Potential role of sugar transporters in cancer and their relationship with anticancer therapy

International Journal of Endocrinology

Volumn 2010, Issue , 2010, Pages

  Aparicio, Luís Antón ^a,c   Calvo, Moisés Blanco ^a   Figueroa, Angélica ^a   Pulido, Enrique Grande ^b   Campelo, Rosario García ^c  

^a UNIVERSITY OF A CORUÑA   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c A Corua University Hospital   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; APIGENIN; CARBOHYDRATE TRANSPORTER; CARRIER PROTEIN; DEOXYGLUCOSE; FASENTIN; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 10; GLUCOSE TRANSPORTER 11; GLUCOSE TRANSPORTER 12; GLUCOSE TRANSPORTER 14; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 4; GLUCOSE TRANSPORTER 5; GLUCOSE TRANSPORTER 6; GLUCOSE TRANSPORTER 7; GLUCOSE TRANSPORTER 8; GLUCOSE TRANSPORTER 9; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; SORAFENIB; SUNITINIB; TAMOXIFEN; TEMSIROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIANGIOGENIC ACTIVITY; BREAST CANCER; CARBOHYDRATE TRANSPORT; COLON CARCINOMA; DRUG SPECIFICITY; DRUG TARGETING; GENE MUTATION; GLUCOSE TRANSPORT; GLYCOLYSIS; HEAD AND NECK CARCINOMA; HUMAN; KIDNEY CARCINOMA; LIVER METASTASIS; LUNG CANCER; MOLECULARLY TARGETED THERAPY; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SOLID TUMOR; STOMACH CANCER;

EID: 79952216550     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2010/205357     Document Type: Review

References (104)

1. Warburg O., On the origin of cancer cells Science 1956 123 3191 309 314
2. Kim J.-W., Dang C. V., Cancer's molecular swe (Pubitemid 44521105)
3. Flier J. S., Mueckler M. M., Usher P., Lodish H. F., Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes Science 1987 235 4795 1492 1495 (Pubitemid 17038084)
4. Scheepers A., Joost H.-G., Schrmann A., The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function Journal of Parenteral and Enteral Nutrition 2004 28 5 364 371 (Pubitemid 39121460)
5. Wood I. S., Trayhurn P., Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins British Journal of Nutrition 2003 89 1 3 9 (Pubitemid 36187532)
6. Uldry M., Thorens B., The SLC2 family of facilitated hexose and polyol transporters Pflugers Archiv European Journal of Physiology 2004 447 5 480 489 (Pubitemid 38241434)
7. Macheda M. L., Rogers S., Best J. D., Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer Journal of Cellular Physiology 2005 202 3 654 662 (Pubitemid 40175840)
8. Montel-Hagen A., Sitbon M., Taylor N., Erythroid glucose transporters Current Opinion in Hematology 2009 16 3 165 172
9. Schwartzenberg-Bar-Yoseph F., Armoni M., Karnieli E., The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression Cancer Research 2004 64 7 2627 2633 (Pubitemid 38523921)
10. Simpson I. A., Dwyer D., Malide D., Moley K. H., Travis A., Vannucci S. J., The facilitative glucose transporter GLUT3: 20 years of distinction American Journal of Physiology 2008 295 2 E242 E253
11. Schmidt S., Hommel A., Gawlik V., Augustin R., Junicke N., Florian S., Richter M., Walther D. J., Montag D., Joost H.-G., Schrmann A., Essential role of glucose transporter GLUT3 for post-implantation embryonic development Journal of Endocrinology 2009 200 1 23 33
12. Heyward C. A., Pettitt T. R., Leney S. E., Welsh G. I., Tavar J. M., Wakelam M. J. O., An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles BMC Cell Biology 2008 9, article 25
13. James D. E., Brown R., Navarro J., Pilch P. F., Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein Nature 1988 333 6169 183 185
14. Kahn B. B., Alterations in glucose transporter expression and function in diabetes: mechanisms for insulin resistance Journal of Cellular Biochemistry 1992 48 2 122 128
15. Zorzano A., Wilkinson W., Kotliar N., Thoidis G., Wadzinkski B. E., Ruoho A. E., Pilch P. F., Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations Journal of Biological Chemistry 1989 264 21 12358 12363 (Pubitemid 19191125)
