosci 2007; 7: 410-422.
6. Shen Y, Zhang J, Sheng R, et al. Synthesis and biological evaluation of novel flavonoid derivatives as dual binding acetylcholinesterase inhibitors. J Enzyme Inhib Med Chem 2008; 24: 372-380.
7. Lim SS, Jung SH, Ji J, Shin KH, Keum SR. Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. J Pharm Pharmacol 2001; 53: 653-668.
8. Min JY, Liao H, Wang JF, Sullivan MF, Ito T, Morgan JP. Genistein attenuates postischemic depressed myocardial function by increasing myofilament ca2+ sensitivity in rat myocardium. Exp Biol Med (Maywood) 2002; 227: 632-638.
9. Pagnotta E, Calonghi N, Hrelia S, Masotti L, Biagi P, Angeloni C. Green tea protects cytoskeleton from oxidative injury in cardiomyocytes. J Agric Food Chem 2006; 54: 10159-10163.
10. Bordoni A, Hrelia S, Angeloni C, et al. Green tea protection of hypoxia/reoxygenation injury in cultured cardiac cells. J Nutr Biochem 2002; 13: 103-111.
11. Hirai M, Hotta Y, Ishikawa N, et al. Protective effects of egcg or gcg, a green tea catechin epimer, against postischemic myocardial dysfunction in guinea-pig hearts. Life Sci 2007; 80: 1020-1032.
12. Pataki T, Bak I, Kovacs P, Bagchi D, Das DK, Tosaki A. Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts. Am J Clin Nutr 2002; 75: 894-899.
13. Ji ES, Yue H, Wu YM, He RR. Effects of phytoestrogen genistein on myocardial ischemia/reperfusion injury and apoptosis in rabbits. Acta Pharmacol Sin 2004; 25: 306-312.
14. Wexler BC, Greenberg BP. Protective effects of clofibrate on isoproterenol-induced myocardial infarction in arteriosclerotic and non-arteriosclerotic rats. Atherosclerosis 1978; 29: 373-395.
15. Nazam Ansari M, Bhandari U, Pillai KK. Protective role of curcumin in myocardial oxidative damage induced by isoproterenol in rats. Hum Exp Toxicol 2007; 26: 933-938.
16. Rajadurai M, Prince PS. Preventive effect of naringin on isoproterenol-induced cardiotoxicity in wistar rats: An in vivo and in vitro study. Toxicology 2007; 232: 216-225.
17. Rajadurai M, Prince PS. Preventive effect of naringin on cardiac mitochondrial enzymes during isoproterenol-induced myocardial infarction in rats: A transmission electron microscopic study. J Biochem Mol Toxicol 2007; 21: 354-361.
18. Rajadurai M, Stanely Mainzen Prince P. Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol induced cardiotoxicity in wistar rats: Biochemical and histopathological evidences. Toxicology 2006; 228: 259-268.
19. Rajadurai M, Stanely Mainzen Prince P. Preventive effect of naringin on lipids, lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in wistar rats. J Biochem Mol Toxicol 2006; 20: 191-197.
20. Aneja R, Hake PW, Burroughs TJ, Denenberg AG, Wong HR, Zingarelli B. Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats. Mol Med 2004; 10: 55-62.
21. Mokni M, Limam F, Elkahoui S, Amri M, Aouani E. Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury. Arch Biochem Biophys 2007; 457: 1-6.
22. Yamazaki KG, Romero-Perez D, Barraza-Hidalgo M, et al. Shortand long-term effects of (-)-epicatechin on myocardial ischemiareperfusion injury. Am J Physiol Heart Circ Physiol 2008; 295:H761-767.
23. Fisher ND, Hollenberg NK. Flavanols for cardiovascular health: The science behind the sweetness. J Hypertens 2005; 23: 1453-1459.
24. Lin JF, Lin SM, Chih CL, et al. Resveratrol reduces infarct size and improves ventricular function after myocardial ischemia in rats. Life Sci 2008; 83: 313-317.
