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Volumn 25, Issue 5, 2009, Pages 205-212

Vaccinating with the genome: a Sisyphean task?

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MALARIA VACCINE; MEMBRANE ANTIGEN;

EID: 65249134014     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2009.02.006     Document Type: Article
Times cited : (26)

References (55)
  • 1
    • 0037086437 scopus 로고    scopus 로고
    • A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea
    • Genton B., et al. A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea. J. Infect. Dis. 185 (2002) 820-827
    • (2002) J. Infect. Dis. , vol.185 , pp. 820-827
    • Genton, B.1
  • 2
    • 33745630355 scopus 로고    scopus 로고
    • A set of glycosylphosphatidyl inositol-anchored membrane proteins of Plasmodium falciparum is refractory to genetic deletion
    • Sanders P.R., et al. A set of glycosylphosphatidyl inositol-anchored membrane proteins of Plasmodium falciparum is refractory to genetic deletion. Infect. Immun. 74 (2006) 4330-4338
    • (2006) Infect. Immun. , vol.74 , pp. 4330-4338
    • Sanders, P.R.1
  • 3
    • 0023689650 scopus 로고
    • Molecular basis for mutation in a surface protein expressed by malaria parasites
    • Hudson D.E., et al. Molecular basis for mutation in a surface protein expressed by malaria parasites. J. Mol. Biol. 203 (1988) 707-714
    • (1988) J. Mol. Biol. , vol.203 , pp. 707-714
    • Hudson, D.E.1
  • 4
    • 0023115214 scopus 로고
    • Vaccination-induced variation in the 140 kD merozoite surface antigen of Plasmodium knowlesi malaria
    • Klotz F.W., et al. Vaccination-induced variation in the 140 kD merozoite surface antigen of Plasmodium knowlesi malaria. J. Exp. Med. 165 (1987) 359-367
    • (1987) J. Exp. Med. , vol.165 , pp. 359-367
    • Klotz, F.W.1
  • 5
    • 42349100173 scopus 로고    scopus 로고
    • The chemical genomic portrait of yeast: uncovering a phenotype for all genes
    • Hillenmeyer M.E., et al. The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science 320 (2008) 362-365
    • (2008) Science , vol.320 , pp. 362-365
    • Hillenmeyer, M.E.1
  • 6
    • 0034900626 scopus 로고    scopus 로고
    • An EBA175 homologue which is transcribed but not translated in erythrocytic stages of Plasmodium falciparum
    • Triglia T., et al. An EBA175 homologue which is transcribed but not translated in erythrocytic stages of Plasmodium falciparum. Mol. Biochem. Parasitol. 116 (2001) 55-63
    • (2001) Mol. Biochem. Parasitol. , vol.116 , pp. 55-63
    • Triglia, T.1
  • 7
    • 2442504694 scopus 로고    scopus 로고
    • A common cross-species function for the double epidermal growth factor-like modules of the highly divergent plasmodium surface proteins MSP-1 and MSP-8
    • Drew D.R., et al. A common cross-species function for the double epidermal growth factor-like modules of the highly divergent plasmodium surface proteins MSP-1 and MSP-8. J. Biol. Chem. 279 (2004) 20147-20153
    • (2004) J. Biol. Chem. , vol.279 , pp. 20147-20153
    • Drew, D.R.1
  • 8
    • 0033958230 scopus 로고    scopus 로고
    • Functional conservation of the malaria vaccine antigen MSP-119 across distantly related Plasmodium species
    • O'Donnell R.A., et al. Functional conservation of the malaria vaccine antigen MSP-119 across distantly related Plasmodium species. Nat. Med. 6 (2000) 91-95
    • (2000) Nat. Med. , vol.6 , pp. 91-95
    • O'Donnell, R.A.1
  • 9
    • 41549149549 scopus 로고    scopus 로고
    • Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development
    • de Koning-Ward T.F., et al. Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development. Mol. Biochem. Parasitol. 159 (2008) 69-72
    • (2008) Mol. Biochem. Parasitol. , vol.159 , pp. 69-72
    • de Koning-Ward, T.F.1
  • 10
    • 0030017335 scopus 로고    scopus 로고
    • Protective immune responses to apical membrane antigen 1 of Plasmodium chabaudi involve recognition of strain-specific epitopes
