Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice

Psychopharmacology

Volumn 214, Issue 2, 2011, Pages 465-476

  Cassano, Tommaso ^a   Gaetani, Silvana ^b   MacHeda, Teresa ^a   Laconca, Leonardo ^a   Romano, Adele ^b   Morgese, Maria Grazia ^a   Cimmino, Concetta Stefania ^a,c   Chiarotti, Flavia ^f   Bambico, Francis R ^d   Gobbi, Gabriella ^d   Cuomo, Vincenzo ^b   Piomelli, Daniele ^e  

^a UNIVERSITY OF FOGGIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Anxiety; Fatty acid amide hydrolase (FAAH) knockout; Frontal cortex; Microdialysis; Open field; Rimonabant; Serotonin; Social interaction; Ventral hippocampus

Indexed keywords

FATTY ACID AMIDASE; POTASSIUM ION; RIMONABANT; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DEPOLARIZATION; EMOTIONALITY; FRONTAL CORTEX; GENOTYPE; HIPPOCAMPUS; IN VIVO STUDY; LIGHT; MICRODIALYSIS; MOTOR ACTIVITY; MOUSE; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SEROTONINERGIC TRANSMISSION; SOCIAL INTERACTION;

AMIDOHYDROLASES; ANALYSIS OF VARIANCE; ANIMALS; ARACHIDONIC ACIDS; BEHAVIOR, ANIMAL; CHI-SQUARE DISTRIBUTION; EMOTIONS; FRONTAL LOBE; GENOTYPE; HABITUATION, PSYCHOPHYSIOLOGIC; HIPPOCAMPUS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRODIALYSIS; MOTOR ACTIVITY; NEURONS; PHENOTYPE; PIPERIDINES; POLYUNSATURATED ALKAMIDES; POTASSIUM; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; SEROTONIN; SOCIAL BEHAVIOR; SYNAPTIC TRANSMISSION; TIME FACTORS;

EID: 79952282058     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-2051-0     Document Type: Article

References (66)

