Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 6, 2011, Pages 1987-1998

  Marvania, Bhavin ^a,d   Lee, Pei Chih ^a   Chaniyara, Ravi ^a,d   Dong, Huajin ^b   Suman, Sharda ^a   Kakadiya, Rajesh ^a   Chou, Ting Chao ^b   Lee, Te Chang ^a   Shah, Anamik ^d   Su, Tsann Long ^a,c  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d SAURASHTRA UNIVERSITY   (India)

Author keywords

Anticancer agents; Cell cycle; DNA interstrand cross linking agents; DNA directed alkylating agents; Nitrogen mustards

Indexed keywords

ANTINEOPLASTIC AGENT; N (2 FLUORO 3 CHLOROPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (3 BROMO 4 FLUOROPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (3 BROMOPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (3 CHLORO 4 FLUOROPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (3 CHLORO 4 METHOXYPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (3 CHLOROPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (3 ETHYNYLPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (3 FLUOROPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (3 METHOXYPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (3,4 DICHLOROPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (3,4,5 TRIMETHOXYPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (4 BROMOPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (4 FLUOROPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N (4 PHENOXYPHENYL) 6 NITROQUINAZOLIN 4 AMINE; N [3 CHLORO 4 (PYRIDIN 2 YLMETHOXY)PHENYL] 6 NITROQUINAZOLIN 4 AMINE; N [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 6 NITROQUINAZOLIN 4 AMINE; N' (2 CYANO 4 NITROPHENYL) N,N DIMETHYLFORMIMIDAMIDE; N4 (2 FLUORO 3 CHLOROPHENYL)QUINAZOLIN 4,6 DIAMINE; N4 (2 FLUORO 3 CHLORPHENYL)QUINAZOLIN 4,6 DIAMINE; N4 (3 BROMOPHENYL)QUINAZOLIN 4,6 DIAMINE; N4 (3 CHLORO 4 FLUOROPHENYL)QUINAZOLIN 4,6 DIAMINE; N4 (3 CHLOROPHENYL)QUINAZOLIN 4,6 DIAMINE; N4 (3 FLUORO 4 CHLOROPHENYL)QUINAZOLIN 4,6 DIAMINE; N4 (3 FLUOROPHENYL)QUINAZOLIN 4,6 DIAMINE; N4 (4 BROMOPHENYL)QUINAZOLIN 4,6 DIAMINE; N4 (4 FLUOROPHENYL)QUINAZOLIN 4,6 DIAMINE; N4 [ 3 (TRIFLUOROMETHYL)PHENYL]QUINAZOLIN 4,6 DIAMINE; PHENYL N MUSTARD QUINAZOLINE CONJUGATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DNA CROSS LINKING; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT; WEIGHT REDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; MICE; MICE, NUDE; MUSTARD PLANT; NEOPLASMS; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; BRASSICACEAE;

EID: 79952438211     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.055     Document Type: Article

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