    • Crewther P.E., et al. Protective immune responses to apical membrane antigen 1 of Plasmodium chabaudi involve recognition of strain-specific epitopes. Infect. Immun. 64 (1996) 3310-3317
    • (1996) Infect. Immun. , vol.64 , pp. 3310-3317
    • Crewther, P.E.1
  • 11
    • 50949124044 scopus 로고    scopus 로고
    • Protection induced by Plasmodium falciparum MSP1(42) is strain-specific, antigen and adjuvant dependent, and correlates with antibody responses
    • Lyon J.A., et al. Protection induced by Plasmodium falciparum MSP1(42) is strain-specific, antigen and adjuvant dependent, and correlates with antibody responses. PLoS One 3 (2008) e2830
    • (2008) PLoS One , vol.3
    • Lyon, J.A.1
  • 12
    • 0032809338 scopus 로고    scopus 로고
    • Plasmodium: immunization with carboxyl-terminal regions of MSP-1 protects against homologous but not heterologous blood-stage parasite challenge
    • Rotman H.L., et al. Plasmodium: immunization with carboxyl-terminal regions of MSP-1 protects against homologous but not heterologous blood-stage parasite challenge. Exp. Parasitol. 91 (1999) 78-85
    • (1999) Exp. Parasitol. , vol.91 , pp. 78-85
    • Rotman, H.L.1
  • 13
    • 57649115306 scopus 로고    scopus 로고
    • Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age
    • Bejon P., et al. Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age. N. Engl. J. Med. 359 (2008) 2521-2532
    • (2008) N. Engl. J. Med. , vol.359 , pp. 2521-2532
    • Bejon, P.1
  • 14
    • 11144327172 scopus 로고    scopus 로고
    • Meningococcal polysaccharide-protein conjugate vaccines
    • Snape M.D., and Pollard A.J. Meningococcal polysaccharide-protein conjugate vaccines. Lancet Infect. Dis. 5 (2005) 21-30
    • (2005) Lancet Infect. Dis. , vol.5 , pp. 21-30
    • Snape, M.D.1    Pollard, A.J.2
  • 15
    • 55549145006 scopus 로고    scopus 로고
    • Malaria vaccines: into a mirror, darkly?
    • Plebanski M., et al. Malaria vaccines: into a mirror, darkly?. Trends Parasitol. 24 (2008) 532-536
    • (2008) Trends Parasitol. , vol.24 , pp. 532-536
    • Plebanski, M.1
  • 16
    • 52049094865 scopus 로고    scopus 로고
    • What should vaccine developers ask? Simulation of the effectiveness of malaria vaccines
    • Penny M.A., et al. What should vaccine developers ask? Simulation of the effectiveness of malaria vaccines. PLoS One 3 (2008) e3193
    • (2008) PLoS One , vol.3
    • Penny, M.A.1
  • 17
    • 0025953526 scopus 로고
    • Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria
    • Sabchareon A., et al. Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria. Am. J. Trop. Med. Hyg. 45 (1991) 297-308
    • (1991) Am. J. Trop. Med. Hyg. , vol.45 , pp. 297-308
    • Sabchareon, A.1
  • 18
    • 8144224632 scopus 로고
    • Gamma-globulin and acquired immunity to human malaria
    • Cohen S., et al. Gamma-globulin and acquired immunity to human malaria. Nature 192 (1961) 733-737
    • (1961) Nature , vol.192 , pp. 733-737
    • Cohen, S.1
  • 19
    • 33750576557 scopus 로고    scopus 로고
    • Critical evaluation of different methods for measuring the functional activity of antibodies against malaria blood stage antigens
    • Bergmann-Leitner E.S., et al. Critical evaluation of different methods for measuring the functional activity of antibodies against malaria blood stage antigens. Am. J. Trop. Med. Hyg. 75 (2006) 437-442
    • (2006) Am. J. Trop. Med. Hyg. , vol.75 , pp. 437-442
    • Bergmann-Leitner, E.S.1
  • 20
    • 51449101218 scopus 로고    scopus 로고
    • Phase 1 trial of AMA1-C1/Alhydrogel plus CPG 7909: an asexual blood-stage vaccine for Plasmodium falciparum malaria
    • Mullen G.E., et al. Phase 1 trial of AMA1-C1/Alhydrogel plus CPG 7909: an asexual blood-stage vaccine for Plasmodium falciparum malaria. PLoS One 3 (2008) e2940
    • (2008) PLoS One , vol.3
    • Mullen, G.E.1
  • 21
    • 21144469605 scopus 로고    scopus 로고
    • Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria
    • Malkin E.M., et al. Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria. Infect. Immun. 73 (2005) 3677-3685
    • (2005) Infect. Immun. , vol.73 , pp. 3677-3685
    • Malkin, E.M.1
  • 22
    • 19944369747 scopus 로고    scopus 로고
    • The clinical-grade 42-kilodalton fragment of merozoite surface protein 1 of Plasmodium falciparum strain FVO expressed in Escherichia coli protects Aotus nancymai against challenge with homologous erythrocytic-stage parasites
    • Darko C.A., et al. The clinical-grade 42-kilodalton fragment of merozoite surface protein 1 of Plasmodium falciparum strain FVO expressed in Escherichia coli protects Aotus nancymai against challenge with homologous erythrocytic-stage parasites. Infect. Immun. 73 (2005) 287-297
    • (2005) Infect. Immun. , vol.73 , pp. 287-297
    • Darko, C.A.1
  • 23
    • 0344717267 scopus 로고    scopus 로고
    • Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies
    • Guevara Patino J.A., et al. Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies. J. Exp. Med. 186 (1997) 1689-1699
    • (1997) J. Exp. Med. , vol.186 , pp. 1689-1699
    • Guevara Patino, J.A.1
  • 24
    • 0029098383 scopus 로고
    • Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages
    • Bouharoun-Tayoun H., et al. Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. J. Exp. Med. 182 (1995) 409-418
    • (1995) J. Exp. Med. , vol.182 , pp. 409-418
    • Bouharoun-Tayoun, H.1
  • 25
    • 0034606288 scopus 로고    scopus 로고
    • Human malaria in immunocompromised mice: an in vivo model to study defense mechanisms against Plasmodium falciparum
    • Badell E., et al. Human malaria in immunocompromised mice: an in vivo model to study defense mechanisms against Plasmodium falciparum. J. Exp. Med. 192 (2000) 1653-1660
    • (2000) J. Exp. Med. , vol.192 , pp. 1653-1660
    • Badell, E.1
  • 26
    • 34249703970 scopus 로고    scopus 로고
    • The importance of human FcγRI in mediating protection to malaria
    • McIntosh R.S., et al. The importance of human FcγRI in mediating protection to malaria. PLoS Pathog. 3 (2007) e72
    • (2007) PLoS Pathog. , vol.3
    • McIntosh, R.S.1
  • 27
    • 55549130548 scopus 로고    scopus 로고
    • An in vitro tool to assess the potential protective efficacy of Plasmodium yoelii MSP119-based immunisation regimens by measuring specific invasion inhibitory antibodies in mouse sera
    • Wang L., et al. An in vitro tool to assess the potential protective efficacy of Plasmodium yoelii MSP119-based immunisation regimens by measuring specific invasion inhibitory antibodies in mouse sera. Int. J. Parasitol. 38 Suppl. 1 (2008) S48
    • (2008) Int. J. Parasitol. , vol.38 , Issue.SUPPL. 1
    • Wang, L.1
  • 28
    • 28444486411 scopus 로고    scopus 로고
    • A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum
    • Druilhe P., et al. A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum. PLoS Med. 2 (2005) e344
    • (2005) PLoS Med. , vol.2
    • Druilhe, P.1
  • 29
    • 0034064657 scopus 로고    scopus 로고
    • Cytophilic immunoglobulin responses to Plasmodium falciparum glutamate-rich protein are correlated with protection against clinical malaria in Dielmo, Senegal
    • Oeuvray C., et al. Cytophilic immunoglobulin responses to Plasmodium falciparum glutamate-rich protein are correlated with protection against clinical malaria in Dielmo, Senegal. Infect. Immun. 68 (2000) 2617-2620
    • (2000) Infect. Immun. , vol.68 , pp. 2617-2620
    • Oeuvray, C.1
  • 30
    • 39849106625 scopus 로고    scopus 로고
    • Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif
    • Villard V., et al. Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif. PLoS One 2 (2007) e645
    • (2007) PLoS One , vol.2
    • Villard, V.1
  • 31
    • 33344467685 scopus 로고    scopus 로고
    • Enhancement of functional antibody responses to AMA1-C1/Alhydrogel, a Plasmodium falciparum malaria vaccine, with CpG oligodeoxynucleotide