1. DC Aguiar AL Terzian FS Guimarães FA Moreira 2009 Anxiolytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats Psychopharmacology 205 217 225 19387617 10.1007/s00213-009-1532-5 1:CAS:528:DC%2BD1MXkvV2jtLg%3D
2. GP Ahern LS Premkumar 2002 Voltage-dependent priming of rat vanilloid receptor: effects of agonist and protein kinase C activation J Physiol 545 441 451 12456824 10.1113/jphysiol.2002.029561 1:CAS:528:DC%2BD3sXktFyjtA%3D%3D (Pubitemid 36004379)
3. A Al-Hayani KN Wease RA Ross RG Pertwee SN Davies 2001 The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice Neuropharmacology 41 1000 1005 11747904 10.1016/S0028-3908(01)00145-9 1:CAS:528:DC%2BD3MXpt1aiurY%3D (Pubitemid 34024995)
4. SH Alves G Pinheiro V Motta J Landeira-Fernandez AP Cruz 2004 Anxiogenic effects in the rat elevated plus-maze of 5-HT(2C) agonists into ventral but not dorsal hippocampus Behav Pharmacol 15 37 43 15075625 10.1097/00008877-200402000- 00005 1:CAS:528:DC%2BD2cXjtVWqsLs%3D (Pubitemid 38241512)
5. E Aso T Renoir G Mengod C Ledent M Hamon R Maldonado L Lanfumey O Valverde 2009 Lack of CB1 receptor activity impairs serotonergic negative feedback J Neurochem 109 935 944 19302195 10.1111/j.1471-4159.2009.06025.x 1:CAS:528:DC%2BD1MXlsFyktbs%3D
6. FR Bambico A Duranti A Tontini G Tarzia G Gobbi 2009 Endocannabinoids in the treatment of mood disorders: evidence from animal models Curr Pharm Des 15 1623 1646 19442178 10.2174/138161209788168029 1:CAS:528:DC%2BD1MXmtValt70%3D
7. FR Bambico T Cassano S Dominguez-Lopez N Katz CD Walker D Piomelli G Gobbi 2010 Genetic deletion of fatty acid amide hydrolase alters emotional behaviour and serotonergic transmission in the dorsal raphe, prefrontal cortex and hippocampus Neuropsychopharmacology 35 2083 2100 20571484 10.1038/npp.2010.80 1:CAS:528:DC%2BC3cXhtVajs7nI
8. DM Bannerman M Grubb RM Deacon BK Yee J Feldon JN Rawlins 2003 Ventral hippocampal lesions affect anxiety but not spatial learning Behav Brain Res 139 197 213 12642189 10.1016/S0166-4328(02)00268-1 1:STN:280:DC%2BD3s7islGhtw%3D%3D (Pubitemid 36298503)
9. LJ Bertoglio AP Carobrez 2002 Behavioral profile of rats submitted to session 1-session 2 in the elevated plus-maze during diurnal/nocturnal phases and under different illumination conditions Behav Brain Res 132 135 143 11997144 10.1016/S0166-4328(01)00396-5 (Pubitemid 34462041)
10. O Berton EJ Nestler 2006 New approaches to antidepressant drug discovery: beyond monoamines Nat Rev Neurosci 7 137 151 16429123 10.1038/nrn1846 1:CAS:528:DC%2BD28XlvV2qug%3D%3D (Pubitemid 43151600)
11. A Best WG Regehr 2008 Serotonin evokes endocannabinoid release and retrogradely suppresses excitatory synapses J Neurosci 28 6508 6515 18562622 10.1523/JNEUROSCI.0678-08.2008 1:CAS:528:DC%2BD1cXotVegtLg%3D
12. G Bhave W Zhu H Wang DJ Brasier GS Oxford RW Gereau 2002 cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation Neuron 35 721 731 12194871 10.1016/S0896-6273(02)00802-4 1:CAS:528:DC%2BD38XmslSlsbg%3D (Pubitemid 35223031)
13. E Choleris AW Thomas M Kavaliers FS Prato 2001 A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field Neurosci Biobehav Rev 25 235 260 11378179 10.1016/S0149-7634(01)00011-2 1:CAS:528:DC%2BD3MXjvV2ntbw%3D (Pubitemid 32506876)
14. R Christensen PK Kristensen EM Bartels H Bliddal A Astrup 2007 Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials Lancet 370 1706 1713 18022033 10.1016/S0140-6736(07)61721-8 1:CAS:528:DC%2BD2sXhtlWrsb7E (Pubitemid 350100788)
15. BF Cravatt K Demarest MP Patricelli MH Bracey DK Giang BR Martin AH Lichtman 2001 Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase Proc Natl Acad Sci USA 98 9371 9376 11470906 10.1073/pnas.161191698 1:CAS:528:DC%2BD3MXlvFSrsbo%3D (Pubitemid 32743923)
16. L Cristino L de Petrocellis G Pryce D Baker V Guglielmotti V Di Marzo 2006 Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain Neuroscience 139 1405 1415 16603318 10.1016/j.neuroscience.2006.02.074 1:CAS:528:DC%2BD28XktVGhu7c%3D
