The pathological roles of ganglioside metabolism in Alzheimer's disease: Effects of gangliosides on neurogenesis

International Journal of Alzheimer's Disease

Volumn , Issue , 2011, Pages

  Yu, Robert K ^a   Ariga, Toshio ^a   Wakade, Chandramohan ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANTIGEN; CHOLESTEROL; CHOLINERGIC SPECIFIC ANTIGEN 1 ALPHA; GANGLIOSIDE; GANGLIOSIDE GM1; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; BETA SHEET; CELL MEMBRANE FLUIDITY; CHOLINERGIC NERVE CELL; HUMAN; NERVE CELL MEMBRANE; NERVOUS SYSTEM DEVELOPMENT; NEUROEPITHELIUM; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; REVIEW; SENILE PLAQUE; TRANSGENIC MOUSE;

EID: 79952176116     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/193618     Document Type: Review

References (138)

1. Ariga T., McDonald M. P., Yu R. K., Role of ganglioside metabolism in the pathogenesis of Alzheimer's diseasea review Journal of Lipid Research 2008 49 6 1157 1175
2. Ariga T., Miyatake T., Yu R. K., Role of proteoglycans and glycosaminoglycans in the pathogenesis of Alzheimer's disease and related disorders: amyloidogenesis and therapeutic strategiesa review Journal of Neuroscience Research 2010 88 11 2303 2315
3. Yu R. K., Nakatani Y., Yanagisawa M., The role of glycosphingolipid metabolism in the developing brain Journal of Lipid Research 2009 50 S440 S445
4. Ngamukote S., Yanagisawa M., Ariga T., Ando S., Yu R. K., Developmental changes of glycosphingolipids and expression of glycog (Pubitemid 350173557)
5. Yanagisawa M., Yu R. K., The expression and functions of glycoconjugates in neural stem cells Glycobiology 2007 17 7 57R 74R (Pubitemid 47050656)
6. Yu R. K., Development regulation of ganglioside metabolism Progress in Brain Research 1994 101 31 44 (Pubitemid 24084736)
7. Ledeen R. W., Wu G., Lu Z. H., Kozireskichuback D., Fang Y., The role of GM1 and other gangliosides in neuronal differentiation: overview and new findings Annals of the New York Academy of Sciences 1998 845 161 175
8. Zhang Q., Huang Y., Li X., Cui X., Zuo P., Li J., GM1 ganglioside prevented the decline of hippocampal neurogenesis associated with D-galactose NeuroReport 2005 16 12 1297 1301 (Pubitemid 41225199)
9. Saito M., Mao R. F., Wang R., Vadasz C., Saito M., Effects of gangliosides on ethanol-induced neurodegeneration in the developing mouse brain Alcoholism: Clinical and Experimental Research 2007 31 4 665 674 (Pubitemid 46434903)
10. Svennerholm L., Brne G., Karlsson I., Lekman A., Ramstrm I., Wikkels C., Alzheimer diseaseeffect of continuous intracerebroventricular treatment with GM1 ganglioside and a systematic activation programme Dementia and Geriatric Cognitive Disorders 2002 14 3 128 136
11. Kawaguchi K., Kitaguchi N., Nakai S., Murakami K., Asakura K., Mutoh T., Fujita Y., Sugiyama S., Novel therapeutic approach for Alzheimer's disease by removing amyloid protein from the brain with an extracorporeal removal system Journal of Artificial Organs 2010 13 1 31 37
12. Matsuoka Y., Saito M., LaFrancois J., Saito M., Gaynor K., Olm V., Wang L., Casey E., Lu Y., Shiratori C., Lemere C., Duff K., Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to -amyloid Journal of Neuroscience 2003 23 1 29 33 (Pubitemid 36050401)
13. Schneider J. S., Roeltgen D. P., Mancall E. L., Chapas-Crilly J., Rothblat D. S., Tatarian G. T., Parkinson's disease improved function with GM1 ganglioside treatment in a randomized placebo-controlled study Neurology 1998 50 6 1630 1636 (Pubitemid 28283228)
14. Lenzi G. L., Grigoletto F., Gent M., Roberts R. S., Walker M. D., Easton J. D., Carolei A., Dorsey F. C., Rocca W. A., Bruno R., Patarnello F., Fieschi C., Early treatment of stroke with monosialoganglioside GM-1: efficacy and safety results of the early stroke trial Stroke 1994 25 8 1552 1558 (Pubitemid 24233957)
