The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease

Cancer Research

Volumn 70, Issue 15, 2010, Pages 6193-6204

  Dierks, Christine ^a,b   Adrian, Francisco ^b   Fisch, Paul ^a   Ma, Hong ^b   Maurer, Helga ^a   Herchenbach, Dieter ^a   Forster, Christine Ulrike ^a   Sprissler, Clara ^a   Liu, Guoxun ^b   Rottmann, Sabine ^b   Guo, Gui Rong ^d   Katja, Zirlik ^a   Veelken, Hendrik ^a   Warmuth, Markus ^b,c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 5; PLECKSTRIN; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL EXPANSION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE FUSION; ITK ONCOGENE; LYMPH NODE; LYMPHOPROLIFERATIVE DISEASE; MALE; MEMBRANE BINDING; MOUSE; NONHUMAN; ONCOGENE; POINT MUTATION; PRIORITY JOURNAL; SKIN; SPLEEN; SYK ONCOGENE; T CELL LYMPHOMA; UPREGULATION;

ANIMALS; B-LYMPHOCYTES; BONE MARROW TRANSPLANTATION; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOPHENOTYPING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE ACTIVATION; LYMPHOMA, T-CELL; LYMPHOPROLIFERATIVE DISORDERS; MALE; MICE; MICE, INBRED BALB C; ONCOGENE PROTEINS, FUSION; POINT MUTATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-CBL; T-LYMPHOCYTES;

EID: 77955368298     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-3719     Document Type: Article

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