17. 2+ signalling Cell Calcium 45 611 624 19356798 10.1016/j.ceca.2009.03.003
18. L De Petrocellis T Bisogno M Maccarrone JB Davis A Finazzi-Agro V Di Marzo 2001 The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism J Biol Chem 276 12856 12863 11278420 10.1074/jbc.M008555200
19. A Degroot D Treit 2004 Anxiety is functionally segregated within the septo-hippocampal system Brain Res 1001 60 71 14972654 10.1016/j.brainres.2003. 10.065 1:CAS:528:DC%2BD2cXht1yrsr0%3D (Pubitemid 38221528)
20. VH Denenberg 1969 Open-field behaviour in the rat: what does it mean? Ann NY Acad Sci 159 852 859 5260302 10.1111/j.1749-6632.1969.tb12983.x 1:STN:280:DyaE3c%2FjsVGgsQ%3D%3D
21. V Di Marzo G Gobbi A Szallasi 2008 Brain TRPV1: a depressing TR(i)P down memory lane? Trends Pharmacol Sci 29 594 600 18947889 10.1016/j.tips.2008.09.004
22. S Engeli J Bohnke M Feldpausch K Gorzelniak J Janke S Batkai P Pacher J Harvey-White FC Luft AM Sharma J Jordan 2005 Activation of the peripheral endocannabinoid system in human obesity Diabetes 54 2838 2843 16186383 10.2337/diabetes.54.10.2838 1:CAS:528:DC%2BD2MXhtV2rs77O (Pubitemid 41401077)
23. SE File P Seth 2003 A review of 25 years of the social interaction test Eur J Pharmacol 463 35 53 12600701 10.1016/S0014-2999(03)01273-1 1:CAS:528:DC%2BD3sXhsVanu7o%3D (Pubitemid 36205071)
24. Franklin KBJ, Paxinos G (1997) The mouse brain in stereotaxic coordinates. Academic Press, San Diego, CA
25. TF Freund I Katona D Piomelli 2003 Role of endogenous cannabinoids in synaptic signaling Physiol Rev 83 1017 1066 12843414 1:CAS:528: DC%2BD3sXmtVGmsLk%3D (Pubitemid 36828930)
26. S Gaetani V Cuomo D Piomelli 2003 Anandamide hydrolysis: a new target for anti-anxiety drugs? Trends Mol Med 9 474 478 14604824 10.1016/j.molmed.2003.09. 005 1:CAS:528:DC%2BD3sXos1Kjurg%3D (Pubitemid 37464283)
27. S Gaetani P Dipasquale A Romano L Righett T Cassano D Piomelli V Cuomo 2009 The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs Int Rev Neurobiol 85 57 72 19607961 10.1016/S0074-7742(09) 85005-8 1:CAS:528:DC%2BD1MXht1Wis7rL
28. G Gobbi FR Bambico R Mangieri M Bortolato P Campolongo M Solinas T Cassano MG Morgese G Debonnel A Duranti A Tontini G Tarzia M Mor V Trezza SR Goldberg V Cuomo D Piomelli 2005 Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis Proc Natl Acad Sci USA 102 18620 18625 16352709 10.1073/pnas.0509591102 1:CAS:528:DC%2BD28Xpt1yq (Pubitemid 43011275)
29. G Griebel J Stemmelin B Scatton 2005 Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents Biol Psychiatry 57 261 267 15691527 10.1016/j.biopsych.2004.10.032 1:CAS:528:DC%2BD2MXhtV2nt7k%3D (Pubitemid 40187370)
30. J Haller N Bakos M Szirmay C Ledent TF Freund 2002 The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety Eur J Neurosci 16 1395 1398 12405999 10.1046/j.1460-9568.2002.02192.x 1:STN:280:DC%2BD38nkslSqsg%3D%3D (Pubitemid 35340861)
31. J Haller B Varga C Ledent I Barna TF Freund 2004 Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice Eur J Neurosci 19 1906 1912 15078564 10.1111/j.1460-9568.2004.03293.x 1:STN:280:DC%2BD2c7otlWntA%3D%3D (Pubitemid 38482578)
32. J Haller B Varga C Ledent TF Freund 2004 CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents Behav Pharmacol 15 299 304 15252281 10.1097/01.fbp. 0000135704.56422.40 1:CAS:528:DC%2BD2cXls1agtbg%3D (Pubitemid 39062560)
33. J Haller I Barna B Barsvari K Gyimesi Pelczer S Yasar LV Panlilio S Goldberg 2009 Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats Psychopharmacology (Berl) 204 607 616 10.1007/s00213-009-1494-7 1:CAS:528:DC%2BD1MXis1Chtbk%3D
34. MN Hill BB Gorzalka 2004 Enhancement of anxiety-like responsiveness to the cannabinoid CB(1) receptor agonist HU-210 following chronic stress Eur J Pharmacol 499 291 295 15381051 10.1016/j.ejphar.2004.06.069 1:CAS:528: DC%2BD2cXnslGnsbY%3D (Pubitemid 39233668)
