Watching worms whither: Modeling neurodegeneration in C. elegans

Progress in Molecular Biology and Translational Science

Volumn 100, Issue , 2011, Pages 499-514

  Wolozin, Benjamin ^a   Gabel, Christopher ^a   Ferree, Andrew ^a   Guillily, Maria ^a   Ebata, Atsushi ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axonal dystrophy; Dopamine; Green fluorescent protein; Laser ablation; Leucine rich repeat kinase 2; Microtubule associated protein tau; Presenilin; Synuclein; Amyloid

Indexed keywords

EID: 79952381800     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-384878-9.00015-7     Document Type: Chapter

References (62)

1. W.B. Wood The Nematode Caenorhabditis elegans. Cold Spring Harbor Monograph Series 17 1988 Cold Spring Harbor Press. Cold Spring Harbor, NY p. 667
2. R.I. Morimoto Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging Genes Dev 22 2008 1427 1438 (Pubitemid 351793077)
3. C. Kaether, C. Haass, and H. Steiner Assembly, trafficking and function of gamma-secretase Neurodegener Dis 3 2006 275 283
4. S. Biskup, and A.B. West Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease Biochim Biophys Acta 1792 2009 625 633
5. A.S. Chen-Plotkin, V.M. Lee, and J.Q. Trojanowski TAR DNA-binding protein 43 in neurodegenerative disease Nat Rev Neurol 6 2010 211 220
6. W. Annaert, and B. De Strooper Presenilins: molecular switches between proteolysis and signal transduction Trends Neurosci 22 1999 439 443 (Pubitemid 29447727)
7. M. Lakso, S. Vartiainen, A.M. Moilanen, J. Sirvio, J.H. Thomas, and R. Nass Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein J Neurochem 86 2003 165 172 (Pubitemid 36753857)
8. R. Nass, and R.D. Blakely The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration Annu Rev Pharmacol Toxicol 43 2003 521 544 (Pubitemid 37372652)
9. T. Kuwahara, A. Koyama, K. Gengyo-Ando, M. Masuda, H. Kowa, and M. Tsunoda Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans J Biol Chem 281 2006 334 340 (Pubitemid 43671193)
10. E.R. Sawin, R. Ranganathan, and H.R. Horvitz C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway Neuron 26 2000 619 631
11. D.J. Selkoe, and D. Schenk Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics Annu Rev Pharmacol Toxicol 43 2003 545 584 (Pubitemid 37372653)
12. W.H. Stoothoff, and G.V. Johnson Tau phosphorylation: physiological and pathological consequences Biochim Biophys Acta 1739 2005 280 297 (Pubitemid 40018545)
13. D. Levitan, T. Doyle, D. Brousseau, M. Lee, G. Thinakaran, and H. Slunt Assessment of normal and mutant human presenilin function in Caenorhabditis elegans Proc Natl Acad Sci USA 93 1996 14940 14944 (Pubitemid 26419074)
14. D. Levitan, and I. Greenwald Facilitation of lin-12 mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene Nature 377 1995 351 355
15. X. Li, and I. Greenwald Membrane topology of the C. elegans SEL-12 presenilin Neuron 17 1996 1015 1021 (Pubitemid 26424027)
16. C.D. Link Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans Proc Natl Acad Sci USA 92 1995 9368 9372
17. C.D. Link, A. Taft, V. Kapulkin, K. Duke, S. Kim, and Q. Fei Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model Neurobiol Aging 24 2003 397 413 (Pubitemid 36205048)
18. D. Boyd-Kimball, H.F. Poon, B.C. Lynn, J. Cai, W.M. Pierce Jr., and J.B. Klein Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): implications for Alzheimer's disease Neurobiol Aging 27 2006 1239 1249 (Pubitemid 44067304)
19. M.L. Florez-McClure, L.A. Hohsfield, G. Fonte, M.T. Bealor, and C.D. Link Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans Autophagy 3 2007 569 580 (Pubitemid 350060053)