15. Hughes R. A., Cornblath D. R., Guillain-Barr syndrome The Lancet 2005 366 9497 1653 1666
16. Verdier Y., Penke B., Binding sites of amyloid -peptide in cell plasma membrane and implications for Alzheimer's disease Current Protein and Peptide Science 2004 5 1 19 31 (Pubitemid 38279402)
17. Wisniewski T., Ghiso J., Frangione B., Biology of A amyloid in Alzheimer's disease Neurobiology of Disease 1997 4 5 313 328
18. Haughey N. J., Sphingolipids in neurodegeneration NeuroMolecular Medicine 2010 12 4 301 305
19. Haughey N. J., Bandaru V. V. R., Bae M., Mattson M. P., Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis Biochimica et Biophysica Acta 2010 1801 8 878 886
20. Mutoh T., Hirabayashi Y., Mihara T., Ueda M., Koga H., Ueda A., Kokura T., Yamamoto H., Role of glycosphingolipids and therapeutic perspectives on Alzheimer's disease CNS and Neurological Disorders-Drug Targets 2006 5 4 375 380 (Pubitemid 44203348)
21. Gorbenko G. P., Kinnunen P. K. J., The role of lipid-protein interactions in amyloid-type protein fibril formation Chemistry and Physics of Lipids 2006 141 1-2 72 82 (Pubitemid 43728804)
22. Grimm M. O. W., Tschpe J. A., Grimm H. S., Zinser E. G., Hartmann T., Altered membrane fluidity and lipid raft composition in presenilin-deficient cells Acta Neurologica Scandinavica 2006 114 185 27 32 (Pubitemid 44015222)
23. Wong P. T., Schauerte J. A., Wisser K. C., Ding H., Lee E. L., Steel D. G., Gafni A., Amyloid- membrane binding and permeabilization are distinct processes influenced separately by membrane charge and fluidity Journal of Molecular Biology 2009 386 1 81 96
24. Iwamoto N., Suzuki Y., Makino Y., Haga C., Kosaka K., Iizuka R., Cell membrane changes in brains manifesting senile plaques: an immunohistochemical study of GM membranous ganglioside Brain Research 1990 522 1 152 156 (Pubitemid 20208800)
25. Takahashi H., Hirokawa K., Ando S., Obata K., Immunohistological study on brains of Alzheimer's disease using antibodies to fetal antigens, C-series gangliosides and microtubule-associated protein 5 Acta Neuropathologica 1991 81 6 626 631
26. Nishinaka T., Iwata D., Shimada S., Kosaka K., Suzuki Y., Anti-ganglioside GD1a monoclonal antibody recognizes senile plaques in the brains of patients with Alzheimer-type dementia Neuroscience Research 1993 17 2 171 176 (Pubitemid 23266174)
27. Terzi E., Holzemann G., Seelig J., Self-association of -amyloid peptide (140) in solution and binding to lipid membranes Journal of Molecular Biology 1995 252 5 633 642
28. Choo-Smith L. P., Garzon-Rodriguez W., Glabe C. G., Surewicz W. K., Acceleration of amyloid fibril formation by specific binding of A -(140) peptide to ganglioside-containing membrane vesicles Journal of Biological Chemistry 1997 272 37 22987 22990 (Pubitemid 27392420)
29. Matsuzaki K., Horikiri C., Interactions of amyloid -peptide (140) with ganglioside-containing membranes Biochemistry 1999 38 13 4137 4142
30. McLaurin J., Chakrabartty A., Membrane disruption by Alzheimer -amyloid peptides mediated through specific binding to either phospholipids or gangliosides. Implications for neurotoxicity Journal of Biological Chemistry 1996 271 43 26482 26489 (Pubitemid 26359045)
31. McLaurin J., Franklin T., Fraser P. E., Chakrabartty A., Structural transitions associated with the interaction of Alzheimer -amyloid peptides with gangliosides Journal of Biological Chemistry 1998 273 8 4506 4515 (Pubitemid 28103191)
32. Choo-Smith L. P., Surewicz W. K., The interaction between Alzheimer amyloid (140) peptide and ganglioside G(M1)-containing membranes FEBS Letters 1997 402 2-3 95 98 (Pubitemid 27078236)
