메뉴 건너뛰기




Volumn 121, Issue 3, 2011, Pages 866-879

Hunk is required for HER2/neu-induced mammary tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; HUNK ENZYME; MYC PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 79952223342     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI42928     Document Type: Article
Times cited : (27)

References (98)
  • 3
    • 0033739742 scopus 로고    scopus 로고
    • Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland
    • Gardner HP, et al. Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland. Development. 2000;127(20):4493-4509.
    • (2000) Development , vol.127 , Issue.20 , pp. 4493-4509
    • Gardner, H.P.1
  • 5
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
    • Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005;1(1):15-25. (Pubitemid 43960587)
    • (2005) Cell Metabolism , vol.1 , Issue.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 6
    • 25444524850 scopus 로고    scopus 로고
    • Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
    • DOI 10.1074/jbc.M502876200
    • Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem. 2005; 280(37):32081-32089. (Pubitemid 41361813)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.37 , pp. 32081-32089
    • Hahn-Windgassen, A.1    Nogueira, V.2    Chen, C.-C.3    Skeen, J.E.4    Sonenberg, N.5    Hay, N.6
  • 9
    • 0035930343 scopus 로고    scopus 로고
    • C-TAK1 Regulates Ras Signaling by Phosphorylating the MAPK Scaffold, KSR1
    • DOI 10.1016/S1097-2765(01)00383-5
    • Muller J, Ory S, Copeland T, Piwnica-Worms H, Morrison DK. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol Cell. 2001;8(5):983-993. (Pubitemid 34031801)
    • (2001) Molecular Cell , vol.8 , Issue.5 , pp. 983-993
    • Muller, J.1    Ory, S.2    Copeland, T.3    Piwnica-Worms, H.4    Morrison, D.K.5
  • 10
    • 0023818801 scopus 로고
    • Loss of a Mr 78,000 marker in chemically induced transplantable carcinomas and primary carcinoma of human pancreas
    • Parsa I. Loss of a Mr 78,000 marker in chemically induced transplantable carcinomas and primary carcinoma of human pancreas. Cancer Res. 1988;48(8):2265-2272.
    • (1988) Cancer Res. , vol.48 , Issue.8 , pp. 2265-2272
    • Parsa, I.1
  • 11
    • 20444399500 scopus 로고    scopus 로고
    • Regulation of SNARK activity in response to cellular stresses
    • DOI 10.1016/j.bbagen.2005.03.015, PII S0304416505000930
    • Lefebvre DL, Rosen CF. Regulation of SNARK activity in response to cellular stresses. Biochim Biophys Acta. 2005;1724(1-2):71-85. (Pubitemid 40799112)
    • (2005) Biochimica et Biophysica Acta - General Subjects , vol.1724 , Issue.1-2 , pp. 71-85
    • Lefebvre, D.L.1    Rosen, C.F.2
  • 14
    • 70349445613 scopus 로고    scopus 로고
    • The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis
    • Wertheim GB, et al. The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proc Natl Acad Sci U S A. 2009;106(37):15855-15860.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.37 , pp. 15855-15860
    • Wertheim, G.B.1
  • 15
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235(4785):177-182. (Pubitemid 17231334)
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 17
    • 17744415869 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast cancer
    • Slamon DJ. Studies of the HER-2/neu proto-oncogene in human breast cancer. Cancer Invest. 1990; 8(2):253.
    • (1990) Cancer Invest. , vol.8 , Issue.2 , pp. 253
    • Slamon, D.J.1
  • 18
    • 0027880138 scopus 로고
    • Prognostic factors and response to therapy in breast cancer
    • Klijn J, Berns E, Foekens J. Prognostic factors and response to therapy in breast cancer. In: Fentiman I, Taylor-Papadimitriou J, eds. Breast Cancer. Cold Spring Harbor, New York, USA: Cold Spring Harbor Laboratory Press; 1993:165-198. (Pubitemid 24110639)
    • (1993) Cancer Surveys , vol.18 , pp. 165-198
    • Klijn, J.G.M.1    Berns, E.M.J.J.2    Foekens, J.A.3
  • 19
    • 0033651234 scopus 로고    scopus 로고
    • The molecular and cellular biology of HER2/neu gene amplification/ overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer
    • Pegram MD, Konecny G, Slamon DJ. The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer. Cancer Treat Res. 2000;103:57-75.
