Cannabidiol injected into the bed nucleus of the stria terminalis modulates baroreflex activity through 5-HT1A receptors

Pharmacological Research

Volumn 62, Issue 3, 2010, Pages 228-236

  Alves, Fernando H F ^a   Crestani, Carlos C ^a   Gomes, Felipe V ^a   Guimarães, Francisco S ^a   Correa, Fernando M A ^a   Resstel, Leonardo B M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

5 HT1A receptors; 8 OH DPAT; Baroreflex; Cannabinoids; WAY100635

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; CANNABIDIOL; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR; CANNABIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; HISTOLOGY; MALE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; STRIA TERMINALIS; ANIMAL; CHEMISTRY; DRUG EFFECTS; HEART; METABOLISM; MICROINJECTION; SEPTUM NUCLEUS; SYNAPTIC TRANSMISSION; WISTAR RAT;

ANIMALS; BAROREFLEX; CANNABIDIOL; CANNABIS; HEART; MALE; MICROINJECTIONS; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; SEPTAL NUCLEI; SYNAPTIC TRANSMISSION;

EID: 77954145403     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.05.003     Document Type: Article

References (73)

1. Casada J.H., Dafny N. Restraint and stimulation of bed nucleus of the stria terminalis produce similar stress-like behaviors. Brain Res Bull 1991, 27:207-212.
2. Dunn J.D. Plasma corticosterone responses to electrical stimulation of the bed nucleus of the stria terminalis. Brain Res 1987, 407:327-331.
3. Dunn J.D., Williams T.J. Cardiovascular responses to electrical stimulation of the bed nucleus of the stria terminalis. J Comp Neurol 1995, 352:227-234.
4. Gelsema A.J., Copeland N.E., Drolet G., Bachelard H. Cardiovascular effects of neuronal activation of the extended amygdala in rats. Brain Res 1993, 626:156-166.
5. Giancola S.B., Roder S., Ciriello J. Contribution of caudal ventrolateral medulla to the cardiovascular responses elicited by activation of bed nucleus of the stria terminalis. Brain Res 1993, 606:162-166.
6. Hatam H., Nasimi A. Glutamatergic systems in the bed nucleus of the stria terminalis, effects on cardiovascular system. Exp Brain Res 2007, 178:394-401.
7. Alves F.H., Crestani C.C., Resstel L.B., Correa F.M. Cardiovascular effects of carbachol microinjected into the bed nucleus of the stria terminalis of the rat brain. Brain Res 2007, 1143:161-168.
8. Crestani C.C., Alves F.H., Resstel L.B., Correa F.M. Cardiovascular effects of noradrenaline microinjection in the bed nucleus of the stria terminalis of the rat brain. J Neurosci Res 2007, 85:1592-1599.
9. Crestani C.C., Alves F.H., Resstel L.B., Correa F.M. Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats. Br J Pharmacol 2008, 153:583-590.
10. Li Y.W., Dampney R.A. Expression of Fos-like protein in brain following sustained hypertension and hypotension in conscious rabbits. Neuroscience 1994, 61:613-634.
11. McKitrick D.J., Krukoff T.L., Calaresu F.R. Expression of c-fos protein in rat brain after electrical stimulation of the aortic depressor nerve. Brain Res 1992, 599:215-222.
12. Potts P.D., Polson J.W., Hirooka Y., Dampney R.A. Effects of sinoaortic denervation on Fos expression in the brain evoked by hypertension and hypotension in conscious rabbits. Neuroscience 1997, 77:503-520.
13. Crestani C.C., Alves F.H., Resstel L.B., Correa F.M. The bed nucleus of the stria terminalis modulates baroreflex in rats. Neuroreport 2006, 17:1531-1535.
14. Alves F.H., Crestani C.C., Resstel L.B., Correa F.M. Bed nucleus of the stria terminalis N-methyl-d-aspartate receptors and nitric oxide modulate the baroreflex cardiac component in unanesthetized rats. J Neurosci Res 2009, 87:1703-1711.
15. Crestani C.C., Alves F.H., Resstel L.B., Correa F.M. Bed nucleus of the stria terminalis alpha(1)-adrenoceptor modulates baroreflex cardiac component in unanesthetized rats. Brain Res 2008, 1245:108-115.
16. Crestani C.C., Alves F.H., Resstel L.B., Correa F.M. The bed nucleus of the stria terminalis modulates exercise-evoked cardiovascular responses in rats. Exp Physiol 2010, 95:69-79.
17. Crestani C.C., Alves F.H., Tavares R.F., Correa F.M. Role of the bed nucleus of the stria terminalis in the cardiovascular responses to acute restraint stress in rats. Stress 2009, 12:268-278.
18. Resstel L.B., Alves F.H., Reis D.G., Crestani C.C., Correa F.M., Guimaraes F.S. Anxiolytic-like effects induced by acute reversible inactivation of the bed nucleus of stria terminalis. Neuroscience 2008, 154:869-876.