33. Ariga T., Kobayashi K., Hasegawa A., Kiso M., Ishida H., Miyatake T., Characterization of high-affinity binding between gangliosides and amyloid -protein Archives of Biochemistry and Biophysics 2001 388 2 225 230 (Pubitemid 32911613)
34. Mandal P. K., Pettegrew J. W., Alzheimer's disease: NMR studies of asialo (GM1) and Trisialo (GT1b) ganglioside interactions with A (140) peptide in a membrane mimic environment Neurochemical Research 2004 29 2 447 453 (Pubitemid 38223028)
35. Nakazawa Y., Suzuki Y., Williamson M. P., Sait H., Asakura T., The interaction of amyloid A (140) with lipid bilayers and ganglioside as studied by P solid-state NMR Chemistry and Physics of Lipids 2009 158 1 54 60
36. Atwood C. S., Moir R. D., Huang X., Scarpa R. C., Bacarra N. M. E., Romano D. M., Hartshorn M. A., Tanzi R. E., Bush A. I., Dramatic aggregation of alzheimer by Cu(II) is induced by conditions representing physiological acidosis Journal of Biological Chemistry 1998 273 21 12817 12826 (Pubitemid 28246837)
37. Chen Y. R., Huang H. B., Chyan C. L., Shiao M. S., Lin T. H., Chen Y. C., The effect of A conformation on the metal affinity and aggregation mechanism studied by circular dichroism spectroscopy Journal of Biochemistry 2006 139 4 733 740 (Pubitemid 43973920)
38. Williamson M. P., Suzuki Y., Bourne N. T., Asakura T., Binding of amyloid -peptide to ganglioside micelles is dependent on histidine-13 Biochemical Journal 2006 397 3 483 490 (Pubitemid 44187506)
39. Zhang H., Ding J., Tian W., Wang L., Huang L., Ruan Y., Lu T., Sha Y., Zhang D., Ganglioside GM1 binding the N-terminus of amyloid precursor protein Neurobiology of Aging 2009 30 8 1245 1253
40. Utsumi M., Yamaguchi Y., Sasakawa H., Yamamoto N., Yanagisawa K., Kato K., Up-and-down topological mode of amyloid -peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters Glycoconjugate Journal 2009 26 8 999 1006
41. Yagi-Utsumi M., Kameda T., Yamaguchi Y., Kato K., NMR characterization of the interactions between lyso-GM1 aqueous micelles and amyloid FEBS Letters 2010 584 4 831 836
42. Yanagisawa K., Odaka A., Suzuki N., Ihara Y., GM1 ganglioside-bound amyloid -protein (AB): a possible form of preamyloid in Alzheimer's disease Nature Medicine 1995 1 10 1062 1066
43. Yanagisawa K., Role of gangliosides in Alzheimer's disease Biochimica et Biophysica Acta 2007 1768 8 1943 1951 (Pubitemid 47125848)
44. Yanagisawa K., Ihara Y., GM1 ganglioside-bound amyloid -protein in Alzheimer's disease brain Neurobiology of Aging 1998 19 1 S65 S67
45. Kimura N., Yanagisawa K., Endosomal accumulation of GM1 ganglioside-bound amyloid -protein in neurons of aged monkey brains NeuroReport 2007 18 16 1669 1673 (Pubitemid 47549131)
46. Kurganov B., Doh M., Arispe N., Aggregation of liposomes induced by the toxic peptides Alzheimer's A s, human amylin and prion (106126): facilitation by membrane-bound GM1 ganglioside Peptides 2004 25 2 217 232 (Pubitemid 38520052)
47. Yamamoto N., Hirabayashi Y., Amari M., Yamaguchi H., Romanov G., Van Nostrand W. E., Yanagisawa K., Assembly of hereditary amyloid -protein variants in the presence of favorable gangliosides FEBS Letters 2005 579 10 2185 2190 (Pubitemid 40469690)
48. Okada T., Ikeda K., Wakabayashi M., Ogawa M., Matsuzaki K., Formation of toxic A (140) fibrils on GM1 ganglioside-containing membranes mimicking lipid rafts: polymorphisms in A (140) fibrils Journal of Molecular Biology 2008 382 4 1066 1074
49. Yanagisawa K., Cholesterol and A aggregation Pharmacopsychiatry 2003 36 2 S127 S129
50. Yanagisawa K., Matsuzaki K., Cholesterol-dependent aggregation of amyloid -protein Annals of the New York Academy of Sciences 2002 977 384 386
