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Volumn 34, Issue 2, 2011, Pages 120-129

Silybin inhibits interleukin-1β-induced production of pro-inflammatory mediators in canine hepatocyte cultures

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; OMEPRAZOLE; PROSTAGLANDIN E2; RIFAMPICIN; SILIBININ; SILIBININ PHOSPHATIDYLCHOLINE COMPLEX;

EID: 79952613343     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2010.01200.x     Document Type: Article
Times cited : (24)

References (76)
  • 1
    • 65749099181 scopus 로고    scopus 로고
    • Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells
    • Al-Anati, L., Essid, E., Reinehr, R. & Petzinger, E. (2009) Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells. Molecular Nutrition & Food Research, 53, 460-466.
    • (2009) Molecular Nutrition & Food Research , vol.53 , pp. 460-466
    • Al-Anati, L.1    Essid, E.2    Reinehr, R.3    Petzinger, E.4
  • 2
    • 0023731912 scopus 로고
    • Non-parenchymal cells as mediators of physiological responses in liver
    • Review).
    • Altin, J.G. & Bygrave, F.L. (1988) Non-parenchymal cells as mediators of physiological responses in liver. Molecular and Cellular Biochemistry, 83, 3-14 (Review).
    • (1988) Molecular and Cellular Biochemistry , vol.83 , pp. 3-14
    • Altin, J.G.1    Bygrave, F.L.2
  • 3
    • 84869011273 scopus 로고    scopus 로고
    • Collagen biomaterial promotes hepatocyte proliferation, phenotype expression, and responsiveness to activation by pro-inflammatory stimuli
    • In, Amsterdam, The Netherlands.
    • Au, A.Y., Hasenwinkel, J.M. & Frondoza, C.G. (2008). Collagen biomaterial promotes hepatocyte proliferation, phenotype expression, and responsiveness to activation by pro-inflammatory stimuli. In Proceedings: World Biomaterials Congress, Amsterdam, The Netherlands.
    • (2008) Proceedings: World Biomaterials Congress
    • Au, A.Y.1    Hasenwinkel, J.M.2    Frondoza, C.G.3
  • 5
    • 62549116131 scopus 로고    scopus 로고
    • Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis
    • Basiglio, C.L., Sanchez Pozzi, E.J., Mottino, A.D. & Roma, M.G. (2008) Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis. Chemico-Biological Interactions, 179, 297-303.
    • (2008) Chemico-Biological Interactions , vol.179 , pp. 297-303
    • Basiglio, C.L.1    Sanchez Pozzi, E.J.2    Mottino, A.D.3    Roma, M.G.4
  • 7
    • 0026532350 scopus 로고
    • Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes
    • Bosisio, E., Benelli, C. & Pirola, O. (1992) Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. Pharmacological Research, 25, 147-154.
    • (1992) Pharmacological Research , vol.25 , pp. 147-154
    • Bosisio, E.1    Benelli, C.2    Pirola, O.3
  • 8
    • 0033855617 scopus 로고    scopus 로고
    • Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins
    • Callejas, N.A., Bosca, L., Williams, C.S., Du, B.R. & Martin-Sanz, P. (2000) Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins. Gastroenterology, 119, 493-501.
    • (2000) Gastroenterology , vol.119 , pp. 493-501
    • Callejas, N.A.1    Bosca, L.2    Williams, C.S.3    Du, B.R.4    Martin-Sanz, P.5
  • 9
    • 0026643016 scopus 로고
    • Lipid peroxidation and irreversible damage in the rat hepatocyte model. Protection by the silybin-phospholipid complex IdB 1016
    • Carini, R., Comoglio, A., Albano, E. & Poli, G. (1992) Lipid peroxidation and irreversible damage in the rat hepatocyte model. Protection by the silybin-phospholipid complex IdB 1016. Biochemical Pharmacology, 43, 2111-2115.
    • (1992) Biochemical Pharmacology , vol.43 , pp. 2111-2115
    • Carini, R.1    Comoglio, A.2    Albano, E.3    Poli, G.4
  • 12
    • 79952589618 scopus 로고    scopus 로고
    • Plateable hepatocytes
    • Celsis International Ltd. In Celsis International Ltd, Baltimore.