35. MN Hill RJ McLaughlin AC Morrish V Viau SB Floresco CJ Hillard BB Gorzalka 2009 Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis Neuropsychopharmacology 34 2733 2745 19710634 10.1038/npp.2009.114 1:CAS:528:DC%2BD1MXhtl2iurfO
36. S Kathuria S Gaetani D Fegley F Valino A Duranti A Tontini M Mor G Tarzia G La Rana A Calignano A Giustino M Tattoli M Palmery V Cuomo D Piomelli 2003 Modulation of anxiety through blockade of anandamide hydrolysis Nat Med 9 76 81 12461523 10.1038/nm803 1:CAS:528:DC%2BD3sXivF2l (Pubitemid 36098263)
37. A Mahmud P Santha CC Paule I Nagy 2009 Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons Neuroscience 162 1202 1211 19463903 10.1016/j.neuroscience.2009.05.024 1:CAS:528:DC%2BD1MXps1aitbs%3D
38. G Marsicano CT Wotjak SC Azad T Bisogno G Rammes MG Cascio H Hermann J Tang C Hofmann W Zieglgansberger V Di Marzo B Lutz 2002 The endogenous cannabinoid system controls extinction of aversive memories Nature 418 530 534 12152079 10.1038/nature00839 1:CAS:528:DC%2BD38Xls12nur4%3D (Pubitemid 34851398)
39. JR Martin TM Ballard GA Higgins 2002 Influence of the 5-HT2C receptor antagonist, SB-242084, in tests of anxiety Pharmacol Biochem Behav 71 615 625 11888553 10.1016/S0091-3057(01)00713-4 1:CAS:528:DC%2BD38XhvVChtbY%3D (Pubitemid 34219212)
40. E Mezey ZE Tóth DN Cortright MK Arzubi JE Krause R Elde A Guo PM Blumberg A Szallasi 2000 Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human Proc Natl Acad Sci USA 97 3655 3660 10725386 10.1073/pnas.060496197 1:CAS:528:DC%2BD3cXitlWqu7w%3D (Pubitemid 30183358)
41. DP Mohapatra C Nau 2003 Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway J Biol Chem 278 50080 50090 14506258 10.1074/jbc.M306619200 1:CAS:528:DC%2BD3sXpslSqs7k%3D (Pubitemid 37548845)
42. 2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase J Biol Chem 280 13424 13432 15691846 10.1074/jbc.M410917200 1:CAS:528:DC%2BD2MXivV2ksbk%3D (Pubitemid 40517230)
43. FA Moreira N Kaiser K Monory B Lutz 2008 Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid- degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors Neuropharmacology 54 141 150 17709120 10.1016/j.neuropharm.2007.07.005 1:CAS:528:DC%2BD1cXhtlCgug%3D%3D (Pubitemid 350299416)
44. N Naderi A Haghparast A Saber-Tehrani N Rezaii AM Alizadeh A Khani F Motamedi 2008 Interaction between cannabinoid compounds and diazepam on anxiety-like behaviour of mice Pharmacol Biochem Behav 89 64 75 18096213 10.1016/j.pbb.2007.11.001 1:CAS:528:DC%2BD1cXovFGquw%3D%3D
45. PS Naidu SA Varvel K Ahn BF Cravatt BR Martin AH Lichtman 2007 Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality Psychopharmacology (Berl) 192 61 70 10.1007/s00213-006-0689-4 1:CAS:528:DC%2BD2sXkslWgs7g%3D (Pubitemid 46673891)
46. M Navarro E Hernandez RM Munoz I del Arco MA Villanua MR Carrera F Rodriguez de Fonseca 1997 Acute administration of the CB1 cannabinoid receptor antagonist SR 141716A induces anxiety-like responses in the rat Neuroreport 8 491 496 9080435 10.1097/00001756-199701200-00023 1:CAS:528:DyaK2sXisVais7Y%3D (Pubitemid 27180108)
47. S Patel CJ Hillard 2006 Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling J Pharmacol Exp Ther 318 304 311 16569753 10.1124/jpet.106.101287 1:CAS:528:DC%2BD28XmsFymt7g%3D
48. S Patel CT Roelke DJ Rademacher WE Cullinan CJ Hillard 2004 Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis Endocrinology 145 5431 5438 15331569 10.1210/en.2004-0638 1:CAS:528:DC%2BD2cXhtVaqu7zO (Pubitemid 39564580)
49. S Patel BF Cravatt CJ Hillard 2005 Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala Neuropsychopharmacology 30 497 507 15280883 10.1038/sj.npp.1300535 1:CAS:528:DC%2BD2MXhtlOrsLs%3D (Pubitemid 40271152)
50. D Piomelli 2003 The molecular logic of endocannabinoid signalling Nat Rev Neurosci 4 873 884 14595399 10.1038/nrn1247 1:CAS:528:DC%2BD3sXosFOktrY%3D (Pubitemid 37351427)
