Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300

Molecular Cell

Volumn 6, Issue 3, 2000, Pages 551-561

  Kundu, Tapas K ^a   Palhan, Vikas B ^a   Wang, Zhengxin ^a   An, Woojin ^a   Cole, Philip A ^b   Roeder, Robert G ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ACYLTRANSFERASE; ETOPOSIDE; HISTONE; PROTEIN P300;

ACETYLATION; ARTICLE; BINDING AFFINITY; CHROMATIN; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOSOME; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; TRANSCRIPTION REGULATION;

EID: 0033635222     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00054-X     Document Type: Article

References (57)

1. The CBP coactivator is a histone acetyltransferase
2. Characterization of physical interactions of the putative transcriptional adaptor, ADA2, with acidic activation domains and TATA-binding protein
3. Cell-free system for assembly of transcriptionally repressed chromatin from Drosophila embryos
4. Tetrahymena histone acetyltransferase A: A homolog of yeast Gcn5p linking histone acetylation to gene activation
5. Activation of yeast polymerase II transcription by herpesvirus VP16 and GAL4 derivatives in vitro
6. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with p/CAF and CBP/p300
7. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
8. Phosphorylated CREB binds specifically to the nuclear protein CBP
9. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle and developmentally regulated promoter
10. Basic analysis of transcription factor binding to nucleosomes
11. Structure and ligand of a histone acetyltransferase bromodomain
12. Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo
13. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes
14. Histone function in transcription
15. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
16. Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes
17. Acetylation of general transcription factors by histone acetyltransferases
18. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
19. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
20. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
21. p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation
22. Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates
23. Cell cycle-regulated histone acetylation required for expression of the yeast HO gene
24. Human TFIIIC relieves chromatin-mediated repression of RNA polymerase III transcription and contains an intrinsic histone acetyltransferase activity
25. Roles of histone acetyltransferase and deacetylases in gene regulation
26. In vivo cross-linking and immunoprecipitation for studying dynamic protein:DNA associations in a chromatin environment
27. Histone acetyltransferase activity of yeast Gcn5 is required for the activation of target genes in vivo
28. Nuclear protein CBP is a coactivator for the transcription factor CREB
29. HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF
30. GAL4 derivatives function alone and synergistically with mammalian activators in vitro
31. Transcriptional regulation through mediator-like coactivators in yeast and metazoan cells
32. Functional similarity and physical association between GCN5 and ADA2: Putative transcriptional adaptors
33. The acetyltransferase activity of CBP stimulates transcription
34. RNA polymerase II holoenzymes and subcomplexes
35. Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors
36. Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin
37. The transcriptional coactivators p300 and CBP are histone acetyltransferases
38. The bromodomain of Gcn5p interacts with specific residues in the N terminus of histone H4
39. Role of chromatin structure in the regulation of transcription by RNA polymerase II
40. Virus infection leads to localized hyperacetylation of histone H3 and H4 at the IFN-β promoter
41. Role of general and gene-specific cofactors in the regulation of eukaryotic transcription
42. The p300/CBP family: Integrating signals with transcription factors and chromatin
43. Steroid receptor coactivator-1 is a histone acetyltransferase
44. Purified histone acetyltransferase complexes stimulate HIV-1 transcription from preassembled nucleosomal arrays
45. Histone acetylation and transcriptional regulatory mechanisms
46. Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex
47. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
48. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes
49. TAFs mediate transcriptional activation and promoter selectivity
50. Distribution of acetylated histones resulting from GAL4-VP16 recruitment of SAGA and NuA4 complexes
51. DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription initiation by RNA polymerase III
52. Critical residues for histone acetylation by Gcn5, functioning in ADA and SAGA complexes, are also required for transcriptional function in vivo
53. Alteration of nucleosome structure as a mechanism of transcriptional regulation
54. Binding of transcription factor TFIID to the major late promoter during in vitro nucleosome assembly potentiates subsequent initiation by RNA polymerase II
55. Glutamine-rich domains activate transcription in yeast Saccharomyces cerevisiae
56. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
57. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300