    • Celsis International Ltd. (20082010). Plateable hepatocytes. In In Vitro ADME-Tox. Celsis International Ltd, Baltimore.
    • (2008) In Vitro ADME-Tox
  • 13
    • 0742288763 scopus 로고    scopus 로고
    • Metabolic, antioxidant, nutraceutical, probiotic, and herbal therapies relating to the management of hepatobiliary disorders
    • vi.
    • Center, S.A. (2004) Metabolic, antioxidant, nutraceutical, probiotic, and herbal therapies relating to the management of hepatobiliary disorders. Veterinary Clinics of North America. Small Animal Practice, 34, 67-172, vi.
    • (2004) Veterinary Clinics of North America. Small Animal Practice , vol.34 , pp. 67-172
    • Center, S.A.1
  • 17
    • 0029879066 scopus 로고    scopus 로고
    • Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin
    • Dehmlow, C., Erhard, J. & de Groot, H. (1996) Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology, 23, 749-754.
    • (1996) Hepatology , vol.23 , pp. 749-754
    • Dehmlow, C.1    Erhard, J.2    de Groot, H.3
  • 18
    • 43049100691 scopus 로고    scopus 로고
    • Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes
    • Detaille, D., Sanchez, C., Sanz, N., Lopez-Novoa, J.M., Leverve, X. & El-Mir, M.Y. (2008) Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes. Life Sciences, 82, 1070-1076.
    • (2008) Life Sciences , vol.82 , pp. 1070-1076
    • Detaille, D.1    Sanchez, C.2    Sanz, N.3    Lopez-Novoa, J.M.4    Leverve, X.5    El-Mir, M.Y.6
  • 20
    • 0024502767 scopus 로고
    • Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration
    • Dunn, J.C., Yarmush, M.L., Koebe, H.G. & Tompkins, R.G. (1989) Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration. The FASEB Journal, 3, 174-177.
    • (1989) The FASEB Journal , vol.3 , pp. 174-177
    • Dunn, J.C.1    Yarmush, M.L.2    Koebe, H.G.3    Tompkins, R.G.4
  • 21
    • 0037415383 scopus 로고    scopus 로고
    • Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum
    • Dvorak, Z., Kosina, P., Walterova, D., Simanek, V., Bachleda, P. & Ulrichova, J. (2003) Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum. Toxicology Letters, 137, 201-212.
    • (2003) Toxicology Letters , vol.137 , pp. 201-212
    • Dvorak, Z.1    Kosina, P.2    Walterova, D.3    Simanek, V.4    Bachleda, P.5    Ulrichova, J.6
  • 23
    • 0033848809 scopus 로고    scopus 로고
    • Silymarin effects on intracellular calcuim and cytotoxicity: a study in perfused rat hepatocytes after oxidative stress injury
    • Farghali, H., Kamenikova, L., Hynie, S. & Kmonickova, E. (2000) Silymarin effects on intracellular calcuim and cytotoxicity: a study in perfused rat hepatocytes after oxidative stress injury. Pharmacological Research, 41, 231-237.
    • (2000) Pharmacological Research , vol.41 , pp. 231-237
    • Farghali, H.1    Kamenikova, L.2    Hynie, S.3    Kmonickova, E.4
  • 26
    • 0032795476 scopus 로고    scopus 로고
    • Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease
    • Fisher, N.C., Neil, D.A., Williams, A. & Adams, D.H. (1999) Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease. Gut, 45, 416-420.
    • (1999) Gut , vol.45 , pp. 416-420
    • Fisher, N.C.1    Neil, D.A.2    Williams, A.3    Adams, D.H.4
  • 27
    • 4344629494 scopus 로고    scopus 로고
    • Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases
    • He, Q., Kim, J. & Sharma, R.P. (2004) Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases. Toxicological Sciences, 80, 335-342.
