HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 6, 2010, Pages 2622-2627

  Quintela Fandino, Miguel ^a,b   Arpaia, Enrico ^a   Brenner, Dirk ^a   Goh, Theo ^a   Yeung, Faith Au ^a   Blaser, Heiko ^a   Alexandrova, Roumiana ^a   Lind, Evan F ^a   Tusche, Mike W ^a   Wakeham, Andrew ^a   Ohashi, Pamela S ^a,c   Mak, Tak W ^a,c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b Centro Nacional de Investigations Oncológicas   (Spain)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COFILIN 1; HORMONALLY UPREGULATED NEU ASSOCIATED KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN SERINE THREONINE KINASE; RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL MOTILITY; FEMALE; MALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ACTINS; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; COFILIN 1; CYTOSKELETON; FEMALE; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN PHOSPHATASE 2; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; TRANSPLANTATION, HETEROLOGOUS;

MURINAE;

EID: 77249126947     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914492107     Document Type: Article

References (28)

1. Christofori G (2006) New signals from the invasive front. Nature 441:444-450.
2. Chambers AF, Groom AC, MacDonald IC (2002) Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2:563-572.
3. Boyer B, Tucker GC, Vallés AM, Franke WW, Thiery JP (1989)Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells. J Cell Biol 109:1495-1509.
4. Sørlie T, et al. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869-10874.
5. Sorlie T, et al. (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 100:8418-8423.
6. Gardner HP, et al. (2000) Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland. Development 127:4493-4509.
7. Gardner HP, et al. (2000) Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. Genomics 63:46-59.
8. Wertheim GB, et al. (2009) The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proc Natl Acad Sci USA 106:15855-15860.
9. Jenkins DE, Hornig YS, Oei Y, Dusich J, Purchio T (2005) Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice. Breast Cancer Res 7:R444-R454.
10. Boivin D, Bilodeau D, Béliveau R (1996) Regulation of cytoskeletal functions by Rho small GTP-binding proteins in normal and cancer cells. Can J Physiol Pharmacol 74:801-810.
11. Nobes CD, Hall A (1999) Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol 144:1235-1244.
12. Wang W, Eddy R, Condeelis J (2007) The cofilin pathway in breast cancer invasion and metastasis. Nat Rev Cancer 7:429-440.
13. Meberg PJ, Ono S, Minamide LS, Takahashi M, Bamburg JR (1998) Actin depolymerizing factor and cofilin phosphorylation dynamics: Response to signals that regulate neurite extension. Cell Motil Cytoskeleton 39:172-190.
14. Moriyama K, Iida K, Yahara I (1996) Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1:73-86.
15. Goldberg Y (1999) Protein phosphatase 2A: Who shall regulate the regulator? Biochem Pharmacol 57:321-328.
16. Janssens V, Goris J (2001) Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 353:417-439.
17. O'Shaughnessy JOC, et al. (2009) Efficacy of BSI-201, a poly (ADP-ribose) polymerase-1 (PARP1) inhibitor, in combination with gemcitabine/carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC): Results of a randomized phase II trial. J Clin Oncol 27 (18S):3.
18. Yang N, et al. (1998) Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 393:809-812.
19. Korobko IV, Zavalishina LE, Kiselev SL, Raǐkhlin NT, Frank GA (2004) [Proteinkinase MAK-V/Hunk as a possible dianostic and prognostic marker of human breast carcinoma]. Arkh Patol 66:6-9.
20. Kim YB, et al. (2008) Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase. c-Src complex. J Biol Chem 283:10089-10096.
21. Smith SC, Theodorescu D (2009) Learning therapeutic lessons from metastasis suppressor proteins. Nat Rev Cancer 9:253-264.
22. Mikaelian I, et al. (2004) Proteotypic classification of spontaneous and transgenic mammary neoplasms. Breast Cancer Res 6:R668-R679.
23. Stewart TA, Pattengale PK, Leder P (1984) Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell 38:627-637.
24. Pei XH, et al. (2009) CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell 15:389-401.
25. Muller WJ, Sinn E, Pattengale PK, Wallace R, Leder P (1988) Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 54:105-115.
26. McCarthy A, et al. (2007) A mouse model of basal-like breast carcinoma with metaplastic elements. J Pathol 211:389-398.
27. Strathdee CA, McLeod MR, Hall JR (1999) Efficient control of tetracycline-responsive gene expression froman autoregulated bi-directional expression vector. Gene 229:21-29.
28. Chan AY, et al. (1998) EGF stimulates an increase in actin nucleation and filament number at the leading edge of the lamellipod in mammary adenocarcinoma cells. J Cell Sci 111:199-211.