19. Mechoulam R., Parker L.A., Gallily R. Cannabidiol: an overview of some pharmacological aspects. J Clin Pharmacol 2002, 42:11S-19S.
20. Crippa J.A., Zuardi A.W., Garrido G.E., Wichert-Ana L., Guarnieri R., Ferrari L., et al. Effects of cannabidiol (CBD) on regional cerebral blood flow. Neuropsychopharmacology 2004, 29:417-426.
21. Zuardi A.W., Crippa J.A., Hallak J.E., Moreira F.A., Guimaraes F.S. Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res 2006, 39:421-429.
22. Zanelati T., Biojone C., Moreira F.A., Guimaraes F.S., Joca S. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT receptors. Br J Pharmacol 2009, 159:122-128.
23. Hampson A.J., Grimaldi M., Axelrod J., Wink D. Cannabidiol and (-)delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA 1998, 95:8268-8273.
24. Iuvone T., Esposito G., Esposito R., Santamaria R., Di Rosa M., Izzo A.A. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem 2004, 89:134-141.
25. Petitet F., Jeantaud B., Reibaud M., Imperato A., Dubroeucq M.C. Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sci 1998, 63:PL1-6.
26. Thomas B.F., Gilliam A.F., Burch D.F., Roche M.J., Seltzman H.H. Comparative receptor binding analyses of cannabinoid agonists and antagonists. J Pharmacol Exp Ther 1998, 285:285-292.
27. 1A receptors. Neurochem Res 2005, 30:1037-1043.
28. 1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. Br J Pharmacol 2009, 156:181-188.
29. 1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology (Berl) 2008, 199:223-230.
30. Resstel L.B., Joca S.R., Moreira F.A., Correa F.M., Guimaraes F.S. Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats. Behav Brain Res 2006, 172:294-298.
31. Lemos J.I., Resstel L.B., Guimaraes F.S. Involvement of the prelimbic prefrontal cortex on cannabidiol-induced attenuation of contextual conditioned fear in rats. Behav Brain Res 2010, 207:105-111.
32. Lowry C.A., Hale M.W., Evans A.K., Heerkens J., Staub D.R., Gasser P.J., et al. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Ann N Y Acad Sci 2008, 1148:86-94.
33. Commons K.G., Connolley K.R., Valentino R.J. A neurochemically distinct dorsal raphe-limbic circuit with a potential role in affective disorders. Neuropsychopharmacology 2003, 28:206-215.
34. Phelix C.F., Liposits Z., Paull W.K. Serotonin-CRF interaction in the bed nucleus of the stria terminalis: a light microscopic double-label immunocytochemical analysis. Brain Res Bull 1992, 28:943-948.
35. Cornea-Hebert V., Riad M., Wu C., Singh S.K., Descarries L. Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat. J Comp Neurol 1999, 409:187-209.
36. Heidmann D.E., Szot P., Kohen R., Hamblin M.W. Function and distribution of three rat 5-hydroxytryptamine7 (5-HT7) receptor isoforms produced by alternative splicing. Neuropharmacology 1998, 37:1621-1632.
37. 1A receptors in the rat central nervous system. J Comp Neurol 1996, 365:289-305.
38. Mengod G., Nguyen H., Le H., Waeber C., Lubbert H., Palacios J.M. The distribution and cellular localization of the serotonin 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution. Neuroscience 1990, 35:577-591.
39. To Z.P., Bonhaus D.W., Eglen R.M., Jakeman L.B. Characterization and distribution of putative 5-ht7 receptors in guinea-pig brain. Br J Pharmacol 1995, 115:107-116.
40. Waeber C., Moskowitz M.A. [3H]sumatriptan labels both 5-HT1D and 5-HT1F receptor binding sites in the guinea pig brain: an autoradiographic study. Naunyn Schmiedebergs Arch Pharmacol 1995, 352:263-275.
41. Waeber C., Sebben M., Nieoullon A., Bockaert J., Dumuis A. Regional distribution and ontogeny of 5-HT4 binding sites in rodent brain. Neuropharmacology 1994, 33:527-541.
42. 1A, 1C, and 2 receptor subtype mRNAs in rat brain. J Comp Neurol 1995, 351:357-373.
43. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1997, Academic Press, Sydney. 2nd ed.
44. Scopinho A.A., Crestani C.C., Alves F.H., Resstel L.B., Correa F.M. The lateral septal area modulates the baroreflex in unanesthetized rats. Auton Neurosci 2007, 137:77-83.
45. Su D.F., Cerutti C., Barres C., Julien C., Vincent M., Paultre C., et al. Arterial baroreflex control of heart period is not related to blood pressure variability in conscious hypertensive and normotensive rats. Clin Exp Pharmacol Physiol 1992, 19:767-776.
46. 1A and 5-HT2 receptors of the dorsal periaqueductal gray in the regulation of the defensive behaviors generated by the elevated T-maze. Brain Res Bull 2004, 64:181-188.