    • (2004) Toxicological Sciences , vol.80 , pp. 335-342
    • He, Q.1    Kim, J.2    Sharma, R.P.3
  • 28
    • 70349241726 scopus 로고    scopus 로고
    • Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes
    • Henkel, J., Neuschafer-Rube, F., Pathe-Neuschafer-Rube, A. & Puschel, G.P. (2009) Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes. Hepatology, 50, 781-790.
    • (2009) Hepatology , vol.50 , pp. 781-790
    • Henkel, J.1    Neuschafer-Rube, F.2    Pathe-Neuschafer-Rube, A.3    Puschel, G.P.4
  • 29
    • 0002272593 scopus 로고    scopus 로고
    • Cytokines and liver disease
    • amp; In, 2nd edn. Eds Remick, D.G. & Friedland, J.S. - Marcel Dekker Inc., New York.
    • Hill, D., Shedlofsky, S., McClain, C., Diehl, A.M. & Tsukamoto, H. (1997) Cytokines and liver disease. In Cytokines in Health and Disease, 2nd edn. Eds Remick, D.G. & Friedland, J.S., pp. 401-425. Marcel Dekker Inc., New York.
    • (1997) Cytokines in Health and Disease , pp. 401-425
    • Hill, D.1    Shedlofsky, S.2    McClain, C.3    Diehl, A.M.4    Tsukamoto, H.5
  • 30
    • 79952596550 scopus 로고    scopus 로고
    • Intracellular signal transduction in liver regeneration
    • In Eds Strain, A. & Diehl, A.M. - Thompson Science Publishers, London.
    • Hoek, J.B. & Rubin, E. (1999) Intracellular signal transduction in liver regeneration. In Liver Growth and Repair. Eds Strain, A. & Diehl, A.M., pp. 366-401. Thompson Science Publishers, London.
    • (1999) Liver Growth and Repair , pp. 366-401
    • Hoek, J.B.1    Rubin, E.2
  • 34
    • 0035988729 scopus 로고    scopus 로고
    • Long-term stable cultures of rat hepatocytes: an in vitro model to study acute and chronic hepatic inflammation
    • Kang, Y.H., Berthiaume, F. & Yarmush, M.L. (2002) Long-term stable cultures of rat hepatocytes: an in vitro model to study acute and chronic hepatic inflammation. Tissue Engineering, 8, 681-693.
    • (2002) Tissue Engineering , vol.8 , pp. 681-693
    • Kang, Y.H.1    Berthiaume, F.2    Yarmush, M.L.3
  • 35
    • 0344687228 scopus 로고    scopus 로고
    • Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1beta and prostaglandin E2 synthesis by silymarin
    • Kang, J.S., Jeon, Y.J., Park, S.K., Yang, K.H. & Kim, H.M. (2004) Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1beta and prostaglandin E2 synthesis by silymarin. Biochemical Pharmacology, 67, 175-181.
    • (2004) Biochemical Pharmacology , vol.67 , pp. 175-181
    • Kang, J.S.1    Jeon, Y.J.2    Park, S.K.3    Yang, K.H.4    Kim, H.M.5
  • 36
    • 0031452445 scopus 로고    scopus 로고
    • Increased levels of soluble adhesion molecules in the serum of patients with hepatitis C. Correlation with cytokine concentrations and liver inflammation and fibrosis
    • Kaplanski, G., Farnarier, C., Payan, M.J., Bongrand, P. & Durand, J.M. (1997) Increased levels of soluble adhesion molecules in the serum of patients with hepatitis C. Correlation with cytokine concentrations and liver inflammation and fibrosis. Digestive Diseases and Sciences, 42, 2277-2284.
    • (1997) Digestive Diseases and Sciences , vol.42 , pp. 2277-2284
    • Kaplanski, G.1    Farnarier, C.2    Payan, M.J.3    Bongrand, P.4    Durand, J.M.5
  • 37
    • 24944537046 scopus 로고    scopus 로고
    • Metabolic studies of hepatocytes cultured on collagen substrata modified to contain glycosaminoglycans
    • Kataropoulou, M., Henderson, C. & Grant, M.H. (2005) Metabolic studies of hepatocytes cultured on collagen substrata modified to contain glycosaminoglycans. Tissue Engineering, 11, 1263-1273.