51. L Prut C Belzung 2003 The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review Eur J Pharmacol 463 3 33 12600700 10.1016/S0014-2999(03)01272-X 1:CAS:528:DC%2BD3sXhsVanu70%3D (Pubitemid 36205070)
52. A Rex JP Voigt H Fink 2005 Anxiety but not arousal increases 5-hydroxytryptamine release in the rat ventral hippocampus in vivo Eur J Neurosci 22 1185 1189 16176361 10.1111/j.1460-9568.2005.04251.x 1:STN:280:DC%2BD2MrgsVKgtA%3D%3D (Pubitemid 41395383)
53. A Roedel C Storch F Holsboer F Ohl 2006 Effects of light or dark phase testing on behavioural and cognitive performance in DBA mice Lab Anim 40 371 381 17018208 10.1258/002367706778476343 1:CAS:528:DC%2BD28XhtFyrsbvI (Pubitemid 44594482)
54. A Roohbakhsh S Keshavarz P Hasanein ME Rezvani AH Moghaddam 2009 Role of endocannabinoid system in the ventral hippocampus of rats in the modulation of anxiety-like behaviours Basic Clin Pharmacol Toxicol 105 333 338 19614892 10.1111/j.1742-7843.2009.00449.x 1:CAS:528:DC%2BD1MXhtlOqu7zF
55. RA Ross 2003 Anandamide and vanilloid TRPV1 receptors Br J Pharmacol 140 790 801 14517174 10.1038/sj.bjp.0705467 1:CAS:528:DC%2BD3sXps1eksr4%3D (Pubitemid 37464060)
56. RA Ross TM Gibson HC Brockie M Leslie G Pashmi SJ Craib V Di Marzo RG Pertwee 2001 Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens Br J Pharmacol 132 631 640 11159715 10.1038/sj.bjp. 0703850 1:CAS:528:DC%2BD3MXhtlOksbg%3D (Pubitemid 32165178)
57. T Rubino N Realini C Castiglioni C Guidali D Vigano E Marras S Petrosino G Perletti M Maccarrone V Di Marzo D Parolaro 2008 Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex Cereb Cortex 18 1292 1301 17921459 10.1093/cercor/bhm161 1:STN:280:DC%2BD1czhtlajtw%3D%3D (Pubitemid 351769783)
58. JF Sanchez JE Krause DN Cortright 2001 The distribution and regulation of vanilloid receptor VR1 and VR1 5′ splice variant RNA expression in rat Neuroscience 107 373 381 11718993 10.1016/S0306-4522(01)00373-6 1:CAS:528:DC%2BD3MXosFKnsr0%3D (Pubitemid 33079114)
59. JC Sipe TM Scott S Murray O Harismendy GM Simon BF Cravatt J Waalen 2010 Biomarkers of endocannabinoid system activation in severe obesity PLoS One 5 e8792 20098695 10.1371/journal.pone.0008792
60. E Takahashi M Katayama K Niimi C Itakura 2008 Additive subthreshold dose effects of cannabinoid CB(1) receptor antagonist and selective serotonin reuptake inhibitor in antidepressant behavioral tests Eur J Pharmacol 589 149 156 18571641 10.1016/j.ejphar.2008.05.020 1:CAS:528:DC%2BD1cXptVCmsLY%3D
61. A Tóth J Boczán N Kedei E Lizanecz Z Bagi Z Papp I Edes L Csiba PM Blumberg 2005 Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain Brain Res Mol Brain Res 135 162 168 15857679 10.1016/j.molbrainres.2004.12.003 (Pubitemid 40602409)
62. ET Tzavara M Wade GG Nomikos 2003 Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action J Neurosci 23 9374 9384 14561865 1:CAS:528:DC%2BD3sXos1GqtL8%3D (Pubitemid 37323037)
63. FP Valle 1970 Effects of strain, sex, and illumination on open-field behavior of rats Am J Psychol 83 103 111 5465190 10.2307/1420860 1:STN:280:DyaE3c3lvFKruw%3D%3D
64. SA Varvel LE Wise F Niyuhire BF Cravatt AH Lichtman 2007 Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task Neuropsychopharmacology 32 1032 1041 17047668 10.1038/sj.npp.1301224 1:CAS:528:DC%2BD2sXkt1Gqsrs%3D (Pubitemid 46631982)
65. M Yamauchi T Tatebayashi K Nagase M Kojima T Imanishi 2004 Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats Pharmacol Biochem Behav 78 683 689 15301922 10.1016/j.pbb.2004.05.003 1:CAS:528:DC%2BD2cXmsVGgtL8%3D (Pubitemid 39037726)
66. M Yamauchi T Miyara T Matsushima T Imanishi 2006 Desensitization of 5-HT2A receptor function by chronic administration of selective serotonin reuptake inhibitors Brain Res 1067 164 169 16360124 10.1016/j.brainres.2005.10. 075 1:CAS:528:DC%2BD28Xos1WgtA%3D%3D (Pubitemid 43133085)