PGE 2 exerts its effect on the LPS-induced release of TNF-α, ET-1, IL-lα, IL-6 and IL-10 via the EP2 and EP4 receptor in rat liver macrophages

Prostaglandins and Other Lipid Mediators

Volumn 74, Issue 1-4, 2004, Pages 113-123

  Treffkorn, Lars ^a   Scheibe, Roland ^a   Maruyama, Takayuki ^b   Dieter, Peter ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

EP2; ET 1; Interleukin; PGE 2; Prostanoid; Rat liver macrophage; TNF

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CYTOKINE; ENDOTHELIN 1; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; ONO AE 1259; ONO AE 1329; ONO AE 248; ONO DI 004; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; PROSTANOID EP1 RECEPTOR; PROSTANOID EP1 RECEPTOR STIMULATING AGENT; PROSTANOID EP2 RECEPTOR; PROSTANOID EP2 RECEPTOR STIMULATING AGENT; PROSTANOID EP3 RECEPTOR; PROSTANOID EP3 RECEPTOR STIMULATING AGENT; PROSTANOID EP4 RECEPTOR; PROSTANOID EP4 RECEPTOR STIMULATING AGENT; THROMBOXANE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; EP4 RECEPTOR; INTERLEUKIN DERIVATIVE; PRIMER DNA; PROSTAGLANDIN EP2 RECEPTOR;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; GENE EXPRESSION; KUPFFER CELL; MACROPHAGE; MALE; MOLECULAR MIMICRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; LIVER; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WISTAR RAT;

ANIMALS; BASE SEQUENCE; DINOPROSTONE; DNA PRIMERS; ENDOTHELIN-1; INTERLEUKINS; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGES; MALE; RATS; RATS, WISTAR; RECEPTORS, PROSTAGLANDIN E; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 5444253143     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2004.07.005     Document Type: Article

References (30)

1. W. Muschol, G.P. Puschel, M. Hulsmann, and K. Jungermann Eicosanoid-mediated increase in glucose and lactate output as well as decrease and redistribution of flow by complement-activated rat serum in perfused rat liver Eur J Biochem. 196 1991 525 530
2. S.L. Friedman Liver fibrosis - from bench to bedside J Hepatol. 38 2003 S38 53
3. K. Decker The response of liver macrophages to inflammatory stimulation Keio J Med. 47 1998 1 9
4. 2 an important regulator of (patho)physiological liver functions: its synthesis and release in Kupffer cells is regulated at multiple levels E. Wisse D.L. Knook R. de Zanger MJP. Arther Cells of the Hepatic Sinusoid 2001 Kupffer Cell Foundation Leiden, Netherlands 6 10
5. 2 affects differently the release of inflammatory mediators from resident macrophages by LPS and muramyl tripeptides Med. Inflamm. 8 1999 295 303
6. A. Fennekohl, H.L. Schieferdecker, K. Jungermann, and G.P. Puschel Differential expression of prostanoid receptors in hepatocytes, Kupffer cells, sinusoidal endothelial cells and stellate cells of rat liver J. Hepatol. 30 1999 38 47
7. K. Tsuboi, Y. Sugimoto, and A. Ichikawa Prostanoid receptor subtypes Prostaglandins Other Lipid Mediat. 68 9 2002 535 556
8. E. Okuda-Ashitaka, K. Sakamoto, T. Ezashi, K. Miwa, S. Ito, and O. Hayaishi Suppression of prostaglandin E receptor signaling by the variant form of EP1 subtype J. Biol. Chem. 271 1996 31255 31261
9. 2 actions in the microcirculation of rat kidney Am J Physiol Renal Physiol. 279 2000 F755 F764
10. 2 receptor EP3 subtype Biochem. Biophys. Res. Commun. 194 1993 885 891
11. J. Kitanaka, H. Hashimoto, and M. Gotoh Expression pattern of messenger RNAs for prostanoid receptors in glial cell cultures Brain Res. 707 1996 282 287
12. K. Takeuchi, N. Takahashi, T. Abe, and K. Abe Two isoforms of the rat kidney EP3 receptor derived by alternative RNA splicing: intrarenal expression co-localization Biochem. Biophys. Res. Commun. 199 1994 834 840
13. 2 receptor splice variant and its expression in rat tissues Prostaglandins Other Lipid Mediat. 63 2001 165 173
14. G. Ramadori, and T. Armbrust Cytokines in the liver Eur J Gastroenterol Hepatol. 13 2001 777 784
15. K. Kitamura, Y. Nakamoto, and M. Akiyama Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis Lab Invest. 82 2002 571 583
16. J.J. Cho, B. Hocher, and H. Herbst An oral endothelin - a receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis Gastroenterology 118 2000 1169 1178
17. R. Mancini, A. Benedetti, and A.M. Jezequel An interleukin-1 receptor antagonist decreases fibrosis induced by dimethylnitrosamine in rat liver Virchows Arch. 424 1994 25 31
18. T. Ezure, T. Sakamoto, and H. Tsuji The development and compensation of biliary cirrhosis in interleukin-6-deficient mice Am J Pathol. 156 2000 1627 1639
19. K.L. Streetz, F. Tacke, and L. Leifeld Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases Hepatology 38 2003 218 229
20. K. Thompson, J. Maltby, J. Fallowfield, M. McAulay, H. Millward-Sadler, and N. Sheron Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis Hepatology 28 1998 1597 1606
21. D.J. Berg, J. Zhang, D.M. Lauricella, and S.A. Moore IL-10 is a central regulator of cyclooxygenase-2 expression and prostaglandin production J Immunol. 166 2001 2674 2680
22. S. Eyhorn, H.J. Schlayer, and H.P. Henninger Rat hepatic sinusoidal endothelial cells in monolayer culture, Biochemical and ultrastructural characteristics J Hepatol. 6 1988 23 35
23. D.A. Flick, and G.E. Gifford Comparison of in vitro cell cytotoxic assays for tumor necrosis factor J Immunol Methods 68 1984 167 175
24. R. Nasrallah, J. Zimpelmann, S. Singh, and R.L. Hebert Molecular and biochemical characterization of prostacyclin receptors in rat kidney Am J Physiol Renal Physiol. 280 2001 F266 F277
25. F. Neuschafer-Rube, E. Engemaier, S. Koch, U. Boer, and G.P. Puschel Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor Biochem J 371 2003 443 449
26. F. Murphy, M. Arthur, and J. Iredale Developing strategies for liver fibrosis treatment Expert Opin Investig Drugs. 11 2002 1575 1585
27. F. Marra Chemokines in liver inflammation and fibrosis Front Biosci. 7 2002 d1899 d1914
28. A. Mallat, C. Gallois, and J. Tao Platelet-derived growth factor-BB and thrombin generate positive and negative signals for human hepatic stellate cell proliferation. Role of a prostaglandin/cyclic AMP pathway and cross-talk with endothelin receptors J Biol Chem. 273 1998 27300 27305
29. D.W. Beno, and B.H. Davis Prostaglandin E suppresses hepatic fibrosis. Section I: the in vivo approach. Section II: the in vitro approach Am J Ther. 2 1995 687 705
30. T. Suzawa, C. Miyaura, and M. Inada The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs Endocrinology 141 2000 1554 1559