16. Studelska D. R., Campbell C., Pang S., Rodnick K. J., James D. E., Developmental expression of insulin-regulatable glucose transporter GLUT-4 American Journal of Physiology 1992 263 1 E102 E106
17. Mitsumoto Y., Burdett E., Grant A., Klip A., Differential expression of the GLUT1 and GLUT4 glucose transporters during differentiation of L6 muscle cells Biochemical and Biophysical Research Communications 1991 175 2 652 659
18. Berger J., Biswas C., Vicario P. P., Strout H. V., Saperstein R., Pilch P. F., Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting Nature 1989 340 6228 70 72 (Pubitemid 19172606)
19. Douen A. G., Ramlal T., Rastogi S., Bilan P. J., Cartee G. D., Vranic M., Holloszy J. O., Klip A., Exercise induces recruitment of the 'insulin-responsive glucose transporter'. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle Journal of Biological Chemistry 1990 265 23 13427 13430
20. Hirshman M. F., Goodyear L. J., Wardzala L. J., Horton E. D., Horton E. S., Identification of an intracellular pool of glucose transporters from basal and insulin-stimulated rat skeletal muscle Journal of Biological Chemistry 1990 265 2 987 991
21. Klip A., Ramlal T., Bilan P. J., Cartee G. D., Gulve E. A., Holloszy J. O., Recruitment of GLUT-4 glucose transporters by insulin in diabetic rat skeletal muscle Biochemical and Biophysical Research Communications 1990 172 2 728 736 (Pubitemid 20384483)
22. Wu X., Freeze H. H., GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms Genomics 2002 80 6 553 557 (Pubitemid 36062642)
23. Douard V., Ferraris R. P., Regulation of the fructose transporter GLUT5 in health and disease American Journal of Physiology 2008 295 2 E227 E237
24. Cheeseman C., GLUT7: a new intestinal facilitated hexose transporter American Journal of Physiology 2008 295 2 E238 E241
25. Doblado M., Moley K. H., Facilitative glucose transporter 9, a unique hexose and urate transporter American Journal of Physiology 2009 297 4 E831 E835
26. Li S., Sanna S., Maschio A., Busonero F., Usala G., Mulas A., Lai S., Dei M., Orr M., Albai G., Bandinelli S., Schlessinger D., Lakatta E., Scuteri A., Najjar S. S., Guralnik J., Naitza S., Crisponi L., Cao A., Abecasis G., Ferrucci L., Uda M., Chen W. M., Nagaraja R., The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts PLoS Genetics 2007 3 11, article e194
27. Matsuo H., Chiba T., Nagamori S., Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia American Journal of Human Genetics 2008 83 6 744 751
28. Matsuo H., Chiba T., Nagamori S., Erratum: mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia American Journal of Human Genetics 2008 83 6 795
29. Preitner F., Bonny O., Laverrire A., Rotman S., Firsov D., Da Costa A., Metref S., Thorens B., Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy Proceedings of the National Academy of Sciences of the United States of America 2009 106 36 15501 15506
30. Augustin R., Carayannopoulos M. O., Dowd L. O., Phay J. E., Moley J. F., Moley K. H., Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking Journal of Biological Chemistry 2004 279 16 16229 16236 (Pubitemid 38509316)
31. Mobasheri A., Neama G., Bell S., Richardson S., Carter S. D., Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9 Cell Biology International 2002 26 3 297 300
32. Evans S. A., Doblado M., Chi M. M., Corbett J. A., Moley K. H., Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic -cells Endocrinology 2009 150 12 5302 5310
33. Scheepers A., Schmidt S., Manolescu A., Cheeseman C. I., Bell A., Zahn C., Joost H.-G., Schrmann A., Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue Molecular Membrane Biology 2005 22 4 339 351 (Pubitemid 41501236)
34. Augustin R., Riley J., Moley K. H., GLUT8 contains [DE]XXXL[LI] sorting motif and localizes to a late endomosal/lysosomal compartment Traffic 2005 6 12 1196 1212 (Pubitemid 41632270)