47. Zangrossi H., Graeff F.G. Behavioral effects of intra-amygdala injections of GABA and 5-HT acting drugs in the elevated plus-maze. Braz J Med Biol Res 1994, 27:2453-2456.
48. Head G.A., McCarty R. Vagal and sympathetic components of the heart rate range and gain of the baroreceptor-heart rate reflex in conscious rats. J Auton Nerv Syst 1987, 21:203-213.
49. Korner P.I., Shaw J., West M.J., Oliver J.R. Central nervous system control of baroreceptor reflexes in the rabbit. Circ Res 1972, 31:637-652.
50. McQueen D.S., Bond S.M., Smith P.J., Balali-Mood K., Smart D. Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats. Eur J Pharmacol 2004, 491:181-189.
51. Bisogno T., Hanus L., De Petrocellis L., Tchilibon S., Ponde D.E., Brandi I., et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 2001, 134:845-852.
52. Watanabe K., Ogi H., Nakamura S., Kayano Y., Matsunaga T., Yoshimura H., et al. Distribution and characterization of anandamide amidohydrolase in mouse brain and liver. Life Sci 1998, 62:1223-1229.
53. Di Marzo V., De Petrocellis L., Bisogno T., Melck D. Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments. Lipids 1999, 34(Suppl.):S319-S325.
54. Izzo A.A., Borrelli F., Capasso R., Di Marzo V., Mechoulam R. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 2009, 30:515-527.
55. Steinbusch H.W. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 1981, 6:557-618.
56. Kellett D.O., Stanford S.C., Machado B.H., Jordan D., Ramage A.G. Effect of 5-HT depletion on cardiovascular vagal reflex sensitivity in awake and anesthetized rats. Brain Res 2005, 1054:61-72.
57. Nalivaiko E., Sgoifo A. Central 5-HT receptors in cardiovascular control during stress. Neurosci Biobehav Rev 2009, 33:95-106.
58. Nalivaiko E., Mastorci F., Sgoifo A. 8-OH-DPAT prevents cardiac arrhythmias and attenuates tachycardia during social stress in rats. Physiol Behav 2009, 96:320-327.
59. 1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits. Am J Physiol Regul Integr Comp Physiol 2005, 289:R596-R604.
60. 1A) receptors attenuates tachycardia induced by restraint stress in rats. Am J Physiol Regul Integr Comp Physiol 2008, 294:R132-R141.
61. Dampney R.A., Horiuchi J., McDowall L.M. Hypothalamic mechanisms coordinating cardiorespiratory function during exercise and defensive behaviour. Auton Neurosci 2008, 142:3-10.
62. Nosaka S. Modifications of arterial baroreflexes: obligatory roles in cardiovascular regulation in stress and poststress recovery. Jpn J Physiol 1996, 46:271-288.
63. Nosaka S., Murata K. Somatosensory inhibition of vagal baroreflex bradycardia: afferent nervous mechanisms. Am J Physiol 1989, 257:R829-R838.
64. Schadt J.C., Hasser E.M. Hemodynamic effects of acute stressors in the conscious rabbit. Am J Physiol 1998, 274:R814-R821.
65. Resstel L.B., Fernandes K.B., Correa F.M. Medial prefrontal cortex modulation of the baroreflex parasympathetic component in the rat. Brain Res 2004, 1015:136-144.
66. Verberne A.J., Lewis S.J., Worland P.J., Beart P.M., Jarrott B., Christie M.J., et al. Medial prefrontal cortical lesions modulate baroreflex sensitivity in the rat. Brain Res 1987, 426:243-249.
67. Schlor K.H., Stumpf H., Stock G. Baroreceptor reflex during arousal induced by electrical stimulation of the amygdala or by natural stimuli. J Auton Nerv Syst 1984, 10:157-165.
68. Jin C.B., Rockhold R.W. Effects of paraventricular hypothalamic microinfusions of kainic acid on cardiovascular and renal excretory function in conscious rats. J Pharmacol Exp Ther 1989, 251:969-975.
69. Crestani C.C., Tavares R.F., Alves F.H., Resstel L.B., Correa F.M. Diagonal band of Broca modulates the cardiac component of the baroreflex in unanesthetized rats. Neurosci Lett 2008, 448:189-193.
70. La Rovere M.T., Pinna G.D., Raczak G. Baroreflex sensitivity: measurement and clinical implications. Ann Noninvas Electrocardiol 2008, 13:191-207.
71. Sykora M., Diedler J., Turcani P., Hacke W., Stainer T. Baroreflex: a new therapeutic target in human stroke?. Stroke 2009, 40:678-682.
72. Mishima K., Hayawawa K., Kohji A., Ikeda T., Egashira N., Iwasaki K., et al. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke 2005, 36:1071-1076.
73. Hampson A.J., Grimald M., Lolic M., Wink D., Rosenthal R., Axelrod J. Neuroprotective antioxidants from marijuana. Ann N Y Acad Sci 2000, 899:274-282.