The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 37, 2009, Pages 15855-15860

  Wertheim, Gerald B W ^a   Yang, Thomas W ^a   Pan, Tien Chi ^a   Ramne, Anna ^a   Liu, Zhandong ^a   Gardner, Heather P ^a   Dugan, Katherine D ^a   Kristel, Petra ^b   Kreike, Bas ^b   Van De Vijver, Marc J ^b   Cardiff, Robert D ^c   Reynolds, Carol ^d   Chodosh, Lewis A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MAYO CLINIC   (United States)

Author keywords

Breast cancer; Knockout mice; Mouse models; Protein kinase

Indexed keywords

MYC PROTEIN; PROTEIN KINASE; SNF 1 RELATED KINASE HUNK; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; BREAST METASTASIS; BREAST TUMOR; CELL INVASION; CELL MIGRATION; COLON CARCINOMA; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C MYC; OUTCOME ASSESSMENT; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; TUMOR CELL; WILD TYPE;

ANIMALS; BREAST NEOPLASMS; CELL MOVEMENT; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROGNOSIS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES;

MOUSE MAMMARY TUMOR VIRUS; MURINAE; MUS; MUS MUSCULUS;

EID: 70349445613     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0906993106     Document Type: Article

References (36)

1. ParkinDM,Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002.CA Cancer J Clin 55:74-108.
2. Jemal A, et al. (2004) Cancer statistics, 2004. CA Cancer J Clin 54:8-29.
3. Fidler IJ (2003) The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited. Nat Rev Cancer 3:453-458.
4. Bernards R, Weinberg RA (2002) A progression puzzle. Nature 418:823.
5. Gardner HP, et al. (2000) Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. Genomics 63:46-59. (Pubitemid 30112238)
6. Gardner HP, et al. (2000) Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland. Development 127:4493-4509.
7. Chodosh LA, et al. (2000) Protein kinase expression during murine mammary development. Dev Biol 219:259-276. (Pubitemid 30152604)
8. Korobko IV, Kabishev AA, Kiselev SL (1997) [Identification of the new protein kinase specifically transcribed in mouse tumors with high metastatic potential]. Dokl Akad Nauk 354:554-556.
9. Stewart TA, Pattengale PK, Leder P (1984) Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell 38:627-637.
10. Naidu R, Wahab NA, Yadav M, Kutty MK (2002) Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction. Int J Mol Med 9:189-196.
11. Guerin M, Barrois M, Terrier MJ, Spielmann M, Riou G (1988) Overexpression of either c-myc or c-erbB-2/neu proto-oncogenes in human breast carcinomas: Correlation with poor prognosis. Oncogene Res 3:21-31. (Pubitemid 19036476)
12. Deming SL, Nass SJ, Dickson RB, Trock BJ (2000) C-myc amplification in breast cancer: Ameta-analysis of its occurrence and prognostic relevance. Br J Cancer 83:1688-1695.
13. Ma XJ, et al. (2004) A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 5:607-616. (Pubitemid 38748922)
14. Oh DS, et al. (2006) Estrogen-regulated genes predict survival in hormone receptorpositive breast cancers. J Clin Oncol 24:1656-1664.
15. van 't Veer LJ, et al. (2002) Gene expression profiling predicts clinical outcome of breast cancer. Nature 415:530-536.
16. van de Vijver MJ, et al. (2002) A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347:1999-2009. (Pubitemid 35461656)
17. Weigelt B, et al. (2003) Gene expression profiles of primary breast tumors maintained in distant metastases. Proc Natl Acad Sci USA 100:15901-15905. (Pubitemid 38021087)
18. Chang HY, et al. (2005) Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci USA 102:3738-3743.
19. Chin K, et al. (2006) Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 10:529-541. (Pubitemid 44854748)
20. Druker BJ, et al. (2001) Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344:1031-1037. (Pubitemid 32267972)
21. Paez JG, et al. (2004) EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304:1497-1500. (Pubitemid 38720929)
22. Hardie DG, Carling D, Carlson M (1998) The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67:821-855. (Pubitemid 28411146)
23. Suzuki A, et al. (2004) IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. Biochem Biophys Res Commun 324:986-992. (Pubitemid 39361605)
24. Lu R, Niida H, Nakanishi M (2004) Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. J Biol Chem 279:31164-31170. (Pubitemid 39037779)
25. Lefebvre DL, et al. (2001) Identification and characterization of a novel sucrose-nonfermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK Biochem J 355:297-305. (Pubitemid 32397787)
26. Lefebvre DL, Rosen CF (2005) Regulation of SNARK activity in response to cellular stresses. Biochim Biophys Acta 1724:71-85. (Pubitemid 40799112)
27. Peng CY, et al. (1998) C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ 9:197-208.
28. Suzuki A, et al. (2003) ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation. Oncogene 22:6177-6182. (Pubitemid 37281647)
29. Suzuki A, et al. (2004) ARK5 is a tumor invasion-associated factor downstream of Akt signaling. Mol Cell Biol 24:3526-3535. (Pubitemid 38452091)
30. Kusakai G, et al. (2004) ARK5 expression in colorectal cancer and its implications for tumor progression. Am J Pathol 164:987-995. (Pubitemid 38235480)
31. Kusakai G, Suzuki A, Ogura T, Kaminishi M, Esumi H (2004) Strong association of ARK5 with tumor invasion and metastasis. J Exp Clin Cancer Res 23:263-268. (Pubitemid 38943558)
32. Suzuki A, et al. (2003) Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. Biochem Biophys Res Commun 311:156-161. (Pubitemid 37297900)
33. Cullen PJ, Sprague GF, Jr (2000) Glucose depletion causes haploid invasive growth in yeast. Proc Natl Acad Sci USA 97:13619-13624.
34. Palecek SP, Parikh AS, Huh JH, Kron SJ (2002) Depression of Saccharomyces cerevisiae invasive growth on non-glucose carbon sources requires the Snf1 kinase. MolMicrobiol 45:453-469.
35. Marquis ST, et al. (1995) The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nat Genet 11:17-26.
36. Leder A, Pattengale PK,KuoA, Stewart TA, Leder P (1986) Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development. Cell 45:485-495. (Pubitemid 16014971)