-
1
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74-108.
-
(2005)
CA Cancer J Clin.
, vol.55
, Issue.2
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
2
-
-
0034004222
-
Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase
-
DOI 10.1006/geno.1999.6078
-
Gardner HP, et al. Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. Genomics. 2000;63(1):46-59. (Pubitemid 30112238)
-
(2000)
Genomics
, vol.63
, Issue.1
, pp. 46-59
-
-
Gardner, H.P.1
Wertheim, G.B.W.2
Ha, S.I.3
Copeland, N.G.4
Gilbert, D.J.5
Jenkins, N.A.6
Marquis, S.T.7
Chodosh, L.A.8
-
3
-
-
0033739742
-
Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland
-
Gardner HP, et al. Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland. Development. 2000;127(20):4493-4509.
-
(2000)
Development
, vol.127
, Issue.20
, pp. 4493-4509
-
-
Gardner, H.P.1
-
4
-
-
0034642870
-
Protein kinase expression during murine mammary development
-
DOI 10.1006/dbio.2000.9614
-
Chodosh LA, Gardner HP, Rajan JV, Stairs DB, Marquis ST, Leder PA. Protein kinase expression during murine mammary development. Dev Biol. 2000;219(2):259-276. (Pubitemid 30152604)
-
(2000)
Developmental Biology
, vol.219
, Issue.2
, pp. 259-276
-
-
Chodosh, L.A.1
Gardner, H.P.2
Rajan, J.V.3
Stairs, D.B.4
Marquis, S.T.5
Leder, P.A.6
-
5
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
-
Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005;1(1):15-25. (Pubitemid 43960587)
-
(2005)
Cell Metabolism
, vol.1
, Issue.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
6
-
-
25444524850
-
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
-
DOI 10.1074/jbc.M502876200
-
Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem. 2005; 280(37):32081-32089. (Pubitemid 41361813)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.37
, pp. 32081-32089
-
-
Hahn-Windgassen, A.1
Nogueira, V.2
Chen, C.-C.3
Skeen, J.E.4
Sonenberg, N.5
Hay, N.6
-
7
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
DOI 10.1016/j.molcel.2005.03.027, PII S1097276505012207
-
Jones RG, et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell. 2005;18(3):283-293. (Pubitemid 41350534)
-
(2005)
Molecular Cell
, vol.18
, Issue.3
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
Birnbaum, M.J.7
Thompson, C.B.8
-
8
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
DOI 10.1073/pnas.0308061100
-
Shaw RJ, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004;101(10):3329-3335. (Pubitemid 38338195)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.10
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
9
-
-
0035930343
-
C-TAK1 Regulates Ras Signaling by Phosphorylating the MAPK Scaffold, KSR1
-
DOI 10.1016/S1097-2765(01)00383-5
-
Muller J, Ory S, Copeland T, Piwnica-Worms H, Morrison DK. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol Cell. 2001;8(5):983-993. (Pubitemid 34031801)
-
(2001)
Molecular Cell
, vol.8
, Issue.5
, pp. 983-993
-
-
Muller, J.1
Ory, S.2
Copeland, T.3
Piwnica-Worms, H.4
Morrison, D.K.5
-
10
-
-
0023818801
-
Loss of a Mr 78,000 marker in chemically induced transplantable carcinomas and primary carcinoma of human pancreas
-
Parsa I. Loss of a Mr 78,000 marker in chemically induced transplantable carcinomas and primary carcinoma of human pancreas. Cancer Res. 1988;48(8):2265-2272.
-
(1988)
Cancer Res.
, vol.48
, Issue.8
, pp. 2265-2272
-
-
Parsa, I.1
-
11
-
-
20444399500
-
Regulation of SNARK activity in response to cellular stresses
-
DOI 10.1016/j.bbagen.2005.03.015, PII S0304416505000930
-
Lefebvre DL, Rosen CF. Regulation of SNARK activity in response to cellular stresses. Biochim Biophys Acta. 2005;1724(1-2):71-85. (Pubitemid 40799112)
-
(2005)
Biochimica et Biophysica Acta - General Subjects
, vol.1724
, Issue.1-2
, pp. 71-85
-
-
Lefebvre, D.L.1
Rosen, C.F.2
-
12
-
-
1242289417
-
Strong association of ARK5 with tumor invasion and metastasis
-
Kusakai G, Suzuki A, Ogura T, Kaminishi M, Esumi H. Strong association of ARK5 with tumor invasion and metastasis. J Exp Clin Cancer Res. 2004; 23(2):263-268. (Pubitemid 38943558)
-
(2004)
Journal of Experimental and Clinical Cancer Research
, vol.23
, Issue.2
, pp. 263-268
-
-
Kusakai, G.1
Suzuki, A.2
Ogura, T.3
Kaminishi, M.4
Esumi, H.5
-
13
-
-
1842505299
-
ARK5 Is a Tumor Invasion-Associated Factor Downstream of Akt Signaling
-
DOI 10.1128/MCB.24.8.3526-3535.2004
-
Suzuki A, Lu J, Kusakai G, Kishimoto A, Ogura T, Esumi H. ARK5 is a tumor invasion-associated factor downstream of Akt signaling. Mol Cell Biol. 2004;24(8):3526-3535. (Pubitemid 38452091)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.8
, pp. 3526-3535
-
-
Suzuki, A.1
Lu, J.2
Kusakai, G.-I.3
Kishimoto, A.4
Ogura, T.5
Esumi, H.6
-
14
-
-
70349445613
-
The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis
-
Wertheim GB, et al. The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proc Natl Acad Sci U S A. 2009;106(37):15855-15860.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.37
, pp. 15855-15860
-
-
Wertheim, G.B.1
-
15
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235(4785):177-182. (Pubitemid 17231334)
-
(1987)
Science
, vol.235
, Issue.4785
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
16
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ, et al. Studies of the HER-2/neu protooncogene in human breast and ovarian cancer. Science. 1989;244(4905):707-712. (Pubitemid 19147683)
-
(1989)
Science
, vol.244
, Issue.4905
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
Holt, J.A.4
Wong, S.G.5
Keith, D.E.6
Levin, W.J.7
Stuart, S.G.8
Udove, J.9
Ullrich, A.10
Press, M.F.11
-
17
-
-
17744415869
-
Studies of the HER-2/neu proto-oncogene in human breast cancer
-
Slamon DJ. Studies of the HER-2/neu proto-oncogene in human breast cancer. Cancer Invest. 1990; 8(2):253.