51. Wakabayashi M., Matsuzaki K., Formation of amyloids by A -(1-42) on NGF-differentiated PC12 cells: roles of gangliosides and cholesterol Journal of Molecular Biology 2007 371 4 924 933 (Pubitemid 47101820)
52. Wang S. S. S., Rymer D. L., Good T. A., Reduction in cholesterol and sialic acid content protects cells from the toxic effects of -amyloid peptides Journal of Biological Chemistry 2001 276 45 42027 42034
53. Lin M. S., Chen L. Y., Wang S. S. S., Chang Y., Chen W. Y., Examining the levels of ganglioside and cholesterol in cell membrane on attenuation the cytotoxicity of beta-amyloid peptide Colloids and Surfaces B 2008 65 2 172 177
54. Zha Q., Ruan Y., Hartmann T., Beyreuther K., Zhang D., GM1 ganglioside regulates the proteolysis of amyloid precursor protein Molecular Psychiatry 2004 9 10 946 952 (Pubitemid 39381958)
55. Hayashi H., Kimura N., Yamaguchi H., Hasegawa K., Yokoseki T., Shibata M., Yamamoto N., Michikawa M., Yoshikawa Y., Terao K., Matsuzaki K., Lemere C. A., Selkoe D. J., Naiki H., Yanagisawa K., A seed for Alzheimer amyloid in the brain Journal of Neuroscience 2004 24 20 4894 4902 (Pubitemid 38668215)
56. Yuyama K., Yanagisawa K., Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease Journal of Neurochemistry 2009 109 5 1250 1260
57. Yamamoto N., Matsubara T., Sato T., Yanagisawa K., Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid -protein fibrillogenesis Biochimica et Biophysica Acta 2008 1778 12 2717 2726
58. Yamamoto N., Yokoseki T., Shibata M., Yamaguchi H., Yanagisawa K., Suppression of A deposition in brain by peripheral administration of Fab fragments of anti-seed antibody Biochemical and Biophysical Research Communications 2005 335 1 45 47 (Pubitemid 41350761)
59. Yuyama K., Yanagisawa K., Sphingomyelin accumulation provides a favorable milieu for GM1 ganglioside-induced assembly of amyloid -protein Neuroscience Letters 2010 481 3 168 172
60. Yanagisawa K., GM1 ganglioside and the seeding of amyloid in Alzheimer's disease: endogenous seed for Alzheimer amyloid Neuroscientist 2005 11 3 250 260 (Pubitemid 40686726)
61. Fantini J., Garmy N., Mahfoud R., Yahi N., Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases Expert Reviews in Molecular Medicine 2002 4 27 1 22
62. Kakio A., Nishimoto S. I., Yanagisawa K., Kozutsumi Y., Matsuzaki K., Interactions of amyloid -protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid Biochemistry 2002 41 23 7385 7390 (Pubitemid 34602456)
63. Mao Y., Shang Z., Imai Y., Hoshino T., Tero R., Tanaka M., Yamamoto N., Yanagisawa K., Urisu T., Surface-induced phase separation of a sphingomyelin/cholesterol/ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates A oligomerization Biochimica et Biophysica Acta 2010 1798 6 1090 1099
64. Matsuzaki K., Kato K., Yanagisawa K., A polymerization through interaction with membrane gangliosides Biochimica et Biophysica Acta 2010 1801 8 868 877
65. Matsuzaki K., Interactions between amyloid betaprotein and gangliosides Tanpakushitsu Kakusan Koso 2002 47 4 351 356
66. Kim S. I., Yi J. S., Ko Y. G., Amyloid oligomerization is induced by brain lipid rafts Journal of Cellular Biochemistry 2006 99 3 878 889
67. Wakabayashi M., Matsuzaki K., Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts FEBS Letters 2009 583 17 2854 2858
68. Yamamoto N., Matsubara E., Maeda S., Minagawa H., Takashima A., Maruyama W., Michikawa M., Yanagisawa K., A ganglioside-induced toxic soluble A assembly: its enhanced formation from A bearing the arctic mutation Journal of Biological Chemistry 2007 282 4 2646 2655 (Pubitemid 47076773)
69. Yamamoto N., Hirabayashi Y., Amari M., Yamaguchi H., Romanov G., Van Nostrand W. E., Yanagisawa K., Assembly of hereditary amyloid -protein variants in the presence of favorable gangliosides FEBS Letters 2005 579 10 2185 2190 (Pubitemid 40469690)
