메뉴 건너뛰기




Volumn 153, Issue 2, 2011, Pages 333-341

The effects of Nigella sativa against oxidative injury in a rat model of subarachnoid hemorrhage

Author keywords

Cerebral ischemia; Cerebral vasospasm; Nigella sativa; Oxidative stress; Subarachnoid hemorrhage

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); GLUTATHIONE; HERBACEOUS AGENT; MALONALDEHYDE; MYELOPEROXIDASE; NEUROPROTECTIVE AGENT; NIGELLA SATIVA OIL; UNCLASSIFIED DRUG;

EID: 79952538038     PISSN: 00016268     EISSN: 09420940     Source Type: Journal    
DOI: 10.1007/s00701-010-0853-9     Document Type: Article
Times cited : (24)

References (62)
  • 1
    • 0038559976 scopus 로고    scopus 로고
    • Pharmacological and toxicological properties of Nigella sativa
    • DOI 10.1002/ptr.1309
    • Ali BH, Blunden G (2003) Pharmacological and toxicological properties of Nigella sativa. Phytother Res 17:299-305 (Pubitemid 36565330)
    • (2003) Phytotherapy Research , vol.17 , Issue.4 , pp. 299-305
    • Ali, B.H.1    Blunden, G.2
  • 2
    • 75449106951 scopus 로고    scopus 로고
    • Subarachnoid hemorrhage induces enhanced expression of thromboxane A2 receptors in rat cerebral arteries
    • Ansar S, Larsen C, Maddahi A, Edvinsson L (2010) Subarachnoid hemorrhage induces enhanced expression of thromboxane A2 receptors in rat cerebral arteries. Brain Res 1316:163-172
    • (2010) Brain Res , vol.1316 , pp. 163-172
    • Ansar, S.1    Larsen, C.2    Maddahi, A.3    Edvinsson, L.4
  • 3
    • 0012113140 scopus 로고    scopus 로고
    • Oxyhemoglobin as the principal cause of cerebral vasospasm: A holistic view of its actions
    • Asano T (1999) Oxyhemoglobin as the principal cause of cerebral vasospasm: a holistic view of its actions. Crit Rev Neurosurg 9:303-318
    • (1999) Crit Rev Neurosurg , vol.9 , pp. 303-318
    • Asano, T.1
  • 4
    • 77953854872 scopus 로고    scopus 로고
    • Connecting the early brain injury of aneurysmal subarachnoid hemorrhage to clinical practice
    • Ayer R, Zhang J (2010) Connecting the early brain injury of aneurysmal subarachnoid hemorrhage to clinical practice. Turk Neurosurg 20:159-166
    • (2010) Turk Neurosurg , vol.20 , pp. 159-166
    • Ayer, R.1    Zhang, J.2
  • 5
    • 39149098768 scopus 로고    scopus 로고
    • Melatonin decreases mortality following severe subarachnoid hemorrhage
    • DOI 10.1111/j.1600-079X.2007.00508.x
    • Ayer RE, Sugawara T, Chen W, Tong W, Zhang JH (2008) Melatonin decreases mortality following severe subarachnoid hemorrhage. J Pineal Res 44:197-204 (Pubitemid 351252923)
    • (2008) Journal of Pineal Research , vol.44 , Issue.2 , pp. 197-204
    • Ayer, R.E.1    Sugawara, T.2    Chen, W.3    Tong, W.4    Zhang, J.H.5
  • 6
    • 85052610021 scopus 로고    scopus 로고
    • Oxidative stress in subarachnoid haemorrhage: Significance in acute brain injury and vasospasm
    • Ayer RE, Zhang JH (2008) Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm. Acta Neurochir Suppl 104:33-41
    • (2008) Acta Neurochir Suppl , vol.104 , pp. 33-41
    • Ayer, R.E.1    Zhang, J.H.2
  • 9
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • Beuge JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 53:302-311
    • (1978) Methods Enzymol , vol.53 , pp. 302-311
    • Beuge, J.A.1    Aust, S.D.2
  • 11
    • 33745964653 scopus 로고    scopus 로고
    • Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage
