Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings

European Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2009, Pages 3056-3059

  Chen, Ching Huang ^a   Lin, Yi Wen ^a   Zhang, Xiuguo ^b   Chou, Ting Chao ^b   Tsai, Tsong Jen ^a   Kapuriya, Naval ^a   Kakadiya, Rajesh ^a   Su, Tsann Long ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

9 Anilinoacridines; Cytotoxic; DNA alkylating agents; Nitrogen mustards

Indexed keywords

3 (9 ACRIDINYLAMINO) 5 HYDROXYMETHYLANILINE; 9 ANILINOACRIDINE DERIVATIVE; [4 [2 [BIS(2 CHLOROETHYL)AMINO]BUTOXY]ACRIDIN 9 YL] [4 [2 [BIS(2 CHLOROETHYL)AMINO]ETHOXY]PHENYL]AMINE; [4 [2 [BIS(2 CHLOROETHYL)AMINO]ETHOXY]ACRIDIN 9 YL] [3 [2 [BIS(2 CHLOROETHYL)AMINO]BUTOXY]PHENYL]AMINE; [4 [2 [BIS(2 CHLOROETHYL)AMINO]ETHOXY]ACRIDIN 9 YL] [3 [2 [BIS(2 CHLOROETHYL)AMINO]ETHOXY]PHENYL]AMINE; [4 [2 [BIS(2 CHLOROETHYL)AMINO]ETHOXY]ACRIDIN 9 YL] [4 [2 [BIS(2 CHLOROETHYL)AMINO]BUTOXY]PHENYL]AMINE; [4 [2 [BIS(2 CHLOROETHYL)AMINO]ETHOXY]ACRIDIN 9 YL] [4 [2 [BIS(2 CHLOROETHYL)AMINO]ETHOXY]PHENYL]AMINE; ANTINEOPLASTIC AGENT; PACLITAXEL; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHATIC LEUKEMIA; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

AMSACRINE; ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MUSTARD COMPOUNDS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 67349207362     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.07.016     Document Type: Article

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