20. B.C. Kraemer, B. Zhang, J.B. Leverenz, J.H. Thomas, J.Q. Trojanowski, and G.D. Schellenberg Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy Proc Natl Acad Sci USA 100 2003 9980 9985 (Pubitemid 37087054)
21. C.R. Guthrie, G.D. Schellenberg, and B.C. Kraemer SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans Hum Mol Genet 18 2009 1825 1838
22. B.C. Kraemer, and G.D. Schellenberg SUT-1 enables tau-induced neurotoxicity in C. elegans Hum Mol Genet 16 2007 1959 1971 (Pubitemid 47354879)
23. R. Nass, D.H. Hall, D.M. Miller 3rd, and R.D. Blakely Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans Proc Natl Acad Sci USA 99 2002 3264 3269 (Pubitemid 34240620)
24. S. Saha, M.D. Guillily, A. Ferree, J. Lanceta, D. Chan, and J. Ghosh LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans J Neurosci 29 2009 9210 9218
25. S. Hamamichi, R.N. Rivas, A.L. Knight, S. Cao, K.A. Caldwell, and G.A. Caldwell Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model Proc Natl Acad Sci USA 105 2008 728 733 (Pubitemid 351171776)
26. L.A. Berkowitz, S. Hamamichi, A.L. Knight, A.J. Harrington, G.A. Caldwell, and K.A. Caldwell Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes J Vis Exp 835 2008 doi: 10.3791/835
27. M. Marvanova, and C.D. Nichols Identification of neuroprotective compounds of Caenorhabditis elegans dopaminergic neurons against 6-OHDA J Mol Neurosci 31 2007 127 137 (Pubitemid 46742296)
28. E. Braungart, M. Gerlach, P. Riederer, R. Baumeister, and M.C. Hoener Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings Neurodegener Dis 1 2004 175 183 (Pubitemid 39551794)
29. J.A. Kritzer, S. Hamamichi, J.M. McCaffery, S. Santagata, T.A. Naumann, and K.A. Caldwell Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models Nat Chem Biol 5 2009 655 663
30. R. Ved, S. Saha, B. Westlund, C. Perrier, L. Burnam, and A. Sluder Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of α-synuclein, Parkin and DJ-1 in C. elegans J Biol Chem 280 2005 42655 42668 (Pubitemid 43049224)
31. A. Sakaguchi-Nakashima, J.Y. Meir, Y. Jin, K. Matsumoto, and N. Hisamoto LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins Curr Biol 17 2007 592 598 (Pubitemid 46497793)
32. J. Samann, J. Hegermann, E. von Gromoff, S. Eimer, R. Baumeister, and E. Schmidt Caenorhabditis elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth J Biol Chem 284 2009 16482 16491
33. A.D. Gitler, B.J. Bevis, J. Shorter, K.E. Strathearn, S. Hamamichi, and L.J. Su The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis Proc Natl Acad Sci USA 105 2008 145 150
34. D.P. Karpinar, M.B. Balija, S. Kugler, F. Opazo, N. Rezaei-Ghaleh, and N. Wender Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models EMBO J 28 2009 3256 3268
35. S. Vartiainen, P. Pehkonen, M. Lakso, R. Nass, and G. Wong Identification of gene expression changes in transgenic C. elegans overexpressing human alpha-synuclein Neurobiol Dis 22 2006 477 486 (Pubitemid 43832121)
36. S. Asikainen, M. Rudgalvyte, L. Heikkinen, K. Louhiranta, M. Lakso, and G. Wong Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models J Mol Neurosci 41 2010 210 218
37. Y. Yang, S. Gehrke, Y. Imai, Z. Huang, Y. Ouyang, and J.W. Wang Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin Proc Natl Acad Sci USA 103 2006 10793 10798 (Pubitemid 44078055)
38. E. Ziviani, R.N. Tao, and A.J. Whitworth Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin Proc Natl Acad Sci USA 107 2010 5018 5023
39. K. Venderova, G. Kabbach, E. Abdel-Messih, Y. Zhang, R.J. Parks, and Y. Imai Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease Hum Mol Genet 18 2009 4390 4404
40. D. Narendra, A. Tanaka, D.F. Suen, and R.J. Youle Parkin is recruited selectively to impaired mitochondria and promotes their autophagy J Cell Biol 183 2008 795 803