    • (2000) Cancer Treat Res. , vol.103 , pp. 57-75
    • Pegram, M.D.1    Konecny, G.2    Slamon, D.J.3
  • 20
    • 0034254775 scopus 로고    scopus 로고
    • Herceptin (trastuzamab) in advanced breast cancer
    • DOI 10.1053/ctrv.2000.0182
    • Stebbing J, Copson E, O'Reilly S. Herceptin (trastuzamab) in advanced breast cancer. Cancer Treat Rev. 2000;26(4):287-290. (Pubitemid 30604039)
    • (2000) Cancer Treatment Reviews , vol.26 , Issue.4 , pp. 287-290
    • Stebbing, J.1    Copson, E.2    O'Reilly, S.3
  • 21
    • 0035680514 scopus 로고    scopus 로고
    • Overview of treatment results with trastuzumab (Herceptin) in metastatic breast cancer
    • Hortobagyi GN. Overview of treatment results with trastuzumab (Herceptin) in metastatic breast cancer. Semin Oncol. 2001;28(6 suppl 18):43-47. (Pubitemid 34062048)
    • (2001) Seminars in Oncology , vol.28 , Issue.6 SUPPL. 18 , pp. 43-47
    • Hortobagyi, G.N.1
  • 22
    • 0035680513 scopus 로고    scopus 로고
    • Targeting HER2: Recent developments and future directions for breast cancer patients
    • Wang SC, Zhang L, Hortobagyi GN, Hung MC. Targeting HER2: recent developments and future directions for breast cancer patients. Semin Oncol. 2001;28(6 suppl 18):21-29. (Pubitemid 34062045)
    • (2001) Seminars in Oncology , vol.28 , Issue.6 SUPPL. 18 , pp. 21-29
    • Shao-Chun, W.1    Lisha, Z.2    Hortobagyi, G.N.3    Mien-Chie, H.4
  • 24
    • 57149096463 scopus 로고    scopus 로고
    • Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer
    • Di Leo A, et al. Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. J Clin Oncol. 2008;26(34):5544-5552.
    • (2008) J Clin Oncol. , vol.26 , Issue.34 , pp. 5544-5552
    • Di Leo, A.1
  • 25
    • 46449113024 scopus 로고    scopus 로고
    • Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer
    • Gomez HL, et al. Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol. 2008;26(18):2999-3005.
    • (2008) J Clin Oncol. , vol.26 , Issue.18 , pp. 2999-3005
    • Gomez, H.L.1
  • 26
    • 42449124652 scopus 로고    scopus 로고
    • Can we circumvent resistance to ErbB2-targeted agents by targeting novel pathways?
    • DOI 10.3816/CBC.2008.s.008
    • Pegram M. Can we circumvent resistance to ErbB2-targeted agents by targeting novel pathways? Clin Breast Cancer. 2008;8 suppl 3:S121-S130. (Pubitemid 351568674)
    • (2008) Clinical Breast Cancer , vol.8 , Issue.SUPPL. 3
    • Pegram, M.1
  • 28
    • 24944450362 scopus 로고    scopus 로고
    • The transcriptional repressor Snail promotes mammary tumor recurrence
    • Moody SE, et al. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell. 2005;8(3):197-209.
    • (2005) Cancer Cell. , vol.8 , Issue.3 , pp. 197-209
    • Moody, S.E.1
  • 29
    • 19044370434 scopus 로고    scopus 로고
    • Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis
    • Moody SE, et al. Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis. Cancer Cell. 2002;2(6):451-461.
