3D Analysis of the TCR/pMHCII Complex Formation in Monkeys Vaccinated with the First Peptide Inducing Sterilizing Immunity against Human Malaria

PLoS ONE

Volumn 5, Issue 3, 2010, Pages

  Patarroyo, Manuel A ^a,b   Bermúdez, Adriana ^a,b   López, Carolina ^a,b   Yepes, Gloria ^a   Patarroyo, Manuel E ^a,c  

^a FUNDACIÓN INSTITUTO DE INMUNOLOGÍA DE COLOMBIA FIDIC   (Colombia)

^b UNIVERSIDAD DEL ROSARIO   (Colombia)

^c UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; HLA-DRB1 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL; AOTUS; ARTICLE; BIOLOGICAL MODEL; CHEMISTRY; GENETIC VARIABILITY; GENOTYPE; HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; MALARIA; METABOLISM; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN CONFORMATION; THREE DIMENSIONAL IMAGING;

ANIMALS; AOTUS TRIVIRGATUS; GENETIC VARIATION; GENOTYPE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DR ANTIGENS; HUMANS; IMAGING, THREE-DIMENSIONAL; IMMUNE SYSTEM; MALARIA; MODELS, GENETIC; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ANTIGEN, T-CELL;

EID: 79952117436     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009771     Document Type: Article

References (46)