    • Mullen G.E., et al. Enhancement of functional antibody responses to AMA1-C1/Alhydrogel, a Plasmodium falciparum malaria vaccine, with CpG oligodeoxynucleotide. Vaccine 24 (2006) 2497-2505
    • (2006) Vaccine , vol.24 , pp. 2497-2505
    • Mullen, G.E.1
  • 32
    • 0033088812 scopus 로고    scopus 로고
    • Human antibodies to the 19kDa C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 inhibit parasite growth in vitro
    • Egan A.F., et al. Human antibodies to the 19kDa C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 inhibit parasite growth in vitro. Parasite Immunol. 21 (1999) 133-139
    • (1999) Parasite Immunol. , vol.21 , pp. 133-139
    • Egan, A.F.1
  • 33
    • 34247355050 scopus 로고    scopus 로고
    • Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naive adults at the Walter Reed Army Institute of Research
    • Polhemus M.E., et al. Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naive adults at the Walter Reed Army Institute of Research. Vaccine 25 (2007) 4203-4212
    • (2007) Vaccine , vol.25 , pp. 4203-4212
    • Polhemus, M.E.1
  • 34
    • 44849126049 scopus 로고    scopus 로고
    • Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial
    • Thera M.A., et al. Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial. PLoS One 3 (2008) e1465
    • (2008) PLoS One , vol.3
    • Thera, M.A.1
  • 35
    • 4644240199 scopus 로고    scopus 로고
    • Merozoite surface protein 4/5 provides protection against lethal challenge with a heterologous malaria parasite strain
    • Goschnick M.W., et al. Merozoite surface protein 4/5 provides protection against lethal challenge with a heterologous malaria parasite strain. Infect. Immun. 72 (2004) 5840-5849
    • (2004) Infect. Immun. , vol.72 , pp. 5840-5849
    • Goschnick, M.W.1
  • 36
    • 45549097494 scopus 로고    scopus 로고
    • Immunity to malaria: more questions than answers
    • Langhorne J., et al. Immunity to malaria: more questions than answers. Nat. Immunol. 9 (2008) 725-732
    • (2008) Nat. Immunol. , vol.9 , pp. 725-732
    • Langhorne, J.1
  • 37
    • 0028869127 scopus 로고
    • Assessment of the role of the humoral response to Plasmodium falciparum MSP2 compared to RESA and SPf66 in protecting Papua New Guinean children from clinical malaria
    • al-Yaman F., et al. Assessment of the role of the humoral response to Plasmodium falciparum MSP2 compared to RESA and SPf66 in protecting Papua New Guinean children from clinical malaria. Parasite Immunol. 17 (1995) 493-501
    • (1995) Parasite Immunol. , vol.17 , pp. 493-501
    • al-Yaman, F.1
  • 38
    • 34249894231 scopus 로고    scopus 로고
    • Towards an effective malaria vaccine
    • Aide P., et al. Towards an effective malaria vaccine. Arch. Dis. Child. 92 (2007) 476-479
    • (2007) Arch. Dis. Child. , vol.92 , pp. 476-479
    • Aide, P.1
  • 39
    • 0035908009 scopus 로고    scopus 로고
    • Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria
    • O'Donnell R.A., et al. Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria. J. Exp. Med. 193 (2001) 1403-1412
    • (2001) J. Exp. Med. , vol.193 , pp. 1403-1412
    • O'Donnell, R.A.1
  • 40
    • 2942746462 scopus 로고    scopus 로고
    • Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa
    • John C.C., et al. Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa. J. Immunol. 173 (2004) 666-672
    • (2004) J. Immunol. , vol.173 , pp. 666-672
    • John, C.C.1
  • 41
    • 4644295135 scopus 로고    scopus 로고
    • The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia
    • Corran P.H., et al. The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia. Infect. Immun. 72 (2004) 6185-6189
    • (2004) Infect. Immun. , vol.72 , pp. 6185-6189
    • Corran, P.H.1
  • 42
    • 8344271026 scopus 로고    scopus 로고
    • Production of recombinant protein therapeutics in cultivated mammalian cells
    • Wurm F.M. Production of recombinant protein therapeutics in cultivated mammalian cells. Nat. Biotechnol. 22 (2004) 1393-1398