70. Yamamoto N., Van Nostrand W. E., Yanagisawa K., Further evidence of local ganglioside-dependent amyloid -protein assembly in brain NeuroReport 2006 17 16 1735 1737 (Pubitemid 44621574)
71. Wakabayashi M., Okada T., Kozutsumi Y., Matsuzaki K., GM1 ganglioside-mediated accumulation of amyloid -protein on cell membranes Biochemical and Biophysical Research Communications 2005 328 4 1019 1023 (Pubitemid 40238737)
72. Yanagisawa M., Ariga T., Yu R. K., Fucosyl-GM1 expression and amyloid- protein accumulation in PC12 cells Journal of Neuroscience Research 2006 84 6 1343 1349 (Pubitemid 44654457)
73. Ariga T., Kobayashi K., Kuroda Y., Yu R. K., Suzuki M., Kitagawa H., Inagaki F., Miyatake T., Characterization of tumor-associated fucogangliosides from PC 12 pheochromocytoma cells Journal of Biological Chemistry 1987 262 29 14146 14153 (Pubitemid 17152096)
74. Yamazaki Y., Horibata Y., Magatsuka Y., Hirabayashi Y., Hashikawa T., Fucoganglioside -fucosyl( -galactosyl)-GM1: a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis Biochemical Journal 2007 407 1 31 40 (Pubitemid 47535578)
75. Ariga T., Macala L. J., Saito M., Margolis R. K., Greene L. A., Margolis R. U., Yu R. K., Lipid composition of PC12 pheochromocytoma cells: characterization of globoside as a major neutral glycolipid Biochemistry 1988 27 1 52 58 (Pubitemid 18036284)
76. Molander-Melin M., Blennow K., Bogdanovic N., Dellheden B., Mnsson J. E., Fredman P., Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains Journal of Neurochemistry 2005 92 1 171 182 (Pubitemid 40193519)
77. Eckert G. P., Wood W. G., Mller W. E., Lipid membranes and -amyloid: a harmful connection Current Protein and Peptide Science 2010 11 5 319 325
78. Kalanj S., Kracun I., Rosner H., Cosovi C., Regional distribution of brain gangliosides in Alzheimer's disease Neurologia Croatica 1991 40 4 269 281
79. Kalanj-Bognar S., Ganglioside catabolism is altered in fibroblasts and leukocytes from Alzheimer's disease patients Neurobiology of Aging 2006 27 9 1354 1356 (Pubitemid 44067301)
80. Svennerholm L., Gottfries C. G., Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II) Journal of Neurochemistry 1994 62 3 1039 1047 (Pubitemid 24064516)
81. Kracun I., Kalanj S., Cosovic C., Talan-Hranilovic J., Brain gangliosides in Alzheimer's disease Journal fr Hirnforschung 1990 31 6 789 793
82. Kracun I., Kalanj S., Talan-Hranilovic J., Cosovic C., Cortical distribution of gangliosides in Alzheimer's disease Neurochemistry International 1992 20 3 433 438
83. Brooksbank B. W. L., McGovern J., Gangliosides in the brain in adult Down's syndrome and Alzheimer's disease Molecular and Chemical Neuropathology 1989 11 3 143 156 (Pubitemid 20322833)
84. Crino P. B., Ullman M. D., Vogt B. A., Bird E. D., Volicer L., Brain gangliosides in dementia of the Alzheimer type Archives of Neurology 1989 46 4 398 401 (Pubitemid 19099332)
85. Ariga T., Yanagisawa M., Wakade C., Ando S., Buccafusco J. J., McDonald M. P., Yu R. K., Ganglioside metabolism in a transgenic mouse model of alzheimer's disease: expression of Chol-1 antigens in the brain ASN Neuro 2010 2 4 233 241
86. Sawamura N., Morishima-Kawashima M., Waki H., Kobayashi K., Kuramochi T., Frosch M. P., Ding K., Ito M., Kim T. W., Tanzi R. E., Oyama F., Tabira T., Ando S., Ihara Y., Mutant presenilin 2 transgenic mice: a large increase in the levels of A 342 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin Journal of Biological Chemistry 2000 275 36 27901 27908