1. Bentley GA, Mariuzza RA (1996) The structure of the T cell antigen receptor. Annu Rev Immunol 14: 563-590.
2. Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, et al. (1996) An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCRMHC complex. Science 274: 209-219.
3. Jorgensen JL, Reay PA, Ehrich EW, Davis MM (1992) Molecular components of T-cell recognition. Annu Rev Immunol 10: 835-873.
4. Arstila TP, Casrouge A, Baron V, Even J, Kanellopoulos J, et al. (1999) A direct estimate of the human alphabeta T cell receptor diversity. Science 286: 958-961.
5. Ishizuka J, Stewart-Jones GB, van der Merwe A, Bell JI, McMichael AJ, et al. (2008) The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain. Immunity 28: 171-182.
6. Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI (2005) The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434: 214-217.
7. Rodriguez LE, Curtidor H, Urquiza M, Cifuentes G, Reyes C, et al. (2008) Intimate molecular interactions of P. falciparum merozoite proteins involved in invasion of red blood cells and their implications for vaccine design. Chem Rev 108: 3656-3705.
8. Rodriguez R, Moreno A, Guzman F, Calvo M, Patarroyo ME (1990) Studies in owl monkeys leading to the development of a synthetic vaccine against the asexual blood stages of Plasmodium falciparum. Am J Trop Med Hyg 43: 339-354.
9. Pico de Coana Y, Barrero C, Cajiao I, Mosquera C, Patarroyo ME, et al. (2004) Quantifying Aotus monkey cytokines by real-time quantitative RT-PCR. Cytokine 27: 129-133.
10. Favre N, Daubenberger C, Marfurt J, Moreno A, Patarroyo M, et al. (1998) Sequence and diversity of T-cell receptor alpha V, J, and C genes of the owl monkey Aotus nancymaae. Immunogenetics 48: 253-259.
11. Moncada CA, Guerrero E, Cardenas P, Suarez CF, Patarroyo ME, et al. (2005) The T-cell receptor in primates: identifying and sequencing new owl monkey TRBV gene sub-groups. Immunogenetics 57: 42-52.
12. Suarez CF, Patarroyo ME, Trujillo E, Estupinan M, Baquero JE, et al. (2006) Owl monkey MHC-DRB exon 2 reveals high similarity with several HLA-DRB lineages. Immunogenetics 58: 542-558.
13. Cifuentes G, Bermudez A, Rodriguez R, Patarroyo MA, Patarroyo ME (2008) Shifting the polarity of some critical residues in malarial peptides' binding to host cells is a key factor in breaking conserved antigens' code of silence. Med Chem 4: 278-292.
14. Patarroyo ME, Patarroyo MA (2008) Emerging rules for subunit-based, multiantigenic, multistage chemically synthesized vaccines. Acc Chem Res 41: 377-386.
15. Polley SD, Conway DJ, Cavanagh DR, McBride JS, Lowe BS, et al. (2006) High levels of serum antibodies to merozoite surface protein 2 of Plasmodium falciparum are associated with reduced risk of clinical malaria in coastal Kenya. Vaccine 24: 4233-4246.
16. Ocampo M, Urquiza M, Guzman F, Rodriguez LE, Suarez J, et al. (2000) Two MSA 2 peptides that bind to human red blood cells are relevant to Plasmodium falciparum merozoite invasion. J Pept Res 55: 216-223.
17. Cifuentes G, Patarroyo ME, Urquiza M, Ramirez LE, Reyes C, et al. (2003) Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective. J Med Chem 46: 2250-2253.
18. Patarroyo ME, Cifuentes G, Vargas LE, Rosas J (2004) Structural modifications enable conserved peptides to fit into MHC molecules thus inducing protection against malaria. Chembiochem 5: 1588-1593.
19. Pannetier C, Even J, Kourilsky P (1995) T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol Today 16: 176-181.
20. Hennecke J, Wiley DC (2002) Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity. J Exp Med 195: 571-581.
21. Hennecke J, Carfi A, Wiley DC (2000) Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1. Embo J 19: 5611-5624.
22. Stern LJ, Brown JH, Jardetzky TS, Gorga JC, Urban RG, et al. (1994) Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368: 215-221.
23. Fremont DH, Hendrickson WA, Marrack P, Kappler J (1996) Structures of an MHC class II molecule with covalently bound single peptides. Science 272: 1001-1004.
24. Dessen A, Lawrence CM, Cupo S, Zaller DM, Wiley DC (1997) X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II. Immunity 7: 473-481.
25. Rammensee HG, Friede T, Stevanoviic S (1995) MHC ligands and peptide motifs: first listing. Immunogenetics 41: 178-228.
26. Sant'Angelo DB, Waterbury G, Preston-Hurlburt P, Yoon ST, Medzhitov R, et al. (1996) The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4: 367-376.
27. Marrack P, Scott-Browne JP, Dai S, Gapin L, Kappler JW (2008) Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol 26: 171-203.
28. Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC (2007) Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nat Immunol 8: 975-983.
29. Dai S, Huseby ES, Rubtsova K, Scott-Browne J, Crawford F, et al. (2008) Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity 28: 324-334.
30. Garcia KC, Teyton L, Wilson IA (1999) Structural basis of T cell recognition. Annu Rev Immunol 17: 369-397.
31. Rudolph MG, Stanfield RL, Wilson IA (2006) How TCRs bind MHCs, peptides, and coreceptors. Annu Rev Immunol 24: 419-466.
32. Fremont DH, Monnaie D, Nelson CA, Hendrickson WA, Unanue ER (1998) Crystal structure of I-Ak in complex with a dominant epitope of lysozyme. Immunity 8: 305-317.
33. Reinherz EL, Tan K, Tang L, Kern P, Liu J, et al. (1999) The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science 286: 1913-1921.
34. Baum J, Maier AG, Good RT, Simpson KM, Cowman AF (2005) Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions. PLoS Pathog 1: e37.
35. Dutta S, Dlugosz LS, Clayton JW, Pool CD, Haynes JD, et al. Alanine mutagenesis of the primary antigenic escape residue cluster, c1, of apical membrane antigen 1. Infect Immun 78: 661-671.
36. Bozdech Z, Llinas M, Pulliam BL, Wong ED, Zhu J, et al. (2003) The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol 1: E5.
37. Lasonder E, Janse CJ, van Gemert GJ, Mair GR, Vermunt AM, et al. (2008) Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity. PLoS Pathog 4: e1000195.
38. Kersh GJ, Miley MJ, Nelson CA, Grakoui A, Horvath S, et al. (2001) Structural and functional consequences of altering a peptide MHC anchor residue. J Immunol 166: 3345-3354.
39. Nino-Vasquez JJ, Vogel D, Rodriguez R, Moreno A, Patarroyo ME, et al. (2000) Sequence and diversity of DRB genes of Aotus nancymaae, a primate model for human malaria parasites. Immunogenetics 51: 219-230.
40. Kriener K, O'HUigin C, Tichy H, Klein J (2000) Convergent evolution of major histocompatibility complex molecules in humans and New World monkeys. Immunogenetics 51: 169-178.
41. Kriener K, O'HUigin C, Klein J (2001) Independent origin of functional MHC class II genes in humans and New World monkeys. Hum Immunol 62: 1-14.
42. Prato S, Maxwell T, Pinzon-Charry A, Schmidt CW, Corradin G, et al. (2005) MHC class I-restricted exogenous presentation of a synthetic 102-mer malaria vaccine polypeptide. Eur J Immunol 35: 681-689.
43. Coppel RL (2009) Vaccinating with the genome: a Sisyphean task? Trends Parasitol 25: 205-212.
44. Richards JS, Beeson JG (2009) The future for blood-stage vaccines against malaria. Immunol Cell Biol 87: 377-390.
45. Houghten RA (1985) General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. Proc Natl Acad Sci U S A 82: 5131-5135.
46. Lu J, Basu A, Melenhorst JJ, Young NS, Brown KE (2004) Analysis of T-cell repertoire in hepatitis-associated aplastic anemia. Blood 103: 4588-4593.