    • (2005) Tissue Engineering , vol.11 , pp. 1263-1273
    • Kataropoulou, M.1    Henderson, C.2    Grant, M.H.3
  • 38
    • 25644448238 scopus 로고    scopus 로고
    • A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos)
    • Kidd, P. & Head, K. (2005) A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Alternative Medicine Review, 10, 193-203.
    • (2005) Alternative Medicine Review , vol.10 , pp. 193-203
    • Kidd, P.1    Head, K.2
  • 39
    • 2442570194 scopus 로고    scopus 로고
    • Complex analysis of genes involved in the inflammatory response: interleukin-1-induced differential transcriptome of cultured human hepatoma HepG2 cells
    • Koj, A. & Jura, J. (2003) Complex analysis of genes involved in the inflammatory response: interleukin-1-induced differential transcriptome of cultured human hepatoma HepG2 cells. Acta Biochimica Polonica, 50, 573-582.
    • (2003) Acta Biochimica Polonica , vol.50 , pp. 573-582
    • Koj, A.1    Jura, J.2
  • 40
    • 22044435364 scopus 로고    scopus 로고
    • Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes
    • Kosina, P., Maurel, P., Ulrichova, J. & Dvorak, Z. (2005) Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes. Journal of Biochemical and Molecular Toxicology, 19, 149-153.
    • (2005) Journal of Biochemical and Molecular Toxicology , vol.19 , pp. 149-153
    • Kosina, P.1    Maurel, P.2    Ulrichova, J.3    Dvorak, Z.4
  • 44
    • 0032715311 scopus 로고    scopus 로고
    • Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis
    • Manna, S.K., Mukhopadhyay, A., Van, N.T. & Aggarwal, B.B. (1999) Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. Journal of Immunology, 163, 6800-6809.
    • (1999) Journal of Immunology , vol.163 , pp. 6800-6809
    • Manna, S.K.1    Mukhopadhyay, A.2    Van, N.T.3    Aggarwal, B.B.4
  • 45
    • 0742295936 scopus 로고    scopus 로고
    • Chemokines in liver inflammation and fibrosis
    • Marra, F. (2002) Chemokines in liver inflammation and fibrosis. Frontiers in Bioscience, 7, d1899-d1914.
    • (2002) Frontiers in Bioscience , vol.7
    • Marra, F.1
  • 46
    • 58949101853 scopus 로고    scopus 로고
    • Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury
    • Mayoral, R., Molla, B., Flores, J.M., Bosca, L., Casado, M. & Martin-Sanz, P. (2008) Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury. The Biochemical Journal, 416, 337-346.
    • (2008) The Biochemical Journal , vol.416 , pp. 337-346
    • Mayoral, R.1    Molla, B.2    Flores, J.M.3    Bosca, L.4    Casado, M.5    Martin-Sanz, P.6
  • 51
    • 0028786743 scopus 로고
    • Leukocyte adhesion molecules in the liver and plasma cytokine levels in endotoxin-induced rat liver injury
    • Ohira, H., Ueno, T., Torimura, T., Tanikawa, K. & Kasukawa, R. (1995) Leukocyte adhesion molecules in the liver and plasma cytokine levels in endotoxin-induced rat liver injury. Scandinavian Journal of Gastroenterology, 30, 1027-1035.
    • (1995) Scandinavian Journal of Gastroenterology , vol.30 , pp. 1027-1035
    • Ohira, H.1    Ueno, T.2    Torimura, T.3    Tanikawa, K.4    Kasukawa, R.5
  • 52
    • 9444285006 scopus 로고    scopus 로고
    • Differential modulation of prostaglandin receptor mRNA abundance by prostaglandins in primary cultured rat hepatocytes
    • Perez, S., Maldonado, E.N., Aspichueta, P., Ochoa, B. & Chico, Y. (2004) Differential modulation of prostaglandin receptor mRNA abundance by prostaglandins in primary cultured rat hepatocytes. Molecular and Cellular Biochemistry, 266, 183-189.
