Prenatal stress: Role in psychotic and depressive diseases

Psychopharmacology

Volumn 214, Issue 1, 2011, Pages 89-106

  Markham, Julie A ^a   Koenig, James I ^a  

^a MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

Anxiety; Brain; Depression; Prenatal immune activation; Prenatal protein malnutrition; Prenatal stress; Prenatal viral infection; Psychosis; Schizophrenia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; POLYINOSINIC POLYCYTIDYLIC ACID; TUMOR NECROSIS FACTOR ALPHA; VITAMIN D;

ANXIETY; BRAIN DEVELOPMENT; COGNITIVE DEFECT; CYTOKINE PRODUCTION; DEPRESSION; ENVIRONMENTAL STRESS; GESTATIONAL AGE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; LEARNED HELPLESSNESS; MALNUTRITION; MATERNAL STRESS; MENTAL STRESS; NEUROANATOMY; NONHUMAN; PARAINFLUENZA VIRUS INFECTION; PHENOTYPE; PRENATAL EXPOSURE; PRENATAL STRESS; PRIORITY JOURNAL; PSYCHOSIS; REVIEW; SCHIZOPHRENIA; VIRUS ACTIVATION; WEIGHT REDUCTION;

ADRENAL CORTEX HORMONES; ANIMALS; BRAIN; CYTOKINES; DEPRESSIVE DISORDER; FEMALE; HUMANS; NEURONS; PREGNANCY; PREGNANCY COMPLICATIONS; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; STRESS, PSYCHOLOGICAL;

EID: 79952283091     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-2035-0     Document Type: Review

References (195)

1. A Abi-Dargham J Rodenhiser D Printz Y Zea-Ponce R Gil LS Kegeles R Weiss TB Cooper JJ Mann RL Van Heertum JM Gorman M Laruelle 2000 Increased baseline occupancy of D2 receptors by dopamine in schizophrenia Proc Natl Acad Sci USA 97 8104 8109 10884434 1:CAS:528:DC%2BD3cXkvFCms7Y%3D (Pubitemid 30460780)
2. A Abi-Dargham E van de Giessen M Slifstein LS Kegeles M Laruelle 2009 Baseline and amphetamine-stimulated dopamine activity are related in drug-naive schizophrenic subjects Biol Psychiatry 65 1091 1093 19167701 1:CAS:528:DC%2BD1MXms1Oqtbg%3D
3. S Akbarian JJ Kim SG Potkin JO Hagman A Tafazzoli WE Bunney Jr EG Jones 1995 Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics Arch Gen Psychiatry 52 258 266 7702443 1:STN:280:DyaK2M3hslSiug%3D%3D
4. SS Almeida J Tonkiss JR Galler 1996 Prenatal protein malnutrition affects exploratory behavior of female rats in the elevated plus-maze test Physiol Behav 60 675 680 8840934 1:CAS:528:DyaK28XkvFShtrs%3D (Pubitemid 26274314)
5. SS Almeida J Tonkiss JR Galler 1996 Prenatal protein malnutrition affects the social interactions of juvenile rats Physiol Behav 60 197 201 8804664 1:CAS:528:DyaK28Xkt1OltL0%3D (Pubitemid 126335874)
6. SJ Alonso R Arevalo D Afonso M Rodriquez 1991 Effects of maternal stress during pregnancy on forced swimming test behavior of the offspring Physiol Behav 50 511 517 1801003 1:STN:280:DyaK387ps1WrtQ%3D%3D
7. SJ Alonso E Navarro M Rodriquez 1994 Permanent dopaminergic alterations in the n. accumbens after prenatal stress Pharmacol Biochem Behav 49 353 358 7824549 1:CAS:528:DyaK2cXmtVagtLY%3D (Pubitemid 24306698)
8. H Ashdown Y Dumont M Ng S Poole P Boksa GN Luheshi 2006 The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia Mol Psychiatry 11 47 55 16189509 1:CAS:528:DC%2BD2MXhtlSksrbO (Pubitemid 43251087)
9. M Baharnoori WG Brake LK Srivastava 2009 Prenatal immune challenge induces developmental changes in the morphology of pyramidal neurons of the prefrontal cortex and hippocampus in rats Schizophr Res 107 99 109 19004618
10. A Becker DW Eyles JJ McGrath G Grecksch 2005 Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats Behav Brain Res 161 306 312 15922058 1:CAS:528:DC%2BD2MXks1ClsL0%3D (Pubitemid 40732414)
11. M Beneyto JH Meador-Woodruff 2008 Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder Neuropsychopharmacology 33 2175 2178 18033238 1:CAS:528:DC%2BD1cXosVOht70%3D
12. BK Bitanihirwe L Weber J Feldon U Meyer 2010 Cognitive impairment following prenatal immune challenge in mice correlates with prefrontal cortical AKT1 deficiency Int J Neuropsychopharmacol 13 981 996 20219156 1:CAS:528:DC%2BC3cXhtVCksLnL
13. Y Bogoch YN Biala M Linial M Weinstock 2007 Anxiety induced by prenatal stress is associated with suppression of hippocampal genes involved in synaptic function J Neurochem 101 1018 1030 17254015 1:CAS:528:DC%2BD2sXmtFGrsr4%3D (Pubitemid 46683862)
14. J Borrell JM Vela A Arevalo-Martin E Molina-Holgado C Guaza 2002 Prenatal immune challenge disrupts sensorimotor gating in adult rats. Implications for the etiopathogenesis of schizophrenia Neuropsychopharmacology 26 204 215 11790516 1:CAS:528:DC%2BD38XktFWrtw%3D%3D (Pubitemid 34093083)
15. OJ Bosch SA Kromer ID Neumann 2006 Prenatal stress: opposite effects on anxiety and hypothalamic expression of vasopressin and corticotropin-releasing hormone in rats selectively bred for high and low anxiety Eur J Neurosci 23 541 551 16420461
16. RE Bowman NJ MacLusky Y Sarmiento M Frankfurt M Gordon VN Luine 2004 Sexually dimorphic effects of prenatal stress on cognition, hormonal responses, and central neurotransmitters Endocrinology 145 3778 3787 15142991 1:CAS:528:DC%2BD2cXmtlCqsLw%3D (Pubitemid 39037565)
17. M Bresnahan CA Schaefer AS Brown ES Susser 2005 Prenatal determinants of schizophrenia: what we have learned thus far? Epidemiol Psichiatr Soc 14 194 197 16396427 (Pubitemid 43036231)
