Preischemic hyperglycemia leads to rapidly developing brain damage with no change in capillary patency

Brain Research

Volumn 782, Issue 1-2, 1998, Pages 175-183

  Li, Ping An ^a   Vogel, Johannes ^b   He, Qing Ping ^a   Smith, Maj Lis ^a   Kuschinsky, Wolfgang ^b   Siesjö, Bo K ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Capillary patency; Cerebral blood flow; Cerebral ischemia; Fluorescent double staining; Hyperglycemia; Microcirculation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN MICROCIRCULATION; CAPILLARY PERMEABILITY; CONTROLLED STUDY; HYPERGLYCEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN DAMAGE, CHRONIC; BRAIN ISCHEMIA; CAPILLARIES; CEREBROVASCULAR CIRCULATION; HYPERGLYCEMIA; MALE; RATS; RATS, WISTAR; REPERFUSION; TIME FACTORS; VASCULAR PATENCY;

EID: 0032567722     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01150-5     Document Type: Article

References (50)

1. Auer R.N., Wieloch T., Olsson Y., Siesjö B.K. Hypoglycemic brain injury in the rat: Correlation of density of brain damage with the EEG isoelectric time. A quantitative study. Diabetes. 33:1984;1090-1098.
2. Bralet J., Schreiber L., Bouvier C. Effect of acidosis and anoxia on iron delocalization from brain homogenates. Biochem. Pharmacol. 43:1992;979-983.
3. Crompton M., Andreeva L. On the involvement of a mitochondrial pore in reperfusion injury. Basic Res. Cardiol. 88:1993;513-523.
4. del Zoppo G.J. Microvascular changes during cerebral ischemia and reperfusion. Cerebovasc. Brain Metab. Rev. 6:1994;47-96.
5. del Zoppo G.J., Schmid-Schönbein G.W., Mori E., Copeland B.R., Chang C.-M. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke. 22:1991;1276-1283.
6. Dietrich W.D., Alonso O., Busto R. Moderate hyperglycemia worsens acute blood-brain barrier injury after forebrain ischemia in rats. Stroke. 24:1993;111-116.
7. Dirnagl U. Cerebral ischemia: the microcirculation as trigger and target. Prog. Brain Res. 96:1993;49-65.
8. Duchen M.R. Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurones. J. Physiol. 424:1990;387-409.
9. Feuerstein G.Z., Liu T., Barone F.C. Cytokines, inflammation, and brain injury: role of tumor necrosis factor-a. Cerebrovasc. Brain Metab. Rev. 6:1994;341-360.
10. J. Folbergrová, P.-A. Li, M.-L. Smith, B.K. Siesjö, Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects, Exp. Brain Res. (1997) in press.
11. Garcia J.H., Liu K.F., Yoshida Y., Lian J., Chen S., del Zoppo G.J. Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat). Am. J. Pathol. 144:1994;188-199.
12. Gebicki J.M., Bielski B.H.J. Comparison of the capacities of the perhydroxyl and the superoxide radicals to initiate chain oxidation of linoleic acid. J. Am. Chem. Soc. 103:1981;7020-7022.
13. Göbel U., Theilen H., Kuschinsky W. Congruence of total and perfused capillary network in rat brains. Circ. Res. 66:1990;271-281.
14. Gregersen M.I., Schiro H. The behavior of the dye T-1824 with respect to its absorption by red blood cells and its fate in blood undergoing coagulation. Am. J. Physiol. 121:1938;284-293.
15. Griffiths E., Halestrap A. Mitochondrial non-specific pores remain closed during cardiac ischemia, but open upon reperfusion. Biochem. J. 307:1995;93-98.
16. Grögaard B., Schürer L., Gerdin B., Arfors K.E. Delayed hypoperfusion after incomplete forebrain ischemia in the rat. The role of polymorphonuclear leukocyte. J. Cereb. Blood Flow Metab. 9:1989;500-505.
17. Hallenbeck J.M. Inflammatory reactions at the blood-endothelial interface in acute stroke. Adv. Neurol. 71:1996;281-300.
18. Kalimo H., Rehncrona S., Söderfeldt B., Olsson Y., Siesjö B.K. Brain lactic acidosis and ischemic cell damage. 2. Histopathology J. Cereb. Blood Flow Metab. 1:1981;313-327.
19. Katsura K., Kristián T., Smith M.-L., Siesjö B.K. Acidosis induced by hypercapnia exaggerates ischemic brain damage. J. Cereb. Blood Flow Metab. 14:1994;243-250.
20. Kirino T. Delayed neuronal death in the gerbil hippocampus following transient ischemia. Brain Res. 239:1982;57-69.
21. Kontos H.A. Oxygen radicals in cerebral vascular injury. Circ. Res. 57:1985;508-516.
22. H.A. Kontos, Oxygen radicals in cerebral ischemia, in: M.D. Ginsberg, W.D. Dietrich (Eds.), Cerebrovascular Diseases, Raven Press, New York, 1989, pp. 365-371.