    • DOI 10.1161/01.STR.0000226995.27230.96, PII 0000767020060700000059
    • Cahill J, Calvert JW, Solaroglu I, Zhang JH (2006) Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage. Stroke 37:1868-1874 (Pubitemid 44297744)
    • (2006) Stroke , vol.37 , Issue.7 , pp. 1868-1874
    • Cahill, J.1    Calvert, J.W.2    Solaroglu, I.3    Zhang, J.H.4
  • 12
    • 0034192486 scopus 로고    scopus 로고
    • Advances in the vascular pathophysiology of ischemic stroke
    • del Zoppo GJ, Hallenbeck JM (2000) Advances in the vascular pathophysiology of ischemic stroke. Thromb Res 98:73-81
    • (2000) Thromb Res , vol.98 , pp. 73-81
    • Del Zoppo, G.J.1    Hallenbeck, J.M.2
  • 13
    • 0031813131 scopus 로고    scopus 로고
    • Ischaemic damage of brain microvessels: Inherent risks for thrombolytic treatment in stroke
    • del Zoppo GJ, von Kummer R, Hamann GF (1998) Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke. J Neurol Neurosurg Psychiatry 65:1-9
    • (1998) J Neurol Neurosurg Psychiatry , vol.65 , pp. 1-9
    • Del Zoppo, G.J.1    Von Kummer, R.2    Hamann, G.F.3
  • 14
    • 0021874495 scopus 로고
    • Subarachnoid haemorrhage in the rat: Angiography and fluorescence microscopy of the major cerebral arteries
    • Delgado TJ, Brismar J, Svendgaard NA (1985) Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries. Stroke 16:595-602 (Pubitemid 15007231)
    • (1985) Stroke , vol.16 , Issue.4 , pp. 595-602
    • Delgado, T.J.1    Brismar, J.2    Svendgaard, N.A.3
  • 15
    • 0034021806 scopus 로고    scopus 로고
    • Molecular keys to the problems of cerebral vasospasm
    • Dietrich HH, Dacey RG Jr (2000) Molecular keys to the problems of cerebral vasospasm. Neurosurgery 46:517-530 (Pubitemid 30146138)
    • (2000) Neurosurgery , vol.46 , Issue.3 , pp. 517-530
    • Dietrich, H.H.1    Dacey Jr., R.G.2
  • 16
    • 0022492761 scopus 로고
    • Blood-brain barrier damage during the acute stage of subarachnoid hemorrhage, as exemplified by a new animal model
    • Doczi T, Joo F, Adam G, Bozoky B, Szerdahelyi P (1986) Blood - brain barrier damage during the acute stage of subarachnoid hemorrhage, as exemplified by a new animal model. Neurosurgery 18:733-739 (Pubitemid 16067827)
    • (1986) Neurosurgery , vol.18 , Issue.6 , pp. 733-739
    • Doczi, T.1    Joo, F.2    Adam, G.3
  • 17
    • 0023276383 scopus 로고
    • Regulation of brain water and electrolyte contents: The possible involvement of central atrial natriuretic factor
    • Doczi T, Joo F, Szerdahelyi P, Bodosi M (1987) Regulation of brain water and electrolyte contents: the possible involvement of central atrial natriuretic factor. Neurosurgery 21:454-458 (Pubitemid 17154021)
    • (1987) Neurosurgery , vol.21 , Issue.4 , pp. 454-458
    • Doczi, T.1    Joo, F.2    Szerdahelyi, P.3    Bodosi, M.4
  • 18
    • 0037298005 scopus 로고    scopus 로고
    • Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats
    • DOI 10.1016/S0378-8741(02)00324-0, PII S0378874102003240
    • El-Abhar HS, Abdallah DM, Saleh S (2003) Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats. J Ethnopharmacol 84:251-258 (Pubitemid 36324264)
    • (2003) Journal of Ethnopharmacology , vol.84 , Issue.2-3 , pp. 251-258
    • El-Abhar, H.S.1    Abdallah, D.M.2    Saleh, S.3
  • 19
    • 0036277862 scopus 로고    scopus 로고
    • Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats
    • DOI 10.1016/S0378-8741(02)00051-X, PII S037887410200051X
    • El-Dakhakhny M, Madi NJ, Lembert N, Ammon HP (2002) Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. J Ethnopharmacol 81:161-164 (Pubitemid 34628498)
    • (2002) Journal of Ethnopharmacology , vol.81 , Issue.2 , pp. 161-164
    • El-Dakhakhny, M.1    Madi, N.J.2    Lembert, N.3    Ammon, H.P.T.4
  • 20
    • 4143051638 scopus 로고    scopus 로고
    • Energy metabolism in mammalian brain during development
    • DOI 10.1016/j.pneurobio.2004.06.003, PII S0301008204001042
    • Erecinska M, Cherian S, Silver IA (2004) Energy metabolism in mammalian brain during development. Prog Neurobiol 73:397-445 (Pubitemid 39099270)
    • (2004) Progress in Neurobiology , vol.73 , Issue.6 , pp. 397-445
    • Erecinska, M.1    Cherian, S.2    Silver, I.A.3
  • 22
    • 76849084850 scopus 로고    scopus 로고
    • Alpha lipoic acid alleviates oxidative stress and preserves blood brain permeability in rats with subarachnoid hemorrhage
    • Ersahin M, Toklu HZ, Cetinel S, Yuksel M, Erzik C, Berkman MZ, Yegen BC, Sener G (2010) Alpha lipoic acid alleviates oxidative stress and preserves blood brain permeability in rats with subarachnoid hemorrhage. Neurochem Res 35:418-428
    • (2010) Neurochem Res , vol.35 , pp. 418-428
    • Ersahin, M.1    Toklu, H.Z.2    Cetinel, S.3    Yuksel, M.4    Erzik, C.5    Berkman, M.Z.6    Yegen, B.C.7    Sener, G.8
  • 24
    • 0000154206 scopus 로고
    • The colorimetric determination of phosphorus
    • Fiske CH, Subbarow Y (1925) The colorimetric determination of phosphorus. J Biol Chem 66:375-400
    • (1925) J Biol Chem , vol.66 , pp. 375-400
    • Fiske, C.H.1    Subbarow, Y.2
  • 25
    • 0026741061 scopus 로고
    • Brain damage following subarachnoid hemorrhage: The imbalance between anti-oxidant systems and lipid peroxidative processes
    • Gaetani P, Lombardi D (1992) Brain damage following subarachnoid hemorrhage: the imbalance between anti-oxidant systems and lipid peroxidative processes. J Neurosurg Sci 36:1-10
    • (1992) J Neurosurg Sci , vol.36 , pp. 1-10
    • Gaetani, P.1    Lombardi, D.2
  • 28
    • 0026746093 scopus 로고
    • Blood - Brain barrier permeability changes after experimental subarachnoid hemorrhage
    • Germano A, d'Avella D, Cicciarello R, Hayes RL, Tomasello F (1992) Blood - brain barrier permeability changes after experimental subarachnoid hemorrhage. Neurosurgery 30:882-886
    • (1992) Neurosurgery , vol.30 , pp. 882-886
    • Germano, A.1    D'Avella, D.2    Cicciarello, R.3    Hayes, R.L.4    Tomasello, F.5
  • 29
    • 33645284493 scopus 로고    scopus 로고
    • Chemiluminescence in the measurement of free radicals. Theory and application on a tissue injury model
    • Haklar GYM, Yalçin AS (1998) Chemiluminescence in the measurement of free radicals. Theory and application on a tissue injury model. Marmara Med J 11:56-60
    • (1998) Marmara Med J , vol.11 , pp. 56-60
    • Haklar, G.Y.M.1    Yalçin, A.S.2
  • 31
    • 1042303460 scopus 로고    scopus 로고
    • Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice
    • DOI 10.1078/0944-7113-00376
    • Hosseinzadeh H, Parvardeh S (2004) Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine 11:56-64 (Pubitemid 38196797)
    • (2004) Phytomedicine , vol.11 , Issue.1 , pp. 56-64
    • Hosseinzadeh, H.1    Parvardeh, S.2