18. K Broadbelt W Byne LB Jones 2002 Evidence for a decrease in basilar dendrites of pyramidal cells in schizophrenic medial prefrontal cortex Schizophr Res 58 75 81 12363393 (Pubitemid 35287286)
19. Bronson SL, Ahlbrand R, Horn PS, Kern JR, Roenker NL, Richtand NM (2009) Environmental influence on maternal response in a prenatal immune activation model of schizophrenia. Biol Psychiatry: 45S
20. AS Brown 2002 Prenatal risk factors and schizophrenia Expert Rev Neurother 2 53 60 19811015 (Pubitemid 34625470)
21. AS Brown ES Susser 2002 In utero infection and adult schizophrenia Ment Retard Dev Disabil Res Rev 8 51 57 11921387 (Pubitemid 34754494)
22. AS Brown ES Susser 2008 Prenatal nutritional deficiency and risk of adult schizophrenia Schizophr Bull 34 1054 1063 18682377
23. AS Brown ES Susser SP Lin R Neugebauer JM Gorman 1995 Increased risk of affective disorders in males after second trimester prenatal exposure to the Dutch hunger winter of 1944-45 Br J Psychiatry 166 601 606 7620744 1:STN:280:DyaK2Mzks1WntA%3D%3D
24. AS Brown J van Os C Driessens HW Hoek ES Susser 2000 Further evidence of relation between prenatal famine and major affective disorder Am J Psychiatry 157 190 195 10671386 1:STN:280:DC%2BD3c7jslKruw%3D%3D (Pubitemid 30080897)
25. AS Brown J Hooton CA Schaefer H Zhang E Petkova V Babulas M Perrin JM Gorman ES Susser 2004 Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring Am J Psychiatry 161 889 895 15121655 (Pubitemid 38625343)
26. PJ Brunton JA Russell 2010 Prenatal social stress in the rat programmes neuroendocrine and behavioural responses to stress in the adult offspring: sex-specific effects J Neuroendocrinol 22 258 271 20136688 1:CAS:528: DC%2BC3cXktFOnsLY%3D
27. TH Burne A Becker J Brown DW Eyles A Mackay-Sim JJ McGrath 2004 Transient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats Behav Brain Res 154 549 555 15313044 1:CAS:528:DC%2BD2cXmslenu7c%3D (Pubitemid 39094006)
28. C Burton V Lovic AS Fleming 2006 Early adversity alters attention and locomotion in adult Sprague-Dawley rats Behav Neurosci 120 665 675 16768618 (Pubitemid 44050546)
29. Carboni E, Barros VG, Ibba M, Silvagni A, Mura C, Antonelli MC (2010) Prenatal restraint stress: an in vivo microdialysis study on catecholamine release in the rat prefrontal cortex. Neuroscience 168:156-166
30. LM Christian A Franco R Glaser JD Iams 2009 Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant women Brain Behav Immun 23 750 754 19258033 1:CAS:528:DC%2BD1MXosVGhtLo%3D
31. S Chung GH Son SH Park E Park KH Lee D Geum K Kim 2005 Differential adaptive responses to chronic stress of maternally stressed male mice offspring Endocrinology 146 3202 3210 15802499 1:CAS:528:DC%2BD2MXlslGht70%3D (Pubitemid 41002829)
32. S Clinton S Miller SJ Watson H Akil 2008 Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivity Psychoneuroendocrinology 33 162 177 18077099 1:CAS:528:DC%2BD1cXhtV2mtL8%3D
33. MS Cratty HE Ward EA Johnson AJ Azzaro DL Birkle 1995 Prenatal stress increases corticotropin-releasing factor content and release in rat amygdala minces Brain Res 675 297 302 7796142 1:CAS:528:DyaK2MXksVyksrY%3D
34. K Cui H Ashdown GN Luheshi P Boksa 2009 Effects of prenatal immune activation on hippocampal neurogenesis in the rat Schizophr Res 113 288 297 19464151
35. J Dahlgren AM Samuelsson T Jansson A Holmang 2006 Interleukin-6 in the maternal circulation reaches the rat fetus in mid-gestation Pediatr Res 60 147 151 16864694 1:CAS:528:DC%2BD28XntFaksb8%3D (Pubitemid 44297583)
36. P Dalitz R Harding SM Rees ML Cock 2003 Prolonged reductions in placental blood flow and cerebral oxygen delivery in preterm fetal sheep exposed to endotoxin: possible factors in white matter injury after acute infection J Soc Gynecol Investig 10 283 290 12853089 1:CAS:528:DC%2BD3sXlt1WmsLo%3D (Pubitemid 36802329)
37. AJ Dwork B Mancevski G Rosoklija 2007 White matter and cognitive function in schizophrenia Int J Neuropsychopharmacol 10 513 536 17313699 1:CAS:528:DC%2BD2sXnt1Kgt7k%3D (Pubitemid 46985263)
38. S Entringer R Kumsta EL Nelson DH Hellhammer PD Wadhwa S Wust 2008 Influence of prenatal psychosocial stress on cytokine production in adult women Dev Psychobiol 50 579 587 18683180 1:CAS:528:DC%2BD1cXhtFGgsLrN
39. C Estanislau S Morato 2005 Prenatal stress produces more behavioral alterations than maternal separation in the elevated plus-maze and in the elevated T-maze Behav Brain Res 163 70 77 15941599
40. European Network of Schizophrenia Networks for the Study of Gene-Environment Interactions 2008 Schizophrenia aetiology: do gene-environment interactions hold the key? Schizophr Res 102 21 26
41. DW Eyles F Rogers K Buller JJ McGrath P Ko K French TH Burne 2006 Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA function Psychoneuroendocrinology 31 958 964 16890375 1:CAS:528:DC%2BD28XotV2ls7w%3D (Pubitemid 44148913)
42. P Falkai WG Honer S David B Bogerts C Majtenyi TA Bayer 1999 No evidence for astrogliosis in brains of schizophrenic patients. A post-mortem study Neuropathol Appl Neurobiol 25 48 53 10194775 1:STN:280:DyaK1M3htVKkuw%3D%3D (Pubitemid 29121694)
43. SH Fatemi R Sidwell P Akhter J Sedgewick P Thuras K Bailey D Kist 1998 Human influenza viral infection in utero increases nNOS expression in hippocampi of neonatal mice Synapse 29 84 88 9552178 1:CAS:528:DyaK1cXit1Gmurk%3D (Pubitemid 28155708)
