Expression of the GLUT1 glucose transporter and p53 in carcinomas of the pancreatobiliary tract

Pathology Research and Practice

Volumn 206, Issue 1, 2010, Pages 24-29

  Sung, Ji Youn ^a   Kim, Gou Young ^a   Lim, Sung Jig ^a   Park, Yong Koo ^a   Kim, Youn Wha ^a  

^a Kyung Hee University Hospital   (South Korea)

Author keywords

GLUT1; Immunohistochemistry; p53; Pancreatobiliary cancer

Indexed keywords

GLUCOSE TRANSPORTER 1; PROTEIN P53;

ADULT; ARTICLE; BILE DUCT; BILE DUCT CARCINOMA; CANCER GRADING; CANCER INVASION; CANCER STAGING; CONTROLLED STUDY; FEMALE; GALLBLADDER CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PANCREAS CARCINOMA; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; VATER PAPILLA CARCINOMA;

AGED; AMPULLA OF VATER; BILE DUCT NEOPLASMS; BILE DUCTS, EXTRAHEPATIC; CARCINOMA; FEMALE; GALLBLADDER NEOPLASMS; GLUCOSE TRANSPORTER TYPE 1; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; NEOPLASM STAGING; PANCREATIC NEOPLASMS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 73649084387     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2009.07.018     Document Type: Article

References (22)

1. Cancer Statistics in Korea, National Cancer Center, 2008.
2. Chandler J.D., Williams E.D., Slavin J.L., Best J.D., and Rogers S. Expression and localization of GLUT1 and GLUT12 in prostate carcinoma. Cancer 97 (2003) 2035-2042
3. Chang S., Lee S., Lee C., Kim J.I., and Kim Y. Expression of the human erythrocyte glucose transporter in transitional cell carcinoma of the bladder. Urology 55 (2000) 448-452
4. Haber R.S., Rathan A., and Weiser K.R. GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. Cancer 83 (1998) 34-40
5. Isselbacher K.J. Sugar and amino acid transport by cells in culture - differences between normal and malignant cells. N Engl J Med 286 (1972) 929-933
6. Jemal A., Siegel R., Ward E., Murray T., Xu J., and Thun M.J. Cancer statistics. CA - Cancer J Clin 57 (2007) 43-66
7. Kang S.S., Chun Y.K., and Hur M.H. Clinical significance of glucose transporter 1 (GLUT1) expression in human breast carcinoma. Jpn J Cancer Res 93 (2002) 1123-1128
8. Kim S.J., Lee H.W., Kim D.C., Rha S.H., Hong S.H., and Jeong J.S. Significance of GLUT1 expression in adenocarcinoma and adenoma of the ampulla of Vater. Pathol Int 58 (2008) 233-238
9. Kim Y.W., Do I.G., and Park Y.K. Expression of the GLUT1 glucose transporter, p63 and p53 in thyroid carcinomas. Pathol Res Pract 202 (2006) 759-765
10. Kim Y.W., Park Y.K., Yoon T.Y., and Lee S.M. Expression of the GLUT1 glucose transporter in gallbladder carcinomas. Hepatogastroenterology 49 (2002) 907-911
11. Lyshchik A., Higashi T., and Hara T. Expression of glucose transporter-1, hexokinase-II, proliferating cell nuclear antigen and survival of patients with pancreatic cancer. Cancer Invest 25 (2007) 154-162
12. Macheda M.L., Rogers S., and Best J.D. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 202 (2005) 654-662
13. Mori Y., Tsukinoki K., Yasuda M., Miyazawa M., Kaneko A., and Watanabe Y. Glucose transporter type 1 expression are associated with poor prognosis in patients with salivary gland tumors. Oral Oncol 43 (2007) 563-569
14. Noguchi Y., Marat D., and Saito A. Expression of facilitative glucose transporters in gastric tumors. Hepatogastroenterology 46 (1999) 2683-2689
15. Ozcan A., Shen S.S., Zhai Q.J., and Truong L.D. Expression of GLUT1 in primary renal tumors: morphologic and biologic implications. Am J Clin Pathol 128 (2007) 245-254
16. Reisser C., Eichhorn K., Herold-Mende C., Born A.I., and Bannasch P. Expression of facilitative glucose transport proteins during development of squamous cell carcinomas of the head and neck. Int J Cancer 80 (1999) 194-198
17. Roh M.S., Jeong J.S., Kim Y.H., Kim M.C., and Hong S.H. Diagnostic utility of GLUT1 in the differential diagnosis of liver carcinomas. Hepatogastroenterology 51 (2004) 1315-1318
18. Schwartzenberg-Bar-Yoseph F., Armoni M., and Karnieli E. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res 64 (2004) 2627-2633
19. Sun H.C., Qiu Z.J., and Liu J. Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis. Int J Oncol 30 (2007) 1359-1367
20. Tsukioka M., Matsumoto Y., and Noriyuki M. Expression of glucose transporters in epithelial ovarian carcinoma: correlation with clinical characteristics and tumor angiogenesis. Oncol Rep 18 (2007) 361-367
21. Wang B.Y., Kalir T., Sabo E., Sherman D.E., Cohen C., and Burstein D.E. Immunohistochemical staining of GLUT1 in benign, hyperplastic, and malignant endometrial epithelia. Cancer 88 (2000) 2774-2781
22. Younes M., Brown R.W., Stephenson M., Gondo M., and Cagle P.T. Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer 80 (1997) 1046-1051