    • (2002) Cancer Cell. , vol.2 , Issue.6 , pp. 451-461
    • Moody, S.E.1
  • 30
    • 0035893560 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
    • Moulder SL, Yakes FM, Muthuswamy SK, Bianco R, Simpson JF, Arteaga CL. Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res. 2001;61(24):8887-8895. (Pubitemid 34013905)
    • (2001) Cancer Research , vol.61 , Issue.24 , pp. 8887-8895
    • Moulder, S.L.1    Yakes, F.M.2    Muthuswamy, S.K.3    Bianco, R.4    Simpson, J.F.5    Arteaga, C.L.6
  • 31
    • 0842349390 scopus 로고    scopus 로고
    • Subcellular localization of MAK-V/Hunk protein kinase expressed in COS-1 cells
    • DOI 10.1016/j.cellbi.2003.10.002
    • Korobko EV, Kiselev SL, Korobko IV. Subcellular localization of MAK-V/Hunk protein kinase expressed in COS-1 cells. Cell Biol Int. 2004;28(1):49-56. (Pubitemid 38169015)
    • (2004) Cell Biology International , vol.28 , Issue.1 , pp. 49-56
    • Korobko, E.V.1    Kiselev, S.L.2    Korobko, I.V.3
  • 32
    • 0027439438 scopus 로고
    • The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP
    • DOI 10.1073/pnas.90.2.442
    • Carrera AC, Alexandrov K, Roberts TM. The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP. Proc Natl Acad Sci U S A. 1993;90(2):442-446. (Pubitemid 23028879)
    • (1993) Proceedings of the National Academy of Sciences of the United States of America , vol.90 , Issue.2 , pp. 442-446
    • Carrera, A.C.1    Alexandrov, K.2    Roberts, T.M.3
  • 33
    • 0029020282 scopus 로고
    • Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
    • Hanks SK, Hunter T. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 1995;9(8):576-596.
    • (1995) FASEB J. , vol.9 , Issue.8 , pp. 576-596
    • Hanks, S.K.1    Hunter, T.2
  • 34
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • DOI 10.1038/sj.onc.1204082
    • Mendelsohn J, Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene. 2000; 19(56):6550-6565. (Pubitemid 32197693)
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 35
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak K, et al. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994;78(1):59-66.
    • (1994) Cell. , vol.78 , Issue.1 , pp. 59-66
    • Polyak, K.1
  • 37
    • 0032511848 scopus 로고    scopus 로고
    • The murine gene p27(Kip 1) is haplo-insufficient for tumour suppression
    • DOI 10.1038/24179
    • Fero ML, Randel E, Gurley KE, Roberts JM, Kemp CJ. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature. 1998; 396(6707):177-180. (Pubitemid 28523620)
    • (1998) Nature , vol.396 , Issue.6707 , pp. 177-180
    • Fero, M.L.1    Randel, E.2    Gurley, K.E.3    Roberts, J.M.4    Kemp, C.J.5
  • 40
    • 0035835828 scopus 로고    scopus 로고
    • Kip1: Regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer
    • DOI 10.1006/excr.2000.5143
    • Philipp-Staheli J, Payne SR, Kemp CJ. p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp Cell Res. 2001;264(1):148-168. (Pubitemid 32989089)
    • (2001) Experimental Cell Research , vol.264 , Issue.1 , pp. 148-168
    • Philipp-Staheli, J.1    Payne, S.R.2    Kemp, C.J.3
  • 41
    • 0034637527 scopus 로고    scopus 로고
    • Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27
    • DOI 10.1074/jbc.C000147200
    • Yang HY, Zhou BP, Hung MC, Lee MH. Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27. J Biol Chem. 2000;275(32):24735-24739. (Pubitemid 30626576)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.32 , pp. 24735-24739
    • Yang, H.-Y.1    Zhou, B.P.2    Hung, M.-C.3    Lee, M.-H.4
  • 42
    • 0033996361 scopus 로고    scopus 로고
    • ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: Receptor overexpression does not determine growth dependency
    • DOI 10.1128/MCB.20.9.3210-3223.2000
    • Lane HA, Beuvink I, Motoyama AB, Daly JM, Neve RM, Hynes NE. ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)- Cdk2 complex formation: receptor overexpression does not determine growth dependency. Mol Cell Biol. 2000;20(9):3210-3223. (Pubitemid 30215033)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.9 , pp. 3210-3223
    • Lane, H.A.1    Beuvink, I.2    Motoyama, A.B.3    Daly, J.M.4    Neve, R.M.5    Hynes, N.E.6
  • 43
    • 0035419867 scopus 로고    scopus 로고
    • Kip1and cyclin D1 through multiple signaling pathways
    • Lenferink AE, Busse D, Flanagan WM, Yakes FM, Arteaga CL. ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways. Cancer Res. 2001;61(17):6583-6591. (Pubitemid 32783268)
    • (2001) Cancer Research , vol.61 , Issue.17 , pp. 6583-6591
    • Lenferink, A.E.G.1    Busse, D.2    Flanagan, W.M.3    Yakes, F.M.4    Arteaga, C.L.5
  • 44
    • 0038607569 scopus 로고    scopus 로고
    • The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition
    • Le XF, et al. The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition. J Biol Chem. 2003;278(26):23441-23450.