-
(1990)
Cancer Invest.
, vol.8
, Issue.2
, pp. 253
-
-
Slamon, D.J.1
-
18
-
-
0027880138
-
Prognostic factors and response to therapy in breast cancer
-
Klijn J, Berns E, Foekens J. Prognostic factors and response to therapy in breast cancer. In: Fentiman I, Taylor-Papadimitriou J, eds. Breast Cancer. Cold Spring Harbor, New York, USA: Cold Spring Harbor Laboratory Press; 1993:165-198. (Pubitemid 24110639)
-
(1993)
Cancer Surveys
, vol.18
, pp. 165-198
-
-
Klijn, J.G.M.1
Berns, E.M.J.J.2
Foekens, J.A.3
-
19
-
-
0033651234
-
The molecular and cellular biology of HER2/neu gene amplification/ overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer
-
Pegram MD, Konecny G, Slamon DJ. The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer. Cancer Treat Res. 2000;103:57-75.
-
(2000)
Cancer Treat Res.
, vol.103
, pp. 57-75
-
-
Pegram, M.D.1
Konecny, G.2
Slamon, D.J.3
-
20
-
-
0034254775
-
Herceptin (trastuzamab) in advanced breast cancer
-
DOI 10.1053/ctrv.2000.0182
-
Stebbing J, Copson E, O'Reilly S. Herceptin (trastuzamab) in advanced breast cancer. Cancer Treat Rev. 2000;26(4):287-290. (Pubitemid 30604039)
-
(2000)
Cancer Treatment Reviews
, vol.26
, Issue.4
, pp. 287-290
-
-
Stebbing, J.1
Copson, E.2
O'Reilly, S.3
-
21
-
-
0035680514
-
Overview of treatment results with trastuzumab (Herceptin) in metastatic breast cancer
-
Hortobagyi GN. Overview of treatment results with trastuzumab (Herceptin) in metastatic breast cancer. Semin Oncol. 2001;28(6 suppl 18):43-47. (Pubitemid 34062048)
-
(2001)
Seminars in Oncology
, vol.28
, Issue.6 SUPPL. 18
, pp. 43-47
-
-
Hortobagyi, G.N.1
-
22
-
-
0035680513
-
Targeting HER2: Recent developments and future directions for breast cancer patients
-
Wang SC, Zhang L, Hortobagyi GN, Hung MC. Targeting HER2: recent developments and future directions for breast cancer patients. Semin Oncol. 2001;28(6 suppl 18):21-29. (Pubitemid 34062045)
-
(2001)
Seminars in Oncology
, vol.28
, Issue.6 SUPPL. 18
, pp. 21-29
-
-
Shao-Chun, W.1
Lisha, Z.2
Hortobagyi, G.N.3
Mien-Chie, H.4
-
23
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
DOI 10.1200/JCO.20.3.719
-
Vogel CL, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2002;20(3):719-726. (Pubitemid 34111379)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.3
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
Slamon, D.J.7
Murphy, M.8
Novotny, W.F.9
Burchmore, M.10
Shak, S.11
Stewart, S.J.12
Press, M.13
-
24
-
-
57149096463
-
Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer
-
Di Leo A, et al. Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. J Clin Oncol. 2008;26(34):5544-5552.
-
(2008)
J Clin Oncol.
, vol.26
, Issue.34
, pp. 5544-5552
-
-
Di Leo, A.1
-
25
-
-
46449113024
-
Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer
-
Gomez HL, et al. Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol. 2008;26(18):2999-3005.
-
(2008)
J Clin Oncol.
, vol.26
, Issue.18
, pp. 2999-3005
-
-
Gomez, H.L.1
-
26
-
-
42449124652
-
Can we circumvent resistance to ErbB2-targeted agents by targeting novel pathways?
-
DOI 10.3816/CBC.2008.s.008
-
Pegram M. Can we circumvent resistance to ErbB2-targeted agents by targeting novel pathways? Clin Breast Cancer. 2008;8 suppl 3:S121-S130. (Pubitemid 351568674)
-
(2008)
Clinical Breast Cancer
, vol.8
, Issue.SUPPL. 3
-
-
Pegram, M.1
-
27
-
-
0036187113
-
A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology
-
DOI 10.1096/fj.01-0551com
-
Gunther EJ, et al. A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology. FASEB J. 2002;16(3):283-292. (Pubitemid 34195290)
-
(2002)
FASEB Journal
, vol.16
, Issue.3
, pp. 283-292
-
-
Gunther, E.J.1
Belka, G.K.2
Wertheim, G.B.W.3
Wang, J.4
Hartman, J.L.5
Boxer, R.B.6
Chodosh, L.A.7
-
28
-
-
24944450362
-
The transcriptional repressor Snail promotes mammary tumor recurrence
-
Moody SE, et al. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell. 2005;8(3):197-209.