    • (2004) Molecular and Cellular Biochemistry , vol.266 , pp. 183-189
    • Perez, S.1    Maldonado, E.N.2    Aspichueta, P.3    Ochoa, B.4    Chico, Y.5
  • 53
    • 36148939830 scopus 로고    scopus 로고
    • The role of cyclooxygenase-2/prostanoid pathway in visceral pain induced liver stress response in rats
    • Piston, D., Wang, S., Feng, Y., Ye, Y.J., Zhou, J., Jiang, K.W., Xu, F., Zhao, Y. & Cui, Z.R. (2007) The role of cyclooxygenase-2/prostanoid pathway in visceral pain induced liver stress response in rats. Chinese Medical Journal, 120, 1813-1819.
    • (2007) Chinese Medical Journal , vol.120 , pp. 1813-1819
    • Piston, D.1    Wang, S.2    Feng, Y.3    Ye, Y.J.4    Zhou, J.5    Jiang, K.W.6    Xu, F.7    Zhao, Y.8    Cui, Z.R.9
  • 54
    • 0034979117 scopus 로고    scopus 로고
    • Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy
    • Polyak, S.J., Khabar, K.S., Rezeiq, M. & Gretch, D.R. (2001) Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy. Journal of Virology, 75, 6209-6211.
    • (2001) Journal of Virology , vol.75 , pp. 6209-6211
    • Polyak, S.J.1    Khabar, K.S.2    Rezeiq, M.3    Gretch, D.R.4
  • 55
    • 0034786816 scopus 로고    scopus 로고
    • Herbal preparations as a source of hepatoprotective agents
    • Ram, V.J. (2001) Herbal preparations as a source of hepatoprotective agents. Drug News & Perspectives, 14, 353-363.
    • (2001) Drug News & Perspectives , vol.14 , pp. 353-363
    • Ram, V.J.1
  • 57
    • 0035999580 scopus 로고    scopus 로고
    • TNF tolerance and cytotoxicity in the liver: the role of interleukin-1beta, inducible nitric oxide-synthase and heme oxygenase-1 in D-galactosamine-sensitized mice
    • Sass, G., Koerber, K. & Tiegs, G. (2002) TNF tolerance and cytotoxicity in the liver: the role of interleukin-1beta, inducible nitric oxide-synthase and heme oxygenase-1 in D-galactosamine-sensitized mice. Inflammation Research, 51, 229-235.
    • (2002) Inflammation Research , vol.51 , pp. 229-235
    • Sass, G.1    Koerber, K.2    Tiegs, G.3
  • 58
    • 0026776782 scopus 로고
    • Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients
    • Schandalik, R., Gatti, G. & Perucca, E. (1992) Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients. Arzneimittel-Forschung, 42, 964-968.
    • (1992) Arzneimittel-Forschung , vol.42 , pp. 964-968
    • Schandalik, R.1    Gatti, G.2    Perucca, E.3
  • 62
    • 79952602751 scopus 로고    scopus 로고
    • In Canine Liver Disease Foundation. Available at: (accessed on 4 June 2010)
    • Smith, L. (2009). In Canine Liver Disease Foundation. Available at: (accessed on 4 June 2010)
    • (2009)
    • Smith, L.1
  • 63
    • 0021254068 scopus 로고
    • Mechanism of action of silibinin. Effect of silibinin on the synthesis of ribosomal RNA, mRNA and tRNA in rat liver in vivo
    • Sonnenbichler, J. & Zetl, I. (1984) Mechanism of action of silibinin. Effect of silibinin on the synthesis of ribosomal RNA, mRNA and tRNA in rat liver in vivo. Hoppe-Seyler's Zeitschrift für Physiologische Chemie, 365, 555-566.
    • (1984) Hoppe-Seyler's Zeitschrift für Physiologische Chemie , vol.365 , pp. 555-566
    • Sonnenbichler, J.1    Zetl, I.2
  • 65
    • 58149397345 scopus 로고    scopus 로고
    • Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes
    • Suh, H.N., Lee, Y.J. & Han, H.J. (2009) Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes. Journal of Cellular Physiology, 218, 643-652.