35. Schmidt S., Joost H.-G., Schrmann A., GLUT8, the enigmatic intracellular hexose transporter American Journal of Physiology 2009 296 4 E614 E618
36. Dawson P. A., Mychaleckyj J. C., Fossey S. C., Mihic S. J., Craddock A. L., Bowden D. W., Sequence and functional analysis of GLUT10: a glucose transporter in the type 2 diabetes-linked region of chromosome 20q12-13.1 Molecular Genetics and Metabolism 2001 74 1-2 186 199 (Pubitemid 32955159)
37. Andersen G., Rose C. S., Hamid Y. H., Drivsholm T., Borch-Johnsen K., Hansen T., Pedersen O., Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits Diabetes 2003 52 9 2445 2448 (Pubitemid 37059519)
38. Bento J. L., Bowden D. W., Mychaleckyj J. C., Hirakawa S., Rich S. S., Freedman B. I., Segade F., Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes BMC Medical Genetics 2005 6, article 42
39. Lin W. H., Chuang L. M., Chen C. H., Yeh J. I., Hsieh P. S., Cheng C. H., Chen Y. T., Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population Diabetologia 2006 49 6 1214 1221
40. Mohlke K. L., Skol A. D., Scott L. J., Valle T. T., Bergman R. N., Tuomilehto J., Boehnke M., Collins F. S., Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns Molecular Genetics and Metabolism 2005 85 4 323 327 (Pubitemid 41074117)
41. Rose C. S., Andersen G., Hamid Y. H., Glmer C., Drivsholm T., Borch-Johnsen K., Jrgensen T., Pedersen O., Hansen T., Studies of relationships between the GLUT10 Ala206Thr polymorphism and impaired insulin secretion Diabetic Medicine 2005 22 7 946 949 (Pubitemid 40942595)
42. Coucke P. J., Willaert A., Wessels M. W., Callewaert B., Zoppi N., De Backer J., Fox J. E., Mancini G. M. S., Kambouris M., Gardella R., Facchetti F., Willems P. J., Forsyth R., Dietz H. C., Barlati S., Colombi M., Loeys B., De Paepe A., Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome Nature Genetics 2006 38 4 452 457
43. Rogers S., Macheda M. L., Docherty S. E., Carty M. D., Henderson M. A., Soeller W. C., Michael Gibbs E., James D. E., Best J. D., Identification of a novel glucose transporter-like protein-GLUT-12 American Journal of Physiology 2002 282 3 E733 E738
44. Gude N. M., Stevenson J. L., Murthi P., Rogers S., Best J. D., Kalionis B., King R. G., Expression of GLUT12 in the fetal membranes of the human placenta Placenta 2005 26 1 67 72 (Pubitemid 40123678)
45. Stuart C. A., Yin D., Howell M. E. A., Dykes R. J., Laffan J. J., Ferrando A. A., Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle American Journal of Physiology 2006 291 5 E1067 E1073
46. Stuart C. A., Howell M. E. A., Zhang Y., Yin D., Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle Journal of Clinical Endocrinology and Metabolism 2009 94 9 3535 3542
47. Uldry M., Ibberson M., Horisberger J.-D., Chatton J.-Y., Riederer B. M., Thorens B., Identification of a mammalian H+ -myo-inositol symporter expressed predominantly in the brain EMBO Journal 2001 20 16 4467 4477 (Pubitemid 32772041)
48. Di Daniel E., Mok M. H. S., Mead E., Mutinelli C., Zambello E., Caberlotto L. L., Pell T. J., Langmead C. J., Shah A. J., Duddy G., Kew J. N. C., Maycox P. R., Evaluation of expression and function of the H+ /myo-inositol transporter HMIT BMC Cell Biology 2009 10, article 54
49. Parry D. M., Pedersen P. L., Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location Journal of Biological Chemistry 1983 258 18 10904 10912 (Pubitemid 13021256)
50. Paul R., Johansson R., Kellokumpu-Lehtinen P. L., Tumor localization with 18F-2-fluoro-2-deoxy-d-glucose: comparative autoradiography, glucose 6-phosphatase histochemistry, and histology of renally implanted sarcoma of the rat Research in Experimental Medicine 1985 185 2 87 94 (Pubitemid 15080798)
51. Graham M. M., Spence A. M., Muzi M., Abbott G. L., Deoxyglucose kinetics in a rat brain tumor Journal of Cerebral Blood Flow and Metabolism 1989 9 3 315 322 (Pubitemid 19134807)
52. Isselbacher K. J., Sugar and amino acid transport by cells in culturedifferences between normal and malignant cells The New England Journal of Medicine 1972 286 17 929 933