41. D.P. Narendra, S.M. Jin, A. Tanaka, D.F. Suen, C.A. Gautier, and J. Shen PINK1 is selectively stabilized on impaired mitochondria to activate Parkin PLoS Biol 8 2010 e1000298
42. T.J. van Ham, K.L. Thijssen, R. Breitling, R.M. Hofstra, R.H. Plasterk, and E.A. Nollen C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging PLoS Genet 4 2008 e1000027
43. A.D. Gitler, A. Chesi, M.L. Geddie, K.E. Strathearn, S. Hamamichi, and K.J. Hill Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity Nat Genet 41 2009 308 315
44. T. Ichibangase, H. Saimaru, N. Takamura, T. Kuwahara, A. Koyama, and T. Iwatsubo Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Parkinson's disease stages Biomed Chromatogr 22 2008 232 234 (Pubitemid 351459935)
45. A.A. Cooper, A.D. Gitler, A. Cashikar, C.M. Haynes, K.J. Hill, and B. Bhullar Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models Science 313 2006 324 328 (Pubitemid 44480951)
46. C. Roodveldt, C.W. Bertoncini, A. Andersson, A.T. van der Goot, S.T. Hsu, and R. Fernandez-Montesinos Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip EMBO J 28 2009 3758 3770
47. L. Qiao, S. Hamamichi, K.A. Caldwell, G.A. Caldwell, T.A. Yacoubian, and S. Wilson Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity Mol Brain 1 2008 17
48. C.V. Gabel Femtosecond lasers in biology: nanoscale surgery with ultrafast optics Contemp Phys 49 2008 391 411
49. M.F. Yanik, H. Cinar, H.N. Cinar, A.D. Chisholm, Y. Jin, and A. Ben-Yakar Neurosurgery: functional regeneration after laser axotomy Nature 432 2004 822 (Pubitemid 40037136)
50. Z. Wu, A. Ghosh-Roy, M.F. Yanik, J.Z. Zhang, Y. Jin, and A.D. Chisholm Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching Proc Natl Acad Sci USA 104 2007 15132 15137 (Pubitemid 47619605)
51. A. Ghosh-Roy, Z. Wu, A. Goncharov, Y. Jin, and A.D. Chisholm Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase J Neurosci 30 2010 3175 3183
52. S.H. Chung, D.A. Clark, C.V. Gabel, E. Mazur, and A.D. Samuel The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablation BMC Neurosci 7 2006 30
53. C.V. Gabel, F. Antoine, C.F. Chuang, A.D. Samuel, and C. Chang Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans Development 135 2008 1129 1136 (Pubitemid 351578141)
54. L.C. Case, and M. Tessier-Lavigne Regeneration of the adult central nervous system Curr Biol 15 2005 R749 R753
55. M. Hammarlund, P. Nix, L. Hauth, E.M. Jorgensen, and M. Bastiani Axon regeneration requires a conserved MAP kinase pathway Science 323 2009 802 806
56. D. Yan, Z. Wu, A.D. Chisholm, and Y. Jin The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration Cell 138 2009 1005 1018
57. S.X. Guo, F. Bourgeois, T. Chokshi, N.J. Durr, M.A. Hilliard, and N. Chronis Femtosecond laser nanoaxotomy lab-on-a-chip for in vivo nerve regeneration studies Nat Methods 5 2008 531 533 (Pubitemid 351761760)
58. S.E. Hulme, S.S. Shevkoplyas, J. Apfeld, W. Fontana, and G.M. Whitesides A microfabricated array of clamps for immobilizing and imaging C. elegans Lab Chip 7 2007 1515 1523 (Pubitemid 350013190)
59. F. Zeng, C.B. Rohde, and M.F. Yanik Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation Lab Chip 8 2008 653 656 (Pubitemid 351585474)
60. Q.L. Ruan Evaluation of pesticide toxicities with differing mechanisms using C. elegans J Toxicol Environ Health A 72 2009 746 751
61. P. Pu, and W. Le Dopamine neuron degeneration induced by MPP+ is independent of CED-4 pathway in C. elegans Cell Res 18 2008 978 981
62. S. Cao Torsin-mediated protection from cellular stress in the dopaminergic neurons of C. elegans J Neurosci 25 2005 3801 3812 (Pubitemid 40570413)