Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver

World Journal of Gastroenterology

Volumn 14, Issue 33, 2008, Pages 5204-5209

  Yildiz, Fahrettin ^a   Coban, Sacit ^b   Terzi, Alpaslan ^a   Ates, Mustafa ^c   Aksoy, Nurten ^a   Cakir, Hale ^a   Ocak, Ali Riza ^a   Bitiren, Muharrem ^a  

^a HARRAN UNIVERSITY   (Turkey)

^b GAZIANTEP UNIVERSITY   (Turkey)

^c MALATYA STATE HOSPITAL   (Turkey)

Author keywords

Ischemia reperfusion injury; Liver; Nigella sativa

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; LACTATE DEHYDROGENASE; MYELOPEROXIDASE; NIGELLA SATIVA EXTRACT; SODIUM CHLORIDE; ANTIOXIDANT; PEROXIDASE; PLANT EXTRACT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; HISTOPATHOLOGY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER INJURY; LIVER ISCHEMIA; LIVER PROTECTION; MALE; MICROSCOPY; NONHUMAN; OXIDATIVE STRESS; RAT; TISSUE LEVEL; ANIMAL; BLACK CUMIN; BLOOD; DISEASE MODEL; DRUG EFFECT; INFUSION; LIVER; LIVER DISEASE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REPERFUSION INJURY; TIME; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; CATALASE; DISEASE MODELS, ANIMAL; INFUSIONS, PARENTERAL; L-LACTATE DEHYDROGENASE; LIVER; LIVER DISEASES; MALE; NIGELLA SATIVA; OXIDATIVE STRESS; PEROXIDASE; PLANT EXTRACTS; RATS; RATS, WISTAR; REPERFUSION INJURY; TIME FACTORS;

EID: 58149240377     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.5204     Document Type: Article

References (34)

1. Shin T, Kuboki S, Huber N, Eismann T, Galloway E, Schuster R, Blanchard J, Pritts TA, Lentsch AB. Activation of peroxisome proliferator-activated receptor-gamma during hepatic ischemia is age-dependent. J Surg Res 2008; 147: 200-205
2. van Gulik TM, de Graaf W, Dinant S, Busch OR, Gouma DJ. Vascular occlusion techniques during liver resection. Dig Surg 2007; 24: 274-281
3. He XS, Ma Y, Wu LW, Wu JL, Hu RD, Chen GH, Huang JF. Dynamical changing patterns of glycogen and enzyme histochemical activities in rat liver graft undergoing warm ischemia injury. World J Gastroenterol 2005; 11: 2662-2665
4. Hassan-Khabbar S, Cottart CH, Wendum D, Vibert F, Clot JP, Savouret JF, Conti M, Nivet-Antoine V. Postischemic treatment by trans-resveratrol in rat liver ischemia-reperfusion: a possible strategy in liver surgery. Liver Transpl 2008; 14: 451-459
5. Montalvo-Jave EE, Escalante-Tattersfield T, Ortega-Salgado JA, Pina E, Geller DA. Factors in the pathophysiology of the liver ischemia-reperfusion injury. J Surg Res 2008; 147: 153-159
6. Polat KY, Aydinli B, Polat O, Aydin U, Yazici P, Ozturk G, Gundogdu C, Kiziltunc A. The protective effect of aprotinin and alpha-tocopherol on ischemia-reperfusion injury of the rat liver. Transplant Proc 2008; 40: 63-68
7. Pulitano C, Aldrighetti L. The protective role of steroids in ischemia-reperfusion injury of the liver. Curr Pharm Des 2008; 14: 496-503
8. Shen SQ, Zhang Y, Xiang JJ, Xiong CL. Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes. World J Gastroenterol 2007; 13: 1953-1961
9. Khalife KH, Lupidi G. Nonenzymatic reduction of thymoquinone in physiological conditions. Free Radic Res 2007;41:153-161
10. Kanter M, Coskun O, Uysal H. The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage. Arch Toxicol 2006; 80: 217-224
11. Morsi NM. Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria. Acta Microbiol Pol 2000; 49: 63-74
12. Bayrak O, Bavbek N, Karatas OF, Bayrak R, Catal F, Cimentepe E, Akbas A, Yildirim E, Unal D, Akcay A. Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys. Nephrol Dial Transplant 2008; 23: 2206-2212
13. Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee T. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine 2007; 14: 621-627
14. El-Abhar HS, Abdallah DM, Saleh S. Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats. J Ethnopharmacol 2003; 84: 251-258
15. Abdel-Fattah AM, Matsumoto K, Watanabe H. Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. Eur J Pharmacol 2000; 400: 89-97
16. Daba MH, Abdel-Rahman MS. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol Lett 1998; 95: 23-29
17. Mansour MA, Ginawi OT, El-Hadiyah T, El-Khatib AS, Al-Shabanah OA, Al-Sawaf HA. Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone. Res Commun Mol Pathol Pharmacol 2001; 110: 239-251
18. Mansour MA, Nagi MN, El-Khatib AS, Al-Bekairi AM. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct 2002; 20: 143-151
19. Turkdogan MK, Ozbek H, Yener Z, Tuncer I, Uygan I, Ceylan E. The role of Urtica dioica and Nigella sativa in the prevention of carbon tetrachloride-induced hepatotoxicity in rats. Phytother Res 2003; 17: 942-946
20. Boskabady MH, Javan H, Sajady M, Rakhshandeh H. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fundam Clin Pharmacol 2007; 21: 559-566
21. Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, Kiesewetter H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res 2003; 17: 1209-1214
22. Dirjomuljono M, Kristyono I, Tjandrawinata RR, Nofiarny D. Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. Int J Clin Pharmacol Ther 2008; 46: 295-306
23. Akhondian J, Parsa A, Rakhshande H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit 2007; 13: CR555-CR559
24. Kanter M, Coskun O, Budancamanak M. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol 2005; 11: 6684-6688
25. El Shenawy NS, Soliman MF, Reyad SI. The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice. Rev Inst Med Trop Sao Paulo 2008; 50: 29-36
26. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004; 37: 112-119
27. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005; 38: 1103-1111
28. Bolukbas C, Bolukbas FF, Horoz M, Aslan M, Celik H, Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis 2005; 5: 95
29. Wei H, Frenkel K. Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis 1993; 14: 1195-1201
30. Goth L. A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 1991; 196: 143-151
31. Sener G, Tosun O, Sehirli AO, Kacmaz A, Arbak S, Ersoy Y, Ayanoglu-Dulger G. Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci 2003; 72: 2707-2718
32. Chouker A, Martignoni A, Schauer RJ, Dugas M, Schachtner T, Kaufmann I, Setzer F, Rau HG, Lohe F, Jauch KW, Peter K, Thiel M. Alpha-gluthathione S-transferase as an early marker of hepatic ischemia/ reperfusion injury after liver resection. World J Surg 2005; 29: 528-534
33. Tarpey MM, Wink DA, Grisham MB. Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. Am J Physiol Regul Integr Comp Physiol 2004; 286: R431-R444
34. Cetinkaya A, Bulbuloglu E, Kurutas EB, Kantarceken B. N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Med Sci Monit 2006; 12: BR274-BR278