3′,4′-Dihydroxyflavonol down-regulates monocyte chemoattractant protein-1 in smooth muscle: Role of focal adhesion kinase and PDGF receptor signalling

British Journal of Pharmacology

Volumn 157, Issue 4, 2009, Pages 597-606

  Jiang, F ^a,b   Guo, N ^a   Dusting, G J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b Bernard O'Brien Institute of Microsurgery   (Australia)

Author keywords

Flavonoid; Focal adhesion kinase; Monocyte chemoattractant protein 1; PDGF receptor; Protein tyrosine kinase; Smooth muscle cell

Indexed keywords

3',4' DIHYDROXYFLAVONOL; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; FLAVONOID; FOCAL ADHESION KINASE; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHOTRANSFERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; QUERCETIN; TEMPOL; UNCLASSIFIED DRUG; 3',4'-DIHYDROXYFLAVONOL; CYTOKINE; FAK RELATED NONKINASE; FAK-RELATED NONKINASE; FLAVONOL DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CELL PROLIFERATION; CELL SPREADING; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSECTION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; IMMUNOPRECIPITATION; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL MOTION; DRUG ANTAGONISM; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINE CCL2; CYTOKINES; DOWN-REGULATION; FLAVONOLS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR;

EID: 70349921185     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00199.x     Document Type: Article

References (37)