    • (2003) J Biol Chem. , vol.278 , Issue.26 , pp. 23441-23450
    • Le, X.F.1
  • 45
    • 22844439340 scopus 로고    scopus 로고
    • HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways
    • Le XF, Pruefer F, Bast RC Jr. HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways. Cell Cycle. 2005;4(1):87-95.
    • (2005) Cell Cycle , vol.4 , Issue.1 , pp. 87-95
    • Le, X.F.1    Pruefer, F.2    Bast Jr., R.C.3
  • 46
    • 6344270303 scopus 로고    scopus 로고
    • Kip1-mediated antiproliferative effect of trastuzumab (Herceptin) on HER2-overexpressing tumor cells
    • DOI 10.1002/ijc.20378
    • Marches R, Uhr JW. Enhancement of the p27Kip1-mediated antiproliferative effect of trastuzumab (Herceptin) on HER2-overexpressing tumor cells. Int J Cancer. 2004;112(3):492-501. (Pubitemid 39390616)
    • (2004) International Journal of Cancer , vol.112 , Issue.3 , pp. 492-501
    • Marches, R.1    Uhr, J.W.2
  • 47
    • 0037099532 scopus 로고    scopus 로고
    • Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
    • Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL. Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res. 2002;62(14):4132-4141. (Pubitemid 34791085)
    • (2002) Cancer Research , vol.62 , Issue.14 , pp. 4132-4141
    • Yakes, F.M.1    Chinratanalab, W.2    Ritter, C.A.3    King, W.4    Seelig, S.5    Arteaga, C.L.6
  • 50
  • 51
    • 0035927582 scopus 로고    scopus 로고
    • p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis
    • werthYang HY, Shao R, Hung MC, Lee MH. p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis. Oncogene. 2001;20(28):3695- 3702.
    • (2001) Oncogene , vol.20 , Issue.28 , pp. 3695-3702
    • WerthYang, H.Y.1    Shao, R.2    Hung, M.C.3    Lee, M.H.4
  • 54
    • 0036710683 scopus 로고    scopus 로고
    • ErbB-2-induced mammary tumor growth: The role of cyclin D1 and p27Kip1
    • DOI 10.1016/S0006-2952(02)01145-0, PII S0006295202011450
    • Hulit J, Lee RJ, Russell RG, Pestell RG. ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1. Biochem Pharmacol. 2002; 64(5-6):827-836. (Pubitemid 35232256)
    • (2002) Biochemical Pharmacology , vol.64 , Issue.5-6 , pp. 827-836
    • Hulit, J.1    Lee, R.J.2    Russell, R.G.3    Pestell, R.G.4
  • 55
    • 0034092911 scopus 로고    scopus 로고
    • Regulation of the Cdk inhibitor p27 and its deregulation in cancer
    • DOI 10.1002/(SICI)1097-4652(200004)183:1<10::AID-JCP2>3.0.CO;2-I
    • Slingerland J, Pagano M. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol. 2000;183(1):10-17. (Pubitemid 30130220)
    • (2000) Journal of Cellular Physiology , vol.183 , Issue.1 , pp. 10-17
    • Slingerland, J.1    Pagano, M.2
  • 56
    • 33644509197 scopus 로고    scopus 로고
    • Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity
    • Wu FY, et al. Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity. Cancer Res. 2006;66(4):2162-2172.
    • (2006) Cancer Res. , vol.66 , Issue.4 , pp. 2162-2172
    • Wu, F.Y.1
  • 58
    • 71049162928 scopus 로고    scopus 로고
    • Exogenous p27KIP1 expression induces anti-tumour effects and inhibits the EGFR/PI3K/Akt signalling pathway in PC3 cells
    • Chen J, Xia D, Luo JD, Wang P. Exogenous p27KIP1 expression induces anti-tumour effects and inhibits the EGFR/PI3K/Akt signalling pathway in PC3 cells. Asian J Androl. 2009;11(6):669-677.