-
(2005)
Cancer Cell.
, vol.8
, Issue.3
, pp. 197-209
-
-
Moody, S.E.1
-
29
-
-
19044370434
-
Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis
-
Moody SE, et al. Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis. Cancer Cell. 2002;2(6):451-461.
-
(2002)
Cancer Cell.
, vol.2
, Issue.6
, pp. 451-461
-
-
Moody, S.E.1
-
30
-
-
0035893560
-
Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
-
Moulder SL, Yakes FM, Muthuswamy SK, Bianco R, Simpson JF, Arteaga CL. Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res. 2001;61(24):8887-8895. (Pubitemid 34013905)
-
(2001)
Cancer Research
, vol.61
, Issue.24
, pp. 8887-8895
-
-
Moulder, S.L.1
Yakes, F.M.2
Muthuswamy, S.K.3
Bianco, R.4
Simpson, J.F.5
Arteaga, C.L.6
-
31
-
-
0842349390
-
Subcellular localization of MAK-V/Hunk protein kinase expressed in COS-1 cells
-
DOI 10.1016/j.cellbi.2003.10.002
-
Korobko EV, Kiselev SL, Korobko IV. Subcellular localization of MAK-V/Hunk protein kinase expressed in COS-1 cells. Cell Biol Int. 2004;28(1):49-56. (Pubitemid 38169015)
-
(2004)
Cell Biology International
, vol.28
, Issue.1
, pp. 49-56
-
-
Korobko, E.V.1
Kiselev, S.L.2
Korobko, I.V.3
-
32
-
-
0027439438
-
The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP
-
DOI 10.1073/pnas.90.2.442
-
Carrera AC, Alexandrov K, Roberts TM. The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP. Proc Natl Acad Sci U S A. 1993;90(2):442-446. (Pubitemid 23028879)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.2
, pp. 442-446
-
-
Carrera, A.C.1
Alexandrov, K.2
Roberts, T.M.3
-
33
-
-
0029020282
-
Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
-
Hanks SK, Hunter T. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 1995;9(8):576-596.
-
(1995)
FASEB J.
, vol.9
, Issue.8
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
34
-
-
0034722889
-
The EGF receptor family as targets for cancer therapy
-
DOI 10.1038/sj.onc.1204082
-
Mendelsohn J, Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene. 2000; 19(56):6550-6565. (Pubitemid 32197693)
-
(2000)
Oncogene
, vol.19
, Issue.56
, pp. 6550-6565
-
-
Mendelsohn, J.1
Baselga, J.2
-
35
-
-
0028176483
-
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
-
Polyak K, et al. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994;78(1):59-66.
-
(1994)
Cell.
, vol.78
, Issue.1
, pp. 59-66
-
-
Polyak, K.1
-
36
-
-
16944363001
-
Decreased levels of the cell-cycle inhibitor p27(Kip1) protein: Prognostic implications in primary breast cancer
-
DOI 10.1038/nm0297-227
-
Catzavelos C, et al. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer. Nat Med. 1997;3(2):227-230. (Pubitemid 27064710)
-
(1997)
Nature Medicine
, vol.3
, Issue.2
, pp. 227-230
-
-
Catzavelos, C.1
Bhattacharya, N.2
Ung, Y.C.3
Wilson, J.A.4
Roncari, L.5
Sandhu, C.6
Shaw, P.7
Yeger, H.8
Morava-Protzner, I.9
Kapusta, L.10
Franssen, E.11
Pritchard, K.I.12
Slingerland, J.M.13
-
37
-
-
0032511848
-
The murine gene p27(Kip 1) is haplo-insufficient for tumour suppression
-
DOI 10.1038/24179
-
Fero ML, Randel E, Gurley KE, Roberts JM, Kemp CJ. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature. 1998; 396(6707):177-180. (Pubitemid 28523620)
-
(1998)
Nature
, vol.396
, Issue.6707
, pp. 177-180
-
-
Fero, M.L.1
Randel, E.2
Gurley, K.E.3
Roberts, J.M.4
Kemp, C.J.5
-
38
-
-
0035065282
-
Correlation of p27 protein expression with HER-2/neu expression in breast cancer
-
DOI 10.1002/mc.1025
-
Newman L, et al. Correlation of p27 protein expression with HER-2/neu expression in breast cancer. Mol Carcinog. 2001;30(3):169-175. (Pubitemid 32274080)
-
(2001)
Molecular Carcinogenesis
, vol.30
, Issue.3
, pp. 169-175
-
-
Newman, L.1
Xia, W.2
Yang, H.-Y.3
Sahin, A.4
Bondy, M.5
Lukmanji, F.6
Hung, M.-C.7
Lee, M.-H.8
-
39
-
-
0037377745
-
Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: Results from International Breast Cancer Study Group Trial V
-
DOI 10.1002/cncr.11224
-
Spataro VJ, et al. Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: results from International Breast Cancer Study Group Trial V. Cancer. 2003;97(7):1591-1600. (Pubitemid 36350701)
-
(2003)
Cancer
, vol.97
, Issue.7
, pp. 1591-1600
-
-
Spataro, V.J.1
Litman, H.2
Viale, G.3
Maffini, F.4
Masullo, M.5
Golouh, R.6
Martinez-Tello, F.J.7
Grigolato, P.8
Shilkin, K.B.9
Gusterson, B.A.10
Castiglione-Gertsch, M.11
Price, K.12
Lindtner, J.13
Cortes-Funes, H.14
Simoncini, E.15
Byrne, M.J.16
Collins, J.17
Gelber, R.D.18
Coates, A.S.19
Goldhirsch, A.20
more..