87. Bernardo A., Harrison F. E., McCord M., Zhao J., Bruchey A., Davies S. S., Jackson Roberts L., Mathews P. M., Matsuoka Y., Ariga T., Yu R. K., Thompson R., McDonald M. P., Elimination of GD3 synthase improves memory and reduces amyloid- plaque load in transgenic mice Neurobiology of Aging 2009 30 11 1777 1791
88. Barrier L., Ingrand S., Damjanac M., Rioux Bilan A., Hugon J., Page G., Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease Neurobiology of Aging 2007 28 12 1863 1872 (Pubitemid 47539690)
89. Ando S., Hirabayashi Y., Kon K., Inagaki F., Tate S., Whittaker V. P., A trisialoganglioside containing a sialyl 2-6 N-acetylgalactosamine residue is a cholinergic-specific antigen, Chol-1 Journal of Biochemistry 1992 111 3 287 290
90. Hirabayashi Y., Nakao T., Irie F., Whittaker V. P., Kon K., Ando S., Structural characterization of a novel cholinergic neuron-specific ganglioside in bovine brain Journal of Biological Chemistry 1992 267 18 12973 12978
91. Derrington E. A., Borroni E., The developmental expression of the cholinergic-specific antigen Chol-1 in the central and peripheral nervous system of the rat Developmental Brain Research 1990 52 1-2 131 140 (Pubitemid 20081070)
92. Ando S., Tanaka Y., Kobayashi S., Fukui F., Iwamoto M., Waki H., Tai T., Hirabayashi Y., Synaptic function of cholinergic-specific Chol-1 ganglioside Neurochemical Research 2004 29 4 857 867 (Pubitemid 38429207)
93. Ando S., Tanaka Y., Waki H., Kon K., Iwamoto M., Fukui F., Gangliosides and sialylcholesterol as modulators of synaptic functions Annals of the New York Academy of Sciences 1998 845 232 239 (Pubitemid 28365314)
94. Chapman J., Bachar O., Korczyn A. D., Wertman E., Michaelson D. M., Antibodies to cholinergic neurons in Alzheimer's disease Journal of Neurochemistry 1988 51 2 479 485
95. Ho N. F., Han S., Dawe G. S., Effect of voluntary running on adult hippocampal neurogenesis in cholinergic lesioned mice BMC Neuroscience 2009 10, article 57
96. Greenberg D. A., Jin K., Neurodegeneration and neurogenesis: focus on Alzheimer's disease Current Alzheimer Research 2006 3 1 25 28
97. Jin K., Galvan V., Xie L., Mao X. O., Gorostiza O. F., Bredesen D. E., Greenberg D. A., Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APP) mice Proceedings of the National Academy of Sciences of the United States of America 2004 101 36 13363 13367 (Pubitemid 39209671)
98. Lopez-Toledano M. A., Faghihi M. A., Patel N. S., Wahlestedt C., Adult neurogenesis: a potential tool for early diagnosis in alzheimer's disease? Journal of Alzheimer's Disease 2010 20 2 395 408
99. Lpez-Toledano M. A., Shelanski M. L., Increased neurogenesis in young transgenic mice overexpressing human APP(Sw, Ind) Journal of Alzheimer's Disease 2007 12 3 229 240 (Pubitemid 350179250)
100. Oikawa N., Yamaguchi H., Ogino K., Taki T., Yuyama K., Yamamoto N., Shin R. W., Furukawa K., Yanagisawa K., Gangliosides determine the amyloid pathology of Alzheimer's disease NeuroReport 2009 20 12 1043 1046
101. Okada M., Itoh M.-I., Haraguchi M., Okajima T., Inoue M., Oishi H., Matsuda Y., Iwamoto T., Kawano T., Fukumoto S., Miyazaki H., Furukawa K., Aizawa S., Furukawa K., b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve Journal of Biological Chemistry 2002 277 3 1633 1636 (Pubitemid 34968730)
102. Gregory G. C., Macdonald V., Schofield P. R., Kril J. J., Halliday G. M., Differences in regional brain atrophy in genetic forms of Alzheimer's disease Neurobiology of Aging 2006 27 3 387 393 (Pubitemid 43186040)
103. Crews L., Masliah E., Molecular mechanisms of neurodegeneration in Alzheimer's disease Human Molecular Genetics 2010 19 1 R12 R20
104. Taupin P., Therapeutic potential of adult neural stem cells Recent Patents on CNS Drug Discovery 2006 1 3 299 303
105. Shruster A., Melamed E., Offen D., Neurogenesis in the aged and neurodegenerative brain Apoptosis 2010 15 11 1415 1421
