Snapin deficiency is associated with developmental defects of the central nervous system

Bioscience Reports

Volumn 31, Issue 2, 2011, Pages 151-158

  Zhou, Bing ^a,b   Zhu, Yi Bing ^a,b   Lin, Lin ^b   Cai, Qian ^a   Sheng, Zu Hang ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptotic cell death; Autophagy; Late endocytic trafficking; Lysosome; Neuronal development; Ubiquitin

Indexed keywords

CELL PROTEIN; POLYUBIQUITIN; SNAPIN; UNCLASSIFIED DRUG; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; PROTEASOME; SNAPIN PROTEIN, MOUSE; UBIQUITINATED PROTEIN; VESICULAR TRANSPORT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN CORTEX; BRAIN VENTRICLE; CELL DENSITY; CELL FUNCTION; CELL SURVIVAL; CELL TRANSPORT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO; ENDOCYTOSIS; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ANIMAL; APOPTOSIS; BRAIN; CONGENITAL MALFORMATION; CYTOLOGY; ENDOSOME; GENETICS; LYSOSOME; METABOLISM; MOUSE MUTANT; NERVE CELL; PHYSIOLOGY; PRENATAL DEVELOPMENT;

MAMMALIA;

ANIMALS; APOPTOSIS; AUTOPHAGY; BRAIN; ENDOSOMES; LYSOSOMES; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITINATED PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 79952469828     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSR20100110     Document Type: Article

References (41)