-
40
-
-
0035835828
-
Kip1: Regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer
-
DOI 10.1006/excr.2000.5143
-
Philipp-Staheli J, Payne SR, Kemp CJ. p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp Cell Res. 2001;264(1):148-168. (Pubitemid 32989089)
-
(2001)
Experimental Cell Research
, vol.264
, Issue.1
, pp. 148-168
-
-
Philipp-Staheli, J.1
Payne, S.R.2
Kemp, C.J.3
-
41
-
-
0034637527
-
Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27
-
DOI 10.1074/jbc.C000147200
-
Yang HY, Zhou BP, Hung MC, Lee MH. Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27. J Biol Chem. 2000;275(32):24735-24739. (Pubitemid 30626576)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.32
, pp. 24735-24739
-
-
Yang, H.-Y.1
Zhou, B.P.2
Hung, M.-C.3
Lee, M.-H.4
-
42
-
-
0033996361
-
ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: Receptor overexpression does not determine growth dependency
-
DOI 10.1128/MCB.20.9.3210-3223.2000
-
Lane HA, Beuvink I, Motoyama AB, Daly JM, Neve RM, Hynes NE. ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)- Cdk2 complex formation: receptor overexpression does not determine growth dependency. Mol Cell Biol. 2000;20(9):3210-3223. (Pubitemid 30215033)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.9
, pp. 3210-3223
-
-
Lane, H.A.1
Beuvink, I.2
Motoyama, A.B.3
Daly, J.M.4
Neve, R.M.5
Hynes, N.E.6
-
43
-
-
0035419867
-
Kip1and cyclin D1 through multiple signaling pathways
-
Lenferink AE, Busse D, Flanagan WM, Yakes FM, Arteaga CL. ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways. Cancer Res. 2001;61(17):6583-6591. (Pubitemid 32783268)
-
(2001)
Cancer Research
, vol.61
, Issue.17
, pp. 6583-6591
-
-
Lenferink, A.E.G.1
Busse, D.2
Flanagan, W.M.3
Yakes, F.M.4
Arteaga, C.L.5
-
44
-
-
0038607569
-
The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition
-
Le XF, et al. The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition. J Biol Chem. 2003;278(26):23441-23450.
-
(2003)
J Biol Chem.
, vol.278
, Issue.26
, pp. 23441-23450
-
-
Le, X.F.1
-
45
-
-
22844439340
-
HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways
-
Le XF, Pruefer F, Bast RC Jr. HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways. Cell Cycle. 2005;4(1):87-95.
-
(2005)
Cell Cycle
, vol.4
, Issue.1
, pp. 87-95
-
-
Le, X.F.1
Pruefer, F.2
Bast Jr., R.C.3
-
46
-
-
6344270303
-
Kip1-mediated antiproliferative effect of trastuzumab (Herceptin) on HER2-overexpressing tumor cells
-
DOI 10.1002/ijc.20378
-
Marches R, Uhr JW. Enhancement of the p27Kip1-mediated antiproliferative effect of trastuzumab (Herceptin) on HER2-overexpressing tumor cells. Int J Cancer. 2004;112(3):492-501. (Pubitemid 39390616)
-
(2004)
International Journal of Cancer
, vol.112
, Issue.3
, pp. 492-501
-
-
Marches, R.1
Uhr, J.W.2
-
47
-
-
0037099532
-
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
-
Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL. Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res. 2002;62(14):4132-4141. (Pubitemid 34791085)
-
(2002)
Cancer Research
, vol.62
, Issue.14
, pp. 4132-4141
-
-
Yakes, F.M.1
Chinratanalab, W.2
Ritter, C.A.3
King, W.4
Seelig, S.5
Arteaga, C.L.6
-
48
-
-
0033060097
-
Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma
-
DOI 10.1002/(SICI)1097-0215(19990621)84:3<315::AID-IJC20>3.0.CO;2-U
-
Fujieda S, et al. Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma. Int J Cancer. 1999;84(3):315-320. (Pubitemid 29256761)
-
(1999)
International Journal of Cancer
, vol.84
, Issue.3
, pp. 315-320
-
-
Fujieda, S.1
Inuzuka, M.2
Tanaka, N.3
Sunaga, H.4
Fan, G.-K.5
Ito, T.6
Sugimoto, C.7
Tsuzuki, H.8
Saito, H.9
-
49
-
-
0033843368
-
1 phase and subsequent apoptosis in HCC-9204 cell line
-
Li J, et al. Overexpression of p27(KIP1) induced cell cycle arrest in G(1) phase and subsequent apoptosis in HCC-9204 cell line. World J Gastroenterol. 2000;6(4):513-521. (Pubitemid 30665261)
-
(2000)
World Journal of Gastroenterology
, vol.6
, Issue.4
, pp. 513-521
-
-
Li, J.1
Yang, X.K.2
Yu, X.X.3
Ge, M.L.4
Wang, W.L.5
Zhang, J.6
Hou, Y.D.7
-
50
-
-
0036124467
-
ErbB2/neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells
-
DOI 10.1128/MCB.22.7.2204-2219.2002
-
Muraoka RS, et al. ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. Mol Cell Biol. 2002;22(7):2204-2219. (Pubitemid 34224627)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.7
, pp. 2204-2219
-
-
Muraoka, R.S.1
Lenferink, A.E.G.2
Law, B.3
Hamilton, E.4
Brantley, D.M.5
Roebuck, L.R.6
Arteaga, C.L.7
-
51
-
-
0035927582
-
p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis
-
werthYang HY, Shao R, Hung MC, Lee MH. p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis. Oncogene. 2001;20(28):3695- 3702.