1. Aiello RJ, Bourassa PA, Lindsey S, Weng W, Natoli E, Rollins BJ et al. (1999). Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 19: 1518-1525. (Pubitemid 29263023)
2. Birdsall HH, Green DM, Trial J, Youker KA, Burns AR, MacKay CR et al. (1997). Complement C5a, TGF-beta 1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion. Circulation 95: 684-692. (Pubitemid 27063046)
3. Cartel NJ, Liu J, Wang J, Post M (2001). PDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation. Am J Physiol. Lung Cell Mol Physiol 281: L786-L798. (Pubitemid 32948162)
4. Charo IF, Taubman MB (2004). Chemokines in the pathogenesis of vascular disease. Circ Res 95: 858-866.
5. Chen Y, Hallenbeck JM, Ruetzler C, Bo D, Thomas K, Berman NE et al. (2003). Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells. J Cereb Blood Flow Metab 23: 748-755.
6. Frangogiannis NG (2004). The role of the chemokines in myocardial ischemia and reperfusion. Curr Vasc Pharmacol 2: 163-174.
7. Funakoshi-Tago M, Sonoda Y, Tanaka S, Hashimoto K, Tago K, Tominaga S et al. (2003). Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts. J Biol Chem 278: 29359-29365.
8. Grandaliano G, Monno R, Ranieri E, Gesualdo L, Schena FP, Martino C et al. (2000). Regenerative and proinflammatory effects of thrombin on human proximal tubular cells. J Am Soc Nephrol 11: 1016-1025. (Pubitemid 30367931)
9. Gu J, Tamura M, Pankov R, Danen EH, Takino T, Matsumoto K et al. (1999). Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol 146: 389-403. (Pubitemid 29369775)
10. Hanks SK, Ryzhova L, Shin NY, BrabekJ (2003). Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front Biosci 8: d982-d996.
11. Hassid A, Huang S, Yao J (1999). Role of FTP-1B in aortic smooth muscle cell motility and tyrosine phosphorylation of focal adhesion proteins. Am J Physiol 277: H192-H198. (Pubitemid 29354693)
12. Hauck CR, Hsia DA, Schlaepfer DD (2000). Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for Chemotaxis migration of vascular smooth muscle cells. J Biol Chem 275: 41092-41099.
13. Hayasaki T, Kaikita K, Okuma T, Yamamoto E, Kuziel WA, Ogawa H et al. (2006). CC chemokine receptor-2 deficiency attenuates oxidative stress and infarct size caused by myocardial ischemiareperfusion in mice. Circ J 70: 342-351. (Pubitemid 43312259)
14. Ishikawa Y, Sugiyama H, Stylianou E, Kitamura M (1999). Bioflavonoid quercetin inhibits interleukin-1-induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB. J Am Soc Nephrol 10: 2290-2296. (Pubitemid 29501461)
15. Jalali S, Li YS, Sotoudeh M, Yuan S, Li S, Chien S et al. (1998). Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells. Arterioscler Thromb Vase Biol 18: 227-234. (Pubitemid 28277599)
16. Jiang F, Dusting GJ (2003). Natural phenolic compounds as cardiovascular therapeutics: potential role of their antiinflammatory effects. Curr Vasc Pharmacol 1: 135-156.
17. Jiang F, Guo N, Dusting GJ (2007). Modulation of NADPH oxidase expression and function by 3′,4′-dihydroxyflavonol in phagocytic and vascular cells. J Pharmacol Exp Ther 324: 261-269.
18. Kanegae K, Tamura M, Kabashima N, Serino R, Tokunaga M, Oikawa S et al. (2005). Synergistic induction of monocyte chemoattractant protein-1 by integrins and platelet-derived growth factor via focal adhesion kinase in mesangial cells. Nephrol Dial Transplant 20: 2080-2088. (Pubitemid 41510081)
19. Lee SK, Kim BS, Yang WS, Kim SB, Park SK, Park JS (2001). High glucose induces MCP-1 expression partly via tyrosine kinase-AP-1 pathway in peritoneal mesothelial cells. Kidney Int 60: 55-64.
20. Mitra SK, Hanson DA, Schlaepfer DD (2005). Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 6: 56-68.
21. Mori E, Komori K, Yamaoka T, Tanii M, Kataoka C, Takeshita A et al. (2002). Essential role of monocyte chemoattractant protein-1 in development of restenotic changes (neointimal hyperplasia and constrictive remodeling) after balloon angioplasty in hypercholesterolemic rabbits. Circulation 105: 2905-2910. (Pubitemid 34666106)
22. Nakayamada S, Saito K, Fujii K, Yasuda M, Tamura M, Tanaka Y (2003). β1 integrin-mediated signaling induces intercellular adhesion molecule 1 and Fas on rheumatoid synovial cells and Fas-mediated apoptosis. Arthritis Rheum 48: 1239-1248. (Pubitemid 36554523)
23. Okada M, Matsumori A, Ono K, Furukawa Y, Shioi T, Iwasaki A et al. (1998). Cyclic stretch upregulates production of lnterleukin-8 and monocyte chemotactlc and activating factor/monocyte chemoattractant protein-1 in human endothelial cells. Arterioscler Thromb Vase Biol 18: 894-901. (Pubitemid 28272582)
24. Owen JD, Ruest PJ, Fry DW, Hanks SK (1999). Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Mol Cell Biol 19: 4806-4818.
25. Owens LV, Xu L, Marston WA, Yang X, Farber MA, Iacocca MV et al. (2001). Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimai hyperplasia. J Vase Surg 34: 344-349. (Pubitemid 33661134)
26. Parsons JT (2003). Focal adhesion kinase: the first ten years. J Cell Sci 116: 1409-1416. (Pubitemid 36527488)
27. Richardson A, Parsons T (1996). A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Nature 380: 538-540. (Pubitemid 26110644)
28. Rollins BJ, Morrison ED, Stiles CD (1988). Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc Natl Acad Sci USA 85: 3738-3742.
29. Rong JX, Berman JW, Taubman MB, Fisher EA (2002). Lysophosphati- dylcholine stimulates monocyte chemoattractant protein-1 gene expression in rat aortic smooth muscle cells. Arterioscler Thromb Vase Biol 22: 1617-1623.
30. Rovin BH, Dickerson JA, Tan LC, Fassler J (1997). Modulation of IL-1-induced chemokine expression in human mesangial cells through alterations in redox status. Cytokine 9: 178-186.
31. Sabe H, Hata A, Okada M, Nakagawa H, Hanafusa H (1994). Analysis of the binding of the Src homology 2 domain of Csk to tyrosinephosphorylated proteins in the suppression and mitotic activation of c-Src. Proc Natl Acad Sci USA 91: 3984-3988. (Pubitemid 24984891)
32. Schaller MD, Parsons JT (1995). pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol Cell Biol 15: 2635-2645.
33. Shyy YJ, Li YS, Kolattukudy PE (1993). Activation of MCP-1 gene expression is mediated through multiple signaling pathways. Biochem Biophys Res Commun 192: 693-699. (Pubitemid 23227378)
34. Taylor JM, Mack CP, Nolan K, Regan CP, Owens GK, Parsons JT (2001). Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells. Mol Cell Biol 21: 1565-1572. (Pubitemid 32156376)
35. Wang S, Dusting GJ, May CN, Woodman OL (2004). 3′,4′- Dihydroxyflavonol reduces infarct size and injury associated with myocardial ischaemia and reperfusion in sheep. Br J Pharmacol 142: 443-452. (Pubitemid 38869857)
36. Watanabe Y, Tamura M, Osajima A, Anal H, Kabashlma N, Serino R et al. (2003). Integrins induce expression of monocyte chemoattractant protein-1 via focal adhesion kinase in mesangial cells. Kidney Int 64: 431-440. (Pubitemid 36871914)
37. Zen K, Masuda J, Sasaguri T, Kosaka C, Shimokado K, Ogata J (1995). Protein tyrosine kinases and protein kinase C are required for gene expression of monocyte chemoattractant protein-1 in human monocytes. Ann N Y Acad Sci 748: 508-509.