44. SH Fatemi ES Emamian D Kist RW Sidwell K Nakajima P Akhter A Shier S Sheikh K Bailey 1999 Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice Mol Psychiatry 4 145 154 10208446 1:CAS:528:DC%2BD3cXlvVWltrs%3D (Pubitemid 29163977)
45. SH Fatemi AE Cuadra EE El-Fakahany RW Sidwell P Thuras 2000 Prenatal viral infection causes alterations in nNOS expression in developing mouse brains NeuroReport 11 1493 1496 10841364 1:CAS:528:DC%2BD3cXktFCqsrw%3D (Pubitemid 30365493)
46. SH Fatemi J Earle R Kanodia D Kist ES Emamian PH Patterson L Shi R Sidwell 2002 Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia Cell Mol Neurobiol 22 25 33 12064515 (Pubitemid 34579406)
47. SH Fatemi ES Emamian RW Sidwell DA Kist JM Stary JA Earle P Thuras 2002 Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice Mol Psychiatry 7 633 640 12140787 1:CAS:528:DC%2BD38XlsFWrtro%3D
48. SH Fatemi M Araghi-Niknam JA Laurence JM Stary RW Sidwell S Lee 2004 Glial fibrillary acidic protein and glutamic acid decarboxylase 65 and 67 kDa proteins are increased in brains of neonatal BALB/c mice following viral infection in utero Schizophr Res 69 121 123 15145478 (Pubitemid 38625766)
49. SH Fatemi DA Pearce AI Brooks RW Sidwell 2005 Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: a potential animal model for schizophrenia and autism Synapse 57 91 99 15906383 1:CAS:528:DC%2BD2MXls1Gqsbg%3D (Pubitemid 40911524)
50. SH Fatemi TD Folsom TJ Reutiman RW Sidwell 2008 Viral regulation of aquaporin 4, connexin 43, microcephalin and nucleolin Schizophr Res 98 163 177 17997079 (Pubitemid 350245593)
51. SH Fatemi TJ Reutiman TD Folsom H Huang K Oishi S Mori DF Smee DA Pearce C Winter R Sohr G Juckel 2008 Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders Schizophr Res 99 56 70 18248790
52. SH Fatemi TD Folsom TJ Reutiman D Abu-Odeh S Mori H Huang K Oishi 2009 Abnormal expression of myelination genes and alterations in white matter fractional anisotropy following prenatal viral influenza infection at E16 in mice Schizophr Res 112 46 53 19487109
53. C Feleder KY Tseng GG Calhoon P O'Donnell 2010 Neonatal intrahippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats Biol Psychiatry 67 386 392 19914600 1:CAS:528:DC%2BC3cXhtl2hsbs%3D
54. Field T, Diego M (2008) Cortisol: the culprit prenatal stress variable. Int J Neurosci 1:1181-1205
55. RD Fields 2008 White matter in learning, cognition and psychiatric disorders Trends Neurosci 31 361 370 18538868 1:CAS:528:DC%2BD1cXnvVGlsL0%3D
56. JP Forder M Tymianski 2009 Postsynaptic mechanisms of excitotoxicity: Involvement of postsynaptic density proteins, radicals, and oxidant molecules Neuroscience 158 293 300 19041375 1:CAS:528:DC%2BD1MXns1ygtQ%3D%3D
57. ME Fortier R Joober GN Luheshi P Boksa 2004 Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring J Psychiatr Res 38 335 345 15003440 (Pubitemid 38299172)
58. ME Fortier GN Luheshi P Boksa 2007 Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancy Behav Brain Res 181 270 277 17553574 (Pubitemid 46898665)
59. E Fride M Weinstock 1988 Prenatal stress increases anxiety related behavior and alters cerebral lateralization of dopamine activity Life Sci 42 1059 1065 3347138 1:CAS:528:DyaL1cXht1GjsLg%3D (Pubitemid 18056843)
60. A Fujioka T Fujioka Y Ishida T Maekawa S Nakamura 2006 Differential effects of prenatal stress on the morphological maturation of hippocampal neurons Neuroscience 141 907 915 16797130 1:CAS:528:DC%2BD28XntFShtro%3D (Pubitemid 44066657)
61. F Fumagalli M Pasini A Frasca F Drago G Racagni MA Riva 2009 Prenatal stress alters glutamatergic system responsiveness in adult rat prefrontal cortex J Neurochem 109 1733 1744 19383086 1:CAS:528:DC%2BD1MXnvVeku7s%3D
62. DA Gayle R Beloosesky M Desai F Amidi SE Nunez MG Ross 2004 Maternal LPS induces cytokines in the amniotic fluid and corticotropin releasing hormone in the fetal rat brain Am J Physiol Regul Integr Comp Physiol 286 R1024 R1029 14988088 1:CAS:528:DC%2BD2cXkvFCqsr4%3D
63. JH Gilmore L Fredrik Jarskog S Vadlamudi JM Lauder 2004 Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNFalpha inhibit cortical neuron dendrite development Neuropsychopharmacology 29 1221 1229 15085088 1:CAS:528:DC%2BD2cXkvFWltL4%3D (Pubitemid 38780645)
64. LA Glantz DA Lewis 2000 Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia Arch Gen Psychiatry 57 65 73 10632234 1:STN:280:DC%2BD3c%2Fps1Sqtw%3D%3D (Pubitemid 30035660)
65. MJ Glenn EM Gibson ED Kirby TJ Mellott JK Blusztajn CL Williams 2007 Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats Eur J Neurosci 25 2473 2482 17445242 (Pubitemid 46625934)
66. MJ Glenn ED Kirby EM Gibson SJ Wong-Goodrich TJ Mellott JK Blusztajn CL Williams 2008 Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats Brain Res 1237 110 123 18786518 1:CAS:528:DC%2BD1cXht1SisLrF
67. JM Gold JA Waltz KJ Prentice SE Morris EA Heerey 2008 Reward processing in schizophrenia: a deficit in the representation of value Schizophr Bull 34 835 847 18591195
68. AA Gotz V Stefanski 2007 Psychosocial maternal stress during pregnancy affects serum corticosterone, blood immune parameters and anxiety behaviour in adult male rat offspring Physiol Behav 90 108 115 17067641 (Pubitemid 44918012)