-
(2001)
Oncogene
, vol.20
, Issue.28
, pp. 3695-3702
-
-
WerthYang, H.Y.1
Shao, R.2
Hung, M.C.3
Lee, M.H.4
-
52
-
-
0142008438
-
Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin
-
DOI 10.1200/JCO.2003.02.021
-
Pohl G, et al. High p27Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin. J Clin Oncol. 2003;21(19):3594-3600. (Pubitemid 46594051)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.19
, pp. 3594-3600
-
-
Pohl, G.1
Rudas, M.2
Dietze, O.3
Lax, S.4
Markis, E.5
Pirker, R.6
Zielinski, C.C.7
Hausmaninger, H.8
Kubista, E.9
Samonigg, H.10
Jakesz, R.11
Filipits, M.12
-
53
-
-
0034238115
-
Down-regulation of p21(WAF1/CIP1) or p27(Kip1) abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells
-
DOI 10.1073/pnas.160016897
-
Cariou S, Donovan JC, Flanagan WM, Milic A, Bhattacharya N, Slingerland JM. Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells. Proc Natl Acad Sci U S A. 2000;97(16):9042-9046. (Pubitemid 30626670)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.16
, pp. 9042-9046
-
-
Cariou, S.1
Donovan, J.C.H.2
Flanagan, W.M.3
Milic, A.4
Bhattacharya, N.5
Slingerland, J.M.6
-
54
-
-
0036710683
-
ErbB-2-induced mammary tumor growth: The role of cyclin D1 and p27Kip1
-
DOI 10.1016/S0006-2952(02)01145-0, PII S0006295202011450
-
Hulit J, Lee RJ, Russell RG, Pestell RG. ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1. Biochem Pharmacol. 2002; 64(5-6):827-836. (Pubitemid 35232256)
-
(2002)
Biochemical Pharmacology
, vol.64
, Issue.5-6
, pp. 827-836
-
-
Hulit, J.1
Lee, R.J.2
Russell, R.G.3
Pestell, R.G.4
-
55
-
-
0034092911
-
Regulation of the Cdk inhibitor p27 and its deregulation in cancer
-
DOI 10.1002/(SICI)1097-4652(200004)183:1<10::AID-JCP2>3.0.CO;2-I
-
Slingerland J, Pagano M. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol. 2000;183(1):10-17. (Pubitemid 30130220)
-
(2000)
Journal of Cellular Physiology
, vol.183
, Issue.1
, pp. 10-17
-
-
Slingerland, J.1
Pagano, M.2
-
56
-
-
33644509197
-
Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity
-
Wu FY, et al. Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity. Cancer Res. 2006;66(4):2162-2172.
-
(2006)
Cancer Res.
, vol.66
, Issue.4
, pp. 2162-2172
-
-
Wu, F.Y.1
-
57
-
-
0035967099
-
Kip1 cyclin-dependent kinase inhibitor gene by c-Myc
-
DOI 10.1038/sj.onc.1204245
-
Yang W, et al. Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc. Oncogene. 2001;20(14):1688- 1702. (Pubitemid 32368016)
-
(2001)
Oncogene
, vol.20
, Issue.14
, pp. 1688-1702
-
-
Yang, W.1
Shen, J.2
Wu, M.3
Arsura, M.4
FitzGerald, M.5
Suldan, Z.6
Kim, D.W.7
Hofmann, C.S.8
Pianetti, S.9
Romieu-Mourez, R.10
Freedman, L.P.11
Sonenshein, G.E.12
-
58
-
-
71049162928
-
Exogenous p27KIP1 expression induces anti-tumour effects and inhibits the EGFR/PI3K/Akt signalling pathway in PC3 cells
-
Chen J, Xia D, Luo JD, Wang P. Exogenous p27KIP1 expression induces anti-tumour effects and inhibits the EGFR/PI3K/Akt signalling pathway in PC3 cells. Asian J Androl. 2009;11(6):669-677.
-
(2009)
Asian J Androl.