  • 32
    • 34547395342 scopus 로고    scopus 로고
    • Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus
    • DOI 10.1016/j.phymed.2006.12.005, PII S0944711306002212
    • Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee T (2007) Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia - reperfusion injury in rat hippocampus. Phytomedicine 14:621-627 (Pubitemid 47176407)
    • (2007) Phytomedicine , vol.14 , Issue.9 , pp. 621-627
    • Hosseinzadeh, H.1    Parvardeh, S.2    Asl, M.N.3    Sadeghnia, H.R.4    Ziaee, T.5
  • 33
    • 17444422880 scopus 로고    scopus 로고
    • Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats
    • Hosseinzadeh H, Parvardeh S, Nassiri-Asl M, Mansouri MT (2005) Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med Sci Monit 11:BR106-BR110
    • (2005) Med Sci Monit , vol.11
    • Hosseinzadeh, H.1    Parvardeh, S.2    Nassiri-Asl, M.3    Mansouri, M.T.4
  • 34
    • 75149187342 scopus 로고    scopus 로고
    • Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
    • Ismail M, Al-Naqeep G, Chan KW (2010) Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic Biol Med 48:664-672
    • (2010) Free Radic Biol Med , vol.48 , pp. 664-672
    • Ismail, M.1    Al-Naqeep, G.2    Chan, K.W.3
  • 35
    • 36949037103 scopus 로고    scopus 로고
    • Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy
    • Kanter M (2008) Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochem Res 33:87-96
    • (2008) Neurochem Res , vol.33 , pp. 87-96
    • Kanter, M.1
  • 36
    • 38949116268 scopus 로고    scopus 로고
    • Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats
    • Kanter M (2008) Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats. Neurochem Res 33:579-588
    • (2008) Neurochem Res , vol.33 , pp. 579-588
    • Kanter, M.1
  • 37
    • 33645981973 scopus 로고    scopus 로고
    • Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats
    • Kanter M, Coskun O, Kalayci M, Buyukbas S, Cagavi F (2006) Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats. Hum Exp Toxicol 25:127-133
    • (2006) Hum Exp Toxicol , vol.25 , pp. 127-133
    • Kanter, M.1    Coskun, O.2    Kalayci, M.3    Buyukbas, S.4    Cagavi, F.5
  • 40
    • 0033404089 scopus 로고    scopus 로고
    • Reversal of cerebral vasospasm by the nitric oxide donor SNAP in an experimental model of subarachnoid haemorrhage
    • Wien discussion 1328-1329
    • Kiris T, Karasu A, Yavuz C, Erdem T, Unal F, Hepgul K, Baloglu H (1999) Reversal of cerebral vasospasm by the nitric oxide donor SNAP in an experimental model of subarachnoid haemorrhage. Acta Neurochir (Wien) 141:1323-1328, discussion 1328-1329
    • (1999) Acta Neurochir , vol.141 , pp. 1323-1328
    • Kiris, T.1    Karasu, A.2    Yavuz, C.3    Erdem, T.4    Unal, F.5    Hepgul, K.6    Baloglu, H.7
  • 43
    • 71849104860 scopus 로고
    • Protein measurements with the folin phenol reagent
    • Lowry OHRN, Farr AL, Randall RJ (1951) Protein measurements with the folin phenol reagent. J Biol Chem 193:265-275
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Ohrn, L.1    Farr, A.L.2    Randall, R.J.3
  • 45
    • 0027242030 scopus 로고
    • Hypercholesterolemia increases endothelial superoxide anion production
    • Ohara Y, Peterson TE, Harrison DG (1993) Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 91:2546-2551 (Pubitemid 23182507)
