Sulfasalazine induced oxidative stress: A possible mechanism of male infertility

Reproductive Toxicology

Volumn 27, Issue 1, 2009, Pages 35-40

  Alonso, Virginia ^a   Linares, Victoria ^a   Bellés, Montserrat ^a   Albina, Maria L ^a   Sirvent, Juan J ^a   Domingo, José L ^a   Sánchez, Domènec J ^a  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

Author keywords

Infertility; Rats; Reactive oxygen species (ROS); Reproductive toxicity; Sulfasalazine (SASP)

Indexed keywords

CATALASE; GLUTATHIONE REDUCTASE; SALAZOSULFAPYRIDINE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADULT ANIMAL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; EPIDIDYMIS; MALE; MALE INFERTILITY; NONHUMAN; OXIDATIVE STRESS; RAT; SPRAGUE DAWLEY RAT; TESTIS;

ADMINISTRATION, ORAL; ANIMALS; CATALASE; EPIDIDYMIS; GASTROINTESTINAL AGENTS; GLUTATHIONE REDUCTASE; INFERTILITY, MALE; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; SULFASALAZINE; SUPEROXIDE DISMUTASE; TESTIS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ANIMALIA; RATTUS;

EID: 58749113228     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2008.10.007     Document Type: Article

References (42)