53. Yun J., Rago C., Cheong I., Pagliarini R., Angenendt P., Rajagopalan H., Schmidt K., Willson J. K. V., Markowitz S., Zhou S., Diaz L. A. Jr., Velculescu V. E., Lengauer C., Kinzler K. W., Vogelstein B., Papadopoulos N., Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells Science 2009 325 5947 1555 1559
54. Behrooz A., Ismail-Beigi F., Dual control of glut1 glucose transporter gene expression by hypoxia and by inhibition of oxidative phosphorylation Journal of Biological Chemistry 1997 272 9 5555 5562 (Pubitemid 27102379)
55. Osthus R. C., Shim H., Kim S., Li Q., Reddy R., Mukherjee M., Xu Y., Wonsey D., Lee L. A., Dang C. V., Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc Journal of Biological Chemistry 2000 275 29 21797 21800 (Pubitemid 30621745)
56. Ganapathy V., Thangaraju M., Prasad P. D., Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond Pharmacology and Therapeutics 2009 121 1 29 40
57. Blais A., Expression of Na+ -coupled sugar transport in HT-29 cells: modulation by glucose American Journal of Physiology 1991 260 6 C1245 C1252
58. Ishikawa N., Oguri T., Isobe T., Fujitaka K., Kohno N., SGLT gene expression in primary lung cancers and their metastatic lesions Japanese Journal of Cancer Research 2001 92 8 874 879 (Pubitemid 32894098)
59. Casneuf V. F., Fonteyne P., Van Damme N., Demetter P., Pauwels P., De Hemptinne B., De Vos M., Van De Wiele C., Peeters M., Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival Cancer Investigation 2008 26 8 852 859
60. Weihua Z., Tsan R., Huang W.-C., Wu Q., Chiu C.-H., Fidler I. J., Hung M.-C., Survival of cancer cells is maintained by EGFR independent of its kinase activity Cancer Cell 2008 13 5 385 393 (Pubitemid 351609444)
61. Godoy A., Ulloa V., Rodrguez F., Reinicke K., Yaez A. J., De Los Angeles Garca M., Medina R. A., Carrasco M., Barberis S., Castro T., Martnez F., Koch X., Vera J. C., Poblete M. T., Figueroa C. D., Peruzzo B., Prez F., Nualart F., Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues Journal of Cellular Physiology 2006 207 3 614 627 (Pubitemid 43668223)
62. Suganuma N., Segade F., Matsuzu K., Bowden D. W., Differential expression of facilitative glucose transporters in normal and tumour kidney tissues British Journal of Urology International 2007 99 5 1143 1149 (Pubitemid 46587915)
63. Ozcan A., Shen S. S., Zhai Q., Truong L. D., Expression of GLUT1 in primary renal tumors: morphologic and biologic implications American Journal of Clinical Pathology 2007 128 2 245 254 (Pubitemid 47262622)
64. Lidgren A., Bergh A., Grankvist K., Rasmuson T., Ljungberg B., Glucose transporter-1 expression in renal cell carcinoma and its correlation with hypoxia inducible factor-1 British Journal of Urology International 2008 101 4 480 484 (Pubitemid 351160927)
65. Chandler J. D., Williams E. D., Slavin J. L., Best J. D., Rogers S., Expression and localization of GLUT1 and GLUT12 in prostate carcinoma Cancer 2003 97 8 2035 2042 (Pubitemid 36397283)
66. Kurata T., Oguri T., Isobe T., Ishioka S.-I., Yamakido M., Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases Japanese Journal of Cancer Research 1999 90 11 1238 1243
67. Younes M., Brown R. W., Stephenson M., Gondo M., Cagle P. T., Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival Cancer 1997 80 6 1046 1051 (Pubitemid 27427603)
68. Rogers S., Docherty S. E., Slavin J. L., Henderson M. A., Best J. D., Differential expression of GLUT12 in breast cancer and normal breast tissue Cancer Letters 2003 193 2 225 233 (Pubitemid 36428906)
69. Zamora-Len S.P., Golde D. W., Concha I. I., Rivas C. I., Delgado-Lpez F., Baselga J., Nualart F., Vera J. C., Expression of the fructose transporter GLUT5 in human breast cancer Proceedings of the National Academy of Sciences of the United States of America 1996 93 5 1847 1852 (Pubitemid 26079842)