, vol.11
, Issue.6
, pp. 669-677
-
-
Chen, J.1
Xia, D.2
Luo, J.D.3
Wang, P.4
-
59
-
-
30344479175
-
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
-
DOI 10.1016/j.ccr.2005.12.019, PII S153561080500396X
-
Landis MW, Pawlyk BS, Li T, Sicinski P, Hinds PW. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell. 2006;9(1):13-22. (Pubitemid 43069507)
-
(2006)
Cancer Cell
, vol.9
, Issue.1
, pp. 13-22
-
-
Landis, M.W.1
Pawlyk, B.S.2
Li, T.3
Sicinski, P.4
Hinds, P.W.5
-
60
-
-
30044434225
-
A role for the scaffolding adapter GAB2 in breast cancer
-
DOI 10.1038/nm1341
-
Bentires-Alj M, et al. A role for the scaffolding adapter GAB2 in breast cancer. Nat Med. 2006; 12(1):114-121. (Pubitemid 43050085)
-
(2006)
Nature Medicine
, vol.12
, Issue.1
, pp. 114-121
-
-
Bentires-Alj, M.1
Gil, S.G.2
Chan, R.3
Wang, Z.C.4
Wang, Y.5
Imanaka, N.6
Harris, L.N.7
Richardson, A.8
Neel, B.G.9
Gu, H.10
-
61
-
-
38149137411
-
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling
-
Brantley-Sieders DM, et al. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest. 2008;118(1):64-78.
-
(2008)
J Clin Invest.
, vol.118
, Issue.1
, pp. 64-78
-
-
Brantley-Sieders, D.M.1
-
62
-
-
1842483852
-
Arf pathway
-
DOI 10.1038/ng1317
-
Bulavin DV, et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet. 2004; 36(4):343-350. (Pubitemid 38437256)
-
(2004)
Nature Genetics
, vol.36
, Issue.4
, pp. 343-350
-
-
Bulavin, D.V.1
Phillips, C.2
Nannenga, B.3
Timofeev, O.4
Donehower, L.A.5
Anderson, C.W.6
Appella, E.7
Fornace Jr., A.J.8
-
63
-
-
33646422461
-
p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis
-
Cabodi S, et al. p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. Cancer Res. 2006;66(9):4672-4680.
-
(2006)
Cancer Res.
, vol.66
, Issue.9
, pp. 4672-4680
-
-
Cabodi, S.1
-
64
-
-
35648970074
-
IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells
-
DOI 10.1073/pnas.0706728104
-
Cao Y, Luo JL, Karin M. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A. 2007;104(40):15852-15857. (Pubitemid 350035388)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.40
, pp. 15852-15857
-
-
Cao, Y.1
Luo, J.-L.2
Karin, M.3
-
65
-
-
0037731266
-
The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis
-
D'Amico M, et al. The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis. Cancer Res. 2003; 63(12):3395-3402. (Pubitemid 36735900)
-
(2003)
Cancer Research
, vol.63
, Issue.12
, pp. 3395-3402
-
-
D'Amico, M.1
Wu, K.2
Di, V.D.3
Reutens, A.T.4
Stahl, M.5
Fu, M.6
Albanese, C.7
Russell, R.G.8
Muller, W.J.9
White, M.10
Negassa, A.11
Lee, H.-W.12
DePinho, R.A.13
Pestell, R.G.14
-
66
-
-
34547463076
-
Role of Gab2 in mammary tumorigenesis and metastasis
-
DOI 10.1038/sj.onc.1210315, PII 1210315
-
Ke Y, et al. Role of Gab2 in mammary tumorigenesis and metastasis. Oncogene. 2007;26(34):4951-4960. (Pubitemid 47172654)
-
(2007)
Oncogene
, vol.26
, Issue.34
, pp. 4951-4960
-
-
Ke, Y.1
Wu, D.2
Princen, F.3
Nguyen, T.4
Pang, Y.5
Lesperance, J.6
Muller, W.J.7
Oshima, R.G.8
Feng, G.-S.9
-
67
-
-
0030946970
-
Neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice
-
Li B, Rosen JM, McMenamin-Balano J, Muller WJ, Perkins AS. neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice. Mol Cell Biol. 1997;17(6):3155-3163. (Pubitemid 27215030)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.6
, pp. 3155-3163
-
-
Li, B.1
Rosen, J.M.2
Mcmenamin-Balano, J.3
Muller, W.J.4
Perkins, A.S.5
-
68
-
-
33846416534
-
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/Neu and MMTV-polyoma middle T transgenic mice
-
DOI 10.1158/0008-5472.CAN-06-3782
-
Maroulakou IG, Oemler W, Naber SP, Tsichlis PN. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res. 2007;67(1):167-177. (Pubitemid 46142772)
-
(2007)
Cancer Research
, vol.67
, Issue.1
, pp. 167-177
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
Tsichlis, P.N.4
-
69
-
-
10144255098
-
Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice
-
Muller WJ, et al. Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice. Mol Cell Biol. 1996;16(10):5726-5736. (Pubitemid 26315093)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.10
, pp. 5726-5736
-
-
Muller, W.J.1
Arteaga, C.L.2
Muthuswamy, S.K.3
Siegel, P.M.4
Webster, M.A.5
Cardiff, R.D.6
Meise, K.S.7
Li, F.8
Halter, S.A.9
Coffey, R.J.10
-
70
-
-
0242552529
-
Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor beta1
-
DOI 10.1128/MCB.23.23.8691-8703.2003
-
Muraoka RS, et al. Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1. Mol Cell Biol. 2003;23(23):8691-8703. (Pubitemid 37433371)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.23
, pp. 8691-8703
-
-
Muraoka, R.S.1
Koh, Y.2
Roebuck, L.R.3
Sanders, M.E.4
Brantley-Sieders, D.5