1. Klinefelter G.R., Strader L.F., Suarez J.D., and Roberts N.L. Bromochloroacetic acid exerts qualitative effects on rat sperm: implications for a novel biomarker. Toxicol Sci 68 (2002) 164-173
2. Pasqualotto F.F., Lucon A.M., Sobreiro B.P., Pasqualotto E.B., and Arap S. Effects of medical therapy, alcohol, smoking, and endocrine disruptors on male infertility. Rev Hosp Clin 59 (2004) 375-382
3. Buchanan J.F., and Davis L.J. Drug-induced infertility. Drug Intel Clin Pharm 18 (1984) 122-132
4. Fukushima T., Kato M., Adachi T., Hamada Y., Horimoto M., Komiyama M., et al. Effects of sulfasalazine on sperm acrosome reaction and gene expression in the male reproductive organs of rats. Toxicol Sci 85 (2005) 675-682
5. Horimoto M., Isobe Y., Isogai Y., and Tachibana M. Rat epididimal sperm motion changes induced by ethylene glycol monoethyl ether, sulfasalazine and 2,5-hexandione. Reprod Toxicol 14 (2000) 55-63
6. Levi A.J., Fisher A.M., Hughes L., and Hendry W.F. Male infertility due to sulphasalazine. Lancet 2 (1979) 276-278
7. Toth A. Male infertility due to sulphasalazine. Lancet 2 (1979) 904
8. Toovey S., Hudson E., Hendry W.F., and Levi A.J. Sulphasalazine and male infertility: reversibility and possible mechanism. Gut 22 (1981) 445-451
9. Fukushima T., Hamada Y., Komiyama M., Matsuno Y., Mori C., and Horii I. Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine. Reprod Toxicol 23 (2007) 153-157
10. Colborn T., vom Saal F.S., and Soto A.M. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 101 (1993) 378-384
11. Chitra K.C., Latchoumycandane C., and Mathur P.P. Induction of oxidative stress by bisphenol A in the epididymal sperm of rats. Toxicology 185 (2003) 119-127
12. Fujii J., Iuchi Y., Matsuki S., and Ishii T. Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues. Asian J Androl 5 (2003) 231-242
13. Garrido N., Meseguer M., Simon C., Pellicer A., and Remohí J. Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility. Asian J Androl 6 (2004) 59-65
14. Hoyt J.A., Fisher L.F., and Swisher D.K. Short-term male reproductive toxicity study with sulfasalazine in the rat. Reprod Toxicol 9 (1995) 315-326
15. Linares M.V., Albina M.L., Bellés M., Mayayo E., Sánchez D.J., and Domingo J.L. Combined action of uranium and stress in the rat. II. Effects on male reproduction. Toxicol Lett 158 (2005) 186-195
16. Llobet J.M., Colomina M.T., Sirvent J.J., Domingo J.L., and Corbella J. Reproductive toxicity evaluation of sodium metavanadate in male mice. Toxicology 80 (1993) 199-206
17. Gurr E. Synthetic dyes in biology, medicine and chemistry (1971), Academic Press, London/New York
18. Wyrobeck A.J., and Bruce W.R. Chemical induction of sperm abnormalities in mice. Proc Natl Acad Sci USA 72 (1975) 4425-4429
19. Usselman M.C., Carr D.W., and Acott T.S. Rat and bull sperm immobilization in the caudal epididymis: a comparison of mechanisms. Ann NY Acad Sci 438 (1984) 530-532
20. Meistrich M.L., Wilson G., Porter K.L., Huhtaniemi I., Shetty G., and Shuttlesworth G.A. Restoration of spermatogenesis in dibromochloropropane (DBCP)-treated rats by hormone suppression. Toxicol Sci 76 (2003) 418-426
21. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
22. Linares M.V., Bellés M., Albina M.L., Sirvent J.J., Sánchez D.J., and Domingo J.L. Assessment of the pro-oxidant activity of uranium in kidney and testis of rats. Toxicol Lett 167 (2006) 152-161
23. Hissin P.J., and Hilf R. A fluorimetric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74 (1976) 214-226
24. Wheeler C.R., Salzman J.A., Elsayed N.M., Omaye S.T., and Korte Jr. D.W. Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Anal Biochem 184 (1990) 193-199
25. Habig W.H., Pabst M.J., and Jacoby W.B. Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249 (1975) 7130-7139
26. Wu F.C., Aitken R.J., and Ferguson A. Inflammatory bowel disease and male infertility: effects of sulfasalazine and 5-aminosalicylic acid on sperm-fertilizing capacity and reactive oxygen species generation. Fertil Steril 52 (1989) 842-845
27. Di Paolo M.C., Paoluzi O.A., Pica R., Lacopini F., Crispido P., Rivera M., et al. Sulphasalazine and 5-aminosalicylic acid in long-term treatment of ulcerative colitis: report on tolerante and side-effects. Digest Liver Dis 33 (2001) 563-569
28. Okada F., Niwa N., Hosokawa S., Kawaguchi T., Okuda Y., and Matsubara Y. Effects of repeated doses of compound E for 4 and 9 weeks on the male reproductive organs. Toxicol Sci 20 (1995) 217-227
29. Aitken R.J. Sperm function tests and fertility. Int J Androl 29 (2006) 69-75
30. Rodríguez C., Mayo J.C., Sainz R.M., Antolin I., Herrera F., Martin V., et al. Regulation of antioxidant enzymes, a significant role for melatonin, a minireview. J Pineal Res 36 (2004) 1-9
31. Nicotera T.M., Notaro J., and Notaro S. Elevated superoxide dismutase in Bloom's syndrome, a genetic condition of oxidative stress. Cancer Res 49 (1989) 5239-5243
32. Gandy J., Millner G.C., Bates H.K., Casciano D.A., and Harbison R.D. Effects of selected chemicals on the glutathione status in the male reproductive system of rats. J Toxicol Environ Health 29 (1990) 45-57
33. Luberda Z. The role of glutathione in mammalian gametes. Reprod Biol 5 (2005) 5-17
34. Knapen M.F., Zusterzeel P.L., Peters W.H., and Steegers E.A. Glutathione and glutathione-related enzymes in reproduction. A review. Eur J Obstet Gyn R Biol 82 (1999) 171-184
35. Kaneko T., Luchi Y., Kobayashi T., Fujii T., Saito H., Kurachi H., et al. The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis. Eur J Biochem 269 (2002) 1570-1578
36. Romeu M., Mulero M., Giralt M., Folch J., Nogués M.R., Torres A., et al. Parameters related to oxygen free radicals in erythrocytes, plasma and epidermis of the hairless rat. Life Sci 71 (2002) 1739-1749
37. Oh S.I., Lee M.S., Kim C.I., Song K.Y., and Park S.C. Aspartate modulates the ethanol-induced oxidative stress and glutathione utilizing enzymes in rat testes. Exp Mol Med 34 (2002) 47-52
38. Linares M.V., Sánchez D.J., Bellés M., Albina M.L., Gomez M., and Domingo J.L. Pro-oxidant effects in the brain of rats concurrently exposed to uranium and stress. Toxicology 236 (2007) 82-91
39. De Lamirande E., and Gagnon C. Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum Reprod 10 (1995) 15-21
40. Pasqualotto F.F., Sharma R.K., Nelson D.R., Thomas Jr. A.J., and Agarwal A. Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation. Fertil Steril 73 (2000) 459-464
41. Kobayashi T., Miyazaki T., Natori M., and Nozawa S. Protective role of superoxide dismutase in human sperm motility: superoxide dismutase activity and lipid peroxide in human seminal plasma and spermatozoa. Hum Reprod 6 (1991) 987-991
42. 1 mice 1997;457:15-21.