    • (2009) Journal of Cellular Physiology , vol.218 , pp. 643-652
    • Suh, H.N.1    Lee, Y.J.2    Han, H.J.3
  • 67
    • 0029951710 scopus 로고    scopus 로고
    • Growth and differentiation in culture of clonogenic hepatocytes that express both phenotypes of hepatocytes and biliary epithelial cells
    • Tateno, C. & Yoshizato, K. (1996) Growth and differentiation in culture of clonogenic hepatocytes that express both phenotypes of hepatocytes and biliary epithelial cells. The American Journal of Pathology, 149, 1593-1605.
    • (1996) The American Journal of Pathology , vol.149 , pp. 1593-1605
    • Tateno, C.1    Yoshizato, K.2
  • 69
    • 5444253143 scopus 로고    scopus 로고
    • PGE2 exerts its effect on the LPS-induced release of TNF-alpha, ET-1, IL-1alpha, IL-6 and IL-10 via the EP2 and EP4 receptor in rat liver macrophages
    • Treffkorn, L., Scheibe, R., Maruyama, T. & Dieter, P. (2004) PGE2 exerts its effect on the LPS-induced release of TNF-alpha, ET-1, IL-1alpha, IL-6 and IL-10 via the EP2 and EP4 receptor in rat liver macrophages. Prostaglandins & Other Lipid Mediators, 74, 113-123.
    • (2004) Prostaglandins & Other Lipid Mediators , vol.74 , pp. 113-123
    • Treffkorn, L.1    Scheibe, R.2    Maruyama, T.3    Dieter, P.4
  • 70
    • 0033060611 scopus 로고    scopus 로고
    • Cytokine regulation of hepatic stellate cells in liver fibrosis
    • Tsukamoto, H. (1999) Cytokine regulation of hepatic stellate cells in liver fibrosis. Alcoholism, Clinical and Experimental Research, 23, 911-916.
    • (1999) Alcoholism, Clinical and Experimental Research , vol.23 , pp. 911-916
    • Tsukamoto, H.1
  • 71
    • 49649089503 scopus 로고    scopus 로고
    • Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism
    • Tuschl, G., Lauer, B. & Mueller, S.O. (2008) Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism. Expert Opinion on Drug Metabolism & Toxicology, 4, 855-870.
    • (2008) Expert Opinion on Drug Metabolism & Toxicology , vol.4 , pp. 855-870
    • Tuschl, G.1    Lauer, B.2    Mueller, S.O.3
  • 72
    • 0024455859 scopus 로고
    • Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat
    • Valenzuela, A., Aspillaga, M., Vial, S. & Guerra, R. (1989) Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Medica, 55, 420-422.
    • (1989) Planta Medica , vol.55 , pp. 420-422
    • Valenzuela, A.1    Aspillaga, M.2    Vial, S.3    Guerra, R.4
  • 73
  • 74
    • 57949097025 scopus 로고    scopus 로고
    • Drug-drug interactions of silymarin on the perspective of pharmacokinetics
    • Wu, J.W., Lin, L.C. & Tsai, T.H. (2009) Drug-drug interactions of silymarin on the perspective of pharmacokinetics. Journal of Ethnopharmacology, 121, 185-193.
    • (2009) Journal of Ethnopharmacology , vol.121 , pp. 185-193
    • Wu, J.W.1    Lin, L.C.2    Tsai, T.H.3
  • 75
    • 33645765320 scopus 로고    scopus 로고
    • De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane
    • Zeisberg, M., Kramer, K., Sindhi, N., Sarkar, P., Upton, M. & Kalluri, R. (2006) De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane. Molecular and Cellular Biochemistry, 283, 181-189.
    • (2006) Molecular and Cellular Biochemistry , vol.283 , pp. 181-189
    • Zeisberg, M.1    Kramer, K.2    Sindhi, N.3    Sarkar, P.4    Upton, M.5    Kalluri, R.6
  • 76
    • 0032717556 scopus 로고    scopus 로고
    • Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention
    • Zhao, J. & Agarwal, R. (1999) Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Carcinogenesis, 20, 2101-2108.
    • (1999) Carcinogenesis , vol.20 , pp. 2101-2108
    • Zhao, J.1    Agarwal, R.2


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