Effects of 2-Deoxy-D-glucose on focal cerebral ischemia in hyperglycemic rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 23, Issue 5, 2003, Pages 556-564

  Wei, Jingna ^a   Cohen, David M ^b   Quast, Michael J ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

2 Deoxy D glucose; Cerebral ischemia; Hyperglycemia; Lactate; Magnetic resonance imaging; NMR spectroscopy

Indexed keywords

DEOXYGLUCOSE; LACTIC ACID; N ACETYLASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN LEVEL; BRAIN PERFUSION; BRAIN REGION; CONTROLLED STUDY; GLUCOSE METABOLISM; HYPERGLYCEMIA; MALE; METABOLIC INHIBITION; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT;

EID: 0038367530     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000056061.18772.72     Document Type: Article

References (56)

1. Axel L (1980) Cerebral blood flow determination by rapid-sequence computed tomography: theoretical analysis. Radiology 137:679-686
2. Bal-Price A, Brown GC (2001) Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J Neurosci 21:6480-6491
3. Combs DJ, Reuland DS, Martin DB, Zelenock GB, D'Alecy LG (1986) Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemiaassociated mortality and morbidity in the ischemic rat. Stroke 17:989-994
4. David SH, Bell MB (1994) Stroke in the diabetic patient. Diabetes Care 17:213-219
5. Davis PL, Wolf GL, Gillen JS (1989) Indicator dilution time-activity curves demonstrated by rapid magnetic resonance imaging techniques and paramagnetic contrast agent. Invest Radiol 24:400-406
6. Duan W, Mattson MP (1999) Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J Neurosci Res 57:195-206
7. Gomi S, Karp A, Greenberg JH (2000) Regional alterations in an excitatory amino-acid transporter, blood flow, and glucose metabolism after middle cerebral artery occlusion in the rat. Exp Brain Res 130:521-528
8. Graham GD, Blamire AM, Rothman DL, Brass LM, Fayad PB, Petroff OA, Prichard JW (1993) Early temporal variation of cerebral metabolites after human stroke: a proton magnetic resonance spectroscopy study. Stroke 24:1891-1896
9. Haase A, Frahm J, Mattaei D (1986) FLASH imaging: rapid NMR imaging using low flip-angle pulses. J Magn Reson 67:258-266
10. Haraldseth O, Nygard O, Gronas T, Southon T, Gisvold SE, Unsgard G (1992) Hyperglycemia in global cerebral ischemia and reperfusion: a 31-phosphorus NMR spectroscopy study in rats. Acta Physiol Scand 36:25-30
11. Horton RW, Meldrum BS, Bachelard HS (1973) Enzymic and cerebral metabolic effects of 2-deoxy-D-glucose. J Neurochem 21:507-520
12. Huang NC, Wei J, Quast MJ (1996) A comparison of the early development of ischemic brain damage in normoglycemic and hyperglycemic rats using magnetic resonance imaging. Exp Brain Res 109:33-42
13. Kent TA, Quast MJ, Kaplan BJ, Lifsey RS, Eisenberg HM (1990) Assessment of a superparamagnetic iron oxide (AMI-25) as a brain contrast agent. Magn Reson Med 13:434-443
14. Kent TA, Quast MJ, Kaplan BJ, Najafi A, Amparo EG, Gevedon RM, Salinas F (1989) Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7T. Am J Neuroradiol 10:335-338
15. Knight RA, Ordidge RJ, Helpern JA, Chopp M, Rodolosi LC, Peck D (1991) Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging. Stroke 22:802-808
16. Kraig RP, Petito CK, Plum F, Pulsinelli WA (1987) Hydrogen ions kill brain at concentrations reached in ischemia. J Cereb Blood Flow Metab 7:379-386
17. Li PA, Liu GJ, He QP, Floyd RA, Siesjo BK (1999) Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia. Free Radical Biol Med 27:1033-1040
18. Li PA, Shamloo M, Smith M, Katsura K, Siesjo BK (1994) The influence of plasma glucose concentrations on ischemic brain damage is a threshold function. Neurosci Lett 177:63-65
19. Li PA, Shuaib A, Miyashita H, He QP, Siesjo BK, Warner DS (2000) Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia. Stroke 31:183-192
20. Li PA, Siesjo BK (1997) Role of hyperglycaemia-related acidosis in ischemic brain damage. Acta Physiol Scand 161:567-580
21. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniotomy in rats. Stroke 20:84-91
22. 2-weighted MRI and spectroscopy. Magn Reson Med 14:330-346
23. Nagasawa H, Kogure K (1989) Correlation between cerebral blood flow and histological changes in a new rat model of middle cerebral artery occlusion. Stroke 20:1037-1043
24. Nedergaard M, Diemer NH (1987) Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration. Acta Neuropathol Berl 73:131-137
25. Niwa M, Hara A, Iwai T, Nakashima M, Yoshimi N, Mori H, Uematsu T (1999) Prevention of ischemia-induced hippocampal neuronal damage by 2-deoxy-D-glucose in gerbils. Life Sci 64:193-198