    • (2009) Asian J Androl. , vol.11 , Issue.6 , pp. 669-677
    • Chen, J.1    Xia, D.2    Luo, J.D.3    Wang, P.4
  • 59
    • 30344479175 scopus 로고    scopus 로고
    • Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
    • DOI 10.1016/j.ccr.2005.12.019, PII S153561080500396X
    • Landis MW, Pawlyk BS, Li T, Sicinski P, Hinds PW. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell. 2006;9(1):13-22. (Pubitemid 43069507)
    • (2006) Cancer Cell , vol.9 , Issue.1 , pp. 13-22
    • Landis, M.W.1    Pawlyk, B.S.2    Li, T.3    Sicinski, P.4    Hinds, P.W.5
  • 61
    • 38149137411 scopus 로고    scopus 로고
    • The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling
    • Brantley-Sieders DM, et al. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest. 2008;118(1):64-78.
    • (2008) J Clin Invest. , vol.118 , Issue.1 , pp. 64-78
    • Brantley-Sieders, D.M.1
  • 63
    • 33646422461 scopus 로고    scopus 로고
    • p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis
    • Cabodi S, et al. p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. Cancer Res. 2006;66(9):4672-4680.
    • (2006) Cancer Res. , vol.66 , Issue.9 , pp. 4672-4680
    • Cabodi, S.1
  • 64
    • 35648970074 scopus 로고    scopus 로고
    • IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells
    • DOI 10.1073/pnas.0706728104
    • Cao Y, Luo JL, Karin M. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A. 2007;104(40):15852-15857. (Pubitemid 350035388)
    • (2007) Proceedings of the National Academy of Sciences of the United States of America , vol.104 , Issue.40 , pp. 15852-15857
    • Cao, Y.1    Luo, J.-L.2    Karin, M.3
  • 68
    • 33846416534 scopus 로고    scopus 로고
    • Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/Neu and MMTV-polyoma middle T transgenic mice
    • DOI 10.1158/0008-5472.CAN-06-3782
    • Maroulakou IG, Oemler W, Naber SP, Tsichlis PN. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res. 2007;67(1):167-177. (Pubitemid 46142772)
    • (2007) Cancer Research , vol.67 , Issue.1 , pp. 167-177
    • Maroulakou, I.G.1    Oemler, W.2    Naber, S.P.3    Tsichlis, P.N.4
  • 72
  • 74
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • DOI 10.1038/35082500
    • Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature. 2001;411(6841):1017-1021. (Pubitemid 32612319)
    • (2001) Nature , vol.411 , Issue.6841 , pp. 1017-1021
    • Yu, Q.1    Geng, Y.2    Sicinski, P.3
  • 75
    • 0347319028 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression
    • DOI 10.1038/sj.onc.1206983
    • Gillgrass A, Cardiff RD, Sharan N, Kannan S, Muller WJ. Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression. Oncogene. 2003; 22(57):9151-9155. (Pubitemid 38067990)
    • (2003) Oncogene , vol.22 , Issue.57 , pp. 9151-9155
    • Gillgrass, A.1    Cardiff, R.D.2    Sharan, N.3    Kannan, S.4    Muller, W.J.5
  • 76
    • 42049084166 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis
    • DOI 10.1158/0008-5472.CAN-07-5727
    • Dourdin N, et al. Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis. Cancer Res. 2008; 68(7):2122-2131. (Pubitemid 351521784)
    • (2008) Cancer Research , vol.68 , Issue.7 , pp. 2122-2131
    • Dourdin, N.1    Schade, B.2    Lesurf, R.3    Hallett, M.4    Munn, R.J.5    Cardiff, R.D.6    Muller, W.J.7
  • 77
    • 0035947771 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function
    • Muraoka RS, et al. Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function. J Cell Biol. 2001;153(5):917-932.
    • (2001) J Cell Biol. , vol.153 , Issue.5 , pp. 917-932
    • Muraoka, R.S.1
  • 80
  • 81
    • 0034682818 scopus 로고    scopus 로고
    • Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability
    • Ishida N, Kitagawa M, Hatakeyama S, Nakayama K. Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. J Biol Chem. 2000;275(33):25146-25154.
    • (2000) J Biol Chem. , vol.275 , Issue.33 , pp. 25146-25154
    • Ishida, N.1    Kitagawa, M.2    Hatakeyama, S.3    Nakayama, K.4
  • 82
    • 12544259437 scopus 로고    scopus 로고
    • Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation
    • Kotake Y, Nakayama K, Ishida N, Nakayama KI. Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J Biol Chem. 2005;280(2):1095-1102.