25. Palfi A, Bartha E, Copf L, et al. Alcohol-free red wine inhibits isoproterenol-induced cardiac remodeling in rats by the regulation of Akt1 and protein kinase C α/β II. J Nutr Biochem 2008; 20: 418-425.
26. Suzuki J, Ogawa M, Maejima Y, et al. Tea catechins attenuate chronic ventricular remodeling after myocardial ischemia in rats. J Mol Cell Cardiol 2007; 42: 432-440.
27. He H, Shi M, Yang J, et al. The correlation between angiogenesis and abnormal expression of serca2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin. Phytother Res 2008; 22: 948-956.
28. Singal PK, Deally CM, Weinberg LE. Sub cellular effects of adriamycin in the heart: a concise review. J Mol Cell Cardiol 1987;19: 817-828.
29. van Acker SA, Kramer K, Grimbergen JA, van den Berg DJ, van der Vijgh WJ, Bast A. Monohydroxyethylrutoside as protector against chronic doxorubicin-induced cardiotoxicity. Br J Pharmacol 1995; 115: 1260-1264.
30. Bast A, Haenen GR, Bruynzeel AM, Van der Vijgh WJ. Protection by flavonoids against anthracycline cardiotoxicity: From chemistry to clinical trials. Cardiovasc Toxicol 2007; 7: 154-159.
31. Du Y, Lou H. Catechin and proanthocyanidin b4 from grape seeds prevent doxorubicin-induced toxicity in cardiomyocytes. Eur J Pharmacol 2008; 591: 96-101.
32. Arafa HM, Abd-Ellah MF, Hafez HF. Abatement by naringenin of doxorubicin-induced cardiac toxicity in rats. J Egypt Natl Canc Inst 2005; 17: 291-300.
33. Abdel-Wahab MH, El-Mahdy MA, Abd-Ellah MF, Helal GK, Khalifa F, Hamada FM. Influence of p-coumaric acid on doxorubicin-induced oxidative stress in rat's heart. Pharmacol Res 2003; 48: 461-465.
34. Kaiserova H, Simunek T, van der Vijgh WJ, Bast A, Kvasnickova E. Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase. Biochim Biophys Acta 2007; 1772: 1065-1074.
35. Wang S, Dusting GJ, May CN, Woodman OL. 3',4'-Dihydroxyflavonol reduces infarct size and injury associated with myocardial ischaemia and reperfusion in sheep. Br J Pharmacol 2004; 142:443-452.
36. Wang S, Thomas CJ, Dusting GJ, Woodman OL, May CN. 3',4'- Dihydroxyflavonol improves post-ischaemic coronary endothelial function following 7 days reperfusion in sheep. Eur J Pharmacol 2009; 624: 31-37.
37. Chan EC, Pannangpetch P, Woodman OL. Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. J Cardiovasc Pharmacol 2000;35: 326-333.
38. Chan EC, Drummond GR, Woodman OL. 3', 4'-dihydroxyflavonol enhances nitric oxide bioavailability and improves vascular function after ischemia and reperfusion injury in the rat. J Cardiovasc Pharmacol 2003; 42: 727-735.
39. Vinten-Johansen J. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res 2004; 61:481-497.
40. Dusting GJ. Nitric oxide in cardiovascular disorders. J Vasc Res 1995; 32: 143-161.
41. Jiang F, Guo N, Dusting GJ. Modulation of nicotinamide adenine dinucleotide phosphate oxidase expression and function by 3',4'-dihydroxyflavonol in phagocytic and vascular cells. J Pharmacol Exp Ther 2008; 324: 261-269.
42. Jiang F, Guo N, Dusting GJ. 3',4'-dihydroxyflavonol suppresses monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by inhibiting tyrosine kinase functions. Br J Pharmacol 2009; 157: 597-606.
43. Frangogiannis NG. The role of the chemokines in myocardial ischemia and reperfusion. Curr Vasc Pharmacol 2004; 2: 163-174.