    • (1993) Journal of Clinical Investigation , vol.91 , Issue.6 , pp. 2546-2551
    • Ohara, Y.1    Peterson, T.E.2    Harrison, D.G.3
  • 46
    • 70449711109 scopus 로고    scopus 로고
    • Impairment of intracerebral arteriole dilation responses after subarachnoid hemorrhage. Laboratory investigation
    • Park IS, Meno JR, Witt CE, Chowdhary A, Nguyen TS, Winn HR, Ngai AC, Britz GW (2009) Impairment of intracerebral arteriole dilation responses after subarachnoid hemorrhage. Laboratory investigation. J Neurosurg 111:1008-1013
    • (2009) J Neurosurg , vol.111 , pp. 1008-1013
    • Park, I.S.1    Meno, J.R.2    Witt, C.E.3    Chowdhary, A.4    Nguyen, T.S.5    Winn, H.R.6    Ngai, A.C.7    Britz, G.W.8
  • 47
    • 0242321736 scopus 로고    scopus 로고
    • Ischemia Triggered by Spreading Neuronal Activation Is Induced by Endothelin-1 and Hemoglobin in the Subarachnoid Space
    • DOI 10.1002/ana.10723
    • Petzold GC, Einhaupl KM, Dirnagl U, Dreier JP (2003) Ischemia triggered by spreading neuronal activation is induced by endothelin-1 and hemoglobin in the subarachnoid space. Ann Neurol 54:591-598 (Pubitemid 37346065)
    • (2003) Annals of Neurology , vol.54 , Issue.5 , pp. 591-598
    • Petzold, G.C.1    Einhaupl, K.M.2    Dirnagl, U.3    Dreier, J.P.4
  • 48
    • 0019005306 scopus 로고
    • The role of cation-activated ATPases in transmitter release from the rat iris
    • Reading HW, Isbir T (1980) The role of cation-activated ATPases in transmitter release from the rat iris. Q J Exp Physiol Cogn Med Sci 65:105-116
    • (1980) Q J Exp Physiol Cogn Med Sci , vol.65 , pp. 105-116
    • Reading, H.W.1    Isbir, T.2
  • 49
    • 0035754146 scopus 로고    scopus 로고
    • Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: A review of the evidence
    • DOI 10.1385/CBB:34:2:237
    • Reiter RJ, Tan DX, Manchester LC, Qi W (2001) Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochem Biophys 34:237-256 (Pubitemid 33615836)
    • (2001) Cell Biochemistry and Biophysics , vol.34 , Issue.2 , pp. 237-256
    • Reiter, R.J.1    Tan, D.-X.2    Manchester, L.C.3    Qi, W.4
  • 50
    • 55349084723 scopus 로고    scopus 로고
    • Neuronal and astrocytic apoptosis after subarachnoid hemorrhage: A possible cause for poor prognosis
    • Sabri M, Kawashima A, Ai J, Macdonald RL (2008) Neuronal and astrocytic apoptosis after subarachnoid hemorrhage: a possible cause for poor prognosis. Brain Res 1238:163-171
    • (2008) Brain Res , vol.1238 , pp. 163-171
    • Sabri, M.1    Kawashima, A.2    Ai, J.3    Macdonald, R.L.4
  • 51
    • 33947638565 scopus 로고    scopus 로고
    • Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    • DOI 10.1111/j.1440-1681.2007.04560.x
    • Sayed-Ahmed MM, Nagi MN (2007) Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol 34:399-405 (Pubitemid 46494460)
    • (2007) Clinical and Experimental Pharmacology and Physiology , vol.34 , Issue.5-6 , pp. 399-405
    • Sayed-Ahmed, M.M.1    Nagi, M.N.2
  • 52
    • 38449089094 scopus 로고    scopus 로고
    • Cerebral blood flow changes in acute subarachnoid hemorrhage
    • Schubert GA, Thome C (2008) Cerebral blood flow changes in acute subarachnoid hemorrhage. Front Biosci 13:1594-1603
    • (2008) Front Biosci , vol.13 , pp. 1594-1603
    • Schubert, G.A.1    Thome, C.2
  • 53
    • 50349098189 scopus 로고    scopus 로고