70. Zamora-Leon S. P., Golde D. W., Concha I. I., Rivas C. I., Delgado-Lopez F., Baselga J., Nualart F., Vera J. C., Erratum: expression of the fructose transporter GLUT5 in human breast cancer Proceedings of the National Academy of Sciences of the United States of America 1996 93 26 15522
71. Brown R. S., Wahl R. L., Overexpression of Glut-1 glucose transporter in human breast cancer: an immunohistochemical study Cancer 1993 72 10 2979 2985 (Pubitemid 23335044)
72. Younes M., Brown R. W., Mody D. R., Fernandez L., Laucirica R., GLUT1 expression in human breast carcinoma: correlation with known prognostic markers Anticancer Research 1995 15 6 2895 2898 (Pubitemid 26095119)
73. Kawamura T., Kusakabe T., Sugino T., Watanabe K., Fukuda T., Nashimoto A., Honma K., Suzuki T., Expression of glucose transporter-1 in human gastric carcinoma: association with tumor aggressiveness, metastasis, and patient survival Cancer 2001 92 3 634 641 (Pubitemid 32735200)
74. Sung J.-Y., Kim G. Y., Lim S.-J., Park Y.-K., Kim Y. W., Expression of the GLUT1 glucose transporter and p53 in carcinomas of the pancreatobiliary tract Pathology Research and Practice 2010 206 24 29
75. Ito H., Duxbury M., Zinner M. J., Ashley S. W., Whang E. E., Glucose transporter-1 gene expression is associated with pancreatic cancer invasiveness and MMP-2 activity Surgery 2004 136 3 548 556 (Pubitemid 39186566)
76. Boden G., Murer E., Mozzoli M., Glucose transporter proteins in human insulinoma Annals of Internal Medicine 1994 121 2 109 112 (Pubitemid 24203493)
77. Boden G., Murer E., Mozzoli M., Erratum: glucose transporter proteins in human insulinoma Annals of Internal Medicine 1994 121 470
78. Haber R. S., Rathan A., Weiser K. R., Pritsker A., Itzkowitz S. H., Bodian C., Slater G., Weiss A., Burstein D. E., GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis Cancer 1998 83 1 34 40 (Pubitemid 28299626)
79. Furudoi A., Tanaka S., Haruma K., Yoshihara M., Sum K. II, Kajiyama G., Shimamoto F., Clinical significance of human erythrocyte glucose transporter 1 expression at the deepest invasive site of advanced colorectal carcinoma Oncology 2001 60 2 162 169 (Pubitemid 32245335)
80. Ebert B. L., Firth J. D., Ratcliffe P. J., Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences Journal of Biological Chemistry 1995 270 49 29083 29089
81. Cooper R., Sariolu S., Skmen S., Fzn M., Kpeliolu A., Valentine H., Grken I. B., Airley R., West C., Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma? British Journal of Cancer 2003 89 5 870 876 (Pubitemid 37175810)
82. Boado R. J., Black K. L., Pardridge W. M., Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors Molecular Brain Research 1994 27 1 51 57 (Pubitemid 24324088)
83. Nishioka T., Oda Y., Seino Y., Yamamoto T., Inagaki N., Yano H., Imura H., Shigemoto R., Kikuchi H., Distribution of the glucose transporters in human brain tumors Cancer Research 1992 52 14 3972 3979
84. Markert J. M., Fuller C. M., Gillespie G. Y., Bubien J. K., McLean L. A., Hong R. L., Lee K., Gullans S. R., Mapstone T. B., Benos D. J., Differential gene expression profiling in human brain tumors Physiol Genomics 2001 5 1 21 33 (Pubitemid 33675199)
85. Sasaki A., Yamaguchi H., Horikoshi Y., Tanaka G., Nakazato Y., Expression of glucose transporter 5 by microglia in human gliomas Neuropathology and Applied Neurobiology 2004 30 5 447 455 (Pubitemid 39423032)
86. Zhou S., Wang S., Wu Q., Fan J., Wang Q., Expression of glucose transporter-1 and -3 in the head and neck carcinomathe correlation of the expression with the biological behaviors Journal for Oto-Rhino-Laryngology and Its Related Specialties 2008 70 3 189 194 (Pubitemid 351595115)
87. Mellanen P., Minn H., Grnman R., Hrknen P., Expression of glucose transporters in head-and-neck tumors International Journal of Cancer 1994 56 5 622 629 (Pubitemid 24086761)
88. Reisser C., Eichhorn K., Herold-Mende C., Born A. I., Bannasch P., Expression of facilitative glucose transport proteins during development of squamous cell carcinomas of the head and neck International Journal of Cancer 1999 80 2 194 198 (Pubitemid 29001721)