44. Xia Y, Frangogiannis NG. Mcp-1/ccl2 as a therapeutic target in myocardial infarction and ischemic cardiomyopathy. Inflamm Allergy Drug Targets 2007; 6: 101-107.
45. Lebeau J, Neviere R, Cotelle N. Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart. Bioorg Med Chem Lett 2001; 11: 23-27.
46. Husken BC, de Jong J, Beekman B, Onderwater RC, van der Vijgh WJ, Bast A. Modulation of the in vitro cardiotoxicity of doxorubicin by flavonoids. Cancer Chemother Pharmacol 1995; 37: 55-62.
47. De Celle T, Heeringa P, Strzelecka AE, Bast A, Smits JF, Janssen BJ. Sustained protective effects of 7-monohydroxyethylrutoside in an in vivo model of cardiac ischemia-reperfusion. Eur J Pharmacol 2004; 494: 205-212.
48. Abou EL, Hassan MA, Verheul HM, et al. The new cardioprotector monohydroxyethylrutoside protects against doxorubicin-induced inflammatory effects in vitro. Br J Cancer 2003; 89: 357-362.
49. Gonzalez-Covarrubias V, Kalabus JL, Blanco JG. Inhibition of polymorphic human carbonyl reductase 1 (cbr1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoher). Pharm Res 2008; 25: 1730-1734.
50. van Acker FA, van Acker SA, Kramer K, Haenen GR, Bast A, van der Vijgh WJ. 7-monohydroxyethylrutoside protects against chronic doxorubicin-induced cardiotoxicity when administered only once per week. Clin Cancer Res 2000; 6: 1337-1341.
51. Bruynzeel AM, Vormer-Bonne S, Bast A, Niessen HW, van der Vijgh WJ. Long-term effects of 7-monohydroxyethylrutoside (monoher) on dox-induced cardiotoxicity in mice. Cancer Chemother Pharmacol 2007; 60: 509-514.
52. Bruynzeel AM, Niessen HW, Bronzwaer JG, et al. The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase ii study. Br J Cancer 2007; 97: 1084-1089.
53. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004; 79: 727-747.
54. Duilio C, Ambrosio G, Kuppusamy P, DiPaula A, Becker LC, Zweier JL. Neutrophils are primary source of o2 radicals during reperfusion after prolonged myocardial ischemia. Am J Physiol Heart Circ Physiol 2001; 280: H2649-H2657.
55. Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial ros-induced ros release: An update and review. Biochim Biophys Acta 2006; 1757:509-517.
56. Dusting GJ, Selemidis S, Jiang F. Mechanisms for suppressing nadph oxidase in the vascular wall. Mem Inst Oswaldo Cruz 2005; 100 Suppl 1: 97-103.
57. Cave AC, Brewer AC, Narayanapanicker A, et al. Nadph oxidases in cardiovascular health and disease. Antioxid Redox Signal 2006; 8: 691-728.
58. Bors W, Michel C. Chemistry of the antioxidant effect of polyphenols. Ann N Y Acad Sci 2002; 957: 57-69.
59. Akhlaghi M, Bandy B. Mechanisms of flavonoid protection against myocardial ischemia-reperfusion injury. J Mol Cell Cardiol 2009; 46: 309-317.
60. Prabhu S, Jainu M, Sabitha KE, Devi CS. Role of mangiferin on biochemical alterations and antioxidant status in isoproterenolinduced myocardial infarction in rats. J Ethnopharmacol 2006; 107: 126-133.
61. Vianna HR, Cortes SF, Ferreira AJ, et al. Antiarrhythmogenic and antioxidant effect of the flavonoid dioclein in a model of cardiac ischemia/reperfusion. Planta Med 2006; 72: 300-303.
62. Reffelmann T, Kloner RA. Microvascular alterations after temporary coronary artery occlusion: The no-reflow phenomenon. J Cardiovasc Pharmacol Ther 2004; 9: 163-172.
63. Jones SP, Bolli R. The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol 2006; 40: 16-23.
64. Burwell LS, Brookes PS. Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury. Antioxid Redox Signal 2008; 10: 579-599.