Gorska, A.E.6
Moses, H.L.7
Arteaga, C.L.8
-
71
-
-
0036086409
-
Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases
-
DOI 10.1172/JCI200215234
-
Muraoka RS, et al. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest. 2002;109(12):1551-1559. (Pubitemid 34663517)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.12
, pp. 1551-1559
-
-
Muraoka, R.S.1
Dumont, N.2
Ritter, C.A.3
Dugger, T.C.4
Brantley, D.M.5
Chen, J.6
Easterly, E.7
Renee, R.L.8
Ryan, S.9
Gotwals, P.J.10
Koteliansky, V.11
Arteaga, C.L.12
-
72
-
-
33745050200
-
Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression
-
DOI 10.1038/sj.onc.1208964, PII 1208964
-
Muraoka-Cook RS, et al. Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene. 2006;25(24):3408-3423. (Pubitemid 43877044)
-
(2006)
Oncogene
, vol.25
, Issue.24
, pp. 3408-3423
-
-
Muraoka-Cook, R.S.1
Shin, I.2
Yi, J.Y.3
Easterly, E.4
Barcellos-Hoff, M.H.5
Yingling, J.M.6
Zent, R.7
Arteaga, C.L.8
-
73
-
-
34547107624
-
Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice
-
DOI 10.1158/0008-5472.CAN-06-4815
-
Ray D, et al. Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice. Cancer Res. 2007; 67(14):6605-6611. (Pubitemid 47105505)
-
(2007)
Cancer Research
, vol.67
, Issue.14
, pp. 6605-6611
-
-
Ray, D.1
Terao, Y.2
Nimbalkar, D.3
Hirai, H.4
Osmundson, E.C.5
Zou, X.6
Franks, R.7
Christov, K.8
Kiyokawa, H.9
-
74
-
-
0035963435
-
Specific protection against breast cancers by cyclin D1 ablation
-
DOI 10.1038/35082500
-
Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature. 2001;411(6841):1017-1021. (Pubitemid 32612319)
-
(2001)
Nature
, vol.411
, Issue.6841
, pp. 1017-1021
-
-
Yu, Q.1
Geng, Y.2
Sicinski, P.3
-
75
-
-
0347319028
-
Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression
-
DOI 10.1038/sj.onc.1206983
-
Gillgrass A, Cardiff RD, Sharan N, Kannan S, Muller WJ. Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression. Oncogene. 2003; 22(57):9151-9155. (Pubitemid 38067990)
-
(2003)
Oncogene
, vol.22
, Issue.57
, pp. 9151-9155
-
-
Gillgrass, A.1
Cardiff, R.D.2
Sharan, N.3
Kannan, S.4
Muller, W.J.5
-
76
-
-
42049084166
-
Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis
-
DOI 10.1158/0008-5472.CAN-07-5727
-
Dourdin N, et al. Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis. Cancer Res. 2008; 68(7):2122-2131. (Pubitemid 351521784)
-
(2008)
Cancer Research
, vol.68
, Issue.7
, pp. 2122-2131
-
-
Dourdin, N.1
Schade, B.2
Lesurf, R.3
Hallett, M.4
Munn, R.J.5
Cardiff, R.D.6
Muller, W.J.7
-
77
-
-
0035947771
-
Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function
-
Muraoka RS, et al. Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function. J Cell Biol. 2001;153(5):917-932.
-
(2001)
J Cell Biol.
, vol.153
, Issue.5
, pp. 917-932
-
-
Muraoka, R.S.1
-
78
-
-
29944440513
-
Kip1 stability, subcellular localization, and tumor suppression
-
DOI 10.1101/gad.1384406
-
Besson A, Gurian-West M, Chen X, Kelly-Spratt KS, Kemp CJ, Roberts JM. A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev. 2006;20(1):47-64. (Pubitemid 43042667)
-
(2006)
Genes and Development
, vol.20
, Issue.1
, pp. 47-64
-
-
Besson, A.1
Gurian-West, M.2
Chen, X.3
Kelly-Spratt, K.S.4
Kemp, C.J.5
Roberts, J.M.6
-
79
-
-
0037242575
-
Kip1 involves a nuclear export signal and links p27 export and proteolysis
-
DOI 10.1091/mbc.E02-06-0319
-
Connor MK, et al. CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis. Mol Biol Cell. 2003;14(1):201-213. (Pubitemid 36106030)
-
(2003)
Molecular Biology of the Cell
, vol.14
, Issue.1
, pp. 201-213
-
-
Connor, M.K.1
Kotchetkov, R.2
Cariou, S.3
Resch, A.4
Lupetti, R.5
Beniston, R.G.6
Melchior, F.7
Hengst, L.8
Slingerland, J.M.9
-
80
-
-
0037177386
-
Kip1on serine 10 is required for its binding to CRM1 and nuclear export
-
DOI 10.1074/jbc.C100762200
-
Ishida N, Hara T, Kamura T, Yoshida M, Nakayama K, Nakayama KI. Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem. 2002; 277(17):14355-14358. (Pubitemid 34952496)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.17
, pp. 14355-14358
-
-
Ishida, N.1
Hara, T.2
Kamura, T.3
Yoshida, M.4
Nakayama, K.5
Nakayama, K.I.6
-
81
-
-
0034682818
-
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability
-
Ishida N, Kitagawa M, Hatakeyama S, Nakayama K. Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. J Biol Chem. 2000;275(33):25146-25154.
-
(2000)
J Biol Chem.
, vol.275
, Issue.33
, pp. 25146-25154
-
-
Ishida, N.1
Kitagawa, M.2
Hatakeyama, S.3
Nakayama, K.4
-
82
-
-
12544259437
-
Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation
-
Kotake Y, Nakayama K, Ishida N, Nakayama KI. Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J Biol Chem. 2005;280(2):1095-1102.