69. MF Green PD Butler Y Chen MA Geyer S Silverstein JK Wynn JH Yoon V Zemon 2009 Perception measurement in clinical trials of schizophrenia: promising paradigms from CNTRICS Schizophr Bull 35 163 181 19023123
70. M Gue A Bravard J Meunier R Veyrier S Gaillet M Recasens T Maurice 2004 Sex differences in learning deficits induced by prenatal stress in juvenile rats Behav Brain Res 150 149 157 15033288 (Pubitemid 38368966)
71. A Guidotti J Auta JM Davis V Di-Giorgi-Gerevini Y Dwivedi DR Grayson F Impagnatiello G Pandey C Pesold R Sharma D Uzunov E Costa 2000 Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study Arch Gen Psychiatry 57 1061 1069 11074872 1:CAS:528:DC%2BD3cXot1WnsL0%3D
72. LR Harms DW Eyles JJ McGrath A Mackay-Sim TH Burne 2008 Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6 J mice Behav Brain Res 187 343 350 17996959 1:CAS:528:DC%2BD1cXotlyjtQ%3D%3D
73. T Hashimoto HH Bazmi K Mirnics Q Wu AR Sampson DA Lewis 2008 Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia Am J Psychiatry 165 479 489 18281411 (Pubitemid 351694291)
74. G Hava L Vered M Yael H Mordechai H Mahoud 2006 Alterations in behavior in adult offspring mice following maternal inflammation during pregnancy Dev Psychobiol 48 162 168 16489598
75. C Henry G Guegant M Cador E Arnauld J Arsaut M LeMoal J Demotes-Mainard 1995 Prenatal stress in rats facilitates amphetamine-induced sensitization and induces long-lasting changes in dopamine receptors in the nucleus accumbens Brain Res Dev Brain Res 685 179 186 1:CAS:528:DyaK2MXntFCksro%3D
76. N Hopwood T Maswanganyi LM Harden 2009 Comparison of anorexia, lethargy, and fever induced by bacterial and viral mimetics in rats Can J Physiol Pharmacol 87 211 220 19295662 1:CAS:528:DC%2BD1MXjsVGjsr4%3D
77. KS Hougaard MB Andersen SL Kjaer AM Hansen T Werge SP Lund 2005 Prenatal stress may increase vulnerability to life events: comparison with the effects of prenatal dexamethasone Brain Res Dev Brain Res 159 55 63 16085319 1:CAS:528:DC%2BD2MXpslCgtbo%3D (Pubitemid 41557713)
78. H Jaaro-Peled A Hayashi-Takagi S Seshadri A Kamiya NJ Brandon A Sawa 2009 Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1 Trends Neurosci 32 485 495 19712980 1:CAS:528:DC%2BD1MXhtFWqu73J
79. LF Jarskog H Xiao MB Wilkie JM Lauder JH Gilmore 1997 Cytokine regulation of embryonic rat dopamine and serotonin neuronal survival in vitro Int J Dev Neurosci 15 711 716 9402221 1:CAS:528:DyaK2sXnvFaitr0%3D (Pubitemid 27478191)
80. DC Javitt 2007 Glutamate and schizophrenia: phencyclidine, N-methyl-d-aspartate receptors, and dopamine-glutamate interactions Int Rev Neurobiol 78 69 108 17349858 1:CAS:528:DC%2BD2sXmt1Gmt74%3D
81. N Jia K Yang Q Sun Q Cai H Li D Cheng X Fan Z Zhu 2010 Prenatal stress causes dendritic atrophy of pyramidal neurons in hippocampal CA3 region by glutamate in offspring rats Dev Neurobiol 70 114 125 19950194 1:CAS:528:DC%2BC3cXhslWitr8%3D
82. JP Jones WH Meck CL Williams WA Wilson HS Swartzwelder 1999 Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation Brain Res Dev Brain Res 118 159 167 10611515 1:CAS:528: DyaK1MXotVOjs74%3D (Pubitemid 30009649)
83. Karege F, Perroud N, Schurhoff F, Meary A, Marillier G, Burkhardt S, Ballmann E, Fernandez R, Jamain S, Leboyer M, La Harpe R, Malafosse A (2010) Association of Akt1 gene variants and protein expression in both schizophrenia and bipolar disorder. Genes Brain Behav 9:503-511
84. MR Katunar T Saez A Brusco MC Antonelli 2010 Ontogenetic expression of dopamine-related transcription factors and tyrosine hydroxylase in prenatally stressed rats Neurotox Res 18 69 81 19936865
85. JP Kesby TH Burne JJ McGrath DW Eyles 2006 Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: An animal model of schizophrenia Biol Psychiatry 60 591 596 16697353 1:CAS:528: DC%2BD28XpvFelsb0%3D (Pubitemid 44402370)
86. AK Kinnunen JI Koenig G Bilbe 2003 Repeated variable prenatal stress alters pre- and postsynaptic gene expression in the rat frontal pole J Neurochem 86 736 748 12859686 1:CAS:528:DC%2BD3sXlvF2nurc%3D (Pubitemid 36897453)
87. JI Koenig 2006 Schizophrenia: a unique translational opportunity in behavioral neuroendocrinology Horm Behav 50 602 611 16870188 1:CAS:528:DC%2BD28XptFCns78%3D (Pubitemid 44314174)
88. JI Koenig GI Elmer PD Shepard PR Lee C Mayo B Joy E Hercher DL Brady 2005 Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia Behav Brain Res 156 251 261 15582111 (Pubitemid 39576065)
89. M Koenigs J Grafman 2009 The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex Behav Brain Res 201 239 243 19428640
90. SC Langley-Evans DS Gardner AA Jackson 1996 Maternal protein restriction influences the programming of the rat hypothalamic-pituitary-adrenal axis J Nutr 126 1578 1585 8648431 1:CAS:528:DyaK28XjtlKktr8%3D (Pubitemid 26182392)
91. M Laruelle A Abi-Dargham R Gil L Kegeles R Innis 1999 Increased dopamine transmission in schizophrenia: relationship to illness phases Biol Psych 46 56 72 1:CAS:528:DyaK1MXksVaqur4%3D (Pubitemid 29296818)
92. PR Lee D Brady RA Shapiro DM Dorsa JI Koenig 2005 Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocin Neuropsychopharmacology 30 1883 1894 15798779 1:CAS:528:DC%2BD2MXhtVSls7jE (published online 2/16/05) (Pubitemid 41486413)