65. Ferdinandy P, Schulz R. Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning. Br J Pharmacol 2003; 138: 532-543.
66. Berges A, Van Nassauw L, Bosmans J, Timmermans JP, Vrints C. Role of nitric oxide and oxidative stress in ischaemic myocardial injury and preconditioning. Acta Cardiol 2003; 58: 119-132.
67. Das S, Falchi M, Bertelli A, Maulik N, Das DK. Attenuation of ischemia/reperfusion injury in rats by the anti-inflammatory action of resveratrol. Arzneimittelforschung 2006; 56: 700-706.
68. Yuan LP, Chen ZW, Li F, Dong LY, Chen FH. Protective effect of total flavones of rhododendra on ischemic myocardial injury in rabbits. Am J Chin Med 2006; 34: 483-492.
69. Ren G, Dewald O, Frangogiannis NG. Inflammatory mechanisms in myocardial infarction. Curr Drug Targets Inflamm Allergy 2003; 2: 242-256.
70. Frangogiannis NG, Youker KA, Rossen RD, et al. Cytokines and the microcirculation in ischemia and reperfusion. J Mol Cell Cardiol 1998; 30: 2567-2576.
71. Kim HJ, Tsoy I, Park JM, Chung JI, Shin SC, Chang KC. Anthocyanins from soybean seed coat inhibit the expression of tnfalpha-induced genes associated with ischemia/reperfusion in endothelial cell by nf-kappab-dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivo. FEBS Lett 2006; 580: 1391-1397.
72. Shigematsu S, Ishida S, Hara M, et al. Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, plateletactivating factor, or oxidants. Free Radic Biol Med 2003; 34: 810-817.
73. Janicki JS, Brower GL, Gardner JD, Chancey AL, Stewart JA Jr. The dynamic interaction between matrix metalloproteinase activity and adverse myocardial remodeling. Heart Fail Rev 2004; 9: 33-42.
74. Demeule M, Brossard M, Page M, Gingras D, Beliveau R. Matrix metalloproteinase inhibition by green tea catechins. Biochim Biophys Acta 2000; 1478: 51-60.
75. Nakamuta M, Higashi N, Kohjima M, et al. Epigallocatechin-3-gallate, a polyphenol component of green tea, suppresses both collagen production and collagenase activity in hepatic stellate cells. Int J Mol Med 2005; 16: 677-681.
76. Oku N, Matsukawa M, Yamakawa S, et al. Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, mt1-mmp. Biol Pharm Bull 2003; 26: 1235-1238.
77. El Bedoui J, Oak MH, Anglard P, Schini-Kerth VB. Catechins prevent vascular smooth muscle cell invasion by inhibiting mt1-mmp activity and mmp-2 expression. Cardiovasc Res 2005; 67:317-325.
78. Grimm T, Schafer A, Hogger P. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Free Radic Biol Med 2004; 36: 811-822.
79. Zibadi S, Yu Q, Rohdewald PJ, Larson DF, Watson RR. Impact of pycnogenol on cardiac extracellular matrix remodeling induced by l-name administration to old mice. Cardiovasc Toxicol 2007; 7: 10-18.
80. Gustafsson AB, Gottlieb RA. Heart mitochondria: gates of life and death. Cardiovasc Res 2008; 77: 334-343.
81. Brookes PS, Digerness SB, Parks DA, Darley-Usmar V. Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin. Free Radic Biol Med 2002; 32: 1220-1228.
82. Guzy J, Kusnir J, Marekova M, Chavkova Z, et al. Effect of quercetin on daunorubicin-induced heart mitochondria changes in rats. Physiol Res 2003; 52: 773-780.
83. Murphy E, Steenbergen C. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev 2008;88: 581-609.
84. Tissier R, Waintraub X, Couvreur N, et al. Pharmacological postconditioning with the phytoestrogen genistein. J Mol Cell Cardiol 2007; 42: 79-87.
85. Zhou B, Wu LJ, Li LH, et al. Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of sirt1. J Pharmacol Sci 2006; 102:387-395.