-
(2005)
J Biol Chem.
, vol.280
, Issue.2
, pp. 1095-1102
-
-
Kotake, Y.1
Nakayama, K.2
Ishida, N.3
Nakayama, K.I.4
-
83
-
-
77449105717
-
An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer
-
Bild AH, et al. An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer. Breast Cancer Res. 2009;11(4):R55.
-
(2009)
Breast Cancer Res.
, vol.11
, Issue.4
-
-
Bild, A.H.1
-
84
-
-
34548863946
-
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
-
Herschkowitz JI, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007;8(5):R76.
-
(2007)
Genome Biol.
, vol.8
, Issue.5
-
-
Herschkowitz, J.I.1
-
85
-
-
68949209109
-
A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response
-
Chandriani S, et al. A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response. PLoS One. 2009;4(8):e6693.
-
(2009)
PLoS One
, vol.4
, Issue.8
-
-
Chandriani, S.1
-
86
-
-
66649093842
-
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
-
Agarwal R, et al. Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer. Clin Cancer Res. 2009;15(11):3654-3662.
-
(2009)
Clin Cancer Res.
, vol.15
, Issue.11
, pp. 3654-3662
-
-
Agarwal, R.1
-
87
-
-
77249126947
-
HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1
-
Quintela-Fandino M, et al. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. Proc Natl Acad Sci U S A. 2010;107(6):2622-2627.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.6
, pp. 2622-2627
-
-
Quintela-Fandino, M.1
-
88
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
DOI 10.1056/NEJM200104053441402
-
Druker BJ, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001;344(14):1038-1042. (Pubitemid 32267973)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
Resta, D.J.4
Reese, S.F.5
Ford, J.M.6
Capdeville, R.7
Talpaz, M.8
-
89
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
DOI 10.1056/NEJM200104053441401
-
Druker BJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001; 344(14):1031-1037. (Pubitemid 32267972)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
90
-
-
0037106377
-
Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: Results of a phase I trial
-
Herbst RS, et al. Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial. J Clin Oncol. 2002; 20(18):3815-3825.
-
(2002)
J Clin Oncol.
, vol.20
, Issue.18
, pp. 3815-3825
-
-
Herbst, R.S.1
-
91
-
-
0032851961
-
Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin)
-
Sliwkowski MX, Lofgren JA, Lewis GD, Hotaling TE, Fendly BM, Fox JA. Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). Semin Oncol. 1999;26(4 suppl 12):60-70. (Pubitemid 29411434)
-
(1999)
Seminars in Oncology
, vol.26
, Issue.4 SUPPL. 12
, pp. 60-70
-
-
Sliwkowski, M.X.1
Lofgren, J.A.2
Lewis, G.D.3
Hotaling, T.E.4
Fendly, B.M.5
Fox, J.A.6
-
92
-
-
0034076307
-
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
-
DOI 10.1038/74704
-
Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med. 2000;6(4):443-446. (Pubitemid 30208162)
-
(2000)
Nature Medicine
, vol.6
, Issue.4
, pp. 443-446
-
-
Clynes, R.A.1
Towers, T.L.2
Presta, L.G.3
Ravetch, J.V.4
-
93
-
-
0028063457
-
Neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors
-
Morrison BW, Leder P. neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. Oncogene. 1994;9(12):3417-3426. (Pubitemid 24359377)
-
(1994)
Oncogene
, vol.9
, Issue.12
, pp. 3417-3426
-
-
Morrison, B.W.1
Leder, P.2
-
94
-
-
0029150669
-
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
-
Kohl NE, et al. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat Med. 1995; 1(8):792-797.
-
(1995)
Nat Med.
, vol.1
, Issue.8
, pp. 792-797
-
-
Kohl, N.E.1
-
95
-
-
23144461051
-
Genes that mediate breast cancer metastasis to lung
-
DOI 10.1038/nature03799
-
Minn AJ, et al. Genes that mediate breast cancer metastasis to lung. Nature. 2005;436(7050):518-524. (Pubitemid 41112921)
-
(2005)
Nature
, vol.436
, Issue.7050
, pp. 518-524
-
-
Minn, A.J.1
Gupta, G.P.2
Siegel, P.M.3
Bos, P.D.4
Shu, W.5
Giri, D.D.6
Viale, A.7
Olshen, A.B.8
Gerald, W.L.9
Massague, J.10
-
96
-
-
24144465745
-
Cloning of short hairpin RNAs for gene knockdown in mammalian cells
-
Paddison PJ, et al. Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Methods. 2004;1(2):163-167.
-
(2004)
Nat Methods
, vol.1
, Issue.2
, pp. 163-167
-
-
Paddison, P.J.1
-
97
-
-
0031569873
-
Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues
-
DOI 10.1006/dbio.1997.8526
-
Rajan JV, Marquis ST, Gardner HP, Chodosh LA. Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev Biol. 1997;184(2):385-401. (Pubitemid 27224359)
-
(1997)
Developmental Biology
, vol.184
, Issue.2
, pp. 385-401
-
-
Rajan, J.V.1
Marquis, S.T.2
Gardner, H.P.3
Chodosh, L.A.4
-
98
-
-
0029115660
-
The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues
-
Marquis ST, et al. The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nat Genet. 1995; 11(1):17-26.
-
(1995)
Nat Genet.
, vol.11
, Issue.1
, pp. 17-26
-
-
Marquis, S.T.1
|