93. PR Lee DL Brady RA Shapiro DM Dorsa JI Koenig 2007 Prenatal stress generates deficits in rat social behavior: reversal by oxytocin Brain Res 1156 152 167 17540347 1:CAS:528:DC%2BD2sXmvVOhsr0%3D (Pubitemid 46920515)
94. J Lehmann CR Pryce J Feldon 2000 Lack of effect of an early stressful life event on sensorimotor gating in adult rats Schizophr Res 41 365 371 10708346 1:STN:280:DC%2BD3c7ntVKnsg%3D%3D (Pubitemid 30077479)
95. V Lemaire M Koehl M Le Moal DN Abrous 2000 Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus Proc Natl Acad Sci USA 97 11032 11037 11005874 1:CAS:528: DC%2BD3cXnt1ahtr0%3D
96. J Lesage B Blondeau M Grino B Breant JP Dupouy 2001 Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat Endocrinology 142 1692 1702 11316731 1:CAS:528:DC%2BD3MXjt1aktrs%3D (Pubitemid 32405922)
97. EA Levay AG Paolini A Govic A Hazi J Penman S Kent 2008 Anxiety-like behaviour in adult rats perinatally exposed to maternal calorie restriction Behav Brain Res 191 164 172 18453007
98. DA Lewis P Levitt 2002 Schizophrenia as a disorder of neurodevelopment Annu Rev Neurosci 25 409 432 12052915 1:CAS:528:DC%2BD38XmtF2hsbw%3D (Pubitemid 34748023)
99. DA Lewis RA Sweet 2009 Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies J Clin Invest 119 706 716 19339762 1:CAS:528:DC%2BD1MXktlSnsbw%3D
100. Q Li C Cheung R Wei ES Hui J Feldon U Meyer S Chung SE Chua PC Sham EX Wu GM McAlonan 2009 Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model PLoS ONE 4 e6354 19629183
101. CS Liverman HA Kaftan L Cui SG Hersperger E Taboada RM Klein NE Berman 2006 Altered expression of pro-inflammatory and developmental genes in the fetal brain in a mouse model of maternal infection Neurosci Lett 399 220 225 16497437 1:CAS:528:DC%2BD28XktVensLo%3D
102. GC Lowe GN Luheshi S Williams 2008 Maternal infection and fever during late gestation are associated with altered synaptic transmission in the hippocampus of juvenile offspring rats Am J Physiol Regul Integr Comp Physiol 295 R1563 R1571 18753265 1:CAS:528:DC%2BD1cXhsVWktbnF
103. M Makinodan K Tatsumi T Manabe T Yamauchi E Makinodan H Matsuyoshi S Shimoda Y Noriyama T Kishimoto A Wanaka 2008 Maternal immune activation in mice delays myelination and axonal development in the hippocampus of the offspring J Neurosci Res 86 2190 2200 18438922 1:CAS:528:DC%2BD1cXptlalsLY%3D
104. CD Mandyam EF Crawford AJ Eisch CL Rivier HN Richardson 2008 Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus Dev Neurobiol 68 575 589 18264994 (Pubitemid 351466289)
105. Markham JA, Taylor AR, Taylor SB, Brady-Bell D, Koenig JI (2010) Characterization of the cognitive impairments induced by prenatal exposure to stress in the rat. In Review
106. E Mattes S McCarthy G Gong JA van Eekelen J Dunstan J Foster SL Prescott 2009 Maternal mood scores in mid-pregnancy are related to aspects of neonatal immune function Brain Behav Immun 23 380 388 19150495 1:CAS:528: DC%2BD1MXisFSqu78%3D
107. JC McCann M Hudes BN Ames 2006 An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring Neurosci Biobehav Rev 30 696 712 16504295 1:CAS:528:DC%2BD28XksVOgs7k%3D (Pubitemid 44294477)
108. J Meunier M Gue M Recasens T Maurice 2004 Attenuation by a sigma1 (sigma1) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats Br J Pharmacol 142 689 700 15205309 1:CAS:528:DC%2BD2cXltlejurk%3D (Pubitemid 38969664)
109. U Meyer J Feldon 2009 Neural basis of psychosis-related behaviour in the infection model of schizophrenia Behav Brain Res 204 322 334 19154759 1:CAS:528:DC%2BD1MXhtVKns7nM
110. U Meyer J Feldon M Schedlowski BK Yee 2005 Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia Neurosci Biobehav Rev 29 913 947 15964075 1:CAS:528:DC%2BD2MXntVGhtro%3D (Pubitemid 41097394)
111. U Meyer J Feldon M Schedlowski BK Yee 2006 Immunological stress at the maternal-foetal interface: a link between neurodevelopment and adult psychopathology Brain Behav Immun 20 378 388 16378711 1:CAS:528: DC%2BD28XltFOks7o%3D (Pubitemid 43775782)
112. U Meyer M Nyffeler A Engler A Urwyler M Schedlowski I Knuesel BK Yee J Feldon 2006 The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology J Neurosci 26 4752 4762 16672647 1:CAS:528:DC%2BD28XkvFSgt7g%3D (Pubitemid 44315314)
113. U Meyer S Schwendener J Feldon BK Yee 2006 Prenatal and postnatal maternal contributions in the infection model of schizophrenia Exp Brain Res 173 243 257 16552558 (Pubitemid 44264888)
114. U Meyer A Engler L Weber M Schedlowski J Feldon 2008 Preliminary evidence for a modulation of fetal dopaminergic development by maternal immune activation during pregnancy Neuroscience 154 701 709 18495356 1:CAS:528:DC%2BD1cXnt1emsL4%3D
115. U Meyer PJ Murray A Urwyler BK Yee M Schedlowski J Feldon 2008 Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling Mol Psychiatry 13 208 221 17579604 1:CAS:528:DC%2BD1cXnt1Gmsg%3D%3D
116. U Meyer M Nyffeler S Schwendener I Knuesel BK Yee J Feldon 2008 Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge Neuropsychopharmacology 33 441 456 17443130 (Pubitemid 350243354)
117. U Meyer M Nyffeler BK Yee I Knuesel J Feldon 2008 Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice Brain Behav Immun 22 469 486 18023140 1:CAS:528:DC%2BD1cXktlGjtrw%3D (Pubitemid 351451821)