106. Crews L., Rockenstein E., Masliah E., APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis Brain Structure and Function 2010 214 2-3 111 126
107. Boekhoorn K., Joels M., Lucassen P. J., Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus Neurobiology of Disease 2006 24 1 1 14 (Pubitemid 44416208)
108. Donovan M. H., Yazdani U., Norris R. D., Games D., German D. C., Eisch A. J., Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease Journal of Comparative Neurology 2006 495 1 70 83 (Pubitemid 43238052)
109. Haughey N. J., Liu D., Nath A., Borchard A. C., Mattson M. P., Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid -peptide: implications for the pathogenesis of Alzheimer's disease NeuroMolecular Medicine 2002 1 2 125 135 (Pubitemid 37012521)
110. Haughey N. J., Nath A., Chan S. L., Borchard A. C., Rao M. S., Mattson M. P., Disruption of neurogenesis by amyloid -peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease Journal of Neurochemistry 2002 83 6 1509 1524 (Pubitemid 35477489)
111. Ermini F. V., Grathwohl S., Radde R., Yamaguchi M., Staufenbiel M., Palmer T. D., Jucker M., Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis American Journal of Pathology 2008 172 6 1520 1528 (Pubitemid 351793346)
112. Zhang C., McNeil E., Dressler L., Siman R., Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease Experimental Neurology 2007 204 1 77 87 (Pubitemid 46330258)
113. Yanagisawa M., Yu R. K., O-linked -N-acetylglucosaminylation in mouse embryonic neural precursor cells Journal of Neuroscience Research 2009 87 16 3535 3545
114. Yanagisawa M., Nakamura K., Taga T., Glycosphingolipid synthesis inhibitor represses cytokine-induced activation of the Ras-MAPK pathway in embryonic neural precursor cells Journal of Biochemistry 2005 138 3 285 291 (Pubitemid 41441960)
115. Chen Y., Dong C., A 40 promotes neuronal cell fate in neural progenitor cells Cell Death and Differentiation 2009 16 3 386 394
116. Koudinov A. R., Berezov T. T., Alzheimer's amyloid-beta (A ) is an essential synaptic protein, not neurotoxic junk Acta Neurobiologiae Experimentalis 2004 64 1 71 79 (Pubitemid 38453807)
117. Lpez-Toledano M. A., Shelanski M. L., Neurogenic effect of -amyloid peptide in the development of neural stem cells Journal of Neuroscience 2004 24 23 5439 5444 (Pubitemid 38747685)
118. Calafiore M., Battaglia G., Zappal A., Trovato-Salinaro E., Caraci F., Caruso M., Vancheri C., Sortino M. A., Nicoletti F., Copani A., Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to -amyloid Neurobiology of Aging 2006 27 4 606 613 (Pubitemid 43290529)
119. Sotthibundhu A., Li Q.-X., Thangnipon W., Coulson E. J., A 1-42 stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor Neurobiology of Aging 2009 30 12 1975 1985
120. Malaplate-Armand C., Florent-Bchard S., Youssef I., Koziel V., Sponne I., Kriem B., Leininger-Muller B., Olivier J.-L., Oster T., Pillot T., Soluble oligomers of amyloid- peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway Neurobiology of Disease 2006 23 1 178 189 (Pubitemid 43922461)
121. Sotthibundhu A., Sykes A. M., Fox B., Underwood C. K., Thangnipon W., Coulson E. J., -amyloid142 induces neuronal death through the p75 neurotrophin receptor Journal of Neuroscience 2008 28 15 3941 3946
122. Hayashi S. I., Sato N., Yamamoto A., Ikegame Y., Nakashima S., Ogihara T., Morishita R., Alzheimer disease-associated peptide, amyloid 40, inhibits vascular regeneration with induction of endothelial autophagy Arteriosclerosis, Thrombosis, and Vascular Biology 2009 29 11 1909 1915