    • (2004) Nat. Biotechnol. , vol.22 , pp. 1393-1398
    • Wurm, F.M.1
  • 43
    • 0035313135 scopus 로고    scopus 로고
    • Protein refolding for industrial processes
    • Clark E.D.B. Protein refolding for industrial processes. Curr. Opin. Biotechnol. 12 (2001) 202-207
    • (2001) Curr. Opin. Biotechnol. , vol.12 , pp. 202-207
    • Clark, E.D.B.1
  • 44
    • 0037015614 scopus 로고    scopus 로고
    • Genome sequence of the human malaria parasite Plasmodium falciparum
    • Gardner M.J., et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419 (2002) 498-511
    • (2002) Nature , vol.419 , pp. 498-511
    • Gardner, M.J.1
  • 45
    • 0035662309 scopus 로고    scopus 로고
    • Prediction of many new exons and introns in Plasmodium falciparum chromosome 2
    • Huestis R., and Fischer K. Prediction of many new exons and introns in Plasmodium falciparum chromosome 2. Mol. Biochem. Parasitol. 118 (2001) 187-199
    • (2001) Mol. Biochem. Parasitol. , vol.118 , pp. 187-199
    • Huestis, R.1    Fischer, K.2
  • 46
    • 10344245559 scopus 로고    scopus 로고
    • A host-targeting signal in virulence proteins reveals a secretome in malarial infection
    • Hiller N.L., et al. A host-targeting signal in virulence proteins reveals a secretome in malarial infection. Science 306 (2004) 1934-1937
    • (2004) Science , vol.306 , pp. 1934-1937
    • Hiller, N.L.1
  • 47
    • 10344250457 scopus 로고    scopus 로고
    • Targeting malaria virulence and remodeling proteins to the host erythrocyte
    • Marti M., et al. Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science 306 (2004) 1930-1933
    • (2004) Science , vol.306 , pp. 1930-1933
    • Marti, M.1
  • 48
    • 33646926281 scopus 로고    scopus 로고
    • Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites
    • Sargeant T.J., et al. Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites. Genome Biol. 7 (2006) R12
    • (2006) Genome Biol. , vol.7
    • Sargeant, T.J.1
  • 49
    • 0037474121 scopus 로고    scopus 로고
    • Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum
    • Foth B.J., et al. Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum. Science 299 (2003) 705-708
    • (2003) Science , vol.299 , pp. 705-708
    • Foth, B.J.1
  • 50
    • 32944465399 scopus 로고    scopus 로고
    • Malaria: new vaccines for old?
    • Waters A. Malaria: new vaccines for old?. Cell 124 (2006) 689-693
    • (2006) Cell , vol.124 , pp. 689-693
    • Waters, A.1
  • 51
    • 0014691965 scopus 로고
    • Action of malarial antibody in vitro
    • Cohen S., et al. Action of malarial antibody in vitro. Nature 223 (1969) 368-371
    • (1969) Nature , vol.223 , pp. 368-371
    • Cohen, S.1
  • 52
    • 0036205858 scopus 로고    scopus 로고
    • Immunoproteomics of Helicobacter pylori infection and relation to gastric disease
    • Haas G., et al. Immunoproteomics of Helicobacter pylori infection and relation to gastric disease. Proteomics 2 (2002) 313-324
    • (2002) Proteomics , vol.2 , pp. 313-324
    • Haas, G.1
  • 53
    • 18144424963 scopus 로고    scopus 로고
    • Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia
    • Havlasova J., et al. Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia. Proteomics 5 (2005) 2090-2103
    • (2005) Proteomics , vol.5 , pp. 2090-2103
    • Havlasova, J.1
  • 54
    • 42949093708 scopus 로고    scopus 로고
    • Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria
    • Osier F.H., et al. Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria. Infect. Immun. 76 (2008) 2240-2248
    • (2008) Infect. Immun. , vol.76 , pp. 2240-2248
    • Osier, F.H.1
  • 55
    • 51349132784 scopus 로고    scopus 로고
    • Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis
    • Ma F., et al. Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 13087-13092
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 13087-13092
    • Ma, F.1


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