    • Targeting nuclear factor-kappa B activation pathway by thymoquinone: Role in suppression of antiapoptotic gene products and enhancement of apoptosis
    • Sethi G, Ahn KS, Aggarwal BB (2008) Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res 6:1059-1070
    • (2008) Mol Cancer Res , vol.6 , pp. 1059-1070
    • Sethi, G.1    Ahn, K.S.2    Aggarwal, B.B.3
  • 54
    • 27144457343 scopus 로고    scopus 로고
    • Functional consequences of oxidative membrane damage
    • Stark G (2005) Functional consequences of oxidative membrane damage. J Membr Biol 205:1-16
    • (2005) J Membr Biol , vol.205 , pp. 1-16
    • Stark, G.1
  • 55
    • 47749143981 scopus 로고    scopus 로고
    • The effect of ecdysterone on cerebral vasospasm following experimental subarachnoid hemorrhage in vitro and in vivo
    • DOI 10.1179/174313208X297986, Chinese Neurosurgery Research
    • Tang WH, Chen Z, Liu Z, Zhang JH, Xi G, Feng H (2008) The effect of ecdysterone on cerebral vasospasm following experimental subarachnoid hemorrhage in vitro and in vivo. Neurol Res 30:571-580 (Pubitemid 352032553)
    • (2008) Neurological Research , vol.30 , Issue.6 , pp. 571-580
    • Tang, W.-H.1    Chen, Z.2    Liu, Z.3    Zhang, J.H.4    Xi, G.5    Feng, H.6
  • 56
    • 77949543599 scopus 로고    scopus 로고
    • Protective effects of Nigella sativa on intestinal ischemia-reperfusion injury in rats
    • Terzi A, Coban S, Yildiz F, Ates M, Bitiren M, Taskin A, Aksoy N (2010) Protective effects of Nigella sativa on intestinal ischemia-reperfusion injury in rats. J Invest Surg 23:21-27
    • (2010) J Invest Surg , vol.23 , pp. 21-27
    • Terzi, A.1    Coban, S.2    Yildiz, F.3    Ates, M.4    Bitiren, M.5    Taskin, A.6    Aksoy, N.7
  • 57
    • 67650921902 scopus 로고    scopus 로고
    • The protective effect of alpha lipoic acid against traumatic brain injury in rats
    • Toklu HZ, Hakan T, Biber N, Solakoglu S, Ogunc AV, Sener G (2009) The protective effect of alpha lipoic acid against traumatic brain injury in rats. Free Radic Res 43:658-667
    • (2009) Free Radic Res , vol.43 , pp. 658-667
    • Toklu, H.Z.1    Hakan, T.2    Biber, N.3    Solakoglu, S.4    Ogunc, A.V.5    Sener, G.6
  • 58
    • 61849106500 scopus 로고    scopus 로고
    • The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats
    • Toklu HZ, Uysal MK, Kabasakal L, Sirvanci S, Ercan F, Kaya M (2009) The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats. J Surg Res 152:238-248
    • (2009) J Surg Res , vol.152 , pp. 238-248
    • Toklu, H.Z.1    Uysal, M.K.2    Kabasakal, L.3    Sirvanci, S.4    Ercan, F.5    Kaya, M.6
  • 60
    • 55549095099 scopus 로고    scopus 로고
    • Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of K ATP channels
    • Yang Y, Zhang XJ, Yin J, Li LT (2008) Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of K ATP channels. Brain Res 1241:168-175
    • (2008) Brain Res , vol.1241 , pp. 168-175
    • Yang, Y.1    Zhang, X.J.2    Yin, J.3    Li, L.T.4
  • 61
    • 0038729614 scopus 로고    scopus 로고
    • Effects of resveratrol on secondary damages after acute spinal cord injury in rats
    • Yang YB, Piao YJ (2003) Effects of resveratrol on secondary damages after acute spinal cord injury in rats. Acta Pharmacol Sin 24:703-710
    • (2003) Acta Pharmacol Sin , vol.24 , pp. 703-710
    • Yang, Y.B.1    Piao, Y.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.