123. Gong Y., Chang L., Viola K. L., Lacor P. N., Lambert M. P., Finch C. E., Krafft G. A., Klein W. L., Alzheimer's disease-affected brain: presence of oligomeric A ligands (ADDLs) suggests a molecular basis for reversible memory loss Proceedings of the National Academy of Sciences of the United States of America 2003 100 18 10417 10422 (Pubitemid 37071893)
124. Heo C., Chang K.-A., Choi H. S., Kim H.-S., Kim S., Liew H., Kim J. A., Yu E., Ma J., Suh Y.-H., Effects of the monomeric, oligomeric, and fibrillar A 42 peptides on the proliferation and differentiation of adult neural stem cells from subventricular zone Journal of Neurochemistry 2007 102 2 493 500 (Pubitemid 47000592)
125. Lee J. T., Xu J., Lee J. M., Ku G., Han X., Yang D. I., Chen S., Hsu C. Y., Amyloid- peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway Journal of Cell Biology 2004 164 1 123 131 (Pubitemid 38082463)
126. Millet P., Silva Lages C., Hak S., Nowak E., Allemand I., Granotier C., Boussin F. D., Amyloid- peptide triggers Fas-independent apoptosis and differentiation of neural progenitor cells Neurobiology of Disease 2005 19 1-2 57 65 (Pubitemid 40544723)
127. Li X., Zuo P., Effects of A on neurogenesis in the adult mouse subventricular zone and dentate gyrus Neurological Research 2005 27 2 218 222 (Pubitemid 40388429)
128. Cazzaniga E., Bulbarelli A., Cassetti A., Lonati E., Re F., Palestini P., Mutoh T., Masserini M., -amyloid (2535) enhances lipid metabolism and protein ubiquitination in cultured neurons Journal of Neuroscience Research 2007 85 10 2253 2261 (Pubitemid 47172157)
129. Copani A., Melchiorri D., Caricasole A., Martini F., Sale P., Carnevale R., Gradini R., Sortino M. A., Lenti L., De Maria R., Nicoletti F., -amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons Journal of Neuroscience 2002 22 10 3963 3968 (Pubitemid 37465704)
130. Yanagisawa M., Ariga T., Yu R. K., Cytotoxic effects of GM1 ganglioside and amyloid -peptide on mouse embryonic neural stem cells ASN Neuro 2010 2 1 49 56
131. Hynds D. L., Burry R. W., Yates A. J., Gangliosides inhibit growth factor-stimulated neurite outgrowth in SH-SY5Y human neuroblastoma cells Journal of Neuroscience Research 1997 47 6 617 625 (Pubitemid 27138744)
132. Leon A., Benvegnu D., Dal Toso R., Dorsal root ganglia and nerve growth factor: a model for understanding the mechanism of GM1 effects on neuronal repair Journal of Neuroscience Research 1984 12 2-3 277 287 (Pubitemid 14023220)
133. Dreyfus H., Ferret B., Harth S., Gorio A., Freysz L., Massarelli R., Effect of exogenous gangliosides on the morphology and biochemistry of cultured neurons Advances in Experimental Medicine and Biology 1984 174 513 524
134. Tsuji S., Yamashita T., Nagai Y., A novel, carbohydrate signal-mediated cell surface protein phosphorylation: ganglioside GQ1b stimulates ecto-protein kinase activity on the cell surface of a human neuroblastoma cell line, GOTO Journal of Biochemistry 1988 104 4 498 503
135. Jankowsky J. L., Slunt H. H., Ratovitski T., Jenkins N. A., Copeland N. G., Borchelt D. R., Co-expression of multiple transgenes in mouse CNS: a comparison of strategies Biomolecular Engineering 2001 17 6 157 165 (Pubitemid 32409891)
136. Wu L., Sluiter A. A., Guo H. F., Balesar R. A., Swaab D. F., Zhou J. N., Verwer R. W. H., Neural stem cells improve neuronal survival in cultured postmortem brain tissue from aged and Alzheimer patients Journal of Cellular and Molecular Medicine 2008 12 5A 1611 1621
137. Matsuzaki K., Noguch T., Wakabayashi M., Ikeda K., Okada T., Ohashi Y., Hoshino M., Naiki H., Inhibitors of amyloid -protein aggregation mediated by GM1-containing raft-like membranes Biochimica et Biophysica Acta 2007 1768 1 122 130 (Pubitemid 44909079)
138. Svennerholm L., The gangliosides Journal of Lipid Research 1964 5 4 145 126