118. Meyer U, Spoerri E, Yee BK, Schwarz MJ, Feldon J (2008e) Evaluating early preventive antipsychotic and antidepressant drug treatment in an infection-based neurodevelopmental mouse model of schizophrenia. Schizophr Bull 34:1083-1094
119. U Meyer J Feldon BK Yee 2009 A review of the fetal brain cytokine imbalance hypothesis of schizophrenia Schizophr Bull 35 959 972 18408229
120. U Meyer I Knuesel M Nyffeler J Feldon 2010 Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis Psychopharmacol Berl 208 531 543 1:CAS:528:DC%2BC3cXisVWntA%3D%3D
121. KA Michelsen DL van den Hove C Schmitz O Segers J Prickaerts HW Steinbusch 2007 Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex BMC Neurosci 8 107 18093285
122. DJ Mokler OI Torres JR Galler PJ Morgane 2007 Stress-induced changes in extracellular dopamine and serotonin in the medial prefrontal cortex and dorsal hippocampus of prenatally malnourished rats Brain Res 1148 226 233 17368432 1:CAS:528:DC%2BD2sXksVOqsLo%3D (Pubitemid 46602176)
123. SS Moy JJ Nadler A Perez RP Barbaro JM Johns TR Magnuson J Piven JN Crawley 2004 Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice Genes Brain Behav 3 287 302 15344922 1:STN:280:DC%2BD2cvjvFektQ%3D%3D (Pubitemid 39277416)
124. Mueller BR, Bale TL (2007) Early prenatal stress impact on coping strategies and learning performance is sex dependent. Physiol Behav 91:51-65
125. BR Mueller TL Bale 2008 Sex-specific programming of offspring emotionality after stress early in pregnancy J Neurosci 28 9055 9065 18768700 1:CAS:528:DC%2BD1cXhtFSmsr%2FM
126. N Muller M Riedel R Gruber M Ackenheil MJ Schwarz 2000 The immune system and schizophrenia. An integrative view Ann NY Acad Sci 917 456 467 11268373 1:CAS:528:DC%2BD3cXovFymsb0%3D
127. MS Murmu S Salomon Y Biala M Weinstock K Braun J Bock 2006 Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy Eur J Neurosci 24 1477 1487 16965544 (Pubitemid 44401670)
128. Neeley EW, Berger R, Koenig JI, Leonard S (2010) Prenatal stress differentially alters BDNF expression and signaling across rat strains. Submitted
129. H Nunez S Ruiz R Soto-Moyano M Navarrete L Valladares A White H Perez 2008 Fetal undernutrition induces overexpression of CRH mRNA and CRH protein in hypothalamus and increases CRH and corticosterone in plasma during postnatal life in the rat Neurosci Lett 448 115 119 18852024 1:CAS:528:DC%2BD1cXhtlyiurjL
130. M Nyffeler U Meyer BK Yee J Feldon I Knuesel 2006 Maternal immune activation during pregnancy increases limbic GABAA receptor immunoreactivity in the adult offspring: implications for schizophrenia Neuroscience 143 51 62 17045750 1:CAS:528:DC%2BD28XhtFKls7zE (Pubitemid 44667305)
131. J O'Loan DW Eyles J Kesby P Ko JJ McGrath TH Burne 2007 Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring Psychoneuroendocrinology 32 227 234 17276604 (Pubitemid 46400276)
132. M Ogawa T Miyata K Nakajima K Yagyu M Seike K Ikenaka H Yamamoto K
133. PL Oliver KE Davies 2009 Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk Hum Mol Genet 18 4576 4589 19729413 1:CAS:528:DC%2BD1MXhtlygs7nF
134. D Owen MH Andrews SG Matthews 2005 Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour Neurosci Biobehav Rev 29 209 226 15811494 1:CAS:528:DC%2BD2MXjtlSqtLw%3D (Pubitemid 40461740)
135. K Ozawa K Hashimoto T Kishimoto E Shimizu H Ishikura M Iyo 2006 Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia Biol Psychiatry 59 546 554 16256957 1:CAS:528:DC%2BD28XitVKhsLw%3D (Pubitemid 43320543)
136. AA Palmer DJ Printz PD Butler SC Dulawa MP Printz 2004 Prenatal protein deprivation in rats induces changes in prepulse inhibition and NMDA receptor binding Brain Res 996 193 201 14697497 1:CAS:528:DC%2BD3sXpvF2lsrc%3D (Pubitemid 38022016)
137. AA Palmer AS Brown D Keegan LD Siska E Susser J Rotrosen PD Butler 2008 Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor binding Brain Res 1237 62 74 18703024 1:CAS:528:DC%2BD1cXht1SisLjI
138. D Pang S Syed P Fine PB Jones 2009 No association between prenatal viral infection and depression in later life-a long-term cohort study of 6152 subjects Can J Psychiatry 54 565 570 19726009
139. C Pesold F Impagnatiello MG Pisu DP Uzunov E Costa A Guidotti HJ Caruncho 1998 Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats Proc Natl Acad Sci USA 95 3221 3226 9501244 1:CAS:528:DyaK1cXitV2itb8%3D
140. T Poltyrev GI Keshet G Kay M Weinstock 1996 Role of experimental conditions in determining differences in exploratory behavior of prenatally stressed rats Dev Psychobiol 29 453 462 8809495 1:STN:280:DyaK28vgsFemtw%3D%3D (Pubitemid 126482680)
141. D Potter A Summerfelt J Gold RW Buchanan 2006 Review of clinical correlates of P50 sensory gating abnormalities in patients with schizophrenia Schizophr Bull 32 692 700 16469942 (Pubitemid 44412856)
142. N Quan EL Stern MB Whiteside M Herkenham 1999 Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat J Neuroimmunol 93 72 80 10378870 1:CAS:528:DyaK1MXhslahug%3D%3D (Pubitemid 29051552)
143. SC Ranade A Rose M Rao J Gallego P Gressens S Mani 2008 Different types of nutritional deficiencies affect different domains of spatial memory function checked in a radial arm maze Neuroscience 152 859 866 18329816 1:CAS:528:DC%2BD1cXksVamurk%3D
144. JL Rapoport AM Addington S Frangou MR Psych 2005 The neurodevelopmental model of schizophrenia: update 2005 Mol Psychiatry 10 434 449 15700048 1:CAS:528:DC%2BD2MXkt1Wksrk%3D (Pubitemid 40646432)
