Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: A neurodevelopmental animal model of schizophrenia

Biological Psychiatry

Volumn 59, Issue 6, 2006, Pages 546-554

  Ozawa, Kimiyoshi ^a   Hashimoto, Kenji ^a   Kishimoto, Takashi ^a   Shimizu, Eiji ^a   Ishikura, Hiroshi ^a   Iyo, Masaomi ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Clozapine; Cognition; Dopamine; Neurodevelopment; Poly I:C; Prenatal immune activation

Indexed keywords

CLOZAPINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOUBLE STRANDED RNA; HALOPERIDOL; METHAMPHETAMINE; PHOSPHATE BUFFERED SALINE; POLYINOSINIC POLYCYTIDYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CHEMICAL ANALYSIS; COGNITIVE DEFECT; CONTROLLED STUDY; DOPAMINE METABOLISM; DOPAMINERGIC SYSTEM; EXPERIMENTAL MODEL; FEMALE; HYPERACTIVITY; IMMUNOSTIMULATION; JUVENILE; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM FUNCTION; NONHUMAN; OBSERVATIONAL STUDY; PREGNANCY; PREPULSE INHIBITION; PRIORITY JOURNAL; PROGENY; RECEPTOR BINDING; RECOGNITION; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; TASK PERFORMANCE; THIGMOTAXIS; VIRUS INFECTION;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, VIRAL; BRAIN; CLOZAPINE; COGNITION; CYTOKINES; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FEMALE; FORM PERCEPTION; MENTAL RECALL; METHAMPHETAMINE; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY; NEURAL INHIBITION; NEUROIMMUNOMODULATION; ORIENTATION; POLY I-C; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY, ANIMAL; PRENATAL EXPOSURE DELAYED EFFECTS; SCHIZOPHRENIA; STARTLE REACTION; VIRUS DISEASES;

EID: 33644610741     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.07.031     Document Type: Article

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