Alagebrium chloride protects the heart against oxidative stress in aging rats

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 64, Issue 6, 2009, Pages 629-635

  Guo, Yan ^a   Lu, Miao ^a   Qian, Jin ^a   Cheng, Yun Lin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Advanced glycation end products (AGEs); Aging heart; Alagebrium chloride (ALT 711); Oxidative stress

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALAGEBRIUM; GLUTATHIONE PEROXIDASE; MITOCHONDRIAL DNA; SUPEROXIDE DISMUTASE; PROTECTIVE AGENT; THIAZOLE DERIVATIVE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DIASTOLE; ENZYME ACTIVITY; FEMALE; GENE DELETION; GLYCATION; HEART CELL CULTURE; HEART FUNCTION; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART PROTECTION; MUSCLE FIBER CULTURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; DRUG EFFECT; ECHOCARDIOGRAPHY; HEART; HEART MUSCLE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

AGING; ANIMALS; DNA, MITOCHONDRIAL; ECHOCARDIOGRAPHY; FEMALE; GLUTATHIONE PEROXIDASE; GLYCOSYLATION END PRODUCTS, ADVANCED; HEART; MYOCARDIUM; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; THIAZOLES;

EID: 66149139773     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/glp023     Document Type: Article

References (28)

1. Brownlee M, Cerami A, Vlassara H. Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med. 1988;318:1315-1321.
2. Bucala R, Cerami A. Advanced glycosylation: chemistry, biology, and implications for diabetes and aging. Adv Pharmacol. 1992;23:1-34.
3. Lakatta EG. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev. 1993;73:413-467.
4. Aronson D. Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. J Hypertens. 2003;21:3-12.
5. Cantini C, Kieffer P, Corman B, Liminana P, Atkinson J, Lartaud-Idjouadiene I. Aminoguanidine and aortic wall mechanics, structure, and composition in aged rats. Hypertension. 2001;38:943-948.
6. Little WC, Zile MR, Kitzman DW, Hundley WG, O'Brien TX, Degroof RC. The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure. J Card Fail. 2005;11:191-195.
7. Uribarri J, Cai W, Peppa M, et al. Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging. J Gerontol A Biol Sci Med Sci. 2007;62:427-433.
8. Li SY, Du M, Dolence EK, et al. Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification. Aging cell. 2005;4:57-64.
9. Wei YH, Lee HC. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp Biol Med (Maywood). 2002;227:671-682.
10. Meissner C. Mutations of mitochondrial DNA - cause or consequence of the ageing process? Z Gerontol Geriatr. 2007;40:325-333.
11. Zieman SJ, Melenovsky V, Clattenburg L, et al. Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension. J Hypertens. 2007;25:577-583.
12. Soldatos G, Cooper ME. Advanced glycation end products and vascular structure and function. Curr Hypertens Rep. 2006;8:472-478.
13. Asif M, Egan J, Vasan S, et al. An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness. Proc Natl Acad Sci U S A. 2000;97:2809-2813.
14. Vaitkevicius PV, Lane M, Spurgeon H, et al. A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys. Proc Natl Acad Sci U S A. 2001;98:1171-1175.
15. Lassila M, Seah KK, Allen TJ, et al. Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: role of advanced glycation end products. J Am Soc Nephrol. 2004;15:2125-2138.
16. Kass DA, Shapiro EP, Kawaguchi M, et al. Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation. 2001;104:1464-1470.
17. Wrobel K, Wrobel K, Garay-Sevilla ME, Nava LE, Malacara JM. Novel analytical approach to monitoring advanced glycosylation end products in human serum with on-line spectrophotometric and spectrofl uorometric detection in a flow system. Clin Chem. 1997;43:1563-1569.
18. Monnier VM, Kohn RR, Cerami A. Accelerated age-related browning of human collagen in diabetes mellitus. Proc Natl Acad Sci U S A. 1984;81:583-587.
19. Simm A, Wagner J, Gursinsky T, et al. Advanced glycation endproducts: a biomarker for age as an outcome predictor after cardiac surgery?. Exp Gerontol. 2007;42:668-675.
20. Schleicher ED, Wagner E, Nerlich AG. Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest. 1997;99:457-468.
21. Coughlan MT, Forbes JM, Cooper ME. Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes. Kidney Int. 2007;106:S54-S60.
22. Wolffenbuttel BH, Boulanger CM, Crijns FR, et al. Breakers of advanced glycation end products restore large artery properties in experimental diabetes. Proc Natl Acad Sci U S A. 1998;95:4630-4634.
23. Basta G, Lazzerini G, Massaro M, et al. Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses. Circulation. 2002;105:816-822.
24. Wautier MP, Chappey O, Corda S, Stern DM, Schmidt AM, Wautier JL. Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. Am J Physiol Endocrinol Metab. 2001;280:E685-E694.
25. Chen J, Brodsky SV, Goligorsky DM, et al. Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells. Circ Res. 2002;90:1290-1298.
26. Judge S, Leeuwenburgh C. Cardiac mitochondrial bioenergetics, oxidative stress, and aging. Am J Physiol. 2007;292:C1983-C1992.
27. Kujoth GC, Hiona A, Pugh TD, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005;309:481-484.
28. Lenaz G, Bovina C, D'Aurelio M, et al. Role of mitochondria in oxidative stress and aging. Ann N Y Acad Sci. 2002;959:199-213.