23. Kristián T., Gidö G., Siesjö B.K. The influence of acidosis on hypoglycemic brain damage. J. Cereb. Blood Flow Metab. 15:1995;78-87.
24. Li P.-A., Uchino H., Elmér E., Siesjö B.K. Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia. Brain Res. 753:1997;133-140.
25. Li P.-A., Kristán T., Shamloo M., Siesjö B.K. Effects of preischemic hyperglycemia on the brain damage incurred by rats subjected to 2.5 and 5 minutes of forebrain ischemia. Stroke. 27:1996;1592-1602.
26. Li P.-A., Kristián T., Siesjö B.K. Brief periods of ischemia in hyperglycemic rats induce hippocampal CA1 damage in the absence of cell membrane depolarization and calcium influx. Neurosci. Res. Commun. 17:1995;217-220.
27. Li P.-A., Shamloo M., Katsura K., Smith M.-L., Siesjö B.K. Critical values for plasma glucose in aggravating ischemic brain damage: correlation to extracellular pH. Neurobiol. Dis. 2:1995;97-108.
28. Li P.-A., Shamloo M., Smith M.-L., Katsura K., Siesjö B.K. The influence of plasma glucose concentrations on ischemic brain damage is a threshold function. Neurosci. Lett. 177:1994;63-65.
29. Lundgren J., Smith M.-L., Siesjö B.K. Influence of moderate hypothermia on ischemic brain damage incurred under hyperglycemic conditions. Exp. Brain Res. 84:1991;91-101.
30. R.E. Myers, Lactic acid accumulation as a cause of brain edema and cerebral necrosis resulting from oxygen deprivation, Adv. Perinatal Neurol. (1979) 85-114.
31. Myers R.E., Yamaguchi S. Nervous system effects of cardiac arrest in monkeys. Arch. Neurol. 34:1977;65-74.
32. Ouyang Y.-B., Kristián T., Mellergård P., Siesjö B.K. The influence of pH on glutamate- and depolarisation-induced increases of intracellular calcium concentration in cortical neurons in primary culture. Brain Res. 646:1994;65-72.
33. Paljärvi L., Rehncrona S., Söderfeldt B., Olsson Y., Kalimo H. Brain lactic acidosis and ischemic cell damage: Quantitative ultrastructural changes in capillaries of rat cerebral cortex. Acta Neuropathol. 60:1983;232-240.
34. Pulsinelli W.A., Brierley J.B., Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11:1982;491-498.
35. 2. J. Cereb. Blood Flow Metabol. 9:1989;65-70.
36. Rehncrona S., Rosén I., Siesjö B.K. Brain lactic acidosis and ischemic cell damage. 1. Biochemistry and neurophysiology J. Cereb. Blood Flow Metab. 1:1981;297-311.
37. Schürer L., Grögaard B., Gerdin B., Arfors K.-E. Effects of neutrophil depletion and superoxide dismutase on postischemic hypoperfusion of rat brain. Adv. Neurol. 52:1990;57-62.
38. Schürer L., Grögaard B., Gerdin B., Kempsi O., Arfors K.E. Leukocyte depletion does not affect postischemic nerve cell damage in the rat. Acta Neurochir. (Wien). 111:1991;54-60.
39. Shen H., Chan J., Kass I.S., Bergold P.J. Transient acidosis induces delayed neurotoxicity in cultured hippocampal slices. Neurosci. Lett. 185:1995;115-118.
40. Siemkowicz E., Hansen A.J. Clinical restitution following cerebral ischemia in hypo-, normo-, and hyperglycemic rats. Acta Neurol. Scand. 58:1978;1-8.
41. Siesjö B.K. Acidosis and ischemic brain damage. Neurochem. Pathol. 9:1988;31-88.
42. Siesjö B.K., Bendek G., Koide T., Westerberg E., Wieloch T. Influence of acidosis on lipid peroxidation in brian tissues in vitro. J. Cereb. Blood Flow Metab. 5:1985;253-258.
43. Siesjö B.K., Katsura K., Kristián T. Acidosis-related damage. Adv. Neurol. 71:1996;209-236.
44. Siesjö B.K., Katsura K., Mellergård P., Ekholm A., Lundgren J., Smith M.-L. Acidosis-related brain damage. Prog. Brain Res. 96:1993;23-48.
45. Siesjö B.K., Siesjö P. Mechanisms of secondary brain injury. Eur. J. Anesthes. 13:1996;247-268.
46. Smith M.-L., Auer R.N., Siesjö B.K. The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol. (Berl.). 64:1984;319-332.
47. Smith M.-L., Bendek G., Dahlgren N., Rosén I., Wieloch T., Siesjö B.K. Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model Acta Neurol. Scand. 69:1984;385-401.
48. Smith M.-L., Kalimo H., Warner D.S., Siesjö B.K. Morphological lesions in the brain preceding the development of postischemic seizures. Acta Neuropathol. (Berl.). 76:1988;253-264.
49. Theilen H., Schröck H., Kuschinsky W. Capillary perfusion during incomplete forebrain ischemia and reperfusion in rat brain. Am. J. Physiol. 265:1993;H642-H648.
50. Zoratti M., Szabó I. The mitochondrial permeability transition. Biochim. Biophys. Acta. 1241:1995;139-176.