145. S Rees R Harding D Walker 2008 An adverse intrauterine environment: implications for injury and altered development of the brain Int J Dev Neurosci 26 3 11 17981423 (Pubitemid 351192272)
146. F Rice I Jones A Thapar 2007 The impact of gestational stress and prenatal growth on emotional problems in offspring: a review Acta Psychiatr Scand 115 171 183 17302617 1:STN:280:DC%2BD2s7gsVSqsw%3D%3D
147. F Rice GT Harold J Boivin M van den Bree DF Hay A Thapar 2010 The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences Psychol Med 40 335 345 19476689 1:STN:280:DC%2BC3c%2Fhs1OksA%3D%3D
148. HN Richardson EP Zorrilla CD Mandyam CL Rivier 2006 Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood Endocrinology 147 2506 2517 16455779 1:CAS:528:DC%2BD28XjvFOqs74%3D
149. E Romero C Ali E Molina-Holgado B Castellano C Guaza J Borrell 2007 Neurobehavioral and immunological consequences of prenatal immune activation in rats. Influence of antipsychotics Neuropsychopharmacology 32 1791 1804 17180123 1:CAS:528:DC%2BD2sXnslGksrY%3D (Pubitemid 47076375)
150. Romero E, Guaza C, Castellano B, Borrell J (2008) Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia. Mol Psychiatry 15:372-383
151. AM Samuelsson E Jennische HA Hansson A Holmang 2006 Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA(A) dysregulation and impaired spatial learning Am J Physiol Regul Integr Comp Physiol 290 R1345 R1356 16357100 1:CAS:528:DC%2BD28XkvFSmurk%3D
152. JR Seckl 2004 Prenatal glucocorticoids and long-term programming Eur J Endocrinol 151 Suppl 3 U49 U62 15554887 1:CAS:528:DC%2BD2cXhtFSht7vL
153. LD Selemon G Rajkowska PS Goldman-Rakic 1998 Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method J Comp Neurol 392 402 412 9511926 1:STN:280:DyaK1c7ntVyktA%3D%3D (Pubitemid 28165894)
154. L Shi SH Fatemi RW Sidwell PH Patterson 2003 Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring J Neurosci 23 297 302 12514227 (Pubitemid 36050430)
155. Short SJ, Lubach GR, Karasin AI, Olsen CW, Styner M, Knickmeyer RC, Gilmore JH, Coe CL (2010) Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey. Biol Psychiatry 67:965-973
156. RW Sidwell JH Huffman EW Call H Alaghamandan PD Cook RK Robins 1986 Effect of selenazofurin on influenza A and B virus infections of mice Antivir Res 6 343 353 3022644 1:CAS:528:DyaL28XlvVenu70%3D (Pubitemid 16023227)
157. A Silvagni VG Barros C Mura MC Antonelli E Carboni 2008 Prenatal restraint stress differentially modifies basal and stimulated dopamine and noradrenaline release in the nucleus accumbens shell: an 'in vivo' microdialysis study in adolescent and young adult rats Eur J Neurosci 28 744 758 18671739
158. SE Smith J Li K Garbett K Mirnics PH Patterson 2007 Maternal immune activation alters fetal brain development through interleukin-6 J Neurosci 27 10695 10702 17913903 1:CAS:528:DC%2BD2sXhtFyitrbL (Pubitemid 47535869)
159. BP Sokolov 2007 Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies? Int J Neuropsychopharmacol 10 547 555 17291372 1:CAS:528: DC%2BD2sXnt1Kgt70%3D (Pubitemid 46985259)
160. GH Son D Geum S Chung EJ Kim JH Jo CM Kim KH Lee H Kim S Choi HT Kim CJ Lee K Kim 2006 Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity J Neurosci 26 3309 3318 16554481 1:CAS:528:DC%2BD28XjsVClt7s%3D
161. J Spauwen L Krabbendam R Lieb HU Wittchen J van Os 2004 Early maternal stress and health behaviours and offspring expression of psychosis in adolescence Acta Psychiatr Scand 110 356 364 15458559 1:STN:280: DC%2BD2cvptVSgsA%3D%3D (Pubitemid 39424837)
162. D St Clair M Xu P Wang Y Yu Y Fang F Zhang X Zheng N Gu G Feng P Sham L He 2005 Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961 Jama 294 557 562 16077049 1:CAS:528:DC%2BD2MXntVOlurw%3D (Pubitemid 41126897)
163. RG Steen C Mull R McClure RM Hamer JA Lieberman 2006 Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies Br J Psychiatry 188 510 518 16738340 (Pubitemid 43844097)
164. AD Stein FH Pierik GH Verrips ES Susser LH Lumey 2009 Maternal exposure to the Dutch famine before conception and during pregnancy: quality of life and depressive symptoms in adult offspring Epidemiology 20 909 915 19752733
165. KE Stevens CE Adams TJ Mellott E Robbins MA Kisley 2008 Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats Brain Res 1237 84 90 18778692 1:CAS:528:DC%2BD1cXht1SisLjK
166. PF Sullivan 2005 The genetics of schizophrenia PLoS Med 2 e212 16033310
167. NR Swerdlow GA Light KS Cadenhead J Sprock MH Hsieh DL Braff 2006 Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function Arch Gen Psychiatry 63 1325 1335 17146007 (Pubitemid 44878517)
168. M Szymanska B Budziszewska L Jaworska-Feil A Basta-Kaim M Kubera M Leskiewicz M Regulska W Lason 2009 The effect of antidepressant drugs on the HPA axis activity, glucocorticoid receptor level and FKBP51 concentration in prenatally stressed rats Psychoneuroendocrinology 34 822 832 19195790 1:CAS:528:DC%2BD1MXltlChsrk%3D
169. NM Talge C Neal V Glover 2007 Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? J Child Psychol Psychiatry 48 245 261 17355398 (Pubitemid 46372120)