26. Obrenovitch TP, Garofalo O, Harris RJ, Bordi L, Ono M, Momma F, Bachelard HS (1988) Brain tissue concentrations of ATP, phosphocreatine, lactate, and tissue pH in relation to reduced cerebral blood flow following experimental acute middle cerebral artery occlusion. J Cereb Blood Flow Metab 8:866-874
27. Patlak CS, Pettigrew KD (1976) A method to obtain infusion schedules for prescribed blood concentration time courses. J Appl Physiol 40:458-463
28. Pellegrini-Giampeitro DE, Cherici G, Alesiani M, Carla V, Moroni F (1988) Excitatory amino acid release from rat hippocampal slices as a consequence of free-radical formation. J Neurochem 51:19601963
29. Pellegrini-Giampeitro DE, Cherici G, Alesiani M, Carla V, Moroni F (1990) Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J Neurosci 10:1035-1041
30. Petito CK, Kraig RP, Pulsinelli WA (1987) Light and electron microscopic evaluation of hydrogen ion-induced brain necrosis. J Cereb Blood Flow Metab 7:625-632
31. Pulsinelli WA, Waldman S, Rawlinson D, Plum F (1982) Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat. Neurology 32:1239-1246
32. Quast MJ, Huang NC, Hillman GR, Kent TA (1993) The evolution of acute stroke recorded by multimodal magnetic resonance imaging. Magn Reson Imag 11:465-471
33. G-nitro-L-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischemia in hyperglycemic rats. Brain Res 677:204-212
34. Quast MJ, Wei J, Huang NC, Brunder DG, Sell SL, Gonzales JM, Hillman GR (1997) Perfusion deficit parallels exacerbation of cerebral ischemia/reperfusion injury in hyperglycemic rats. J Cereb Blood Flow Metab 17:553-559
35. Rejdak K, Rejdak R, Sieklucka-Dziuba M, Stelmasiak Z, Grieb P (2001) 2-Deoxyglucose enhances epileptic tolerance evoked by transient incomplete brain ischemia in mice. Epilepsy Res 43:271278
36. Rosen BR, Bellivean JW, Vevea JM, Brady TJ (1990) Perfusion imaging with NMR contrast agents. Magn Reson Med 14:249-265
37. 1H NMR. In: Proceedings of the Society of Magnetic Resonance Medicine, Ninth Annual Meeting, August 18-24, 1990. New York: 1990:107.
38. Siemkowicz E, Gjedde A (1980) Post-ischemic coma in rat: effect of different pre-ischemic blood glucose levels on cerebral metabolic recovery after ischemia. Acta Physiol Scand 110:225-232
39. Siesjo BK, Ekholm A, Katsura K, Theander S (1990) Acid-base change during complete brain ischemia. Stroke 21:194-199
40. Siesjo BK, Katsura K, Mellergard P, Ekholm A, Lundgren J, Smith M (1993) Acidosis-related brain damage. Prog Brain Res 96:23-48
41. Starmer CF, Clark DO (1970) Computer computations of cardiac output using the gamma function. J Appl Phys 28:219-220
42. 31P magnetic resonance spectroscopy. Diabetes 41:1328-1334
43. Tanaka K, Greenberg JH, Gonatas NK, Reivich M (1985) Regional flow-metabolism couple following middle cerebral artery occlusion in cats. J Cereb Blood Flow Metab 5:241-252
44. Tekkok S, Krnjevic K (1995) Long-term potentiation in hippocampal slices induced by temporary suppression of glycolysis. J Neurophysiol 74:2763-2766
45. Thompson HK, Starmer CF, Whalen RE, McIntosh HD (1964) Indicator transit time considered as a gamma variate. Circ Res XIV:502-515
46. Tyson R, Peeling J, Sutherland G (1993) Metabolic changes associated with altering blood glucose level in short duration fore brain ischemia. Brain Res 608:288-298
47. Verheul HB, Balazs R, Berkelbach van der Sprenkel JW, Tulleken CA, Nicolay K, Tamminga KS, Van lookeren Campagne M (1994) Comparison of diffusion-weighted MRI with changes in cell volume in a rat model of brain injury. NMR Biomed 7:96-100
48. Volterra A, Trotti D, Tromba C, Floridi S, Racagni G (1994) Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J Neurosci 14:2924-2932
49. Wei J, Huang NC, Quast MJ (1997) Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion. Free Radical Biol Med 23:986-995
50. Wei J, Quast MJ (1998) Effect of nitric oxide synthase inhibitor on a hyperglycemic rat model of reversible focal ischemia: detection of excitatory amino acids release and hydroxyl radical formation. Brain Res 791:146-156
51. Weisskoff RM, Chesler D, Boxerman JL, Rosen BR (1993) Pitfalls in MR measurement of tissue blood flow with intravascular tracers: which mean transit time? Magn Reson Med 29:553-559
52. Widmer H, Abiko H, Faden AI, James TL, Weinstein PR (1992) Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels. J Cereb Blood Flow Metab 12:456-468
53. 14C] antipyrine technique. Proc Natl Acad Sci U S A 92:1846-1850
54. Yip PK, He YY, Hsu CY, Garg N, Marangos P, Hogan EL (1991) Effect of plasma glucose on infarct size in focal cerebral ischemiareperfusion. Neurology 41:899-905
55. Yu ZF, Mattson MP (1999) Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism. J Neurosci Res 57:830-839
56. Zierler KL (1962) Theoretical basis of indicator-dilution methods for measuring flow and volume. Circ Res 10:393-407