    • (2005) J Biol Chem. , vol.280 , Issue.2 , pp. 1095-1102
    • Kotake, Y.1    Nakayama, K.2    Ishida, N.3    Nakayama, K.I.4
  • 83
    • 77449105717 scopus 로고    scopus 로고
    • An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer
    • Bild AH, et al. An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer. Breast Cancer Res. 2009;11(4):R55.
    • (2009) Breast Cancer Res. , vol.11 , Issue.4
    • Bild, A.H.1
  • 84
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz JI, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007;8(5):R76.
    • (2007) Genome Biol. , vol.8 , Issue.5
    • Herschkowitz, J.I.1
  • 85
    • 68949209109 scopus 로고    scopus 로고
    • A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response
    • Chandriani S, et al. A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response. PLoS One. 2009;4(8):e6693.
    • (2009) PLoS One , vol.4 , Issue.8
    • Chandriani, S.1
  • 86
    • 66649093842 scopus 로고    scopus 로고
    • Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
    • Agarwal R, et al. Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer. Clin Cancer Res. 2009;15(11):3654-3662.
    • (2009) Clin Cancer Res. , vol.15 , Issue.11 , pp. 3654-3662
    • Agarwal, R.1
  • 87
    • 77249126947 scopus 로고    scopus 로고
    • HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1
    • Quintela-Fandino M, et al. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. Proc Natl Acad Sci U S A. 2010;107(6):2622-2627.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.6 , pp. 2622-2627
    • Quintela-Fandino, M.1
  • 88
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • DOI 10.1056/NEJM200104053441402
    • Druker BJ, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001;344(14):1038-1042. (Pubitemid 32267973)
    • (2001) New England Journal of Medicine , vol.344 , Issue.14 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3    Resta, D.J.4    Reese, S.F.5    Ford, J.M.6    Capdeville, R.7    Talpaz, M.8
  • 90
    • 0037106377 scopus 로고    scopus 로고
    • Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: Results of a phase I trial
    • Herbst RS, et al. Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial. J Clin Oncol. 2002; 20(18):3815-3825.
    • (2002) J Clin Oncol. , vol.20 , Issue.18 , pp. 3815-3825
    • Herbst, R.S.1
  • 92
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
    • DOI 10.1038/74704
    • Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med. 2000;6(4):443-446. (Pubitemid 30208162)
    • (2000) Nature Medicine , vol.6 , Issue.4 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 93
    • 0028063457 scopus 로고
    • Neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors
    • Morrison BW, Leder P. neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. Oncogene. 1994;9(12):3417-3426. (Pubitemid 24359377)
    • (1994) Oncogene , vol.9 , Issue.12 , pp. 3417-3426
    • Morrison, B.W.1    Leder, P.2
  • 94
    • 0029150669 scopus 로고
    • Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
    • Kohl NE, et al. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat Med. 1995; 1(8):792-797.
    • (1995) Nat Med. , vol.1 , Issue.8 , pp. 792-797
    • Kohl, N.E.1
  • 96
    • 24144465745 scopus 로고    scopus 로고
    • Cloning of short hairpin RNAs for gene knockdown in mammalian cells
    • Paddison PJ, et al. Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Methods. 2004;1(2):163-167.
    • (2004) Nat Methods , vol.1 , Issue.2 , pp. 163-167
    • Paddison, P.J.1
  • 97
    • 0031569873 scopus 로고    scopus 로고
    • Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues
    • DOI 10.1006/dbio.1997.8526
    • Rajan JV, Marquis ST, Gardner HP, Chodosh LA. Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev Biol. 1997;184(2):385-401. (Pubitemid 27224359)
    • (1997) Developmental Biology , vol.184 , Issue.2 , pp. 385-401
    • Rajan, J.V.1    Marquis, S.T.2    Gardner, H.P.3    Chodosh, L.A.4
  • 98
    • 0029115660 scopus 로고
    • The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues
    • Marquis ST, et al. The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nat Genet. 1995; 11(1):17-26.
    • (1995) Nat Genet. , vol.11 , Issue.1 , pp. 17-26
    • Marquis, S.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.