86. Montero M, Lobaton CD, Hernandez-Sanmiguel E, et al. Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem J 2004; 384: 19-24.
87. Santos AC, Uyemura SA, Lopes JL, Bazon JN, Mingatto FE, Curti C. Effect of naturally occurring flavonoids on lipid peroxidation and membrane permeability transition in mitochondria. Free Radic Biol Med 1998; 24: 1455-1461.
88. Schroeder EK, Kelsey NA, Doyle J, et al. Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective anti-apoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxid Redox Signal 2008; 11: 469-480.
89. Davis JM, Murphy EA, Carmichael MD, Davis B. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol Regul Integr Comp Physiol 2009; 296:R1071-1077.
90. Bohmont C, Aaronson LM, Mann K, Pardini RS. Inhibition of mitochondrial nadh oxidase, succinoxidase, and atpase by naturally occurring flavonoids. J Nat Prod 1987; 50: 427-433.
91. Dorta DJ, Pigoso AA, Mingatto FE, et al. The interaction of flavonoids with mitochondria: Effects on energetic processes. Chem Biol Interact 2005; 152: 67-78.
92. Ferdinandy P, Schulz R, Baxter GF. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev 2007; 59: 418-458.
93. Downey JM, Davis AM, Cohen MV. Signaling pathways in ischemic preconditioning. Heart Fail Rev 2007; 12: 181-188.
94. Andreadou I, Iliodromitis EK, Koufaki M, Kremastinos DT. Pharmacological pre- and post- conditioning agents: Reperfusioninjury of the heart revisited. Mini Rev Med Chem 2008; 8: 952-959.
95. McCully JD, Levitsky S. Mitochondrial atp-sensitive potassium channels in surgical cardioprotection. Arch Biochem Biophys 2003; 420: 237-245.
96. Das S, Das DK. Resveratrol: a therapeutic promise for cardiovascular diseases. Recent Patents Cardiovasc Drug Discov 2007; 2:133-138.
97. Das DK, Maulik N. Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Mol Interv 2006; 6: 36-47.
98. Das S, Cordis GA, Maulik N, Das DK. Pharmacological preconditioning with resveratrol: Role of creb-dependent bcl-2 signaling via adenosine a3 receptor activation. Am J Physiol Heart Circ Physiol 2005; 288: H328-335.
99. Zhang JH, Chen ZW, Wu Z. Late protective effect of pharmacological preconditioning with total flavones of rhododendra against myocardial ischemia-reperfusion injury. Can J Physiol Pharmacol 2008; 86: 131-138.
100. Hattori R, Otani H, Maulik N, Das DK. Pharmacological preconditioning with resveratrol: Role of nitric oxide. Am J Physiol Heart Circ Physiol 2002; 282: H1988-1995.
101. Penna C, Mancardi D, Raimondo S, Geuna S, Pagliaro P. The paradigm of postconditioning to protect the heart. J Cell Mol Med 2008; 12: 435-458.
102. Kundu TK, Palhan VB, Wang Z, An W, Cole PA, Roeder RG. Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300. Mol Cell 2000; 6: 551-561.
103. Miyamoto S, Kawamura T, Morimoto T, et al. Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo. Circulation 2006; 113: 679-690.
104. Takaya T, Kawamura T, Morimoto T, et al. Identification of p300- targeted acetylated residues in gata4 during hypertrophic responses in cardiac myocytes. J Biol Chem 2008; 283: 9828-9835.
105. Yanazume T, Hasegawa K, Morimoto T, et al. Cardiac p300 is involved in myocyte growth with decompensated heart failure. Mol Cell Biol 2003; 23: 3593-3606.
106. Balasubramanyam K, Varier RA, Altaf M, et al. Curcumin, a novel p300/creb-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J Biol Chem 2004; 279: 51163-51171.
107. Morimoto T, Sunagawa Y, Kawamura T, et al. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest 2008; 118: 868-878.