89. Kunkel M., Reichert T. E., Benz P., Lehr H.-A., Jeong J.-H., Wieand S., Bartenstein P., Wagner W., Whiteside T. L., Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma Cancer 2003 97 4 1015 1024 (Pubitemid 36173153)
90. Tateishi U., Hasegawa T., Seki K., Terauchi T., Moriyama N., Arai Y., Disease activity and 18F-FDG uptake in organising pneumonia: semi-quantitative evaluation using computed tomography and positron emission tomography European Journal of Nuclear Medicine and Molecular Imaging 2006 33 8 906 912 (Pubitemid 44127439)
91. Endo M., Tateishi U., Seki K., Yamaguchi U., Nakatani F., Kawai A., Chuman H., Beppu Y., Prognostic implications of glucose transporter protein-1 (Glut-1) overexpression in bone and soft-tissue sarcomas Japanese Journal of Clinical Oncology 2007 37 12 955 960 (Pubitemid 351176488)
92. Goldman N. A., Katz E. B., Glenn A. S., Weldon R. H., Jones J. G., Lynch U., Fezzari M. J., Runowicz C. D., Goldberg G. L., Charron M. J., GLUT1 and GLUT8 in endometrium and endometrial adenocarcinoma Modern Pathology 2006 19 11 1429 1436 (Pubitemid 44624161)
93. Matsuzu K., Segade F., Matsuzu U., Carter A., Bowden D. W., Perrier N. D., Differential expression of glucose transporters in normal and pathologic thyroid tissue Thyroid 2004 14 10 806 812 (Pubitemid 39489004)
94. Jiang X., Kenerson H., Aicher L., Miyaoka R., Eary J., Bissler J., Yeung R. S., The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake American Journal of Pathology 2008 172 6 1748 1756 (Pubitemid 351793365)
95. Edinger A. L., Linardic C. M., Chiang G. G., Thompson C. B., Abraham R. T., Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells Cancer Research 2003 63 23 8451 8460 (Pubitemid 37549501)
96. Thomas G. V., Tran C., Mellinghoff I. K., Welsbie D. S., Chan E., Fueger B., Czernin J., Sawyers C. L., Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer Nature Medicine 2006 12 1 122 127 (Pubitemid 43050086)
97. Fraenkel M., Ketzinel-Gilad M., Ariav Y., Pappo O., Karaca M., Castel J., Berthault M.-F., Magnan C., Cerasi E., Kaiser N., Leibowitz G., mTOR inhibition by rapamycin prevents -cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes Diabetes 2008 57 4 945 957
98. Wood T. E., Dalili S., Simpson C. D., Hurren R., Mao X., Saiz F. S., Gronda M., Eberhard Y., Minden M. D., Bilan P. J., Klip A., Batey R. A., Schimmer A. D., A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death Molecular Cancer Therapeutics 2008 7 11 3546 3555
99. Melstrom L. G., Salabat M. R., Ding X.-Z., Milam B. M., Strouch M., Pelling J. C., Bentrem D. J., Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/akt pathway in human pancreatic cancer cells Pancreas 2008 37 4 426 431
100. Pelicano H., Martin D. S., Xu R.-H., Huang P., Glycolysis inhibition for anticancer treatment Oncogene 2006 25 34 4633 4646 (Pubitemid 44187614)
101. Gounder M. K., Lin H., Stein M. N., Goodin S., Bertino J. R., DiPaola R. S., Phase I trial of 2-deoxyglucose for treatment of advanced solid tumors and hormone refractory prostate cancer: a pharmacokinetics (PK) assessment Proceedings of the AACR 101st Annual Meeting 2010. abstract 2756
102. Maschek G., Savaraj N., Priebe W., Braunschweiger P., Hamilton K., Tidmarsh G. F., De Young L. R., Lampidis T. J., 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo Cancer Research 2004 64 1 31 34 (Pubitemid 38114078)
103. Chan K. K., Chan J. Y. W., Chung K. K. W., Fung K.-P., Inhibition of cell proliferation in human breast tumor cells by antisense oligonucleotides against facilitative glucose transporter 5 Journal of Cellular Biochemistry 2004 93 6 1134 1142 (Pubitemid 44264127)
104. Mitani T., Hoshikawa H., Mori T., Hosokawa T., Tsukamoto I., Yamaguchi F., Kamitori K., Tokuda M., Mori N., Growth inhibition of head and neck carcinomas by D-allose Head and Neck 2009 31 8 1049 1055