170. EF Torrey RR Rawlings JM Ennis DD Merrill DS Flores 1996 Birth seasonality in bipolar disorder, schizophrenia, schizoaffective disorder and stillbirths Schizophr Res 21 141 149 8885042 1:STN:280:DyaK2s%2FjvFCqsg%3D%3D (Pubitemid 26298406)
171. A Urakubo LF Jarskog JA Lieberman JH Gilmore 2001 Prenatal exposure to maternal infection alters cytokine expression in the placenta, amniotic fluid, and fetal brain Schizophr Res 47 27 36 11163542 1:STN:280:DC%2BD3M3isFegtw%3D%3D (Pubitemid 32121768)
172. DL Van den Hove CE Blanco B Aendekerk L Desbonnet M Bruschettini HP Steinbusch J Prickaerts HW Steinbusch 2005 Prenatal restraint stress and long-term affective consequences Dev Neurosci 27 313 320 16137989 (Pubitemid 41243219)
173. Van Den Hove DL, Steinbusch HW, Scheepens A, Van De Berg WD, Kooiman LA, Boosten BJ, Prickaerts J, Blanco CE (2006) Prenatal stress and neonatal rat brain development. Neuroscience 137:145-155 (Pubitemid 43031482)
174. van Os J, Rutten BP, Poulton R (2008) Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr Bull 34:1066-1082
175. Vucetic Z, Totoki K, Schoch H, Whitaker KW, Hill-Smith T, Lucki I, Reyes TM (2010) Early life protein restriction alters dopamine circuitry. Neuroscience 168:359-370
176. S Vuillermot L Weber J Feldon U Meyer 2010 A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia J Neurosci 30 1270 1287 20107055 1:CAS:528:DC%2BC3cXhsVOrur4%3D
177. AA Walf CA Frye 2007 Estradiol decreases anxiety behavior and enhances inhibitory avoidance and gestational stress produces opposite effects Stress 10 251 260 17613939 1:CAS:528:DC%2BD2sXnt1Wgtb4%3D (Pubitemid 47037198)
178. JB Watson SA Mednick M Huttunen X Wang 1999 Prenatal teratogens and the development of adult mental illness Dev Psychopathol 11 457 466 10532619 1:STN:280:DC%2BD3c%2FgtVCiuw%3D%3D
179. M Weinstock 2005 The potential influence of maternal stress hormones on development and mental health of the offspring Brain Behav Immun 19 296 308 15944068 1:CAS:528:DC%2BD2MXltFaqt78%3D (Pubitemid 40797985)
180. Weinstock M (2008) The long-term behavioural consequences of prenatal stress. Neurosci Biobehav Rev 32:1073-1086
181. LA Welberg JR Seckl MC Holmes 2000 Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring Eur J Neurosci 12 1047 1054 10762336 1:STN:280: DC%2BD3c3is1alsw%3D%3D (Pubitemid 30168784)
182. LA Welberg KV Thrivikraman PM Plotsky 2005 Chronic maternal stress inhibits the capacity to up-regulate placental 11beta-hydroxysteroid dehydrogenase type 2 activity J Endocrinol 186 R7 R12 16135661 1:CAS:528:DC%2BD2MXhtVygt73M
183. C Winter TJ Reutiman TD Folsom R Sohr RJ Wolf G Juckel SH Fatemi 2008 Dopamine and serotonin levels following prenatal viral infection in mouse-implications for psychiatric disorders such as schizophrenia and autism Eur Neuropsychopharmacol 18 712 716 18693086 1:CAS:528:DC%2BD1cXhtVartLrK
184. C Winter A Djodari-Irani R Sohr R Morgenstern J Feldon G Juckel U Meyer 2009 Prenatal immune activation leads to multiple changes in basal neurotransmitter levels in the adult brain: implications for brain disorders of neurodevelopmental origin such as schizophrenia Int J Neuropsychopharmacol 12 513 524 18752727 1:CAS:528:DC%2BD1MXkslKlsbk%3D
185. AR Wolff DK Bilkey 2008 Immune activation during mid-gestation disrupts sensorimotor gating in rat offspring Behav Brain Res 190 156 159 18367260 1:CAS:528:DC%2BD1cXkvVyjsrk%3D
186. SJ Wong-Goodrich MJ Glenn TJ Mellott JK Blusztajn WH Meck CL Williams 2008 Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero Brain Res 1237 153 166 18778697 1:CAS:528:DC%2BD1cXht1SisLvI
187. SD Wright RA Ramos PS Tobias RJ Ulevitch JC Mathison 1990 CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein Science 249 1431 1433 1698311 1:CAS:528:DyaK3MXksV2q
188. MQ Xu WS Sun BX Liu GY Feng L Yu L Yang G He P Sham E Susser D St Clair L He 2009 Prenatal malnutrition and adult schizophrenia: further evidence from the 1959-1961 Chinese famine Schizophr Bull 35 568 576 19155344
189. R Yaka S Salomon H Matzner M Weinstock 2007 Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats Behav Brain Res 179 126 132 17320196 1:CAS:528: DC%2BD2sXjsVegtb0%3D (Pubitemid 46441493)
190. L Yang K Lindholm Y Konishi R Li Y Shen 2002 Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways J Neurosci 22 3025 3032 11943805 1:CAS:528:DC%2BD38XjtF2hsbY%3D (Pubitemid 35379191)
191. J Yang H Han J Cao L Li L Xu 2006 Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring Hippocampus 16 431 436 16598704 (Pubitemid 44712066)
192. G Zagron M Weinstock 2006 Maternal adrenal hormone secretion mediates behavioural alterations induced by prenatal stress in male and female rats Behav Brain Res 175 323 328 17023059 1:CAS:528:DC%2BD28Xht1ersr%2FI (Pubitemid 44781115)
193. L Zuckerman I Weiner 2005 Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring J Psychiatr Res 39 311 323 15725430 (Pubitemid 40255916)
194. L Zuckerman M Rehavi R Nachman I Weiner 2003 Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia Neuropsychopharmacology 28 1778 1789 12865897 1:CAS:528:DC%2BD3sXnsVyisbs%3D (Pubitemid 41070843)
195. AR Zuena J Mairesse P Casolini C Cinque GS Alema S Morley-Fletcher V Chiodi LG Spagnoli R Gradini A Catalani F Nicoletti S Maccari 2008 Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats PLoS ONE 3 e2170 18478112