108. Li HL, Liu C, de Couto G, et al. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2008; 118: 879-893.
109. Meja KK, Rajendrasozhan S, Adenuga D, et al. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining hdac2. Am J Respir Cell Mol Biol 2008; 39: 312-323.
110. Granger A, Abdullah I, Huebner F, et al. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. Faseb J 2008; 22: 3549-3560.
111. Dayangac-Erden D, Bora G, Ayhan P, et al. Histone deacetylase inhibition activity and molecular docking of (e)-resveratrol: Its therapeutic potential in spinal muscular atrophy. Chem Biol Drug Des 2009; 73: 355-364.
112. Son IH, Chung IM, Lee SI, Yang HD, Moon HI. Pomiferin, histone deacetylase inhibitor isolated from the fruits of maclura pomifera. Bioorg Med Chem Lett 2007; 17: 4753-4755.
113. Fang M, Chen D, Yang CS. Dietary polyphenols may affect DNA methylation. J Nutr 2007; 137: 223S-228S.
114. Katsuyama Y, Funa N, Miyahisa I, Horinouchi S. Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in escherichia coli. Chem Biol 2007; 14: 613-621.
115. Moskaug JO, Borge GI, Fagervoll AM, Paur I, Carlsen H, Blomhoff R. Dietary polyphenols identified as intracellular protein kinase a inhibitors. Eur J Nutr 2008; 47: 460-469.
116. Wu TW, Fung KP, Zeng LH, et al. Molecular properties and myocardial salvage effects of morin hydrate. Biochem Pharmacol 1995; 49: 537-543.
117. Shen YC, Sung YJ, Chen CF. Magnolol inhibits mac-1 (cd11b/cd18)-dependent neutrophil adhesion: relationship with its antioxidant effect. Eur J Pharmacol 1998; 343: 79-86.
118. Hong CY, Huang SS, Tsai SK. Magnolol reduces infarct size and suppresses ventricular arrhythmia in rats subjected to coronary ligation. Clin Exp Pharmacol Physiol 1996; 23: 660-664.
119. Facino RM, Carini M, Aldini G, et al. Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats. Life Sci 1999; 64: 627-642.
120. Sato M, Maulik G, Ray PS, Bagchi D, Das DK. Cardioprotective effects of grape seed proanthocyanidin against ischemic reperfusion injury. J Mol Cell Cardiol 1999; 31: 1289-1297.
121. Ray PS, Maulik G, Cordis GA, Bertelli AA, Bertelli A, Das DK. The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury. Free Radic Biol Med 1999; 27:160-169.
122. Shao ZH, Li CQ, Vanden Hoek TL, et al. Extract from scutellaria baicalensis georgi attenuates oxidant stress in cardiomyocytes. J Mol Cell Cardiol 1999; 31: 1885-1895.
123. Shao ZH, Vanden Hoek TL, Qin Y, et al. Baicalein attenuates oxidant stress in cardiomyocytes. Am J Physiol Heart Circ Physiol 2002; 282: H999-1006.
124. Hung LM, Su MJ, Chu WK, Chiao CW, Chan WF, Chen JK. The protective effect of resveratrols on ischaemia-reperfusion injuries of rat hearts is correlated with antioxidant efficacy. Br J Pharmacol 2002; 135: 1627-1633.
125. Manna C, Migliardi V, Golino P, et al. Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. J Nutr Biochem 2004; 15: 461-466.
126. Kruk I, Aboul-Enein HY, Michalska T, Lichszteld K, Kladna A. Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein. Luminescence 2005; 20: 81-89.
127. Lin JK, Chen PC, Ho CT, Lin-Shiau SY. Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in hl-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3- gallate, and propyl gallate. J Agric Food Chem 2000; 48: 2736-2743.
128. Sanchez M, Galisteo M, Vera R, et al. Quercetin downregulates nadph oxidase, increases enos activity and prevents endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 2006;24: 75-84.
129. Afanas'ev IB, Dorozhko AI, Brodskii AV, Kostyuk VA, Potapovitch AI. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem Pharmacol 1989; 38: 1763-1769.