Novel DNA-directed alkylating agents: Design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 3, 2009, Pages 1264-1275

  Kapuriya, Naval ^a   Kapuriya, Kalpana ^a   Dong, Huajin ^b   Zhang, Xiuguo ^b   Chou, Ting Chao ^b   Chen, Yu Ting ^a   Lee, Te Chang ^a,d   Lee, Wen Chuan ^c   Tsai, Tung Hu ^c   Naliapara, Yogesh ^e   Su, Tsann Long ^a,f  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^e SAURASHTRA UNIVERSITY   (India)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

9 Anilinoacridines; Cytotoxic; DNA directed alkylating agents; Phenyl nitrogen mustards

Indexed keywords

[2 METHYL 5 (4 METHYLACRIDIN 9 YLAMINO)PHENYL]CARBAMIC ACID 4 [BIS(2 CHLOROETHYL)AMINO]PHENYL ESTER; [3 (ACRIDIN 9 YLAMINO) 5 HYDROXYMETHYLPHENYL]CARBAMIC ACID 4 [BIS(2 CHLOROETHYL)AMINO]PHENYL ESTER; [3 (ACRIDIN 9 YLAMINO) 5 METHOXYPHENYL]CARBAMIC ACID 4 [BIS(2 CHLOROETHYL)AMINO]PHENYL ESTER; [3 HYDROXYMETHYL 5 (4 METHYLACRIDIN 9 YLAMINO)PHENYL]CARBAMIC ACID 4 [BIS(2 CHLOROETHYL)AMINO]PHENYL ESTER; ACRIDINE DERIVATIVE; ALKYLATING AGENT; CARBAMIC ACID; CARBONIC ACID; CARBONIC ACID 3 (ACRIDIN 9 YLAMINO) 5 ETHOXYCARBONYLAMINOBENZYL ESTER 4 [BIS(2 CHLOROETHYL)AMINO]PHENYL ESTER; CISPLATIN; PACLITAXEL; PHENYL N MUSTARD 9 ANILINOACRIDINE DERIVATIVE; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA CROSS LINKING; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NONHUMAN; PHARMACOPHORE; TUMOR; TUMOR XENOGRAFT;

ACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CARBAMATES; CARBONATES; CELL LINE, TUMOR; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HALF-LIFE; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICE; MICE, NUDE; NEOPLASMS; RATS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

BRASSICACEAE; MUS; MUS MUSCULUS; RATTUS;

EID: 58949093580     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.022     Document Type: Article

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