1. Luzio, J. P., Pryor, P. R. and Bright, N. A. (2007) Lysosomes: fusion and function. Nat. Rev. Mol. Cell. Biol. 8, 622-632
2. Overly, C. C. and Hollenbeck, P. J. (1996) Dynamic organization of endocytic pathways in axons of cultured sympathetic neurons. J. Neurosci. 16, 6056-6064 (Pubitemid 26313981)
3. Cai, Q., Lu, L., Tian, J.-H., Zhu, Y.-B., Qiao, H. and Sheng, Z.-H. (2010) Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons. Neuron 68, 73-86
4. Lee, J. H., Yu, W. H., Kumar, A., Lee, S., Mohan, P. S., Peterhoff, C. M., Wolfe, D. M., Martinez-Vicente, M., Massey, A. C., Sovak, G. et al. (2010) Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141, 1146-158
5. Rubinsztein, D. C. (2006) The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443, 780-786
6. Levine, B. and Kroemer, G. (2008) Autophagy in the pathogenesis of disease. Cell 132, 27-42
7. Yue, Z., Jin, S., Yang, C., Levine, A. J. and Heintz, N. (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 100, 15077-15082
8. Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y. et al. (2005) Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 169, 425-434 (Pubitemid 40686693)
9. Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T. and Mizushima, N. (2004) The role of autophagy during the early neonatal starvation period. Nature 432, 1032-1036 (Pubitemid 40052234)
10. Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H. and Mizushima, N. (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885-889
11. Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E. and Tanaka, K. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880-884
12. Fimia, G. M., Stoykova, A., Romagnoli, A., Giunta, L., Di Bartolomeo, S., Nardacci, R., Corazzari, M., Fuoco, C., Ucar, A., Schwartz, P. et al. (2007) Ambrai regulates autophagy and development of the nervous system. Nature 447, 1121-1125 (Pubitemid 47014434)
13. Tian, J. H., Wu, Z. X., Unzicker, M., Lu, L., Cai, Q., Li, C., Schirra, C., Matti, U., Stevens, D., Deng, C. et al. (2005) The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. J. Neurosci. 25, 10546-10555 (Pubitemid 41628456)
14. Pan, P. Y., Tian, J. H. and Sheng, Z. H. (2009) Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron 61, 412-424
15. Buxton, P., Zhang, X. M., Walsh, B., Sriratana, A., Schenberg, I., Manickam, E. and Rowe, T. (2003) Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. Biochem. J. 375, 433-440 (Pubitemid 37315451)
16. Starcevic, M. and Dell'Angelica, E. C. (2004) Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J. Biol. Chem. 279, 28393-28401
17. Lu, L., Cai, Q., Tian, J. H. and Sheng, Z. H. (2009) Snapin associates with late endocytic compartments and interacts with late endosomal SNAREs. Biosci. Rep. 29, 261-269
18. Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y. and Yoshimori, T. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728
19. Dunn, Jr, W. A. (1994) Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol. 4, 139-143
20. Klionsky, D. J. and Emr, S. D. (2000) Autophagy as a regulated pathway of cellular degradation. Science 290, 1717-1721
21. Mizushima, N., Ohsumi, Y. and Yoshimori, T. (2002) Autophagosome formation in mammalian cells. Cell Struct. Funct. 27, 421-429
22. Levine, B. and Klionsky, D. J. (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 6, 463-477 (Pubitemid 38456176)
23. Levine, B. and Yuan, J. (2005) Autophagy in cell death: an innocent convict? J. Clin. Invest. 115, 2679-2688
24. Kroemer, G. and Jaattela, M. (2005) Lysosomes and autophagy in cell death control. Nat. Rev. Cancer 5, 886-97
25. Cecconi, F. and Levine, B. (2008) The role of autophagy in mammalian development: cell makeover rather than cell death. Dev. Cell 15, 344-357
26. Levine, B. and Kroemer, G. (2009) Autophagy in aging, disease and death: the true identity of a cell death impostor. Cell Death Differ. 16, 1-2
27. Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R. and Tashiro, Y. (1998) Bafilomycin Al prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct. Funct. 23, 33-42 (Pubitemid 28223394)
28. Boya, P., Gonzalez-Polo, R. A., Casares, N., Perfettini, J. L., Dessen, P., Larochette, N., Metivier, D., Meley, D., Souquere, S., Yoshimori, T. et al. (2005) Inhibition of macroautophagy triggers apoptosis. Mol. Cell. Biol. 25, 1025-1040
29. Xie, Z. and Klionsky, D. J. (2007) Autophagosome formation: core machinery and adaptations. Nat. Cell Biol. 9, 1102-1109
30. Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H. and Levine, B. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672-676 (Pubitemid 129516338)
31. Tai, H. C. and Schuman, E. M. (2008) Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction. Nat. Rev. Neurosci. 9, 826-838
32. Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J. and Rubinsztein, D. C. (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36, 585-595
33. Wong, E. and Cuervo, A. M. Autophagy gone awry in neurodegenerative diseases. Nat. Neurosci. 13, 805-811
34. Webb, J. L., Ravikumar, B., Atkins, J., Skepper, J. N. and Rubinsztein, D. C. (2003) α-Synuclein is degraded by both autophagy and the proteasome. J. Biol. Chem. 278, 25009-25013
35. Qin, Z. H., Wang, Y., Kegel, K. B., Kazantsev, A., Apostol, B. L., Thompson, L. M., Yoder, J., Aronin, N. and DiFiglia, M. (2003) Autophagy regulates the processing of amino terminal huntingtin fragments. Hum. Mol. Genet. 12, 3231-3244
36. Iwata, A., Riley, B. E., Johnston, J. A. and Kopito, R. R. (2005) HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J. Biol. Chem. 280, 40282-40292
37. Berger, Z., Ravikumar, B., Menzies, F. M., Oroz, L. G., Underwood, B. R., Pangalos, M. N., Schmitt, I., Wullner, U., Evert, B.O., O'Kane, C. J. and Rubinsztein, D. C. (2006) Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum. Mol. Genet. 15, 433-442
38. Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, B. and Yuan, J. (2006) Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J. Biol. Chem. 281, 14474-14485
39. Deinhardt, K., Salinas, S., Verastegui, C., Watson, R., Worth, D., Hanrahan, S., Bucci, C. and Schiavo, G. (2006) Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron 52, 293-305 (Pubitemid 44548343)
40. Perlson, E., Jeong, G. B., Ross, J. L., Dixit, R., Wallace, K. E., Kalb, R. G. and Holzbaur, E. L. (2009) A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration. J. Neurosci. 29, 9903-9917
41. Cosker, K. E., Courchesne, S. L. and Segal, R. A. (2008) Action in the axon: generation and transport of signaling endosomes. Curr. Opin. Neurobiol. 18, 270-275